{"id":"https://openalex.org/W2621700964","doi":"https://doi.org/10.1002/hon.2437_35","title":"L\u2010MIND: MOR208 COMBINED WITH LENALIDOMIDE (LEN) IN PATIENTS WITH RELAPSED OR REFRACTORY DIFFUSE LARGE B\u2010CELL LYMPHOMA (R\u2010R DLBCL) \u2013 A SINGLE\u2010ARM PHASE II STUDY","display_name":"L\u2010MIND: MOR208 COMBINED WITH LENALIDOMIDE (LEN) IN PATIENTS WITH RELAPSED OR REFRACTORY DIFFUSE LARGE B\u2010CELL LYMPHOMA (R\u2010R DLBCL) \u2013 A SINGLE\u2010ARM PHASE II STUDY","publication_year":2017,"publication_date":"2017-06-01","ids":{"openalex":"https://openalex.org/W2621700964","doi":"https://doi.org/10.1002/hon.2437_35","mag":"2621700964"},"language":"en","primary_location":{"id":"doi:10.1002/hon.2437_35","doi":"https://doi.org/10.1002/hon.2437_35","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hon.2437_35","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hon.2437_35","source":{"id":"https://openalex.org/S23714410","display_name":"Hematological Oncology","issn_l":"0278-0232","issn":["0278-0232","1099-1069"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematological Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hon.2437_35","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086354986","display_name":"Gilles A. Salles","orcid":"https://orcid.org/0000-0002-9541-8666","observed_orcids":["https://orcid.org/0000-0002-9541-8666"]},"institutions":[{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]},{"id":"https://openalex.org/I4210113288","display_name":"H\u00f4pital Lyon Sud","ror":"https://ror.org/023xgd207","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210113288"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"G. Salles","raw_affiliation_strings":["Service d'H\u00e9matologie, Hospices Civils de Lyon Centre Hospitalier Lyon Sud  Pierre B\u00e9nite France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'H\u00e9matologie, Hospices Civils de Lyon Centre Hospitalier Lyon Sud  Pierre B\u00e9nite France","institution_ids":["https://openalex.org/I4210100596","https://openalex.org/I4210113288"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048566051","display_name":"Eva M. Gonz\u00e1lez-Barca","orcid":"https://orcid.org/0000-0002-1323-1508","observed_orcids":["https://orcid.org/0000-0002-1323-1508"]},"institutions":[{"id":"https://openalex.org/I4210087039","display_name":"Institut d'Investigaci\u00f3 Biom\u00e9dica de Bellvitge","ror":"https://ror.org/0008xqs48","country_code":"ES","type":"facility","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210087039","https://openalex.org/I4210096656","https://openalex.org/I4210106543","https://openalex.org/I4210107147","https://openalex.org/I4210153292","https://openalex.org/I4387153040","https://openalex.org/I71999127"]},{"id":"https://openalex.org/I4210107147","display_name":"Institut Catal\u00e0 d'Oncologia","ror":"https://ror.org/01j1eb875","country_code":"ES","type":"government","lineage":["https://openalex.org/I4210107147"]},{"id":"https://openalex.org/I4210143012","display_name":"Duran i Reynals Hospital","ror":"https://ror.org/03qwghy04","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210143012"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"E. Gonz\u00e1lez Barca","raw_affiliation_strings":["Department of Hematology, Institut Catal\u00e1 d'Oncolog\u00eda Hospital Duran i Reynals, IDIBELL  Barcelona Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Institut Catal\u00e1 d'Oncolog\u00eda Hospital Duran i Reynals, IDIBELL  Barcelona Spain","institution_ids":["https://openalex.org/I4210087039","https://openalex.org/I4210107147","https://openalex.org/I4210143012"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102788725","display_name":"Wojciech J. Jurczak","orcid":"https://orcid.org/0000-0003-1879-8084","observed_orcids":["https://orcid.org/0000-0003-1879-8084"]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"W. Jurczak","raw_affiliation_strings":["Department of Hematology Jagiellonian University  Krak\u00f3w Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology Jagiellonian University  Krak\u00f3w Poland","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049135933","display_name":"A. M. Liberati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123105","display_name":"Azienda Ospedaliera S.Maria","ror":"https://ror.org/02t96cy48","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123105"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A.M. Liberati","raw_affiliation_strings":["SC Oncoematologia, Azienda Ospedaliera Santa Maria, Terni, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SC Oncoematologia, Azienda Ospedaliera Santa Maria, Terni, Italy","institution_ids":["https://openalex.org/I4210123105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061317839","display_name":"Johannes