{"id":"https://openalex.org/W2619787175","doi":null,"title":"Hormonal Responses that Regulate the Metabolic Benefits of Exercise: The Contribution of the Melanocortin System and the Fibroblast Growth Factor 21 (FGF21) Signaling Pathway","display_name":"Hormonal Responses that Regulate the Metabolic Benefits of Exercise: The Contribution of the Melanocortin System and the Fibroblast Growth Factor 21 (FGF21) Signaling Pathway","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2619787175","mag":"2619787175"},"language":"en","primary_location":{"id":"pmh:oai:etd.ohiolink.edu:ucin1421331671","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1421331671","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1421331671","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1421331671","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1421331671","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051533310","display_name":"Christine Loyd","orcid":"https://orcid.org/0000-0002-6402-6547","observed_orcids":["https://orcid.org/0000-0002-6402-6547"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christine Loyd","raw_affiliation_strings":["University of Cincinnati**"],"raw_orcid":"https://orcid.org/0000-0002-6402-6547","affiliations":[{"raw_affiliation_string":"University of Cincinnati**","institution_ids":["https://openalex.org/I63135867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5051533310"],"corresponding_institution_ids":["https://openalex.org/I63135867"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.25799004,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.024299999698996544,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.7089999914169312},{"id":"https://openalex.org/keywords/melanocortin-system","display_name":"melanocortin system","score":0.9589999914169312},{"id":"https://openalex.org/keywords/melanocortin-4-receptor","display_name":"melanocortin-4 receptor","score":0.9860000014305115},{"id":"https://openalex.org/keywords/fgf21","display_name":"FGF21","score":0.9879999756813049},{"id":"https://openalex.org/keywords/energy-homeostasis","display_name":"energy homeostasis","score":0.9290000200271606},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.781000018119812},{"id":"https://openalex.org/keywords/diet-induced-obesity","display_name":"diet-induced obesity","score":0.8149999976158142},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.6700000166893005},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.6159999966621399},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.6729999780654907},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.9860000014305115}],"concepts":[{"id":"https://openalex.org/C106646824","wikidata":"https://www.wikidata.org/wiki/Q5425475","display_name":"FGF21","level":4,"score":0.9260392189025879},{"id":"https://openalex.org/C2779993316","wikidata":"https://www.wikidata.org/wiki/Q6591465","display_name":"Melanocortin","level":3,"score":0.7379899024963379},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.6302467584609985},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.586452305316925},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5503754019737244},{"id":"https://openalex.org/C2909567013","wikidata":"https://www.wikidata.org/wiki/Q6591465","display_name":"Melanocortins","level":4,"score":0.5049102902412415},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4552411735057831},{"id":"https://openalex.org/C66400584","wikidata":"https://www.wikidata.org/wiki/Q5446458","display_name":"Fibroblast growth factor receptor 4","level":5,"score":0.43782562017440796},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.4206972122192383},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41454678773880005},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41385674476623535},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39343124628067017},{"id":"https://openalex.org/C82867764","wikidata":"https://www.wikidata.org/wiki/Q24780051","display_name":"Fibroblast