{"id":"https://openalex.org/W2619829249","doi":"https://doi.org/10.1038/nchem.2782","title":"A reductive aminase from Aspergillus oryzae","display_name":"A reductive aminase from Aspergillus oryzae","publication_year":2017,"publication_date":"2017-05-29","ids":{"openalex":"https://openalex.org/W2619829249","doi":"https://doi.org/10.1038/nchem.2782","mag":"2619829249","pmid":"https://pubmed.ncbi.nlm.nih.gov/28937665"},"language":"en","primary_location":{"id":"doi:10.1038/nchem.2782","doi":"https://doi.org/10.1038/nchem.2782","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nchem.2782","pdf_url":null,"source":{"id":"https://openalex.org/S202193212","display_name":"Nature Chemistry","issn_l":"1755-4330","issn":["1755-4330","1755-4349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://eprints.whiterose.ac.uk/id/eprint/117344/1/Grogan_Nature_Chem_Accepted_Manuscript.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082562695","display_name":"Godwin A. Aleku","orcid":"https://orcid.org/0000-0003-0969-5526","observed_orcids":["https://orcid.org/0000-0003-0969-5526"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Godwin A. Aleku","raw_affiliation_strings":["School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester M1 7DN, UK","School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester, M1 7DN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester M1 7DN, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester, M1 7DN, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082058174","display_name":"Scott P. France","orcid":"https://orcid.org/0000-0003-1679-6165","observed_orcids":["https://orcid.org/0000-0003-1679-6165"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Scott P. France","raw_affiliation_strings":["School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester M1 7DN, UK","School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester, M1 7DN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester M1 7DN, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester, M1 7DN, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113715270","display_name":"Henry Man","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52099693","display_name":"University of York","ror":"https://ror.org/04m01e293","country_code":"GB","type":"education","lineage":["https://openalex.org/I52099693"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Henry Man","raw_affiliation_strings":["York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK","Department of Chemistry, York Structural Biology Laboratory, University of York, Heslington, YO10 5DD, York, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK","institution_ids":["https://openalex.org/I52099693"]},{"raw_affiliation_string":"Department of Chemistry, York Structural Biology Laboratory, University of York, Heslington, YO10 5DD, York, UK","institution_ids":["https://openalex.org/I52099693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030110881","display_name":"Juan Mangas\u2010S\u00e1nchez","orcid":"https://orcid.org/0000-0002-3364-1512","observed_orcids":["https://orcid.org/0000-0002-3364-1512"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Juan Mangas-Sanchez","raw_affiliation_strings":["School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester M1 7DN, UK","School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester, M1 7DN, UK"],"raw_orcid":"https://orcid.org/0000-0002-3364-1512","affiliations":[{"raw_affiliation_string":"School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester M1 7DN, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester, M1 7DN, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026316102","display_name":"Sarah L. Montgomery","orcid":"https://orcid.org/0000-0003-3703-4338","observed_orcids":["https://orcid.org/0000-0003-3703-4338"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sarah L. Montgomery","raw_affiliation_strings":["School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester M1 7DN, UK","School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester, M1 7DN, UK"],"raw_orcid":"https://orcid.org/0000-0003-3703-4338","affiliations":[{"raw_affiliation_string":"School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester M1 7DN, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester, M1 7DN, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003708026","display_name":"Mahima Sharma","orcid":"https://orcid.org/0000-0003-3960-2212","observed_orcids":["https://orcid.org/0000-0003-3960-2212"]},"institutions":[{"id":"https://openalex.org/I52099693","display_name":"University of York","ror":"https://ror.org/04m01e293","country_code":"GB","type":"education","lineage":["https://openalex.org/I52099693"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mahima Sharma","raw_affiliation_strings":["York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK","Department of Chemistry, York Structural Biology Laboratory, University of York, Heslington, YO10 5DD, York, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK","institution_ids":["https://openalex.org/I52099693"]},{"raw_affiliation_string":"Department of Chemistry, York Structural Biology Laboratory, University of York, Heslington, YO10 5DD, York, UK","institution_ids":["https://openalex.org/I52099693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066439204","display_name":"Friedemann Leipold","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Friedemann Leipold","raw_affiliation_strings":["School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester M1 7DN, UK","School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester, M1 7DN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester M1 7DN, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester, M1 7DN, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042327231","display_name":"Shahed Hussain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Shahed Hussain","raw_affiliation_strings":["School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester M1 7DN, UK","School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester, M1 