{"id":"https://openalex.org/W2619155476","doi":"https://doi.org/10.1099/mic.0.000444","title":"Microbe Profile: Akkermansia muciniphila: a conserved intestinal symbiont that acts as the gatekeeper of our mucosa","display_name":"Microbe Profile: Akkermansia muciniphila: a conserved intestinal symbiont that acts as the gatekeeper of our mucosa","publication_year":2017,"publication_date":"2017-05-01","ids":{"openalex":"https://openalex.org/W2619155476","doi":"https://doi.org/10.1099/mic.0.000444","mag":"2619155476","pmid":"https://pubmed.ncbi.nlm.nih.gov/28530168"},"language":"en","primary_location":{"id":"doi:10.1099/mic.0.000444","doi":"https://doi.org/10.1099/mic.0.000444","is_oa":true,"landing_page_url":"https://doi.org/10.1099/mic.0.000444","pdf_url":null,"source":{"id":"https://openalex.org/S196799759","display_name":"Microbiology","issn_l":"1350-0872","issn":["1350-0872","1465-2080"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1099/mic.0.000444","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054572740","display_name":"Willem M. de Vos","orcid":"https://orcid.org/0000-0002-0273-3166","observed_orcids":["https://orcid.org/0000-0002-0273-3166"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I913481162","display_name":"Wageningen University & Research","ror":"https://ror.org/04qw24q55","country_code":"NL","type":"education","lineage":["https://openalex.org/I913481162"]}],"countries":["FI","NL"],"is_corresponding":true,"raw_author_name":"Willem M de Vos","raw_affiliation_strings":["Immunobiology Research Program, University of Helsinki, Finland","Laboratory of Microbiology, Wageningen University, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunobiology Research Program, University of Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Laboratory of Microbiology, Wageningen University, The Netherlands","institution_ids":["https://openalex.org/I913481162"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5054572740"],"corresponding_institution_ids":["https://openalex.org/I133731052","https://openalex.org/I913481162"],"apc_list":null,"apc_paid":null,"fwci":5.3337,"has_fulltext":false,"cited_by_count":158,"citation_normalized_percentile":{"value":0.97014914,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"163","issue":"5","first_page":"646","last_page":"648"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/akkermansia-muciniphila","display_name":"Akkermansia muciniphila","score":1.0},{"id":"https://openalex.org/keywords/intestinal-symbionts","display_name":"intestinal symbionts","score":0.7860000133514404},{"id":"https://openalex.org/keywords/verrucomicrobiota","display_name":"Verrucomicrobia","score":0.9319999814033508},{"id":"https://openalex.org/keywords/mucin-degradation","display_name":"mucin degradation","score":0.8399999737739563},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.6660000085830688},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.8399999737739563},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9559999704360962},{"id":"https://openalex.org/keywords/host-microbe-interactions","display_name":"host-microbe interactions","score":0.8370000123977661},{"id":"https://openalex.org/keywords/immune-signaling","display_name":"immune signaling","score":0.7440000176429749},{"id":"https://openalex.org/keywords/metabolic-signalling","display_name":"metabolic signalling","score":0.7490000128746033},{"id":"https://openalex.org/keywords/competitive-exclusion-principle","display_name":"competitive exclusion","score":0.8600000143051147},{"id":"https://openalex.org/keywords/mucosa","display_name":"mucosa","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C2775941767","wikidata":"https://www.wikidata.org/wiki/Q15020908","display_name":"Akkermansia muciniphila","level":3,"score":0.9871363043785095},{"id":"https://openalex.org/C2777907754","wikidata":"https://www.wikidata.org/wiki/Q18667425","display_name":"Verrucomicrobia","level":5,"score":0.8228408098220825},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7339992523193359},{"id":"https://openalex.org/C179264091","wikidata":"https://www.wikidata.org/wiki/Q410862","display_name":"Mucin","level":2,"score":0.6293845176696777},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6136413216590881},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.513297975063324},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.4443408250808716},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3510844111442566},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34023961424827576},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.28820136189460754},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.20131853222846985},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1531885266304016},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1347750723361969},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12983179092407227},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1078820526599884},{"id":"https://openalex.org/C2778169975","wikidata":"https://www.wikidata.org/wiki/Q130914","display_name":"Actinobacteria","level":4,"score":0.0},{"id":"https://openalex.org/C42062724","wikidata":"https://www.wikidata.org/wiki/Q1209205","display_name":"16S