{"id":"https://openalex.org/W2620249579","doi":"https://doi.org/10.1038/cddis.2017.12","title":"ADAR1-mediated 3\u2032 UTR editing and expression control of antiapoptosis genes fine-tunes cellular apoptosis response","display_name":"ADAR1-mediated 3\u2032 UTR editing and expression control of antiapoptosis genes fine-tunes cellular apoptosis response","publication_year":2017,"publication_date":"2017-05-25","ids":{"openalex":"https://openalex.org/W2620249579","doi":"https://doi.org/10.1038/cddis.2017.12","mag":"2620249579","pmid":"https://pubmed.ncbi.nlm.nih.gov/28542129"},"language":"en","primary_location":{"id":"doi:10.1038/cddis.2017.12","doi":"https://doi.org/10.1038/cddis.2017.12","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cddis.2017.12","pdf_url":"https://www.nature.com/articles/cddis201712.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/cddis201712.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020081789","display_name":"Chang\u2010Ching Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chang-Ching Yang","raw_affiliation_strings":["Department of Biomedical Sciences, College of Medicine, Chang Gung University, Kueishan, Taoyuan, Taiwan","Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Kueishan, Taoyuan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, College of Medicine, Chang Gung University, Kueishan, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]},{"raw_affiliation_string":"Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Kueishan, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076094624","display_name":"Yi\u2010Tung Chen","orcid":"https://orcid.org/0000-0001-9715-648X","observed_orcids":["https://orcid.org/0000-0001-9715-648X"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yi-Tung Chen","raw_affiliation_strings":["Department of Biomedical Sciences, College of Medicine, Chang Gung University, Kueishan, Taoyuan, Taiwan","Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Kueishan, Taoyuan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, College of Medicine, Chang Gung University, Kueishan, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]},{"raw_affiliation_string":"Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Kueishan, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018381751","display_name":"Yi-Feng Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yi-Feng Chang","raw_affiliation_strings":["Molecular Medicine Research Center, Chang Gung University, Kueishan, Taoyuan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Medicine Research Center, Chang Gung University, Kueishan, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038535929","display_name":"Hsuan Liu","orcid":"https://orcid.org/0000-0003-4691-2518","observed_orcids":["https://orcid.org/0000-0003-4691-2518","https://orcid.org/0000-0002-0806-7643"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210116208","display_name":"Linkou Chang Gung Memorial Hospital","ror":"https://ror.org/02dnn6q67","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970","https://openalex.org/I4210116208"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsuan Liu","raw_affiliation_strings":["Department of Biochemistry, College of Medicine, Chang Gung University, Kueishan, Taoyuan, Taiwan","Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan","Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Kueishan, Taoyuan, Taiwan","Molecular Medicine Research Center, Chang Gung University, Kueishan, Taoyuan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, College of Medicine, Chang Gung University, Kueishan, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]},{"raw_affiliation_string":"Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan","institution_ids":["https://openalex.org/I3020100970","https://openalex.org/I4210116208"]},{"raw_affiliation_string":"Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Kueishan, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]},{"raw_affiliation_string":"Molecular Medicine Research Center, Chang Gung University, Kueishan, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065257812","display_name":"Yu\u2010Ping Kuo","orcid":"https://orcid.org/0000-0002-3429-9982","observed_orcids":["https://orcid.org/0000-0002-3429-9982"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Ping Kuo","raw_affiliation_strings":["Department of Biomedical Sciences, College of Medicine, Chang Gung University, Kueishan, Taoyuan, Taiwan","Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Kueishan, Taoyuan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, College of Medicine, Chang Gung University, Kueishan, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]},{"raw_affiliation_string":"Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Kueishan, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032327984","display_name":"Chieh\u2010Tien Shih","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chieh-Tien Shih","raw_affiliation_strings":["Department of Biomedical Sciences, College of Medicine, Chang Gung University, Kueishan, Taoyuan, Taiwan","Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Kueishan, Taoyuan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, College of Medicine, Chang Gung University, Kueishan, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]},{"raw_affiliation_string":"Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Kueishan, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103121345","display_name":"Wei\u2010Chao Liao","orcid":"https://orcid.org/0000-0002-4737-2675","observed_orcids":["https://orcid.org/0000-0002-4737-2675"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wei-Chao Liao","raw_affiliation_strings":["Molecular