{"id":"https://openalex.org/W2620137608","doi":"https://doi.org/10.1016/j.conb.2017.05.011","title":"Closing the gap: long-term presynaptic plasticity in brain function and disease","display_name":"Closing the gap: long-term presynaptic plasticity in brain function and disease","publication_year":2017,"publication_date":"2017-05-30","ids":{"openalex":"https://openalex.org/W2620137608","doi":"https://doi.org/10.1016/j.conb.2017.05.011","mag":"2620137608","pmid":"https://pubmed.ncbi.nlm.nih.gov/28570863","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5554717"},"language":"en","primary_location":{"id":"doi:10.1016/j.conb.2017.05.011","doi":"https://doi.org/10.1016/j.conb.2017.05.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.conb.2017.05.011","pdf_url":null,"source":{"id":"https://openalex.org/S120775027","display_name":"Current Opinion in Neurobiology","issn_l":"0959-4388","issn":["0959-4388","1873-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Neurobiology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC5554717","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020590226","display_name":"Hannah R. Monday","orcid":"https://orcid.org/0000-0003-3969-492X","observed_orcids":["https://orcid.org/0000-0003-3969-492X"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hannah R Monday","raw_affiliation_strings":["Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, United States","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030446679","display_name":"Pablo E. Castillo","orcid":"https://orcid.org/0000-0002-9834-1801","observed_orcids":["https://orcid.org/0000-0002-9834-1801"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pablo E Castillo","raw_affiliation_strings":["Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, United States. Electronic address: pablo.castillo@einstein.yu.edu","Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, United States. Electronic address: pablo.castillo@einstein.yu.edu","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, United States","institution_ids":["https://openalex.org/I129975664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5030446679"],"corresponding_institution_ids":["https://openalex.org/I129975664"],"apc_list":{"value":4320,"currency":"USD","value_usd":4320},"apc_paid":null,"fwci":0.822,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.60906516,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"45","issue":null,"first_page":"106","last_page":"112"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/presynaptic-plasticity","display_name":"presynaptic plasticity","score":0.9729999899864197},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.8600000143051147},{"id":"https://openalex.org/keywords/neurotransmitter-release","display_name":"neurotransmitter release","score":0.9340000152587891},{"id":"https://openalex.org/keywords/long-term-plasticity","display_name":"long-term plasticity","score":0.6840000152587891},{"id":"https://openalex.org/keywords/bidirectional-plasticity","display_name":"bidirectional plasticity","score":0.7300000190734863},{"id":"https://openalex.org/keywords/synaptopathy","display_name":"synaptopathy","score":0.7770000100135803},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.9879999756813049},{"id":"https://openalex.org/keywords/addiction","display_name":"addiction","score":0.9959999918937683},{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.8870000243186951},{"id":"https://openalex.org/keywords/neuromodulation","display_name":"neuromodulation","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.8205444812774658},{"id":"https://openalex.org/C194973443","wikidata":"https://www.wikidata.org/wiki/Q1420291","display_name":"Metaplasticity","level":4,"score":0.790271520614624},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.660336434841156},{"id":"https://openalex.org/C5687787","wikidata":"https://www.wikidata.org/wiki/Q5889850","display_name":"Homeostatic plasticity","level":5,"score":0.5962650775909424},{"id":"https://openalex.org/C26410512","wikidata":"https://www.wikidata.org/wiki/Q3906363","display_name":"Nonsynaptic plasticity","level":5,"score":0.5870038270950317},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.582936704158783},{"id":"https://openalex.org/C79186407","wikidata":"https://www.wikidata.org/wiki/Q472074","display_name":"Plasticity","level":2,"score":0.5768285393714905},{"id":"https://openalex.org/C83119035","wikidata":"https://www.wikidata.org/wiki/Q17030659","display_name":"Homosynaptic plasticity","level":5,"score":0.5518737435340881},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.550340473651886},{"id":"https://openalex.org/C86878447","wikidata":"https://www.wikidata.org/wiki/Q5266812","display_name":"Developmental plasticity","level":3,"score":0.5358615517616272},{"id":"https://openalex.org/C117718741","wikidata":"https://www.wikidata.org/wiki/Q7662041","display_name":"Synaptic scaling","level":5,"score":0.5284507274627686},{"id":"https://openalex.org/C159919123","wikidata":"https://www.wikidata.org/wiki/Q7577157","display_name":"Spike-timing-dependent plasticity","level":4,"score":0.4365558922290802},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3998318016529083},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3575754165649414},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.27170002460479736},{"id":"https://openalex.org/C95293801","wikidata":"https://www.wikidata.org/wiki/Q7662035","display_name":"Synaptic augmentation","level":4,"score":0.22934365272521973},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.16178229451179504},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017729","descriptor_name":"Presynaptic Terminals","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.conb.2017.05.011","doi":"https://doi.org/10.1016/j.conb.2017.05.