ribosomal RNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D009077","descriptor_name":"Mucins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013559","descriptor_name":"Symbiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061327","descriptor_name":"Verrucomicrobia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D061327","descriptor_name":"Verrucomicrobia","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D061327","descriptor_name":"Verrucomicrobia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1099/mic.0.000444","doi":"https://doi.org/10.1099/mic.0.000444","is_oa":true,"landing_page_url":"https://doi.org/10.1099/mic.0.000444","pdf_url":null,"source":{"id":"https://openalex.org/S196799759","display_name":"Microbiology","issn_l":"1350-0872","issn":["1350-0872","1465-2080"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology","raw_type":"journal-article"},{"id":"pmid:28530168","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28530168","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology (Reading, England)","raw_type":"Journal Article"},{"id":"pmh:oai:library.wur.nl:wurpubs/523491","doi":null,"is_oa":true,"landing_page_url":"https://research.wur.nl/en/publications/microbe-profile-akkermansia-muciniphila-a-conserved-intestinal-sy","pdf_url":null,"source":{"id":"https://openalex.org/S4210201231","display_name":"Socio-Environmental Systems Modeling","issn_l":"2663-3027","issn":["2663-3027"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1350-0872","raw_type":"Article/Letter to editor"},{"id":"pmh:wur:oai:library.wur.nl:wurpubs/523491","doi":null,"is_oa":true,"landing_page_url":"https://research.wur.nl/en/publications/microbe-profile-akkermansia-muciniphila-a-conserved-intestinal-sy","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Microbiology, 163(5), 646 - 648","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1099/mic.0.000444","doi":"https://doi.org/10.1099/mic.0.000444","is_oa":true,"landing_page_url":"https://doi.org/10.1099/mic.0.000444","pdf_url":null,"source":{"id":"https://openalex.org/S196799759","display_name":"Microbiology","issn_l":"1350-0872","issn":["1350-0872","1465-2080"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W2027352386","https://openalex.org/W2068495545","https://openalex.org/W2134241692","https://openalex.org/W2484808885","https://openalex.org/W2559267012"],"related_works":["https://openalex.org/W4281253881","https://openalex.org/W2994817824","https://openalex.org/W4294549693","https://openalex.org/W2267861477","https://openalex.org/W2899470865","https://openalex.org/W4281797937","https://openalex.org/W3126944193","https://openalex.org/W2990142981","https://openalex.org/W2883041645","https://openalex.org/W2588157141"],"abstract_inverted_index":{"Akkermansia":[0],"muciniphila":[1,41,83],"is":[2,17],"an":[3],"abundant":[4],"inhabitant":[5],"of":[6,10,22],"the":[7,18,23,75,99],"intestinal":[8,20,43,93,100],"tract":[9],"humans":[11],"and":[12,28,36,48,51,63,69,88],"many":[13],"other":[14,38],"animals.":[15],"It":[16],"sole":[19],"representative":[21],"verrucomicrobia":[24],"in":[25,30,53,98],"human":[26],"stools":[27],"depleted":[29],"adults":[31],"suffering":[32],"from":[33],"obesity,":[34],"diabetes":[35],"several":[37],"diseases.":[39],"A.":[40,82],"degrades":[42],"mucin":[44],"into":[45],"mainly":[46],"propionic":[47],"acetic":[49],"acid,":[50],"lives":[52],"symbiosis":[54],"with":[55],"its":[56,79],"host,":[57],"marked":[58],"by":[59],"signalling":[60],"to":[61],"immune":[62],"metabolic":[64],"pathways,":[65],"priming":[66],"trophic":[67],"chains":[68],"likely":[70],"providing":[71],"competitive":[72],"exclusion":[73],"at":[74],"host-microbe":[76],"interface.":[77],"Since":[78],"recent":[80],"discovery,":[81],"has":[84],"increasingly":[85],"been":[86],"studied":[87],"recognized":[89],"as":[90],"a":[91],"true":[92],"symbiont":[94],"promoting":[95],"beneficial":[96],"interactions":[97],"tract.":[101]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":23},{"year":2021,"cited_by_count":25},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-06-05T00:00:00"}