7DN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester M1 7DN, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester, M1 7DN, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003700886","display_name":"Gideon Grogan","orcid":"https://orcid.org/0000-0003-1383-7056","observed_orcids":["https://orcid.org/0000-0003-1383-7056"]},"institutions":[{"id":"https://openalex.org/I52099693","display_name":"University of York","ror":"https://ror.org/04m01e293","country_code":"GB","type":"education","lineage":["https://openalex.org/I52099693"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Gideon Grogan","raw_affiliation_strings":["York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK","Department of Chemistry, York Structural Biology Laboratory, University of York, Heslington, YO10 5DD, York, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK","institution_ids":["https://openalex.org/I52099693"]},{"raw_affiliation_string":"Department of Chemistry, York Structural Biology Laboratory, University of York, Heslington, YO10 5DD, York, UK","institution_ids":["https://openalex.org/I52099693"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073735499","display_name":"Nicholas John Turner","orcid":"https://orcid.org/0000-0002-8708-0781","observed_orcids":["https://orcid.org/0000-0002-8708-0781","https://orcid.org/0000-0001-8937-0873"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Nicholas J. Turner","raw_affiliation_strings":["School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester M1 7DN, UK","School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester, M1 7DN, UK"],"raw_orcid":"https://orcid.org/0000-0002-8708-0781","affiliations":[{"raw_affiliation_string":"School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester M1 7DN, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester, M1 7DN, UK","institution_ids":["https://openalex.org/I28407311"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5003700886","https://openalex.org/A5073735499"],"corresponding_institution_ids":["https://openalex.org/I28407311","https://openalex.org/I52099693"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":14.9394,"has_fulltext":true,"cited_by_count":397,"citation_normalized_percentile":{"value":0.99498764,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"9","issue":"10","first_page":"961","last_page":"969"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11281","display_name":"Asymmetric Hydrogenation and Catalysis","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aspergillus-oryzae","display_name":"Aspergillus oryzae","score":0.9869999885559082},{"id":"https://openalex.org/keywords/reductive-amination","display_name":"reductive amination","score":0.9419999718666077},{"id":"https://openalex.org/keywords/chiral-amines","display_name":"chiral amines","score":0.7950000166893005},{"id":"https://openalex.org/keywords/imine-formation","display_name":"Schiff base formation","score":0.7960000038146973},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.7129999995231628},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.6919999718666077},{"id":"https://openalex.org/keywords/rasagiline","display_name":"rasagiline","score":0.8420000076293945},{"id":"https://openalex.org/keywords/biocatalysis","display_name":"biocatalysis","score":0.7630000114440918},{"id":"https://openalex.org/keywords/enantioselectivity","display_name":"enantioselectivity","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C2779938440","wikidata":"https://www.wikidata.org/wiki/Q549876","display_name":"Reductive amination","level":3,"score":0.9417262077331543},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9329211711883545},{"id":"https://openalex.org/C2776573223","wikidata":"https://www.wikidata.org/wiki/Q408057","display_name":"Imine","level":3,"score":0.593957781791687},{"id":"https://openalex.org/C131779359","wikidata":"https://www.wikidata.org/wiki/Q471875","display_name":"Amine gas treating","level":2,"score":0.55433189868927},{"id":"https://openalex.org/C73969872","wikidata":"https://www.wikidata.org/wiki/Q899698","display_name":"Turnover number","level":3,"score":0.5360276103019714},{"id":"https://openalex.org/C2781204770","wikidata":"https://www.wikidata.org/wiki/Q22662068","display_name":"Aspergillus oryzae","level":3,"score":0.5327892899513245},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.45305484533309937},{"id":"https://openalex.org/C2779379725","wikidata":"https://www.wikidata.org/wiki/Q2914572","display_name":"Artificial enzyme","level":3,"score":0.4475046396255493},{"id":"https://openalex.org/C2776910235","wikidata":"https://www.wikidata.org/wiki/Q18574","display_name":"Reactivity (psychology)","level":3,"score":0.4222891926765442},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.3884811997413635},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3791552186012268},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.3420335054397583},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.30279219150543213},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000586","descriptor_name":"Amination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000586","descriptor_name":"Amination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000586","descriptor_name":"Amination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000588","descriptor_name":"Amines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000588","descriptor_name":"Amines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000588","descriptor_name":"Amines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000619","descriptor_name":"Aminohydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000619","descriptor_name":"Aminohydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000619","descriptor_name":"Aminohydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000619","descriptor_name":"Aminohydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000619","descriptor_name":"Aminohydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000619","descriptor_name":"Aminohydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000619","descriptor_name":"Aminohydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000619","descriptor_name":"Aminohydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000619","descriptor_name":"Aminohydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001236","descriptor_name":"Aspergillus