growth factor receptor","level":4,"score":0.3374088406562805},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2933024764060974},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.15890410542488098},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.14514338970184326}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:etd.ohiolink.edu:ucin1421331671","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1421331671","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1421331671","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1421331671","raw_type":"text"},{"id":"mag:2619787175","doi":null,"is_oa":false,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1421331671","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:etd.ohiolink.edu:ucin1421331671","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1421331671","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1421331671","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1421331671","raw_type":"text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2619787175.pdf","grobid_xml":"https://content.openalex.org/works/W2619787175.grobid-xml"},"referenced_works_count":353,"referenced_works":["https://openalex.org/W6748264","https://openalex.org/W38147224","https://openalex.org/W46140566","https://openalex.org/W46560487","https://openalex.org/W167568639","https://openalex.org/W173790621","https://openalex.org/W177634429","https://openalex.org/W191749779","https://openalex.org/W1254243414","https://openalex.org/W1503357410","https://openalex.org/W1506981847","https://openalex.org/W1512875938","https://openalex.org/W1525701947","https://openalex.org/W1527237994","https://openalex.org/W1539401343","https://openalex.org/W1542691236","https://openalex.org/W1558601380","https://openalex.org/W1561443084","https://openalex.org/W1576809876","https://openalex.org/W1580646470","https://openalex.org/W1602687822","https://openalex.org/W1622799587","https://openalex.org/W1630621223","https://openalex.org/W1651866740","https://openalex.org/W1753097959","https://openalex.org/W1774190872","https://openalex.org/W1774419690","https://openalex.org/W1790807154","https://openalex.org/W1820085648","https://openalex.org/W1844998737","https://openalex.org/W1848122305","https://openalex.org/W1859469442","https://openalex.org/W1864159588","https://openalex.org/W1872744326","https://openalex.org/W1902966654","https://openalex.org/W1918701009","https://openalex.org/W1924506987","https://openalex.org/W1938033115","https://openalex.org/W1963540950","https://openalex.org/W1963683487","https://openalex.org/W1966181749","https://openalex.org/W1966218079","https://openalex.org/W1966732677","https://openalex.org/W1967485751","https://openalex.org/W1968091833","https://openalex.org/W1968251114","https://openalex.org/W1970205234","https://openalex.org/W1970622371","https://openalex.org/W1970638023","https://openalex.org/W1972062612","https://openalex.org/W1972522933","https://openalex.org/W1972762474","https://openalex.org/W1973123665","https://openalex.org/W1975388439","https://openalex.org/W1975716130","https://openalex.org/W1977757297","https://openalex.org/W1978354120","https://openalex.org/W1978544170","https://openalex.org/W1979439475","https://openalex.org/W1981025527","https://openalex.org/W1982254200","https://openalex.org/W1982492614","https://openalex.org/W1983417944","https://openalex.org/W1984652711","https://openalex.org/W1984755033","https://openalex.org/W1987367618","https://openalex.org/W1987588766","https://openalex.org/W1988869711","https://openalex.org/W1989400130","https://openalex.org/W1991918541","https://openalex.org/W1993343317","https://openalex.org/W1994041994","https://openalex.org/W1994554353","https://openalex.org/W1996464827","https://openalex.org/W1996671408","https://openalex.org/W1998493448","https://openalex.org/W1999083162","https://openalex