{"id":"https://openalex.org/W2620635945","doi":null,"title":"A polymer, microfluidic analyzer for mutation detection","display_name":"A polymer, microfluidic analyzer for mutation detection","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2620635945","mag":"2620635945"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.lsu.edu:biosci_pubs-1164","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.lsu.edu/biosci_pubs/165","pdf_url":null,"source":{"id":"https://openalex.org/S4210169993","display_name":"Civil War Book Review","issn_l":"1528-6592","issn":["1528-6592"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315936","host_organization_name":"Louisiana State University","host_organization_lineage":["https://openalex.org/P4310315936"],"host_organization_lineage_names":["Louisiana State University"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Publications","raw_type":"text"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036033512","display_name":"Tae Yoon Lee","orcid":"https://orcid.org/0000-0003-1139-6269","observed_orcids":["https://orcid.org/0000-0003-1139-6269"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lee, Tae Yoon","raw_affiliation_strings":["Louisiana State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Louisiana State University","institution_ids":["https://openalex.org/I121820613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075086208","display_name":"Kyudong Han","orcid":"https://orcid.org/0000-0001-6791-2408","observed_orcids":["https://orcid.org/0000-0001-6791-2408"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Han, Kyudong","raw_affiliation_strings":["Louisiana State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Louisiana State University","institution_ids":["https://openalex.org/I121820613"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Nikitopoulos, Dimitris E.","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikitopoulos, Dimitris E.","raw_affiliation_strings":["Louisiana State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Louisiana State University","institution_ids":["https://openalex.org/I121820613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038208939","display_name":"Steven A. Soper","orcid":"https://orcid.org/0000-0002-8292-7058","observed_orcids":["https://orcid.org/0000-0002-8292-7058"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Soper, Steven S.","raw_affiliation_strings":["Louisiana State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Louisiana State University","institution_ids":["https://openalex.org/I121820613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048181679","display_name":"Mark A. Batzer","orcid":"https://orcid.org/0000-0001-5699-863X","observed_orcids":["https://orcid.org/0000-0001-5699-863X"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Batzer, Mark A.","raw_affiliation_strings":["Louisiana State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Louisiana State University","institution_ids":["https://openalex.org/I121820613"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087283200","display_name":"Michael C. Murphy","orcid":"https://orcid.org/0000-0003-1108-3238","observed_orcids":["https://orcid.org/0000-0003-1108-3238"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Murphy, Michael C.","raw_affiliation_strings":["Louisiana State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Louisiana State University","institution_ids":["https://openalex.org/I121820613"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I121820613"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.37496915,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/point-mutation-detection","display_name":"point mutation detection","score":0.9399999976158142},{"id":"https://openalex.org/keywords/ligase-detection-reaction","display_name":"ligase detection reaction","score":0.9620000123977661},{"id":"https://openalex.org/keywords/modular-microfluidic-system","display_name":"modular microfluidic system","score":0.593999981880188},{"id":"https://openalex.org/keywords/colorectal-cancer-diagnosis","display_name":"colorectal cancer diagnosis","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.7241606712341309},{"id":"https://openalex.org/C158007255","wikidata":"https://www.wikidata.org/wiki/Q1055222","display_name":"Spectrum analyzer","level":2,"score":0.6379820108413696},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5164661407470703},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.44107481837272644},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3288196325302124},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.29904186725616455},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.26627323031425476},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21265360713005066},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1954185962677002},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14297756552696228},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.07826712727546692},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.lsu.edu:biosci_pubs-1164","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.lsu.edu/biosci_pubs/165","pdf_url":null,"source":{"id":"https://openalex.org/S4210169993","display_name":"Civil War Book Review","issn_l":"1528-6592","issn":["1528-6592"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315936","host_organization_name":"Louisiana State University","host_organization_lineage":["https://openalex.org/P4310315936"],"host_organization_lineage_names":["Louisiana State University"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Publications","raw_type":"text"},{"id":"pmh:oai:repository.lsu.edu:mechanical_engineering_pubs-2796","doi":null,"is_oa":false,"landing_page_url":"https://repository.lsu.edu/mechanical_engineering_pubs/1796","pdf_url":null,"source":{"id":"https://openalex.org/S4210169993","display_name":"Civil War Book Review","issn_l":"1528-6592","issn":["1528-6592"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315936","host_organization_name":"Louisiana State University","host_organization_lineage":["https://openalex.org/P4310315936"],"host_organization_lineage_names":["Louisiana State University"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Publications","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2763138759","https://openalex.org/W1969057700","https://openalex.org/W7021029300","https://openalex.org/W2007592621","https://openalex.org/W2549763438","https://openalex.org/W1964943245","https://openalex.org/W2101659207","https://openalex.org/W2155931474","https://openalex.org/W2002278365","https://openalex.org/W2110517222"],"abstract_inverted_index":{"Recognition":[0],"of":[1,7,17,20,82,97,121,127],"point":[2,34],"mutations":[3,35],"in":[4,22,36,74,129],"codon":[5],"12":[6],"the":[8,14,80,105,110,135,140],"K-ras":[9],"gene":[10],"is":[11],"useful":[12],"for":[13,79,90],"early":[15],"diagnosis":[16],"several":[18],"types":[19],"cancer":[21],"humans,":[23],"including":[24,49],"colorectal":[25],"cancer.":[26],"A":[27],"microfluidic":[28,51,64,112],"analyzer,":[29],"that":[30],"can":[31],"detect":[32],"low-abundance":[33],"human":[37],"genomic":[38],"DNA,":[39],"was":[40,70],"developed":[41,78],"using":[42,100,143],"a":[43,50,57,63,119],"modular":[44],"approach.":[45],"Each":[46],"functional":[47],"device,":[48],"polymerase":[52],"chain":[53],"reaction":[54,67],"(PCR)":[55],"reactor,":[56,61,69],"passive":[58],"diffusional":[59],"micromixer":[60],"and":[62,72,93],"ligase":[65],"detection":[66],"(LDR)":[68],"designed":[71],"fabricated":[73],"polycarbonate.":[75],"Interconnects":[76],"were":[77,116],"passage":[81],"analyte":[83],"between":[84],"reactors,":[85],"to":[86,94,103,124,138],"ensure":[87],"adequate":[88],"spacing":[89],"thermal":[91],"isolation":[92],"facilitate":[95],"assembly":[96],"these":[98],"reactors":[99],"adhesive":[101],"bonding":[102],"form":[104],"PCR/LDR":[106],"processing":[107],"system.":[108],"Using":[109],"polymer":[111],"system,":[113],"LDR":[114],"products":[115],"produced":[117],"from":[118],"mixture":[120],"mutant":[122],"DNA":[123],"wild":[125],"type":[126],"1:200":[128],"about":[130,133],"1":[131],"h,":[132],"half":[134],"time":[136],"needed":[137],"execute":[139],"same":[141],"protocol":[142],"conventional":[144],"instrumentation.":[145],"\u00a9":[146],"2009":[147],"CBMS.":[148]},"counts_by_year":[],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2025-10-10T00:00:00"}