{"id":"https://openalex.org/W2620137489","doi":"https://doi.org/10.1007/978-3-319-59876-5_60","title":"Retinal Biomarkers of Alzheimer\u2019s Disease: Insights from Transgenic Mouse Models","display_name":"Retinal Biomarkers of Alzheimer\u2019s Disease: Insights from Transgenic Mouse Models","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2620137489","doi":"https://doi.org/10.1007/978-3-319-59876-5_60","mag":"2620137489"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-319-59876-5_60","doi":"https://doi.org/10.1007/978-3-319-59876-5_60","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-319-59876-5_60","pdf_url":null,"source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2617986283","display_name":"Image Analysis and Recognition"},"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10400.2/7102","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064063105","display_name":"Rui Bernardes","orcid":"https://orcid.org/0000-0002-6677-2754","observed_orcids":["https://orcid.org/0000-0002-6677-2754"]},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Rui Bernardes","raw_affiliation_strings":["Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), ICNAS, University of Coimbra, Coimbra, Portugal","Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), ICNAS, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043880995","display_name":"Gilberto Tadeu Reis da Silva","orcid":"https://orcid.org/0000-0002-0595-0780","observed_orcids":["https://orcid.org/0000-0002-0595-0780"]},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Gilberto Silva","raw_affiliation_strings":["Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044431902","display_name":"Samuel Chiquita","orcid":"https://orcid.org/0000-0001-6578-3251","observed_orcids":["https://orcid.org/0000-0001-6578-3251"]},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Samuel Chiquita","raw_affiliation_strings":["Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003891187","display_name":"Pedro Serranho","orcid":"https://orcid.org/0000-0003-2176-3923","observed_orcids":["https://orcid.org/0000-0003-2176-3923"]},"institutions":[{"id":"https://openalex.org/I201025148","display_name":"Universidade Aberta","ror":"https://ror.org/02rv3w387","country_code":"PT","type":"education","lineage":["https://openalex.org/I201025148"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Pedro Serranho","raw_affiliation_strings":["Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), ICNAS, University of Coimbra, Coimbra, Portugal","Department of Sciences and Technology, Universidade Aberta, Lisboa, Portugal","Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), ICNAS, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Department of Sciences and Technology, Universidade Aberta, Lisboa, Portugal","institution_ids":["https://openalex.org/I201025148"]},{"raw_affiliation_string":"Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075909802","display_name":"Ant\u00f3nio Francisco Ambr\u00f3sio","orcid":"https://orcid.org/0000-0002-0477-1641","observed_orcids":["https://orcid.org/0000-0002-0477-1641"]},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Ant\u00f3nio Francisco Ambr\u00f3sio","raw_affiliation_strings":["Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5064063105"],"corresponding_institution_ids":["https://openalex.org/I76903346"],"apc_list":{"value":5000,"currency":"EUR","value_usd":5392},"apc_paid":null,"fwci":4.0671,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.95217966,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"541","last_page":"550"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.08009999990463257,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9869999885559082},{"id":"https://openalex.org/keywords/retinal-biomarkers","display_name":"retinal biomarkers","score":0.9940000176429749},{"id":"https://openalex.org/keywords/transgenic-mouse-model","display_name":"transgenic mouse model","score":0.9449999928474426},{"id":"https://openalex.org/keywords/optical-coherence-tomography","display_name":"optical coherence tomography","score":0.9279999732971191},{"id":"https://openalex.org/keywords/retinal-imaging","display_name":"retinal imaging","score":0.7229999899864197},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"support vector machine","score":0.7580000162124634},{"id":"https://openalex.org/keywords/gaussian-kernel","display_name":"Gaussian kernel","score":0.7860000133514404},{"id":"https://openalex.org/keywords/disease-classification","display_name":"disease classification","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.8275249004364014},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.684760570526123},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.6144511699676514},{"id":"https://openalex.org/C2776391266","wikidata":"https://www.wikidata.org/wiki/Q9612","display_name":"Fundus (uterus)","level":2,"score":0.582012951374054},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.47446519136428833},{"id":"https://openalex.org/C2778818243","wikidata":"https://www.wikidata.org/wiki/Q899552","display_name":"Optical coherence tomography","level":2,"score":0.4593084752559662},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.41783440113067627},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4129420816898346},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.397991418838501},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37665069103240967},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.36097991466522217},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.3327617049217224},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31801921129226685},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.261709064245224},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/978-3-319-59876-5_60","doi":"https://doi.org/10.1007/978-3-319-59876-5_60","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-319-59876-5_60","pdf_url":null,"source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"},{"id":"pmh:oai:repositorioaberto.uab.pt:10400.2/7102","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10400.2/7102","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"conference object"}],"best_oa_location":{"id":"pmh:oai:repositorioaberto.uab.pt:10400.2/7102","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10400.2/7102","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"conference object"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W119623630","https://openalex.org/W239547030","https://openalex.org/W1567125428","https://openalex.org/W1574975037","https://openalex.org/W1818874142","https://openalex.org/W1967375871","https://openalex.org/W1980541833","https://openalex.org/W2056064381","https://openalex.org/W2076100143","https://openalex.org/W2081232564","https://openalex.org/W2084100156","https://openalex.org/W2100756624","https://openalex.org/W2105593439","https://openalex.org/W2127318120","https://openalex.org/W2164774194","https://openalex.org/W2222655853","https://openalex.org/W2278413365","https://openalex.org/W2418802570","https://openalex.org/W2531924552","https://openalex.org/W2800115878","https://openalex.org/W4205687621","https://openalex.org/W4242738387","https://openalex.org/W4247537352"],"related_works":["https://openalex.org/W2904923493","https://openalex.org/W4226246119","https://openalex.org/W3163012737","https://openalex.org/W4285029151","https://openalex.org/W3184265569","https://openalex.org/W4312080966","https://openalex.org/W4283028911","https://openalex.org/W4291004587","https://openalex.org/W3154777360","https://openalex.org/W2976339812"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-06-05T00:00:00"}