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.conb.2017.05.011","pdf_url":null,"source":{"id":"https://openalex.org/S120775027","display_name":"Current Opinion in Neurobiology","issn_l":"0959-4388","issn":["0959-4388","1873-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Neurobiology","raw_type":"journal-article"},{"id":"pmid:28570863","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28570863","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in neurobiology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5018519","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5554717","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5554717","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5554717","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Neurobiol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5018519","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5554717","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6529170049","display_name":"Presynaptic forms of long-term plasticity in the CNS","funder_award_id":"R01DA017392","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G6756513870","display_name":"Activity-dependent synaptic plasticity expressed by NMDARs","funder_award_id":"R01MH081935","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":81,"referenced_works":["https://openalex.org/W226968899","https://openalex.org/W1168911763","https://openalex.org/W1484560798","https://openalex.org/W1533589220","https://openalex.org/W1588711699","https://openalex.org/W1909310686","https://openalex.org/W1964400547","https://openalex.org/W1985878543","https://openalex.org/W1986172894","https://openalex.org/W1991182470","https://openalex.org/W1993386709","https://openalex.org/W1997619755","https://openalex.org/W2000274925","https://openalex.org/W2008792865","https://openalex.org/W2013364818","https://openalex.org/W2016174164","https://openalex.org/W2016756702","https://openalex.org/W2024613165","https://openalex.org/W2026717174","https://openalex.org/W2031926980","https://openalex.org/W2034086077","https://openalex.org/W2034643906","https://openalex.org/W2036581163","https://openalex.org/W2039953940","https://openalex.org/W2040301525","https://openalex.org/W2041018266","https://openalex.org/W2042613656","https://openalex.org/W2044129894","https://openalex.org/W2045281865","https://openalex.org/W2045927851","https://openalex.org/W2049146547","https://openalex.org/W2051609565","https://openalex.org/W2057195252","https://openalex.org/W2059358487","https://openalex.org/W2060647065","https://openalex.org/W2061955146","https://openalex.org/W2065034289","https://openalex.org/W2083844864","https://openalex.org/W2084743064","https://openalex.org/W2086896638","https://openalex.org/W2089736335","https://openalex.org/W2106214171","https://openalex.org/W2112475172","https://openalex.org/W2113064032","https://openalex.org/W2113068318","https://openalex.org/W2113658726","https://openalex.org/W2115750331","https://openalex.org/W2124165589","https://openalex.org/W2131485156","https://openalex.org/W2133582447","https://openalex.org/W2135286498","https://openalex.org/W2136974683","https://openalex.org/W2137087019","https://openalex.org/W2138805659","https://openalex.org/W2142948853","https://openalex.org/W2145656910","https://openalex.org/W2146732533","https://openalex.org/W2165151662","https://openalex.org/W2167916157","https://openalex.org/W2195210638","https://openalex.org/W2207017804","https://openalex.org/W2229474614","https://openalex.org/W2230836247","https://openalex.org/W2290470375","https://openalex.org/W2346053509","https://openalex.org/W2346454019","https://openalex.org/W2346619804","https://openalex.org/W2410082173","https://openalex.org/W2440302195","https://openalex.org/W2463983240","https://openalex.org/W2469872342","https://openalex.org/W2511348936","https://openalex.org/W2517512733","https://openalex.org/W2527920703","https://openalex.org/W2535255747","https://openalex.org/W2536391716","https://openalex.org/W2537787732","https://openalex.org/W2577961466","https://openalex.org/W2614847871","https://openalex.org/W4285719527","https://openalex.org/W6983794798"],"related_works":["https://openalex.org/W2800557840","https://openalex.org/W2000274925","https://openalex.org/W7097762261","https://openalex.org/W2133971320","https://openalex.org/W2349606236","https://openalex.org/W1508126093","https://openalex.org/W2107000947","https://openalex.org/W2004341780","https://openalex.org/W173814335","https://openalex.org/W1967075253"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":11}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-06-05T00:00:00"}