Medicine Research Center, Chang Gung University, Kueishan, Taoyuan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Medicine Research Center, Chang Gung University, Kueishan, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007605702","display_name":"Hui\u2010Wen Chen","orcid":"https://orcid.org/0000-0002-0595-3420","observed_orcids":["https://orcid.org/0000-0002-0595-3420"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hui-Wen Chen","raw_affiliation_strings":["Department of Biomedical Sciences, College of Medicine, Chang Gung University, Kueishan, Taoyuan, Taiwan","Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Kueishan, Taoyuan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, College of Medicine, Chang Gung University, Kueishan, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]},{"raw_affiliation_string":"Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Kueishan, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034490079","display_name":"Wen\u2010Sy Tsai","orcid":"https://orcid.org/0000-0001-6873-2863","observed_orcids":["https://orcid.org/0000-0001-6873-2863"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210116208","display_name":"Linkou Chang Gung Memorial Hospital","ror":"https://ror.org/02dnn6q67","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970","https://openalex.org/I4210116208"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wen-Sy Tsai","raw_affiliation_strings":["Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan","Graduate Institute of Clinical Medical Science, College of Medicine, Chang Gung University, Kueishan, Taoyuan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan","institution_ids":["https://openalex.org/I3020100970","https://openalex.org/I4210116208"]},{"raw_affiliation_string":"Graduate Institute of Clinical Medical Science, College of Medicine, Chang Gung University, Kueishan, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088084981","display_name":"Bertrand Chin\u2010Ming Tan","orcid":"https://orcid.org/0000-0002-2218-7115","observed_orcids":["https://orcid.org/0000-0002-2218-7115"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210116208","display_name":"Linkou Chang Gung Memorial Hospital","ror":"https://ror.org/02dnn6q67","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970","https://openalex.org/I4210116208"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Bertrand Chin-Ming Tan","raw_affiliation_strings":["Department of Biomedical Sciences, College of Medicine, Chang Gung University, Kueishan, Taoyuan, Taiwan","Department of Neurosurgery, Lin-Kou Medical Center, Chang Gung Memorial Hospital, Linkou, Taiwan","Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Kueishan, Taoyuan, Taiwan","Molecular Medicine Research Center, Chang Gung University, Kueishan, Taoyuan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, College of Medicine, Chang Gung University, Kueishan, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]},{"raw_affiliation_string":"Department of Neurosurgery, Lin-Kou Medical Center, Chang Gung Memorial Hospital, Linkou, Taiwan","institution_ids":["https://openalex.org/I3020100970","https://openalex.org/I4210116208"]},{"raw_affiliation_string":"Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Kueishan, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]},{"raw_affiliation_string":"Molecular Medicine Research Center, Chang Gung University, Kueishan, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5088084981"],"corresponding_institution_ids":["https://openalex.org/I173093425","https://openalex.org/I3020100970","https://openalex.org/I4210116208"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":1.4559,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.81239623,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"8","issue":"5","first_page":"e2833","last_page":"e2833"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adar1","display_name":"ADAR1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/a-to-i-rna-editing","display_name":"A-to-I RNA editing","score":0.9100000262260437},{"id":"https://openalex.org/keywords/xiap","display_name":"XIAP","score":0.7960000038146973},{"id":"https://openalex.org/keywords/mdm2","display_name":"MDM2","score":1.0},{"id":"https://openalex.org/keywords/apoptosis-regulation","display_name":"apoptosis regulation","score":0.7609999775886536},{"id":"https://openalex.org/keywords/stau1","display_name":"STAU1","score":0.968999981880188},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/translation-efficiency","display_name":"translation efficiency","score":0.42500001192092896}],"concepts":[{"id":"https://openalex.org/C21786251","wikidata":"https://www.wikidata.org/wiki/Q14886350","display_name":"RNA editing","level":4,"score":0.8236156702041626},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7537459135055542},{"id":"https://openalex.org/C33195913","wikidata":"https://www.wikidata.org/wiki/Q20970121","display_name":"XIAP","level":5,"score":0.7032697200775146},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5337333083152771},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.5063515901565552},{"id":"https://openalex.org/C2191507","wikidata":"https://www.wikidata.org/wiki/Q7277185","display_name":"RNA silencing","level":5,"score":0.5006487369537354},{"id":"https://openalex.org/C89604277","wikidata":"https://www.wikidata.org/wiki/Q424345","display_name":"Untranslated