oryzae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001236","descriptor_name":"Aspergillus oryzae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001236","descriptor_name":"Aspergillus oryzae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055162","descriptor_name":"Biocatalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055162","descriptor_name":"Biocatalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055162","descriptor_name":"Biocatalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/nchem.2782","doi":"https://doi.org/10.1038/nchem.2782","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nchem.2782","pdf_url":null,"source":{"id":"https://openalex.org/S202193212","display_name":"Nature Chemistry","issn_l":"1755-4330","issn":["1755-4330","1755-4349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Chemistry","raw_type":"journal-article"},{"id":"pmid:28937665","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28937665","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.whiterose.ac.uk:117344","doi":null,"is_oa":true,"landing_page_url":"https://eprints.whiterose.ac.uk/id/eprint/117344/1/Grogan_Nature_Chem_Accepted_Manuscript.pdf","pdf_url":"https://eprints.whiterose.ac.uk/id/eprint/117344/1/Grogan_Nature_Chem_Accepted_Manuscript.pdf","source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/721ce210-3af1-48c3-9fa8-bd757afa1c88","doi":null,"is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/publications/721ce210-3af1-48c3-9fa8-bd757afa1c88","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Aleku, G, France, S, Man, H, Mangas-Sanchez, J, Montgomery, S, Sharma, M, Leipold, F, Hussain, S, Grogan, G & Turner, N 2017, 'A reductive aminase from Aspergillus oryzae', Nature Chemistry, vol. 9, pp. 961-969. https://doi.org/10.1038/nchem.2782","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:eprints.whiterose.ac.uk:117344","doi":null,"is_oa":true,"landing_page_url":"https://eprints.whiterose.ac.uk/id/eprint/117344/1/Grogan_Nature_Chem_Accepted_Manuscript.pdf","pdf_url":"https://eprints.whiterose.ac.uk/id/eprint/117344/1/Grogan_Nature_Chem_Accepted_Manuscript.pdf","source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3171208691","display_name":"Imine Reductases: Biochemistry, Engineering and Application","funder_award_id":"BB/M006832/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G6838378020","display_name":null,"funder_award_id":"BB/M006832/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G7779400787","display_name":null,"funder_award_id":"BB/M006611/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G8249965444","display_name":"Imine Reductases: Biochemistry, Engineering and Application","funder_award_id":"BB/M006611/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G8517555687","display_name":"Chemical Manufacturing Methods for the 21st Century Pharmaceutical Industries","funder_award_id":"115360","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320314178","display_name":"European Federation of Pharmaceutical Industries and Associations","ror":"https://ror.org/00g1x4v36"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2619829249.pdf","grobid_xml":"https://content.openalex.org/works/W2619829249.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W108366826","https://openalex.org/W1161703962","https://openalex.org/W1488002996","https://openalex.org/W1501907526","https://openalex.org/W1553335616","https://openalex.org/W1563999781","https://openalex.org/W1656293431","https://openalex.org/W1869265908","https://openalex.org/W1964504466","https://openalex.org/W1970743754","https://openalex.org/W1986056153","https://openalex.org/W1992488465","https://openalex.org/W1998057326","https://openalex.org/W2006789930","https://openalex.org/W2006843428","https://openalex.org/W2007809174","https://openalex.org/W2025439384","https://openalex.org/W2025856735","https://openalex.org/W2029565299","https://openalex.org/W2033556576","https://openalex.org/W2036557444","https://openalex.org/W2058841148","https://openalex.org/W2059338233","https://openalex.org/W2060621401","https://openalex.org/W2064529557","https://openalex.org/W2076691675","https://openalex.org/W2089863129","https://openalex.org/W2091800889","https://openalex.org/W2093414987","https://openalex.org/W2104244931","https://openalex.org/W2107587779","https://openalex.org/W2108017017","https://openalex.org/W2111528632","https://openalex.org/W2112189586","https://openalex.org/W2122527879","https://openalex.org/W2138444778","https://openalex.org/W2147825522","https://openalex.org/W2159910931","https://openalex.org/W2208581252","https://openalex.org/W2266239956","https://openalex.org/W2278391238","https://openalex.org/W2290817274","https://openalex.org/W2300247830","https://openalex.org/W2314220527","https://openalex.org/W2384353002","https://openalex.org/W2398757352","https://openalex.org/W2405071734","https://openalex.org/W2496645452","https://openalex.org/W2513627815","https://openalex.org/W2560971454","https://openalex.org/W2585700541","https://openalex.org/W4233515050"],"related_works":["https://openalex.org/W2378354510","https://openalex.org/W2937695583","https://openalex.org/W2384713980","https://openalex.org/W1925373159","https://openalex.org/W2385294241","https://openalex.org/W2367006028","https://openalex.org/W4252438383","https://openalex.org/W2467159142","https://openalex.org/W2062618910","https://openalex.org/W2619829249"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":28},{"year":2025,"cited_by_count":43},{"year":2024,"cited_by_count":38},{"year":2023,"cited_by_count":43},{"year":2022,"cited_by_count":47},{"year":2021,"cited_by_count":44},{"year":2020,"cited_by_count":46},{"year":2019,"cited_by_count":46},{"year":2018,"cited_by_count":40},{"year":2017,"cited_by_count":21}],"updated_date":"2026-10-22T09:42:04.148104","created_date":"2025-10-10T00:00:00"}