{"id":"https://openalex.org/W2619644430","doi":null,"title":"Serotonin Receptor Electrophysiology in Cortical Neurons Critical for the Response to Antidepressants","display_name":"Serotonin Receptor Electrophysiology in Cortical Neurons Critical for the Response to Antidepressants","publication_year":2015,"publication_date":"2015-03-01","ids":{"openalex":"https://openalex.org/W2619644430","mag":"2619644430"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/94508","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/94508","pdf_url":"https://utoronto.scholaris.ca/bitstreams/0c2d6e3a-7cb4-48e0-97f3-45cff2064f86/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/0c2d6e3a-7cb4-48e0-97f3-45cff2064f86/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025777817","display_name":"Kristina Elice Perit","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kristina Elice Perit","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5025777817"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.76419997215271,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.76419997215271,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.20909999310970306,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.02280000038444996,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serotonin-receptors","display_name":"serotonin receptors","score":0.8669999837875366},{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":0.8769999742507935},{"id":"https://openalex.org/keywords/fluoxetine","display_name":"fluoxetine","score":0.9610000252723694},{"id":"https://openalex.org/keywords/p11","display_name":"p11","score":0.7699999809265137},{"id":"https://openalex.org/keywords/layer-5-pyramidal-neurons","display_name":"layer 5 pyramidal neurons","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cortical-neurons","display_name":"cortical neurons","score":0.75},{"id":"https://openalex.org/keywords/antidepressant-action","display_name":"antidepressant action","score":0.5820000171661377},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.6380000114440918},{"id":"https://openalex.org/keywords/motor-cortex","display_name":"motor cortex","score":0.6570000052452087},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":1.0},{"id":"https://openalex.org/keywords/chronic-stress","display_name":"chronic stress","score":0.8360000252723694}],"concepts":[{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.7251583337783813},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.7047892808914185},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6750928163528442},{"id":"https://openalex.org/C53910766","wikidata":"https://www.wikidata.org/wiki/Q238516","display_name":"5-HT receptor","level":4,"score":0.4513612389564514},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.43016114830970764},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.382110595703125},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32444462180137634},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.29972314834594727},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2418835163116455}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/94508","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/94508","pdf_url":"https://utoronto.scholaris.ca/bitstreams/0c2d6e3a-7cb4-48e0-97f3-45cff2064f86/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2619644430","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/bitstream/1807/94508/1/Perit_Kristina_E_201503_MSc_thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/94508","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/94508","pdf_url":"https://utoronto.scholaris.ca/bitstreams/0c2d6e3a-7cb4-48e0-97f3-45cff2064f86/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2619644430.pdf","grobid_xml":"https://content.openalex.org/works/W2619644430.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W143884444","https://openalex.org/W160287770","https://openalex.org/W202333777","https://openalex.org/W1574537340","https://openalex.org/W1966993210","https://openalex.org/W1974729332","https://openalex.org/W1986982510","https://openalex.org/W1986988181","https://openalex.org/W1987194328","https://openalex.org/W1990388039","https://openalex.org/W1994153884","https://openalex.org/W1997270590","https://openalex.org/W1997279263","https://openalex.org/W2004911098","https://openalex.org/W2010360024","https://openalex.org/W2012945651","https://openalex.org/W2014001501","https://openalex.org/W2014643576","https://openalex.org/W2016983964","https://openalex.org/W2021135844","https://openalex.org/W2023249364","https://openalex.org/W2028541643","https://openalex.org/W2040527392","https://openalex.org/W2057352698","https://openalex.org/W2057779233","https://openalex.org/W2062782191","https://openalex.org/W2063176562","https://openalex.org/W2071200330","https://openalex.org/W2074483296","https://openalex.org/W2075566185","https://openalex.org/W2078147213","https://openalex.org/W2081366242","https://openalex.org/W2082074719","https://openalex.org/W2084320547","https://openalex.org/W2087877032","https://openalex.org/W2094536684","https://openalex.org/W2114600491","https://openalex.org/W2117267094","https://openalex.org/W2118163991","https://openalex.org/W2122902216","https://openalex.org/W2135447632","https://openalex.org/W2149154629","https://openalex.org/W2156868152","https://openalex.org/W2166359858","https://openalex.org/W2166722832","https://openalex.org/W2170771167","https://openalex.org/W2318164852","https://openalex.org/W4414041363"],"related_works":["https://openalex.org/W1997270590","https://openalex.org/W1995258260","https://openalex.org/W2063176562","https://openalex.org/W2141630998","https://openalex.org/W2730823877","https://openalex.org/W4389371178","https://openalex.org/W1989443831","https://openalex.org/W4313200135","https://openalex.org/W4396776926","https://openalex.org/W2807300532"],"abstract_inverted_index":{"The":[0],"gold":[1],"standard":[2],"for":[3,33],"treating":[4],"depression":[5],"is":[6,137],"a":[7,21,73,102],"class":[8],"of":[9,23,37,87,97,105,139],"medicines":[10],"known":[11],"as":[12],"selective":[13],"serotonin":[14,77],"reuptake":[15],"inhibitors":[16],"(SSRIs).":[17],"Recent":[18],"research":[19],"identified":[20],"subgroup":[22],"layer":[24],"V":[25],"pyramidal":[26],"neurons":[27,46,53,117,126],"in":[28,83,101,118,129,147],"the":[29,34,65,95],"cerebral":[30],"cortex":[31],"important":[32],"antidepressant":[35],"action":[36],"SSRIs.":[38],"Using":[39],"transgenic":[40],"mice":[41],"that":[42,109,124,135],"have":[43],"these":[44,52],"p11-expressing":[45,125,148],"labeled":[47],"with":[48,64,72],"GFP,":[49],"I":[50,107],"characterized":[51],"and":[54,60,89,121,134,144],"their":[55,130],"neighbours":[56],"under":[57],"control":[58],"conditions":[59],"after":[61],"chronic":[62,98,110],"treatment":[63,100,112,146],"SSRI":[66],"fluoxetine":[67],"(FLX).":[68],"Experiments":[69],"were":[70],"conducted":[71],"particular":[74],"focus":[75],"on":[76,116],"(5-HT)":[78],"responses,":[79],"using":[80],"whole-cell":[81],"recording":[82],"acute":[84],"brain":[85],"slices":[86],"motor":[88,120],"prefrontal":[90,122],"cortex.":[91],"Further":[92],"investigation":[93],"explored":[94],"effects":[96,115],"FLX":[99,111,145],"mouse":[103],"model":[104],"stress.":[106],"found":[108],"has":[113],"significant":[114],"both":[119],"cortices,":[123],"differ":[127],"subtly":[128],"response":[131],"to":[132],"5-HT,":[133],"there":[136],"evidence":[138],"an":[140],"interaction":[141],"between":[142],"stress":[143],"neurons.":[149]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-06-05T00:00:00"}