region","level":4,"score":0.4939149022102356},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.465970516204834},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.44937023520469666},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.4428529739379883},{"id":"https://openalex.org/C2776192174","wikidata":"https://www.wikidata.org/wiki/Q18028978","display_name":"Mdm2","level":3,"score":0.43714362382888794},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4362668991088867},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4179905354976654},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39429253339767456},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.37713128328323364},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3222357928752899},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.18847519159317017},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.119749516248703},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.08289992809295654}],"mesh":[{"descriptor_ui":"D000243","descriptor_name":"Adenosine Deaminase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000243","descriptor_name":"Adenosine Deaminase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000243","descriptor_name":"Adenosine Deaminase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000243","descriptor_name":"Adenosine Deaminase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000243","descriptor_name":"Adenosine Deaminase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000243","descriptor_name":"Adenosine Deaminase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017393","descriptor_name":"RNA Editing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017393","descriptor_name":"RNA Editing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017393","descriptor_name":"RNA Editing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019610","descriptor_name":"Cytoprotection","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019610","descriptor_name":"Cytoprotection","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019610","descriptor_name":"Cytoprotection","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020087","descriptor_name":"Alu Elements","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020087","descriptor_name":"Alu Elements","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020087","descriptor_name":"Alu Elements","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020413","descriptor_name":"3' Untranslated Regions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020413","descriptor_name":"3' Untranslated Regions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020413","descriptor_name":"3' Untranslated Regions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034443","descriptor_name":"RNA Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034443","descriptor_name":"RNA Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034443","descriptor_name":"RNA Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051636","descriptor_name":"X-Linked Inhibitor of Apoptosis Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051636","descriptor_name":"X-Linked Inhibitor of Apoptosis Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051636","descriptor_name":"X-Linked Inhibitor of Apoptosis Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051736","descriptor_name":"Proto-Oncogene Proteins c-mdm2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051736","descriptor_name":"Proto-Oncogene Proteins c-mdm2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051736","descriptor_name":"Proto-Oncogene Proteins c-mdm2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056945","descriptor_name":"Hep G2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056945","descriptor_name":"Hep G2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056945","descriptor_name":"Hep G2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/cddis.2017.12","doi":"https://doi.org/10.1038/cddis.2017.12","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cddis.2017.12","pdf_url":"https://www.nature.com/articles/cddis201712.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"},{"id":"pmid:28542129","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28542129","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell death & disease","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5520689","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5520689","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Death Dis","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/cddis.2017.12","doi":"https://doi.org/10.1038/cddis.2017.12","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cddis.2017.12","pdf_url":"https://www.nature.com/articles/cddis201712.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.46810001134872437,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5699999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1052468712","display_name":null,"funder_award_id":"MOST 105-","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G1215496084","display_name":null,"funder_award_id":"2314-B-182","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G2204100926","display_name":"Functional Decoding of Development-Associated Rna Editomes---Skeletal Myogenesis as a Research Model","funder_award_id":"MOST104-2320-B182-029-MY3","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G4125000601","display_name":"Decoding the Cryptic Messages of Rna Recoding Events in Protein Functions and Developmental Processes: Tmem63b as an Example","funder_award_id":"MOST105-2314-B182-061-MY4","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G456520585","display_name":null,"funder_award_id":"MOST-103","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G6084538606","display_name":"Connecting Alterations in Genome, Proteome and Metabolomics to Explore Oscc Pathogenesis and Translational Medicine Potential( III )","funder_award_id":"MOST105-2632-B182-001","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G6333418398","display_name":"Comprehensive