.org/W2000665430","https://openalex.org/W2003198450","https://openalex.org/W2004469782","https://openalex.org/W2005693445","https://openalex.org/W2005778535","https://openalex.org/W2008269253","https://openalex.org/W2008500674","https://openalex.org/W2009624930","https://openalex.org/W2010142606","https://openalex.org/W2010367429","https://openalex.org/W2010735403","https://openalex.org/W2010763118","https://openalex.org/W2011172334","https://openalex.org/W2012285073","https://openalex.org/W2012898950","https://openalex.org/W2014887370","https://openalex.org/W2014995994","https://openalex.org/W2016194457","https://openalex.org/W2017032820","https://openalex.org/W2017888726","https://openalex.org/W2017931973","https://openalex.org/W2018135697","https://openalex.org/W2018973416","https://openalex.org/W2019542890","https://openalex.org/W2019691564","https://openalex.org/W2020358612","https://openalex.org/W2021308683","https://openalex.org/W2021657723","https://openalex.org/W2021976026","https://openalex.org/W2021982751","https://openalex.org/W2025106732","https://openalex.org/W2025365257","https://openalex.org/W2027239974","https://openalex.org/W2027987462","https://openalex.org/W2028051051","https://openalex.org/W2030470141","https://openalex.org/W2030610610","https://openalex.org/W2030636484","https://openalex.org/W2030817984","https://openalex.org/W2031363576","https://openalex.org/W2031446629","https://openalex.org/W2031532881","https://openalex.org/W2033112320","https://openalex.org/W2034661254","https://openalex.org/W2034766774","https://openalex.org/W2035731143","https://openalex.org/W2036370991","https://openalex.org/W2036396440","https://openalex.org/W2038839492","https://openalex.org/W2038863889","https://openalex.org/W2038901278","https://openalex.org/W2039264048","https://openalex.org/W2040466763","https://openalex.org/W2040791098","https://openalex.org/W2041502315","https://openalex.org/W2042444876","https://openalex.org/W2042706232","https://openalex.org/W2042911346","https://openalex.org/W2043832763","https://openalex.org/W2044482587","https://openalex.org/W2044674035","https://openalex.org/W2044772342","https://openalex.org/W2045208326","https://openalex.org/W2045948521","https://openalex.org/W2047257800","https://openalex.org/W2047820724","https://openalex.org/W2048109379","https://openalex.org/W2049379194","https://openalex.org/W2050259739","https://openalex.org/W2050689899","https://openalex.org/W2051909291","https://openalex.org/W2051977733","https://openalex.org/W2053054105","https://openalex.org/W2054689428","https://openalex.org/W2055811732","https://openalex.org/W2057919452","https://openalex.org/W2058138221","https://openalex.org/W2059842910","https://openalex.org/W2060836453","https://openalex.org/W2060977299","https://openalex.org/W2061405430","https://openalex.org/W2062663604","https://openalex.org/W2064120191","https://openalex.org/W2064125892","https://openalex.org/W2065389660","https://openalex.org/W2066898102","https://openalex.org/W2067096633","https://openalex.org/W2067507037","https://openalex.org/W2069487168","https://openalex.org/W2071790408","https://openalex.org/W2073362042","https://openalex.org/W2073582448","https://openalex.org/W2073761151","https://openalex.org/W2073926725","https://openalex.org/W2074894911","https://openalex.org/W2075307485","https://openalex.org/W2077230920","https://openalex.org/W2077799214","https://openalex.org/W2078161791","https://openalex.org/W2080080514","https://openalex.org/W2080117039","https://openalex.org/W2081941025","https://openalex.org/W2082930819","https://openalex.org/W2085645788","https://openalex.org/W2085655607","https://openalex.org/W2086082646","https://openalex.org/W2086991865","https://openalex.org/W2087136121","https://openalex.org/W2088511431","https://openalex.org/W2089817491","https://openalex.org/W2090060547","https://openalex.org/W2090313537","https://openalex.org/W2090770958","https://openalex.org/W2091166942","https://openalex.org/W2091576257","https://openalex.org/W2091749040","https://openalex.org/W2092167628","https://openalex.org/W2092834808","https://openalex.org/W2093664117","https://openalex.org/W2094270070","https://openalex.org/W2094680407","https://openalex.org/W2096773810","https://openalex.org/W2098161436","https://openalex.org/W2098635799","https://openalex.org/W2099485290","https://openalex.org/W2104303595","https://openalex.org/W2104838529","https://openalex.org/W2105244824","https://openalex.org/W2105880387","https://openalex.org/W2105894327","https://openalex.org/W2106457742","https://openalex.org/W2106563675","https://openalex.org/W2106762651","https://openalex.org/W2107526227","https://openalex.org/W2107945166","https://openalex.org/W2108596481","https://openalex.org/W2111653877","https://openalex.org/W2111803150","https://openalex.org/W2112258023","https://openalex.org/W2112858824","https://openalex.org/W2113318243","https://openalex.org/W2113940018","https://openalex.org/W2114349736","https://openalex.org/W2114473678","https://openalex.org/W2114650931","https://openalex.org/W2114809267","https://openalex.org/W2115433418","https://openalex.org/W2116891025","https://openalex.org/W2117483382","https://openalex.org/W2119087377","https://openalex.org/W2119245928","https://openalex.org/W2119331212","https://openalex.org/W2119351413","https://openalex.org/W2119711962","https://openalex.org/W2120034293","https://openalex.org/W2120282127","https://openalex.org/W2121049950","https://openalex.org/W2122189341","https://openalex.org/W2122328189","https://openalex.org/W2122953585","https://openalex.org/W2123352794","https://openalex.org/W2123429601","https://openalex.org/W2123931921","https://openalex.org/W2124111649","https://openalex.org/W2125668983","https://openalex.org/W2125732396","https://openalex.org/W2127615810","https://openalex.org/W2127809854","https://openalex.org/W2128621051","https://openalex.org/W2128798701","https://openalex.org/W2128952056","https://openalex.org/W2129150286","https://openalex.org/W2129275826","https://openalex.org/W2130394237","https://openalex.org/W2130850001","https://openalex.org/W2130935482","https://openalex.org/W2131192628","https://openalex.org/W2131294862","https://openalex.org/W2131622156","https://openalex.org/W2132054542","https://openalex.org/W2132513137","https://openalex.org/W2132574064","https://openalex.org/W2133059852","https://openalex.org/W2134944069","https://openalex.org/W2135704900","https://openalex.org/W2136769963","https://openalex.org/W2137814128","https://openalex.org/W2138700089","https://openalex.org/W2138955957","https://openalex.org/W2139742430","https://openalex.org/W2140653847","https://openalex.org/W2140808124","https://openalex.org/W2141060229","https://openalex.org/W2141295252","https://openalex.org/W2141356353","https://openalex.org/W2141777618","https://openalex.org/W2142066344","https://openalex.org/W2142072453","https://openalex.org/W2142602157","https://openalex.org/W2143269930","https://openalex.org/W2144154938","https://openalex.org/W2147888023","https://openalex.org/W2148562280","https://openalex.org/W2148897749","https://openalex.org/W2149342673","https://openalex.org/W2150879111","https://openalex.org/W2151175711","https://openalex.org/W2151831322","https://openalex.org/W2151877899","https://openalex.org/W2152488097","https://openalex.org/W2152956628","https://openalex.org/W2153449155","https://openalex.org/W2154024784","https://openalex.org/W2154052663","https://openalex.org/W2155271458","https://openalex.org/W2155506878","https://openalex.org/W2155534957","https://openalex.org/W2157037423","https://openalex.org/W2157197482","https://openalex.org/W2157513821","https://openalex.org/W2158822657","https://openalex.org/W2159896083","https://openalex.org/W2160234571","https://openalex.org/W2161839691","https://openalex.org/W2162613917","https://openalex.org/W2163239863","https://openalex.org/W2163548934","https://openalex.org/W2164849270","https://openalex.org/W2165670787","https://openalex.org/W2165678227","https://openalex.org/W2167558739","https://openalex.org/W2167909421","https://openalex.org/W2168627519","https://openalex.org/W2169007440","https://openalex.org/W2169357653","https://openalex.org/W2169469988","https://openalex.org/W2169632698","https://openalex.org/W2169826533","https://openalex.org/W2170869159","https://openalex.org/W2171748868","https://openalex.org/W2172189555","https://openalex.org/W2175518322","https://openalex.org/W2176414067","https://openalex.org/W2181119124","https://openalex.org/W2184995059","https://openalex.org/W2200246245","https://openalex.org/W2227813149","https://openalex.org/W2230786058","https://openalex.org/W2237508147","https://openalex.org/W2261014137","https://openalex.org/W2263689279","https://openalex.org/W2276914493","https://openalex.org/W2278312781","https://openalex.org/W2285139807","https://openalex.org/W2286784035","https://openalex.org/W2296784018","https://openalex.org/W2303071711","https://openalex.org/W2306265054","https://openalex.org/W2310793383","https://openalex.org/W2312946897","https://openalex.org/W2315090378","https://openalex.org/W2319231450","https://openalex.org/W2328294727","https://openalex.org/W2331249853","https://openalex.org/W2334337188","https://openalex.org/W2337102266","https://openalex.org/W2338252498","https://openalex.org/W2339156076","https://openalex.org/W2397872804","https://openalex.org/W2410476363","https://openalex.org/W2419378202","https://openalex.org/W2424311285","https://openalex.org/W2431468329","https://openalex.org/W2499426752","https://openalex.org/W3138780921","https://openalex.org/W4365786794"],"related_works":["https://openalex.org/W2497460640","https://openalex.org/W2983168799","https://openalex.org/W2919268122","https://openalex.org/W2617372432","https://openalex.org/W2935697200","https://openalex.org/W2740981173","https://openalex.org/W2089641177","https://openalex.org/W7096222291","https://openalex.org/W2979586265","https://openalex.org/W7095814936"],"abstract_inverted_index":{"Exercise":[0],"has":[1,130],"benefits":[2,141],"on":[3,234,354,394],"body":[4,175],"and":[5,10,40,65,80,82,91,96,103,150,176,180,183,241,248,304,312,323,343,411,452,462,467,476,505,510,525,528,533,539],"fat":[6,177],"mass,":[7],"glucose":[8,81,182,361,395],"metabolism,":[9],"lipid":[11,83,184,242],"metabolism.Likewise,":[12],"exercise":[13,30,61,104,117,129,160,202,220,276,284,319,357,373,393,400,419],"is":[14,72,204,222,249,270,285,291,386,401],"an":[15,223,457],"effective":[16,331,402],"therapy":[17],"against":[18],"the":[19,22,26,37,41,67,116,136,191,198,214,219,264,275,278,352,389,414,433,439,442,465,487,501],"metabolic":[20,92,140,210,279,405,430],"syndrome.Yet,":[21],"molecular":[23],"pathways":[24,51],"underlying":[25],"advantageous":[27],"effects":[28,233,266,391],"of":[29,55,60,77,85,100,107,142,186,216,267,281,296,335,349,392,416,428,435,441,460,469,545],"are":[31,58],"imperfectly":[32],"understood.Emerging":[33],"evidence":[34,119,271],"suggests":[35],"that":[36,111,123,135,190,272,289,383,399,489],"melanocortin":[38,63,68,112,126,137,192],"system":[39,138,193],"fibroblast":[42],"growth":[43],"factor":[44,225],"21":[45],"(FGF21)":[46],"signaling":[47,113,127],"axis,":[48],"two":[49],"endocrine":[50,224],"involved":[52,196],"in":[53,88,94,105,197,218,244,255,332,344,363,378,403,412,426,432,484,536],"regulation":[54,76,106,295],"energy":[56,78,108,297,355],"homeostasis,":[57],"mediators":[59],"benefits.The":[62],"system,":[64],"specifically":[66],"4":[69],"receptor":[70],"(MC4R),":[71],"required":[73,206,292,387],"for":[74,161,169,200,253,293,320,388,499,506],"normal":[75],"balance,":[79,356],"homeostasis.Inactivation":[84],"MC4R":[86,101,409],"results":[87,381],"severe":[89],"obesity":[90,337],"syndrome":[93,406,431],"rodents":[95],"humans.The":[97],"overlapping":[98],"roles":[99],