{"id":"https://openalex.org/W2620525720","doi":"https://doi.org/10.1038/nrmicro.2017.42","title":"Persistent bacterial infections and persister cells","display_name":"Persistent bacterial infections and persister cells","publication_year":2017,"publication_date":"2017-05-22","ids":{"openalex":"https://openalex.org/W2620525720","doi":"https://doi.org/10.1038/nrmicro.2017.42","mag":"2620525720","pmid":"https://pubmed.ncbi.nlm.nih.gov/28529326"},"language":"en","primary_location":{"id":"doi:10.1038/nrmicro.2017.42","doi":"https://doi.org/10.1038/nrmicro.2017.42","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrmicro.2017.42","pdf_url":null,"source":{"id":"https://openalex.org/S56802129","display_name":"Nature Reviews Microbiology","issn_l":"1740-1526","issn":["1740-1526","1740-1534"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Microbiology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029834103","display_name":"Robert A. Fisher","orcid":"https://orcid.org/0000-0002-0387-290X","observed_orcids":["https://orcid.org/0000-0002-0387-290X"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Robert A. Fisher","raw_affiliation_strings":["MRC Centre for Molecular Bacteriology and Infection, Flowers Building, Armstrong Road, Imperial College London, London, SW7 2AZ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Centre for Molecular Bacteriology and Infection, Flowers Building, Armstrong Road, Imperial College London, London, SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110560818","display_name":"Bridget Gollan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Bridget Gollan","raw_affiliation_strings":["MRC Centre for Molecular Bacteriology and Infection, Flowers Building, Armstrong Road, Imperial College London, London, SW7 2AZ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Centre for Molecular Bacteriology and Infection, Flowers Building, Armstrong Road, Imperial College London, London, SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062018268","display_name":"Sophie H\u00e9laine","orcid":"https://orcid.org/0000-0002-9877-4180","observed_orcids":["https://orcid.org/0000-0002-9877-4180"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Sophie Helaine","raw_affiliation_strings":["MRC Centre for Molecular Bacteriology and Infection, Flowers Building, Armstrong Road, Imperial College London, London, SW7 2AZ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Centre for Molecular Bacteriology and Infection, Flowers Building, Armstrong Road, Imperial College London, London, SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5062018268"],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":null,"apc_paid":null,"fwci":10.1023,"has_fulltext":false,"cited_by_count":1247,"citation_normalized_percentile":{"value":0.99430524,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"15","issue":"8","first_page":"453","last_page":"464"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.013100000098347664,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/persister-cells","display_name":"persister cells","score":0.9010000228881836},{"id":"https://openalex.org/keywords/persistent-bacterial-infection","display_name":"persistent bacterial infection","score":0.9160000085830688},{"id":"https://openalex.org/keywords/antibiotic-tolerance","display_name":"antibiotic tolerance","score":0.9959999918937683},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.9110000133514404},{"id":"https://openalex.org/keywords/phenotypic-heterogeneity","display_name":"phenotypic heterogeneity","score":0.9369999766349792},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.6589999794960022},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.8849999904632568},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.699999988079071},{"id":"https://openalex.org/keywords/growth-arrest","display_name":"growth arrest","score":0.3580000102519989}],"concepts":[{"id":"https://openalex.org/C136622501","wikidata":"https://www.wikidata.org/wiki/Q6934671","display_name":"Multidrug tolerance","level":4,"score":0.9098796844482422},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8457422256469727},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.7310982942581177},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6568117737770081},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.5947974324226379},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.5586931109428406},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.5429584383964539},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5026326179504395},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.47947582602500916},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.4384496212005615},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3052825331687927},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.15133213996887207},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10709935426712036},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07263621687889099},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024901","descriptor_name":"Drug Resistance, Multiple, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1038/nrmicro.2017.42","doi":"https://doi.org/10.1038/nrmicro.2017.42","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrmicro.2017.42","pdf_url":null,"source":{"id":"https://openalex.org/S56802129","display_name":"Nature Reviews Microbiology","issn_l":"1740-1526","issn":["1740-1526","1740-1534"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Microbiology","raw_type":"journal-article"},{"id":"pmid:28529326","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28529326","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature reviews. Microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/53563","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10044/1/53563","pdf_url":null,"source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"464","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3417484844","display_name":"Centre for Molecular Bacteriology and Infection","funder_award_id":"MR/J006874/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G4226335755","display_name":"Persistent Salmonella infection: characterization of non-replicating bacteria and Toxin-Antitoxin module