Profiling of Pathologically Relevant Exosomal Mirnas in Colorectal Cancer (Crc) and Functional Characterization: a Next-Generation Sequencing (Ngs)-Based Approach","funder_award_id":"MOST105-2320-B182-017","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G89566315","display_name":null,"funder_award_id":"EX105","funder_id":"https://openalex.org/F4320322845","funder_display_name":"National Health Research Institutes"}],"funders":[{"id":"https://openalex.org/F4320322767","display_name":"Chang Gung Medical Foundation","ror":"https://ror.org/02verss31"},{"id":"https://openalex.org/F4320322795","display_name":"Ministry of Science and Technology, Taiwan","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320322845","display_name":"National Health Research Institutes","ror":"https://ror.org/02r6fpx29"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2620249579.pdf","grobid_xml":"https://content.openalex.org/works/W2620249579.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1972257514","https://openalex.org/W1977627012","https://openalex.org/W1977957409","https://openalex.org/W1978974023","https://openalex.org/W1980599684","https://openalex.org/W1986923087","https://openalex.org/W1996713482","https://openalex.org/W1998642504","https://openalex.org/W2000418940","https://openalex.org/W2006462446","https://openalex.org/W2007249806","https://openalex.org/W2008476211","https://openalex.org/W2012800815","https://openalex.org/W2013132763","https://openalex.org/W2013733230","https://openalex.org/W2014008375","https://openalex.org/W2026313856","https://openalex.org/W2029728313","https://openalex.org/W2030837160","https://openalex.org/W2035653590","https://openalex.org/W2041676007","https://openalex.org/W2056530510","https://openalex.org/W2057129777","https://openalex.org/W2060270119","https://openalex.org/W2064718875","https://openalex.org/W2076961967","https://openalex.org/W2082726623","https://openalex.org/W2096979028","https://openalex.org/W2107920354","https://openalex.org/W2110076038","https://openalex.org/W2115221577","https://openalex.org/W2123497973","https://openalex.org/W2124521545","https://openalex.org/W2138825103","https://openalex.org/W2148923106","https://openalex.org/W2155139766","https://openalex.org/W2161556727","https://openalex.org/W2168420558","https://openalex.org/W2170786603","https://openalex.org/W2171233220"],"related_works":["https://openalex.org/W3032774863","https://openalex.org/W3027589383","https://openalex.org/W2156891661","https://openalex.org/W1532171675","https://openalex.org/W4285606978","https://openalex.org/W2909784611","https://openalex.org/W3027254392","https://openalex.org/W2944756943","https://openalex.org/W4289745435","https://openalex.org/W2063652063"],"abstract_inverted_index":{"Adenosine-to-inosine":[0],"RNA":[1,28,49,87,148,217],"editing":[2,50,95,218],"constitutes":[3],"a":[4,53,103,163,191],"crucial":[5],"component":[6],"of":[7,26,46,55,96,109,130,156,178,184,194,214,223],"the":[8,27,40,47,69,85,107,120,125,147,157,179,211,220,224],"cellular":[9],"transcriptome":[10],"and":[11,16,65,98,100,159,175,216,228,238],"critically":[12],"underpins":[13],"organism":[14],"survival":[15],"development.":[17],"While":[18],"recent":[19],"high-throughput":[20],"approaches":[21],"have":[22],"provided":[23,230],"comprehensive":[24],"documentation":[25],"editome,":[29],"its":[30],"functional":[31,79],"output":[32],"remains":[33],"mostly":[34],"unresolved,":[35],"particularly":[36],"for":[37,233],"events":[38],"in":[39,124,132,169,236],"non-coding":[41],"regions.":[42],"Gene":[43],"ontology":[44],"analysis":[45],"known":[48,212],"targets":[51,91],"unveiled":[52],"preponderance":[54],"genes":[56],"related":[57],"to":[58,152,219],"apoptosis":[59],"regulation,":[60],"among":[61],"which":[62],"proto-oncogenes":[63],"XIAP":[64,97,158],"MDM2":[66,160],"encode":[67],"two":[68],"most":[70],"abundantly":[71],"edited":[72],"transcripts.":[73,181],"To":[74],"further":[75,101],"decode":[76],"this":[77,92,201],"potential":[78],"connection,":[80],"here":[81],"we":[82,139],"showed":[83],"that":[84,141],"main":[86],"editor":[88],"ADAR1":[89,142,165,185,215],"directly":[90],"3'":[93,126],"UTR":[94,127],"MDM2,":[99],"exerts":[102],"negative":[104],"regulation":[105],"on":[106,204],"expression":[108,186,199],"their":[110],"protein":[111],"products.":[112],"This":[113],"post-transcriptional":[114],"silencing":[115],"role":[116],"was":[117],"mediated":[118],"via":[119],"inverted":[121],"Alu":[122],"elements":[123],"but":[128],"independent":[129],"alteration":[131],"transcript":[133,144],"stability":[134],"or":[135,187],"miRNA":[136],"targeting.":[137],"Rather,":[138],"discovered":[140],"competes":[143],"occupancy":[145],"with":[146],"shuttling":[149],"factor":[150],"STAU1":[151],"facilitate":[153],"nuclear":[154],"retention":[155],"mRNAs.":[161],"As":[162],"consequence,":[164],"may":[166],"acquire":[167],"functionality":[168],"part":[170],"by":[171],"conferring":[172],"spatial":[173],"distribution":[174],"translation":[176],"efficiency":[177],"target":[180],"Finally,":[182],"abrogation":[183],"catalytic":[188],"activity":[189],"elicited":[190],"XIAP-dependent":[192],"suppression":[193],"apoptotic":[195,226],"response,":[196],"whereas":[197],"ectopic":[198],"reversed":[200],"protective":[202],"effect":[203],"cell":[205],"death.":[206],"Together,":[207],"our":[208],"results":[209],"extended":[210],"functions":[213],"critical":[221],"fine-tuning":[222],"intracellular":[225],"signaling":[227],"also":[229],"mechanistic":[231],"explanation":[232],"ADAR1's":[234],"roles":[235],"development":[237],"tumorigenesis.":[239]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}
