{"id":"https://openalex.org/W2620728448","doi":"https://doi.org/10.1021/acs.biochem.7b00403","title":"Time-Resolved Investigations of Heterobimetallic Cofactor Assembly in R2lox Reveal Distinct Mn/Fe Intermediates","display_name":"Time-Resolved Investigations of Heterobimetallic Cofactor Assembly in R2lox Reveal Distinct Mn/Fe Intermediates","publication_year":2017,"publication_date":"2017-06-02","ids":{"openalex":"https://openalex.org/W2620728448","doi":"https://doi.org/10.1021/acs.biochem.7b00403","mag":"2620728448","pmid":"https://pubmed.ncbi.nlm.nih.gov/28574263","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5680038"},"language":"en","primary_location":{"id":"doi:10.1021/acs.biochem.7b00403","doi":"https://doi.org/10.1021/acs.biochem.7b00403","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.biochem.7b00403","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5680038","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028627219","display_name":"Effie C. Kisgeropoulos","orcid":"https://orcid.org/0000-0003-1842-5691","observed_orcids":["https://orcid.org/0000-0003-1842-5691"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Effie K. Miller","raw_affiliation_strings":["Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","\u2020 Department of Chemistry and Biochemistry, \u2021 The Ohio State Biochemistry Program, and \u00a7 The Ohio State Biophysics Program, The Ohio State University, Columbus, Ohio 43210, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"\u2020 Department of Chemistry and Biochemistry, \u2021 The Ohio State Biochemistry Program, and \u00a7 The Ohio State Biophysics Program, The Ohio State University, Columbus, Ohio 43210, United States","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018864736","display_name":"Nicholas E. Trivelas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas E. Trivelas","raw_affiliation_strings":["Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","\u2020 Department of Chemistry and Biochemistry, \u2021 The Ohio State Biochemistry Program, and \u00a7 The Ohio State Biophysics Program, The Ohio State University, Columbus, Ohio 43210, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"\u2020 Department of Chemistry and Biochemistry, \u2021 The Ohio State Biochemistry Program, and \u00a7 The Ohio State Biophysics Program, The Ohio State University, Columbus, Ohio 43210, United States","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001224514","display_name":"Pearson T. Maugeri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pearson T. Maugeri","raw_affiliation_strings":["Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","\u2020 Department of Chemistry and Biochemistry, \u2021 The Ohio State Biochemistry Program, and \u00a7 The Ohio State Biophysics Program, The Ohio State University, Columbus, Ohio 43210, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"\u2020 Department of Chemistry and Biochemistry, \u2021 The Ohio State Biochemistry Program, and \u00a7 The Ohio State Biophysics Program, The Ohio State University, Columbus, Ohio 43210, United States","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043425353","display_name":"Elizabeth J. Blaesi","orcid":"https://orcid.org/0000-0003-2601-8367","observed_orcids":["https://orcid.org/0000-0003-2601-8367"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth J. Blaesi","raw_affiliation_strings":["Department\rof Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037354262","display_name":"Hannah S. Shafaat","orcid":"https://orcid.org/0000-0003-0793-4650","observed_orcids":["https://orcid.org/0000-0003-0793-4650"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hannah S. Shafaat","raw_affiliation_strings":["Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","\u2020 Department of Chemistry and Biochemistry, \u2021 The Ohio State Biochemistry Program, and \u00a7 The Ohio State Biophysics Program, The Ohio State University, Columbus, Ohio 43210, United States"],"raw_orcid":"https://orcid.org/0000-0003-0793-4650","affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"\u2020 Department of Chemistry and Biochemistry, \u2021 The Ohio State Biochemistry Program, and \u00a7 The Ohio State Biophysics Program, The Ohio State University, Columbus, Ohio 43210, United States","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5037354262"],"corresponding_institution_ids":["https://openalex.org/I130769515","https://openalex.org/I52357470"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.046,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.73983254,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"56","issue":"26","first_page":"3369","last_page":"3379"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2105","display_name":"Renewable