Duell","orcid":"https://orcid.org/0000-0001-6935-7997","observed_orcids":["https://orcid.org/0000-0001-6935-7997"]},"institutions":[{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Duell","raw_affiliation_strings":["Medizinische Klinik und Poliklinik II University Hospital of W\u00fcrzburg  W\u00fcrzburg Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik und Poliklinik II University Hospital of W\u00fcrzburg  W\u00fcrzburg Germany","institution_ids":["https://openalex.org/I4210126310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101865823","display_name":"Zsolt Nagy","orcid":"https://orcid.org/0000-0001-9756-5427","observed_orcids":["https://orcid.org/0000-0001-9756-5427"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Z. Nagy","raw_affiliation_strings":["First Department of Internal Medicine, Semmelweis University, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Semmelweis University, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023239518","display_name":"Tom\u00e1\u0161 Papaj\u00edk","orcid":"https://orcid.org/0000-0001-5779-1139","observed_orcids":["https://orcid.org/0000-0001-5779-1139"]},"institutions":[{"id":"https://openalex.org/I4210107161","display_name":"University Hospital Olomouc","ror":"https://ror.org/01jxtne23","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210107161"]},{"id":"https://openalex.org/I70703428","display_name":"Palack\u00fd University Olomouc","ror":"https://ror.org/04qxnmv42","country_code":"CZ","type":"education","lineage":["https://openalex.org/I70703428"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"T. Papaj\u00edk","raw_affiliation_strings":["Department of Hemato\u2010Oncology Palack\u00fd University Olomouc and the University Hospital Olomouc  Olomouc Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hemato\u2010Oncology Palack\u00fd University Olomouc and the University Hospital Olomouc  Olomouc Czech Republic","institution_ids":["https://openalex.org/I4210107161","https://openalex.org/I70703428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077504536","display_name":"Marc P.E. Andr\u00e9","orcid":"https://orcid.org/0000-0001-7101-810X","observed_orcids":["https://orcid.org/0000-0001-7101-810X"]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"M. Andre","raw_affiliation_strings":["Department of Hematology, Universit\u00e9 catholique de Louvain CHU UCL Namur  Yvoir Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Universit\u00e9 catholique de Louvain CHU UCL Namur  Yvoir Belgium","institution_ids":["https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014125875","display_name":"Nagesh Kalakonda","orcid":"https://orcid.org/0000-0002-5300-1360","observed_orcids":["https://orcid.org/0000-0002-5300-1360"]},"institutions":[{"id":"https://openalex.org/I2802775644","display_name":"Royal Liverpool University Hospital","ror":"https://ror.org/01ycr6b80","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802729160","https://openalex.org/I2802775644"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"N. Kalakonda","raw_affiliation_strings":["Department of Haematology, Royal Liverpool University Hospital, Liverpool, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Royal Liverpool University Hospital, Liverpool, UK","institution_ids":["https://openalex.org/I2802775644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046049357","display_name":"Martin H. Dreyling","orcid":"https://orcid.org/0000-0002-0358-5249","observed_orcids":["https://orcid.org/0000-0002-0358-5249"]},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Dreyling","raw_affiliation_strings":["Medizinische Klinik und Poliklinik III, University Hospital of LMU, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik und Poliklinik III, University Hospital of LMU, Munich, Germany","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091882595","display_name":"Pier Luigi Zinzani","orcid":"https://orcid.org/0000-0002-2112-2651","observed_orcids":["https://orcid.org/0000-0002-2112-2651"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P.L. Zinzani","raw_affiliation_strings":["Institute of Hematology \u201cL. e A. Ser\u00e0gnoli\u201d University of Bologna  Bologna Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Hematology \u201cL. e A. Ser\u00e0gnoli\u201d University of Bologna  Bologna Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007316044","display_name":"Sumeet Ambarkhane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I144094060","display_name":"MorphoSys (Germany)","ror":"https://ror.org/00ew7rg06","country_code":"DE","type":"company","lineage":["https://openalex.org/I144094060"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S. Ambarkhane","raw_affiliation_strings":["Clinical Development, MorphoSys AG, Planegg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Development, MorphoSys AG, Planegg, Germany","institution_ids":["https://openalex.org/I144094060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007901103","display_name":"Johannes Weirather","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I144094060","display_name":"MorphoSys (Germany)","ror":"https://ror.org/00ew7rg06","country_code":"DE","type":"company","lineage":["https://openalex.org/I144094060"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Weirather","raw_affiliation_strings":["Clinical Development, MorphoSys AG, Planegg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Development, MorphoSys AG, Planegg, Germany","institution_ids":["https://openalex.org/I144094060"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024389256","display_name":"Kami J. Maddocks","orcid":"https://orcid.org/0000-0001-8519-8404","observed_orcids":["https://orcid.org/0000-0001-8519-8404"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Maddocks","raw_affiliation_strings":["Department of Internal Medicine, Division of Hematology, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Hematology, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA","institution_ids":["https://openalex.org/I2799885155"]}]}],"institutions":[],"countries_distinct_count":10,"institutions_distinct_count":18,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":0.2654,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.60685993,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"35","issue":"S2","first_page":"51","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lenalidomide","display_name":"lenalidomide","score":0.9819999933242798},{"id":"https://openalex.org/keywords/diffuse-large-b-cell-lymphoma","display_name":"diffuse large B-cell lymphoma","score":0.9200000166893005},{"id":"https://openalex.org/keywords/relapsed-refractory-lymphoma","display_name":"relapsed/refractory lymphoma","score":0.9419999718666077},{"id":"https://openalex.org/keywords/overall-response-rate","display_name":"overall response rate","score":0.6389999985694885},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8709999918937683},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.5460000038146973},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.7129999995231628},{"id":"https://openalex.org/keywords/treatment-emergent-adverse-events","display_name":"treatment-emergent adverse events","score":0.7039999961853027},{"id":"https://openalex.org/keywords/rituximab-refractory-disease","display_name":"rituximab-refractory disease","score":0.7110000252723694},{"id":"https://openalex.org/keywords/cell-of-origin","display_name":"cell of origin","score":0.6010000109672546},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8092343807220459},{"id":"https://openalex.org/C2776063141","wikidata":"https://www.wikidata.org/wiki/Q425681","display_name":"Lenalidomide","level":3,"score":0.797563910484314},{"id":"https://openalex.org/C2778559949","wikidata":"https://www.wikidata.org/wiki/Q2626074","display_name":"Diffuse large B-cell lymphoma","level":3,"score":0.6171464920043945},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5779936909675598},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5637356638908386},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.5299416780471802},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.5127938389778137},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.47292807698249817},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.4478609263896942},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.43854591250419617},{"id":"https://openalex.org/C2776907518","wikidata":"https://www.wikidata.org/wiki/Q1734165","display_name":"Performance status","level":3,"score":0.41367512941360474},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4099922478199005},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.38793984055519104},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3803277611732483},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2601911723613739},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2548179626464844},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.18562591075897217},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/hon.2437_35","doi":"https://doi.org/10.1002/hon.2437_35","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hon.2437_35","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hon.2437_35","source":{"id":"https://openalex.org/S23714410","display_name":"Hematological Oncology","issn_l":"0278-0232","issn":["0278-0232","1099-1069"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematological Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1002/hon.2437_35","doi":"https://doi.org/10.1002/hon.2437_35","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hon.2437_35","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hon.2437_35","source":{"id":"https://openalex.org/S23714410","display_name":"Hematological Oncology","issn_l":"0278-0232","issn":["0278-0232","1099-1069"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematological Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2621700964.pdf","grobid_xml":"https://content.openalex.org/works/W2621700964.