function","funder_award_id":"MR/M009629/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":155,"referenced_works":["https://openalex.org/W1528273806","https://openalex.org/W1604915411","https://openalex.org/W1629906295","https://openalex.org/W1666867306","https://openalex.org/W1725358412","https://openalex.org/W1745270175","https://openalex.org/W1786795173","https://openalex.org/W1792186902","https://openalex.org/W1899580745","https://openalex.org/W1915856409","https://openalex.org/W1926820725","https://openalex.org/W1934154653","https://openalex.org/W1940390013","https://openalex.org/W1962093706","https://openalex.org/W1965653329","https://openalex.org/W1968722509","https://openalex.org/W1969244937","https://openalex.org/W1974053222","https://openalex.org/W1974285350","https://openalex.org/W1975213539","https://openalex.org/W1980789775","https://openalex.org/W1981509058","https://openalex.org/W1982148012","https://openalex.org/W1982958351","https://openalex.org/W1983301189","https://openalex.org/W1985002373","https://openalex.org/W1989761771","https://openalex.org/W1990815901","https://openalex.org/W1991795415","https://openalex.org/W1992572387","https://openalex.org/W1996890828","https://openalex.org/W1999369806","https://openalex.org/W2003028136","https://openalex.org/W2007296377","https://openalex.org/W2008088946","https://openalex.org/W2008937743","https://openalex.org/W2011208940","https://openalex.org/W2012016148","https://openalex.org/W2015318086","https://openalex.org/W2015442594","https://openalex.org/W2015785632","https://openalex.org/W2016691753","https://openalex.org/W2017165733","https://openalex.org/W2019835759","https://openalex.org/W2021277836","https://openalex.org/W2024331073","https://openalex.org/W2034441019","https://openalex.org/W2039808886","https://openalex.org/W2041350348","https://openalex.org/W2041367172","https://openalex.org/W2043678651","https://openalex.org/W2044079597","https://openalex.org/W2044917835","https://openalex.org/W2048991954","https://openalex.org/W2051780892","https://openalex.org/W2056432511","https://openalex.org/W2061878956","https://openalex.org/W2062765174","https://openalex.org/W2063199331","https://openalex.org/W2065204248","https://openalex.org/W2065737889","https://openalex.org/W2067620134","https://openalex.org/W2069830287","https://openalex.org/W2070242840","https://openalex.org/W2072760254","https://openalex.org/W2073824449","https://openalex.org/W2075329036","https://openalex.org/W2075518131","https://openalex.org/W2076809355","https://openalex.org/W2078606044","https://openalex.org/W2081183202","https://openalex.org/W2085619657","https://openalex.org/W2087186232","https://openalex.org/W2088550607","https://openalex.org/W2089289014","https://openalex.org/W2090486365","https://openalex.org/W2090627629","https://openalex.org/W2093178459","https://openalex.org/W2093814623","https://openalex.org/W2094177464","https://openalex.org/W2095442519","https://openalex.org/W2096792353","https://openalex.org/W2100096695","https://openalex.org/W2100365268","https://openalex.org/W2100619015","https://openalex.org/W2101366952","https://openalex.org/W2105988740","https://openalex.org/W2107600014","https://openalex.org/W2107741098","https://openalex.org/W2110599421","https://openalex.org/W2111555302","https://openalex.org/W2111967267","https://openalex.org/W2114439673","https://openalex.org/W2114537906","https://openalex.org/W2114899090","https://openalex.org/W2115712103","https://openalex.org/W2117402223","https://openalex.org/W2122700664","https://openalex.org/W2123022837","https://openalex.org/W2126573196","https://openalex.org/W2130269036","https://openalex.org/W2134878069","https://openalex.org/W2135133274","https://openalex.org/W2136369541","https://openalex.org/W2138419639","https://openalex.org/W2141365940","https://openalex.org/W2141883227","https://openalex.org/W2141984091","https://openalex.org/W2142513910","https://openalex.org/W2142693274","https://openalex.org/W2144440398","https://openalex.org/W2148323109","https://openalex.org/W2148421484","https://openalex.org/W2149116450","https://openalex.org/W2153148799","https://openalex.org/W2153955036","https://openalex.org/W2156672979","https://openalex.org/W2158831027","https://openalex.org/W2159239386","https://openalex.org/W2165005601","https://openalex.org/W2167727944","https://openalex.org/W2168606178","https://openalex.org/W2171186968","https://openalex.org/W2171392588","https://openalex.org/W2239735144","https://openalex.org/W2276760947","https://openalex.org/W2298249827","https://openalex.org/W2312205455","https://openalex.org/W2318048689","https://openalex.org/W2319149979","https://openalex.org/W2323776798","https://openalex.org/W2324745658","https://openalex.org/W2336504120","https://openalex.org/W2336625825","https://openalex.org/W2341166238","https://openalex.org/W2343929623","https://openalex.org/W2346518485","https://openalex.org/W2346538456","https://openalex.org/W2415055120","https://openalex.org/W2417855243","https://openalex.org/W2513670426","https://openalex.org/W2523512393","https://openalex.org/W2530896984","https://openalex.org/W2536074408","https://openalex.org/W2539169413","https://openalex.org/W2547834298","https://openalex.org/W2554823382","https://openalex.org/W2562944419","https://openalex.org/W2586386056","https://openalex.org/W2586590237","https://openalex.org/W2592202891","https://openalex.org/W2592418271","https://openalex.org/W4211163608","https://openalex.org/W4213353716","https://openalex.org/W4255815110"],"related_works":["https://openalex.org/W4388982589","https://openalex.org/W4400748219","https://openalex.org/W2591498398","https://openalex.org/W2796472927","https://openalex.org/W3202476745","https://openalex.org/W4404409130","https://openalex.org/W2972649058","https://openalex.org/W2970914092","https://openalex.org/W2001382009","https://openalex.org/W2100053975"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":146},{"year":2025,"cited_by_count":163},{"year":2024,"cited_by_count":162},{"year":2023,"cited_by_count":162},{"year":2022,"cited_by_count":157},{"year":2021,"cited_by_count":140},{"year":2020,"cited_by_count":132},{"year":2019,"cited_by_count":97},{"year":2018,"cited_by_count":79},{"year":2017,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-06-05T00:00:00"}