Energy, Sustainability and the Environment"},"field":{"id":"https://openalex.org/fields/21","display_name":"Energy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reaction-mechanism","display_name":"reaction mechanism","score":0.6769999861717224},{"id":"https://openalex.org/keywords/electron-spin-resonance","display_name":"electron spin resonance","score":0.6840000152587891},{"id":"https://openalex.org/keywords/optical-absorption-spectroscopy","display_name":"optical absorption spectroscopy","score":0.609000027179718},{"id":"https://openalex.org/keywords/kinetic-modeling","display_name":"kinetic modeling","score":0.7289999723434448},{"id":"https://openalex.org/keywords/isotopic-substitution","display_name":"isotopic substitution","score":0.871999979019165}],"concepts":[{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.7839412689208984},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7407035231590271},{"id":"https://openalex.org/C187961010","wikidata":"https://www.wikidata.org/wiki/Q260463","display_name":"Electron paramagnetic resonance","level":2,"score":0.6327500939369202},{"id":"https://openalex.org/C2776910235","wikidata":"https://www.wikidata.org/wiki/Q18574","display_name":"Reactivity (psychology)","level":3,"score":0.6296678781509399},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.6210001111030579},{"id":"https://openalex.org/C2778074193","wikidata":"https://www.wikidata.org/wiki/Q3498942","display_name":"Carboxylate","level":2,"score":0.4888743758201599},{"id":"https://openalex.org/C139210041","wikidata":"https://www.wikidata.org/wiki/Q2145840","display_name":"Resonance (particle physics)","level":2,"score":0.4788793921470642},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.43943560123443604},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.4304351508617401},{"id":"https://openalex.org/C105768512","wikidata":"https://www.wikidata.org/wiki/Q7458208","display_name":"Reaction intermediate","level":3,"score":0.4290861487388611},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4194120168685913},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.29673925042152405},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.2227688431739807},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.20090946555137634},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08980026841163635},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C109214941","wikidata":"https://www.wikidata.org/wiki/Q18334","display_name":"Particle physics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001051","descriptor_name":"Apoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001051","descriptor_name":"Apoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001051","descriptor_name":"Apoenzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003067","descriptor_name":"Coenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003067","descriptor_name":"Coenzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004578","descriptor_name":"Electron Spin Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004795","descriptor_name":"Enzyme Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007503","descriptor_name":"Iron Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008345","descriptor_name":"Manganese","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008345","descriptor_name":"Manganese","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013053","descriptor_name":"Spectrophotometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041961","descriptor_name":"Deuterium Exchange Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056506","descriptor_name":"Geobacillus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/acs.biochem.7b00403","doi":"https://doi.org/10.1021/acs.biochem.7b00403","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.biochem.7b00403","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:28574263","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28574263","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Comparative Study"},{"id":"pmh:oai:europepmc.org:4979901","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5680038","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5680038","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5680038","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochemistry","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4979901","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5680038","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2482616649","display_name":"Cellular, molecular, and