{"id":"https://openalex.org/W2620176696","doi":"https://doi.org/10.4049/jimmunol.194.supp.140.15","title":"Selective ROCK2 inhibitor reverses experimental chronic graft-versus-host disease via concurrent regulation of STAT3/STAT5 phosphorylation (TRAN1P.933)","display_name":"Selective ROCK2 inhibitor reverses experimental chronic graft-versus-host disease via concurrent regulation of STAT3/STAT5 phosphorylation (TRAN1P.933)","publication_year":2015,"publication_date":"2015-05-01","ids":{"openalex":"https://openalex.org/W2620176696","doi":"https://doi.org/10.4049/jimmunol.194.supp.140.15","mag":"2620176696"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.194.supp.140.15","doi":"https://doi.org/10.4049/jimmunol.194.supp.140.15","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.194.supp.140.15","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017454682","display_name":"Alexandra Zanin\u2010Zhorov","orcid":"https://orcid.org/0000-0002-9807-7713","observed_orcids":["https://orcid.org/0000-0002-9807-7713"]},"institutions":[{"id":"https://openalex.org/I4387155476","display_name":"Kadmon Corporation (United States)","ror":"https://ror.org/0391bdf37","country_code":null,"type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210111804","https://openalex.org/I4387155476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra Zanin-Zhorov","raw_affiliation_strings":["Kadmon Research Institute , New York, NY","1Kadmon Research Institute, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kadmon Research Institute , New York, NY","institution_ids":["https://openalex.org/I4387155476"]},{"raw_affiliation_string":"1Kadmon Research Institute, New York, NY","institution_ids":["https://openalex.org/I4387155476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110237542","display_name":"Ryan P Flynn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan Flynn","raw_affiliation_strings":["Division of Blood and Marrow Transplantation, University of Minnesota , Minneapolis, MN","2Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Blood and Marrow Transplantation, University of Minnesota , Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"2Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014659694","display_name":"Leo Luznik","orcid":"https://orcid.org/0009-0005-7951-5190","observed_orcids":["https://orcid.org/0009-0005-7951-5190"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leo Luznik","raw_affiliation_strings":["Department of Oncology, Johns Hopkins Univ. Sch. of Med. , Baltimore, MD","3Department of Oncology, Johns Hopkins Univ. Sch. of Med., Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Johns Hopkins Univ. Sch. of Med. , Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"3Department of Oncology, Johns Hopkins Univ. Sch. of Med., Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076689903","display_name":"Melanie S. Nyuydzefe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387155476","display_name":"Kadmon Corporation (United States)","ror":"https://ror.org/0391bdf37","country_code":null,"type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210111804","https://openalex.org/I4387155476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"melanie Nyuydzefe","raw_affiliation_strings":["Kadmon Research Institute , New York, NY","1Kadmon Research Institute, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kadmon Research Institute , New York, NY","institution_ids":["https://openalex.org/I4387155476"]},{"raw_affiliation_string":"1Kadmon Research Institute, New York, NY","institution_ids":["https://openalex.org/I4387155476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045561472","display_name":"Angela Panoskaltsis\u2010Mortari","orcid":"https://orcid.org/0000-0003-1802-1785","observed_orcids":["https://orcid.org/0000-0003-1802-1785"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela Panoskaltsis-Mortari","raw_affiliation_strings":["Division of Blood and Marrow Transplantation, University of Minnesota , Minneapolis, MN","2Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Blood and Marrow Transplantation, University of Minnesota , Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"2Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101178695","display_name":"Jing Du","orcid":"https://orcid.org/0000-0002-9488-8092","observed_orcids":["https://orcid.org/0000-0002-9488-8092"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Du","raw_affiliation_strings":["Division of Blood and Marrow Transplantation, University of Minnesota , Minneapolis, MN","2Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Blood and Marrow Transplantation, University of Minnesota , Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"2Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063787986","display_name":"Katelyn Goodman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katelyn Goodman","raw_affiliation_strings":["Division of Blood and Marrow Transplantation, University of Minnesota , Minneapolis, MN","2Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Blood and Marrow Transplantation, University of Minnesota , Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"2Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004928669","display_name":"Jonathan M. Weiss","orcid":"https://orcid.org/0000-0002-4467-5611","observed_orcids":["https://orcid.org/0000-0002-4467-5611"]},"institutions":[{"id":"https://openalex.org/I4387155476","display_name":"Kadmon Corporation (United