{"id":"https://openalex.org/W2621537573","doi":null,"title":"Ca2+ dysregulation mediated by presenilins in Familial Alzheimer's Disease: causing or modulating factor?","display_name":"Ca2+ dysregulation mediated by presenilins in Familial Alzheimer's Disease: causing or modulating factor?","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2621537573","mag":"2621537573"},"language":"en","primary_location":{"id":"pmh:oai:www.research.unipd.it:11577/119753","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11577/119753","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022357653","display_name":"Enrico Zampese","orcid":"https://orcid.org/0000-0002-8851-2566","observed_orcids":["https://orcid.org/0000-0002-8851-2566"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Enrico Zampese","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8851-2566","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Lucia Brunello","orcid":"https://orcid.org/0000-0002-1093-0557","observed_orcids":["https://orcid.org/0000-0002-1093-0557"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lucia Brunello","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1093-0557","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032894425","display_name":"Cristina Fasolato","orcid":"https://orcid.org/0000-0002-9816-7751","observed_orcids":["https://orcid.org/0000-0002-9816-7751"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cristina Fasolato","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9816-7751","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5029856776","display_name":"Paola Pizzo","orcid":"https://orcid.org/0000-0001-6077-3265","observed_orcids":["https://orcid.org/0000-0001-6077-3265"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paola Pizzo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6077-3265","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1171,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.47863791,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"3","issue":null,"first_page":"1","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/familial-alzheimer-s-disease","display_name":"familial Alzheimer's disease","score":0.9100000262260437},{"id":"https://openalex.org/keywords/presenilin-1","display_name":"presenilin 1","score":0.906000018119812},{"id":"https://openalex.org/keywords/psen2","display_name":"presenilin 2","score":1.0},{"id":"https://openalex.org/keywords/calcium-dysregulation","display_name":"calcium dysregulation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/calcium-homeostasis","display_name":"calcium homeostasis","score":0.871999979019165},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-calcium","display_name":"endoplasmic reticulum calcium","score":0.8980000019073486},{"id":"https://openalex.org/keywords/excitotoxicity","display_name":"excitotoxicity","score":0.8759999871253967},{"id":"https://openalex.org/keywords/mitochondrial-calcium-uptake","display_name":"mitochondrial calcium uptake","score":0.8669999837875366},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8059999942779541},{"id":"https://openalex.org/keywords/ad-pathogenesis","display_name":"AD pathogenesis","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C175344181","wikidata":"https://www.wikidata.org/wiki/Q907198","display_name":"Presenilin","level":4,"score":0.5827971696853638},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5575138330459595},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5101609230041504},{"id":"https://openalex.org/C2780194698","wikidata":"https://www.wikidata.org/wiki/Q6005429","display_name":"Immune dysregulation","level":3,"score":0.4174266457557678},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.40855488181114197},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.40440982580184937},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40186887979507446},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23518231511116028}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.research.unipd.it:11577/119753","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11577/119753","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2621537573","doi":null,"is_oa":false,"landing_page_url":"https://www.research.unipd.it/handle/11577/119753","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2979346464","https://openalex.org/W7036286541","https://openalex.org/W7096444596","https://openalex.org/W2583453912","https://openalex.org/W7000475496","https://openalex.org/W2061707053","https://openalex.org/W1995529305","https://openalex.org/W3002259709","https://openalex.org/W207852625","https://openalex.org/W2087733977"],"abstract_inverted_index":{"Ca2+,":[0],"one":[1,37],"of":[2,23,38,44,50,75,98,136,229],"the":[3,21,39,45,48,68,73,80,122,133,137,227,232],"major":[4],"intracellular":[5,117],"messengers,":[6],"plays":[7],"essential":[8],"roles":[9],"in":[10,20,33,60,72,90,115,161,183,185,203,219,223,247],"neuronal":[11,147],"development,":[12],"synaptic":[13],"transmission":[14],"and":[15,87,101,146,168,231],"plasticity,":[16],"as":[17,19,239],"well":[18],"regulation":[22],"metabolic":[24],"pathways.":[25,119],"A":[26],"perturbed":[27],"Ca2+":[28,99,118,134,158,166,198,217],"homeostasis":[29],"has":[30,176,200],"been":[31,94,106,201],"demonstrated":[32],"Alzheimer\u2019s":[34],"Disease":[35],"(AD),":[36],"most":[40],"devastating":[41],"neurological":[42],"disorder":[43],"elderly.":[46],"Although":[47],"majority":[49],"AD":[51,248],"cases":[52],"are":[53],"sporadic,":[54],"a":[55,61,109,191,240,244],"small":[56],"fraction":[57],"is":[58,152,221],"inherited":[59],"dominant":[62],"pattern":[63],"(Familial":[64],"AD,":[65],"FAD).":[66],"Of":[67],"three":[69],"genes":[70],"involved":[71],"pathogenesis":[74],"FAD,":[76],"two":[77],"code":[78],"for":[79,112,127],"ubiquitously":[81],"expressed":[82],"proteins":[83,114],"presenilin":[84],"(PS)":[85],"1":[86],"2.":[88],"Mutations":[89],"PSs":[91],"have":[92,105],"variably":[93],"correlated":[95],"to":[96,121,144,155,180,187],"alterations":[97],"signalling":[100],"different":[102,174],"molecular":[103],"targets":[104],"identified,":[107],"suggesting":[108],"physiological":[110],"role":[111],"these":[113,213],"multiple":[116],"According":[120],"renewed":[123],"\u201cCa2+":[124],"overload\u201d":[125],"hypothesis":[126],"FAD":[128,209,220],"pathogenesis,":[129],"PS":[130],"mutations":[131],"increase":[132],"content":[135,199],"endoplasmic":[138],"reticulum":[139],"(ER),":[140],"thus":[141,237],"sensitizing":[142],"neurons":[143],"excitotoxicity":[145],"degeneration.":[148],"The":[149],"latter":[150],"process":[151],"closely":[153],"linked":[154],"exaggerated":[156],"ER":[157,197],"release":[159],"that,":[160],"turn,":[162],"causes":[163],"abnormal":[164],"mitochondrial":[165],"uptake":[167],"cell":[169,233],"death.":[170],"New":[171],"evidence":[172],"from":[173],"groups":[175],"however":[177],"shown":[178],"exceptions":[179],"this":[181],"scenario:":[182],"fact,":[184],"addition":[186],"an":[188,195],"increased,":[189],"also":[190],"reduced,":[192],"or":[193,208],"even":[194],"unchanged,":[196],"described":[202],"cells":[204],"over-expressing":[205],"wild":[206],"type":[207,228],"mutant":[210],"PSs.":[211],"Altogether,":[212],"findings":[214],"suggest":[215],"that":[216],"dysregulation":[218],"variable":[222],"nature,":[224],"depending":[225],"on":[226],"mutation":[230],"model":[234],"under":[235],"investigation,":[236],"appearing":[238],"modulator":[241],"rather":[242],"than":[243],"causing":[245],"event":[246],"pathogenesis.":[249]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2017-06-15T00:00:00"}