"activation":[102],"homeostasis":[109,243],"indicate":[110],"might":[114,194],"regulate":[115],"response.Moreover,":[118],"from":[120],"our":[121,470,474],"group":[122],"illustrates":[124],"hypothalamic":[125],"following":[128],"lead":[131],"us":[132],"to":[133,207,257,309,315,359,371,482,497,518],"hypothesize":[134],"mediates":[139],"exercise.To":[143],"test":[144],"this,":[145],"we":[146,212,397],"provided":[147],"wild-type":[148],"(WT)":[149],"Mc4r":[151,502],"-/-(HOM)":[152],"rats":[153,188],"with":[154,230,263,423],"ad":[155],"libitum":[156],"running":[157,172,317,328],"wheel":[158,318],"iii":[159],"5":[162],"weeks.We":[163],"found":[164],"that,":[165],"despite":[166,351,486],"reduced":[167,174,375],"capacity":[168,199],"exercise,":[170],"voluntary":[171,201,316],"activity":[173,377,385],"mass":[178,341],"gain,":[179,342],"improved":[181],"metabolism":[185],"HOM":[187],"suggesting":[189],"be":[195,491],"but":[203],"not":[205],"mediate":[208],"exercise-induced":[209],"benefits.Next,":[211],"examined":[213],"function":[215,280],"FGF21":[217,236,273,282,290,384,437],"response.FGF21":[221],"regulated":[226],"by":[227,301,338,408],"nutritional":[228],"status":[229],"numerous":[231],"beneficial":[232,390],"metabolism.Exogenous":[235],"improves":[237],"insulin":[238],"sensitivity,":[239],"glucose,":[240],"diabetic":[245],"animal":[246],"models":[247],"currently":[250],"being":[251],"investigated":[252],"use":[254],"humans":[256],"treat":[258],"type":[259],"2":[260],"diabetes.In":[261],"line":[262,504],"therapeutic":[265],"FGF21,":[268],"there":[269],"regulates":[274],"response.Yet,":[277],"during":[283],"largely":[286],"undescribed.We":[287],"hypothesized":[288],"exercise-mediated":[294],"homeostasis.We":[298],"tested":[299],"this":[300],"challenging":[302],"WT":[303],"FGF21-deficient":[305],"(Fgf21":[306],"-/-)":[307],"mice":[308],"high-fat":[310],"diet":[311],"allowing":[313],"access":[314],"12":[321],"weeks.WT":[322],"Fgf21":[324,366],"-/-mice":[325,367],"exhibited":[326],"similar":[327],"behavior.Exercise":[329],"was":[330],"reducing":[333,339],"development":[334,415],"diet-induced":[336,429],"body/fat":[340],"improving":[345],"plasma":[346],"lipidemia":[347],"independent":[348],"genotype.However,":[350],"effect":[353],"failed":[358],"improve":[360],"tolerance":[362],"FGF21deficient":[364],"mice.Furthermore,":[365],"had":[368],"impaired":[369,436],"adaptation":[370],"chronic":[372],"including":[374],"AMPK":[376],"skeletal":[379],"muscle.These":[380],"demonstrate":[382],"metabolism.Overall,":[396],"conclude":[398],"ameliorating":[404],"caused":[407],"inactivation":[410],"preventing":[413],"dietary":[417],"obesity.Yet,":[418],"may":[420],"require":[421],"supplementation":[422],"other":[424],"therapeutics":[425],"prevention":[427],"context":[434],"signaling.To":[438],"members":[440],"Obici":[443],"Laboratory,":[444],"especially":[445],"Jack":[446],"Magrisso,":[447],"Michael":[448],"Haas,":[449],"Joram":[450,498],"Mul,":[451],"Sonia":[453],"Lipp-you":[454],"have":[455,530,541],"been":[456,542],"incredible":[458],"source":[459,544],"knowledge":[461],"help":[463],"throughout":[464,512,548],"trials":[466],"tribulations":[468],"projects.I":[471],"will":[472,490],"miss":[473],"conversations":[475],"seeing":[477],"you":[478,540,552],"every":[479],"day.I":[480],"hope":[481],"stay":[483],"touch":[485],"distance":[488],"between":[492],"us.Also,":[493],"a":[494,543],"special":[495],"thanks":[496],"providing":[500],"-/-rat":[503],"your":[507],"constant":[508],"encouragement":[509],"guidance":[511],"my":[513,520,526,537,549],"studies.I":[514],"would":[515],"also":[516],"like":[517],"acknowledge":[519],"mom,":[521],"Randy,":[522],"Sissy,":[523],"Susan,":[524],"nieces":[527],"nephew-you":[529],"always":[531],"supported":[532],"encouraged":[534],"me":[535],"endeavors,":[538],"unconditional":[546],"love":[547,551],"life.I":[550]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-06-05T00:00:00"}