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2899239653","https://openalex.org/W2953058729","https://openalex.org/W2959649660","https://openalex.org/W2950927135","https://openalex.org/W7053361791","https://openalex.org/W2623935570","https://openalex.org/W2556811747","https://openalex.org/W2890781621","https://openalex.org/W2988395771","https://openalex.org/W2622798357"],"abstract_inverted_index":{"Introduction:":[0],"The":[1,168,268,325],"Fc-enhanced":[2],"CD19":[3],"antibody":[4],"MOR208":[5,21,50,114,160,328],"and":[6,22,29,47,93,130,190,194,200,258,293,334,344,355],"the":[7,45,172],"immunomodulatory":[8],"drug":[9],"LEN":[10,23,52,138,330],"have":[11,24],"demonstrated":[12],"single":[13],"agent":[14],"activity":[15,337],"in":[16,27,30,32,53,338],"patients":[17,54,214,233,300,339,347],"with":[18,55,64,312,340],"R-R":[19,56,65,341],"DLBCL.":[20,57,342],"shown":[25],"synergy":[26],"vitro":[28],"vivo":[31],"preclinical":[33],"lymphoma":[34,364],"models.":[35],"This":[36],"ongoing":[37],"phase":[38],"II":[39],"study":[40],"was":[41,207,226,308,321],"designed":[42],"to":[43,109,155,218,319],"assess":[44],"safety":[46,205],"efficacy":[48],"of":[49,62,113,127,145,159,187,198,211,232,238,327,346,353],"plus":[51,137,329],"Methods:":[58],"Patients":[59,148],">18":[60],"years":[61,228],"age":[63,225],"DLBCL,":[66],"ECOG":[67],"performance":[68],"status":[69],"0\u20132,":[70],"adequate":[71],"organ":[72],"function,":[73],"having":[74],"previously":[75],"received":[76,234],"at":[77,88],"least":[78,89],"1":[79,90],"but":[80],"not":[81,96],"more":[82],"than":[83],"3":[84,277],"prior":[85,217,236],"therapies,":[86],"including":[87],"CD20-targeting":[91],"regimen":[92],"who":[94],"are":[95,104,351],"candidates":[97],"for":[98],"autologous":[99],"stem":[100],"cell":[101,197,352],"transplant":[102],"(ASCT),":[103],"eligible.":[105],"Treatment":[106],"comprises":[107],"up":[108,154],"12,":[110],"28-day":[111],"cycles":[112,121,135,152,158],"12":[115,151,156,161],"mg/kg":[116,162],"IV,":[117,163],"administered":[118,141,164],"weekly":[119],"during":[120,134],"1\u20133":[122],"(loading":[123],"dose":[124],"day":[125],"4":[126],"cycle":[128],"1)":[129],"every":[131,165],"second":[132,166],"week":[133],"4\u201312":[136],"25":[139],"mg":[140],"po":[142],"days":[143],"1\u201321":[144],"each":[146],"cycle.":[147],"progression-free":[149,189],"after":[150],"receive":[153],"additional":[157],"week.":[167],"primary":[169],"endpoint":[170],"is":[171,331,348],"overall":[173,191],"response":[174,195,298,320],"rate":[175],"(ORR)":[176],"by":[177,196],"central":[178],"radiology":[179],"assessment.":[180],"Secondary":[181],"endpoints":[182],"include":[183],"disease":[184],"control,":[185],"duration":[186],"response,":[188],"survival,":[192],"safety,":[193],"origin":[199,354],"other":[201,356],"biomarkers.":[202],"A":[203],"preplanned":[204],"evaluation":[206],"undertaken.":[208],"Results:":[209],"31":[210],"80":[212],"planned":[213],"were":[215,280],"enrolled":[216],"data":[219],"cutoff":[220],"(3":[221],"January":[222],"2017).":[223],"Median":[224,317],"74":[227],"(range":[229],"47\u201382);":[230],"45%":[231],"\u22652":[235],"lines":[237],"therapy;":[239],"23%":[240],"had":[241,246,253,260],"rituximab":[242],"refractory":[243],"disease;":[244,251],"74%":[245],"Ann":[247],"Arbor":[248],"stage":[249],"\u2265III":[250],"65%":[252],"elevated":[254],"lactate":[255],"dehydrogenase":[256],"level,":[257],"52%":[259],"a":[261],"poor":[262],"revised":[263],"International":[264],"Prognostic":[265],"Index":[266],"(3\u20135).":[267],"most":[269],"common":[270],"treatment-emergent":[271],"adverse":[272],"events":[273],"(any":[274],"grade/grade":[275],"\u2265":[276],"[%":[278],"patients])":[279],"neutropenia":[281],"(39/26),":[282],"anemia":[283],"(23/0)":[284],"thrombocytopenia":[285],"(16/6),":[286],"infections":[287],"(26/10)":[288],"diarrhea":[289],"(13/0),":[290,292],"pyrexia":[291],"rashes":[294],"(13/6).":[295],"Of":[296],"26":[297],"evaluable":[299],"(median":[301],"follow-up":[302,345],"3.3":[303],"months),":[304],"ORR":[305],"(investigator":[306],"assessed)":[307],"58%":[309],"(15":[310],"patients),":[311],"7":[313],"(27%)":[314],"complete":[315],"responses.":[316],"time":[318],"1.8":[322],"months.":[323],"Conclusions:":[324],"combination":[326],"well":[332],"tolerated":[333],"shows":[335],"promising":[336],"Accrual":[343],"ongoing,":[349],"as":[350],"biomarker":[357],"analyses.":[358],"Keywords:":[359],"CD19;":[360],"diffuse":[361],"large":[362],"B-cell":[363],"(DLBCL);":[365],"lenalidomide.":[366]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2017-06-15T00:00:00"}