States)","ror":"https://ror.org/0391bdf37","country_code":null,"type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210111804","https://openalex.org/I4387155476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Weiss","raw_affiliation_strings":["Kadmon Research Institute , New York, NY","1Kadmon Research Institute, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kadmon Research Institute , New York, NY","institution_ids":["https://openalex.org/I4387155476"]},{"raw_affiliation_string":"1Kadmon Research Institute, New York, NY","institution_ids":["https://openalex.org/I4387155476"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wei Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387155476","display_name":"Kadmon Corporation (United States)","ror":"https://ror.org/0391bdf37","country_code":null,"type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210111804","https://openalex.org/I4387155476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Chen","raw_affiliation_strings":["Kadmon Research Institute , New York, NY","1Kadmon Research Institute, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kadmon Research Institute , New York, NY","institution_ids":["https://openalex.org/I4387155476"]},{"raw_affiliation_string":"1Kadmon Research Institute, New York, NY","institution_ids":["https://openalex.org/I4387155476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026510629","display_name":"Jonathan Stuart Serody","orcid":"https://orcid.org/0000-0003-4568-1092","observed_orcids":["https://orcid.org/0000-0003-4568-1092"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Serody","raw_affiliation_strings":["Cancer Center, University of North Carolina , Chapel Hill, NC","4Cancer Center, University of North Carolina, Chapel Hill, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, University of North Carolina , Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]},{"raw_affiliation_string":"4Cancer Center, University of North Carolina, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086464749","display_name":"Kelli P. A. MacDonald","orcid":"https://orcid.org/0000-0003-3451-4221","observed_orcids":["https://orcid.org/0000-0003-3451-4221"]},"institutions":[{"id":"https://openalex.org/I217937681","display_name":"QIMR Berghofer Medical Research Institute","ror":"https://ror.org/004y8wk30","country_code":"AU","type":"facility","lineage":["https://openalex.org/I217937681"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kelli MacDonald","raw_affiliation_strings":["The Queensland Institute of Medical Research , Brisbane, ACT ,","5The Queensland Institute of Medical Research, Brisbane, ACT, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Queensland Institute of Medical Research , Brisbane, ACT ,","institution_ids":["https://openalex.org/I217937681"]},{"raw_affiliation_string":"5The Queensland Institute of Medical Research, Brisbane, ACT, Australia","institution_ids":["https://openalex.org/I217937681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053083873","display_name":"Geoffrey R. Hill","orcid":"https://orcid.org/0000-0003-2994-0429","observed_orcids":["https://orcid.org/0000-0003-2994-0429"]},"institutions":[{"id":"https://openalex.org/I217937681","display_name":"QIMR Berghofer Medical Research Institute","ror":"https://ror.org/004y8wk30","country_code":"AU","type":"facility","lineage":["https://openalex.org/I217937681"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Geoffrey Hill","raw_affiliation_strings":["The Queensland Institute of Medical Research , Brisbane, ACT ,","5The Queensland Institute of Medical Research, Brisbane, ACT, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Queensland Institute of Medical Research , Brisbane, ACT ,","institution_ids":["https://openalex.org/I217937681"]},{"raw_affiliation_string":"5The Queensland Institute of Medical Research, Brisbane, ACT, Australia","institution_ids":["https://openalex.org/I217937681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061857523","display_name":"John J. O\u2019Shea","orcid":"https://orcid.org/0000-0002-6456-9752","observed_orcids":["https://orcid.org/0000-0002-6456-9752"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John O'Shea","raw_affiliation_strings":["National Institutes of Health , Bethesda, MD","6National Institutes of Health, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health , Bethesda, MD","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"6National Institutes of Health, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109904503","display_name":"Samuel D. Waksal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387155476","display_name":"Kadmon Corporation (United States)","ror":"https://ror.org/0391bdf37","country_code":null,"type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210111804","https://openalex.org/I4387155476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel Waksal","raw_affiliation_strings":["Kadmon Research Institute , New York, NY","1Kadmon Research Institute, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kadmon Research Institute , New York, NY","institution_ids":["https://openalex.org/I4387155476"]},{"raw_affiliation_string":"1Kadmon Research Institute, New York, NY","institution_ids":["https://openalex.org/I4387155476"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058268746","display_name":"Bruce R. Blazar","orcid":"https://orcid.org/0000-0002-9608-9841","observed_orcids":["https://orcid.org/0000-0002-9608-9841"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce Blazar","raw_affiliation_strings":["Division