biochemical sciences training grant","funder_award_id":"T32GM086252","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G284592385","display_name":"Mechanisms of Radical Translocation in Class I Ribonucleotide Reductases","funder_award_id":"F32GM116353","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5225898439","display_name":"A Systems Biology Approach for Targeted Drug Discovery for Leishmaniasis","funder_award_id":"R21AI127582","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5356207468","display_name":null,"funder_award_id":"GM116353-01","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320309374","display_name":"Ohio State University","ror":"https://ror.org/00rs6vg23"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W105526937","https://openalex.org/W1172722524","https://openalex.org/W1967314547","https://openalex.org/W1979040032","https://openalex.org/W1986375296","https://openalex.org/W1986696172","https://openalex.org/W1991166835","https://openalex.org/W1998885514","https://openalex.org/W2001053812","https://openalex.org/W2006202862","https://openalex.org/W2006309936","https://openalex.org/W2007891637","https://openalex.org/W2010785482","https://openalex.org/W2013741926","https://openalex.org/W2016902958","https://openalex.org/W2018063951","https://openalex.org/W2032882299","https://openalex.org/W2035832119","https://openalex.org/W2036385366","https://openalex.org/W2036735919","https://openalex.org/W2041930594","https://openalex.org/W2044218686","https://openalex.org/W2044428152","https://openalex.org/W2045888308","https://openalex.org/W2049884621","https://openalex.org/W2055548616","https://openalex.org/W2056383496","https://openalex.org/W2060473826","https://openalex.org/W2070370981","https://openalex.org/W2070503573","https://openalex.org/W2077749836","https://openalex.org/W2082840768","https://openalex.org/W2084784543","https://openalex.org/W2087027286","https://openalex.org/W2129832199","https://openalex.org/W2134352877","https://openalex.org/W2148579806","https://openalex.org/W2149859312","https://openalex.org/W2218428609","https://openalex.org/W2330733544","https://openalex.org/W2337530796","https://openalex.org/W2403439780","https://openalex.org/W2417681284","https://openalex.org/W2463046758","https://openalex.org/W2575733432"],"related_works":["https://openalex.org/W4389022584","https://openalex.org/W2337530796","https://openalex.org/W3006049259","https://openalex.org/W2049884621","https://openalex.org/W2218428609","https://openalex.org/W2513389631","https://openalex.org/W2911479833","https://openalex.org/W3173948619","https://openalex.org/W4409717155","https://openalex.org/W2980181826"],"abstract_inverted_index":{"The":[0],"assembly":[1,97],"mechanism":[2,107],"of":[3,11,58,98],"the":[4,17,56,67,96,124,134],"Mn/Fe":[5,79,99,125],"ligand-binding":[6],"oxidases":[7],"(R2lox),":[8],"a":[9],"family":[10],"proteins":[12],"that":[13,31,111,123,140],"are":[14,47],"homologous":[15],"to":[16,60,72],"nonheme":[18],"diiron":[19,62],"carboxylate":[20],"enzymes,":[21],"has":[22,117],"been":[23,70,118],"investigated":[24],"using":[25],"time-resolved":[26],"techniques.":[27],"Multiple":[28],"heterobimetallic":[29],"intermediates":[30],"exhibit":[32],"unique":[33],"spectral":[34,82],"features,":[35],"including":[36],"visible":[37],"absorption":[38],"bands":[39],"and":[40,51,64,77,88],"exceptionally":[41],"broad":[42],"electron":[43],"paramagnetic":[44],"resonance":[45,53],"signatures,":[46],"observed":[48],"through":[49],"optical":[50],"magnetic":[52],"spectroscopies.":[54],"On":[55],"basis":[57],"comparison":[59],"known":[61],"species":[63],"model":[65],"compounds,":[66],"spectra":[68],"have":[69],"attributed":[71],"(\u03bc-peroxo)-Mn":[73],"III":[74,76],"/Fe":[75],"high-valent":[78],"species.":[80],"Global":[81],"analysis":[83],"coupled":[84],"with":[85,114],"isotopic":[86],"substitution":[87],"kinetic":[89],"modeling":[90],"reveals":[91],"elementary":[92],"rate":[93],"constants":[94],"for":[95,108,136],"R2lox":[100],"under":[101],"aerobic":[102],"conditions.":[103],"A":[104],"complete":[105],"reaction":[106],"cofactor":[109,126],"maturation":[110],"is":[112],"consistent":[113],"experimental":[115],"data":[116],"developed.":[119],"These":[120],"results":[121],"suggest":[122],"can":[127],"perform":[128],"direct":[129],"C\u2013H":[130],"bond":[131],"abstraction,":[132],"demonstrating":[133],"potential":[135],"potent":[137],"chemical":[138],"reactivity":[139],"remains":[141],"unexplored.":[142]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-06-09T00:00:00"}