of Blood and Marrow Transplantation, University of Minnesota , Minneapolis, MN","2Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Blood and Marrow Transplantation, University of Minnesota , Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"2Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"194","issue":"1_Supplement","first_page":"140.15","last_page":"140.15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-graft-versus-host-disease","display_name":"chronic graft-versus-host disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/stat3-phosphorylation","display_name":"STAT3 phosphorylation","score":0.9070000052452087},{"id":"https://openalex.org/keywords/stat5-phosphorylation","display_name":"STAT5 phosphorylation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/il-21","display_name":"IL-21","score":0.9929999709129333},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":0.8949999809265137},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.8489999771118164},{"id":"https://openalex.org/keywords/germinal-center","display_name":"germinal center","score":0.9150000214576721},{"id":"https://openalex.org/keywords/t-cell-signaling","display_name":"T cell signaling","score":0.45100000500679016},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.4970000088214874},{"id":"https://openalex.org/keywords/rho-kinase","display_name":"Rho kinase","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C2779331819","wikidata":"https://www.wikidata.org/wiki/Q18034313","display_name":"ROCK2","level":4,"score":0.8317877054214478},{"id":"https://openalex.org/C2779391668","wikidata":"https://www.wikidata.org/wiki/Q4210018","display_name":"STAT5","level":3,"score":0.7686058282852173},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.6133290529251099},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6098874807357788},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47528496384620667},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.46622681617736816},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.45489755272865295},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43491077423095703},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.42996805906295776},{"id":"https://openalex.org/C201800478","wikidata":"https://www.wikidata.org/wiki/Q24721770","display_name":"Rho-associated protein kinase","level":3,"score":0.2816934585571289},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.17169228196144104}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.194.supp.140.15","doi":"https://doi.org/10.4049/jimmunol.194.supp.140.15","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.194.supp.140.15","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8100000023841858,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2917410143","https://openalex.org/W2039312480","https://openalex.org/W2041205265","https://openalex.org/W3087149089","https://openalex.org/W2013748221","https://openalex.org/W2082620866","https://openalex.org/W2620176696","https://openalex.org/W2092932197","https://openalex.org/W2796176973","https://openalex.org/W2130731768"],"abstract_inverted_index":{"Abstract":[0],"Rho-associated":[1],"kinase":[2],"2":[3],"(ROCK2)":[4],"was":[5,141],"recently":[6],"shown":[7],"to":[8,58,87,90,163],"be":[9],"implicated":[10],"in":[11,18,63,81,103,113,118,129,137,181,200],"regulation":[12,202],"of":[13,66,76,84,95,106,125,134,174,188,197,203,210],"IL-21":[14,45],"and":[15,20,28,46,78,115,185,206],"IL-17":[16],"secretion":[17,205],"mice":[19,86,96,148],"humans.":[21,130],"Here,":[22],"we":[23],"report":[24],"that":[25,147],"the":[26,64,82,104,122,164,172,195,208],"potent":[27],"highly":[29],"selective":[30],"ROCK2":[31,127,198,212],"inhibitor":[32],"KD025":[33,55,99,169],"effectively":[34,170],"reverses":[35],"an":[36,49],"established":[37],"chronic":[38],"graft-versus-host":[39],"(cGVHD)":[40],"murine":[41],"model":[42,140,177],"driven":[43],"by":[44,48,144,179],"characterized":[47,178],"aggressive":[50],"multiorgan":[51],"system":[52],"fibrotic":[53],"disease.":[54],"treatment":[56],"leads":[57],"a":[59,73,101,111],"dose":[60],"dependent":[61],"decrease":[62,102],"development":[65],"pathogenic":[67],"pulmonary":[68,160],"function":[69,161],"which":[70],"correlates":[71],"with":[72,98,110,150],"marked":[74],"reduction":[75,112],"antibody":[77],"collagen":[79],"deposition":[80],"lungs":[83],"treated":[85,97,189],"levels":[88],"comparable":[89,162],"non-cGVHD":[91],"controls.":[92,167],"The":[93,131],"spleens":[94],"had":[100,159],"frequency":[105],"germinal":[107],"centers":[108],"associated":[109],"STAT3":[114,135,152],"concurrent":[116],"increase":[117],"STAT5":[119],"phosphorylation,":[120],"supporting":[121],"molecular":[123],"mechanism":[124],"targeted":[126,211],"inhibition":[128,213],"critical":[132],"role":[133],"activation":[136],"this":[138],"cGVHD":[139,176,215],"further":[142],"confirmed":[143],"data":[145,193],"showing":[146],"transplanted":[149],"inducible":[151],"deficient":[153],"T":[154],"cells":[155,158],"or":[156],"BM":[157],"healthy":[165],"negative":[166],"Finally,":[168],"blocked":[171],"progression":[173],"sclerodermatous":[175],"improvements":[180],"weight":[182],"loss,":[183],"posture":[184],"skin":[186],"integrity":[187],"animals.":[190],"Together,":[191],"these":[192],"demonstrate":[194],"importance":[196],"signaling":[199],"STAT3-dependent":[201],"cytokine":[204],"highlight":[207],"potential":[209],"for":[214],"therapy.":[216]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}