{"id":"https://openalex.org/W2619083483","doi":"https://doi.org/10.1038/ncomms15530","title":"Structural basis for perception of diverse chemical substances by T1r taste receptors","display_name":"Structural basis for perception of diverse chemical substances by T1r taste receptors","publication_year":2017,"publication_date":"2017-05-23","ids":{"openalex":"https://openalex.org/W2619083483","doi":"https://doi.org/10.1038/ncomms15530","mag":"2619083483","pmid":"https://pubmed.ncbi.nlm.nih.gov/28534491"},"language":"en","primary_location":{"id":"doi:10.1038/ncomms15530","doi":"https://doi.org/10.1038/ncomms15530","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ncomms15530","pdf_url":"https://www.nature.com/articles/ncomms15530.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/ncomms15530.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068085811","display_name":"Nipawan Nuemket","orcid":"https://orcid.org/0009-0005-5252-9488","observed_orcids":["https://orcid.org/0009-0005-5252-9488"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]},{"id":"https://openalex.org/I4210104871","display_name":"SPring-8","ror":"https://ror.org/01d1kv753","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210104871","https://openalex.org/I4210110652","https://openalex.org/I4210111000"]},{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nipawan Nuemket","raw_affiliation_strings":["Laboratory of Structural Biology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1, Tsushima-naka, Okayama 700-8530, Japan","RIKEN SPring-8 Center, 1-1-1, Kouto, Hyogo 679-5148, Japan","Laboratory of Structural Biology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1, Tsushima-naka, Okayama, 700-8530, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Structural Biology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1, Tsushima-naka, Okayama 700-8530, Japan","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"RIKEN SPring-8 Center, 1-1-1, Kouto, Hyogo 679-5148, Japan","institution_ids":["https://openalex.org/I4210104871","https://openalex.org/I4210110652"]},{"raw_affiliation_string":"Laboratory of Structural Biology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1, Tsushima-naka, Okayama, 700-8530, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026203045","display_name":"N. Yasui","orcid":"https://orcid.org/0000-0001-7117-3070","observed_orcids":["https://orcid.org/0000-0001-7117-3070"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Norihisa Yasui","raw_affiliation_strings":["Laboratory of Structural Biology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1, Tsushima-naka, Okayama 700-8530, Japan","Laboratory of Structural Biology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1, Tsushima-naka, Okayama, 700-8530, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Structural Biology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1, Tsushima-naka, Okayama 700-8530, Japan","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Laboratory of Structural Biology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1, Tsushima-naka, Okayama, 700-8530, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102987607","display_name":"Yuko Kusakabe","orcid":"https://orcid.org/0000-0002-2960-5041","observed_orcids":["https://orcid.org/0000-0002-2960-5041"]},"institutions":[{"id":"https://openalex.org/I4210096597","display_name":"Food Research Institute","ror":"https://ror.org/00by9f077","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1323638106","https://openalex.org/I4210096597"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuko Kusakabe","raw_affiliation_strings":["Food Research Institute, NARO, 2-1-12, Kannondai, Tsukuba 305-8642, Japan","Food Research Institute, NARO, 2-1-12, Kannondai, Tsukuba, 305-8642, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Food Research Institute, NARO, 2-1-12, Kannondai, Tsukuba 305-8642, Japan","institution_ids":["https://openalex.org/I4210096597"]},{"raw_affiliation_string":"Food Research Institute, NARO, 2-1-12, Kannondai, Tsukuba, 305-8642, Japan","institution_ids":["https://openalex.org/I4210096597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085280227","display_name":"Yukiyo Nomura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukiyo Nomura","raw_affiliation_strings":["Laboratory of Structural Biology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1, Tsushima-naka, Okayama 700-8530, Japan","Laboratory of Structural Biology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1, Tsushima-naka, Okayama, 700-8530, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Structural Biology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1, Tsushima-naka, Okayama 700-8530, Japan","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Laboratory of Structural Biology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1, Tsushima-naka, Okayama, 700-8530, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109436765","display_name":"Nanako Atsumi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nanako Atsumi","raw_affiliation_strings":["Laboratory of Structural Biology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1, Tsushima-naka, Okayama 700-8530, Japan","Laboratory of Structural Biology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1, Tsushima-naka, Okayama, 700-8530, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Structural Biology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1, Tsushima-naka, Okayama 700-8530, Japan","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Laboratory of Structural Biology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1, Tsushima-naka, Okayama, 700-8530, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071330832","display_name":"Shuji Akiyama","orcid":"https://orcid.org/0000-0002-7184-189X","observed_orcids":["https://orcid.org/0000-0002-7184-189X"]},"institutions":[{"id":"https://openalex.org/I199525922","display_name":"National Institutes of Natural Sciences","ror":"https://ror.org/055n47h92","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1319490839","https://openalex.org/I199525922"]},{"id":"https://openalex.org/I200475212","display_name":"The Graduate University for Advanced Studies, SOKENDAI","ror":"https://ror.org/0516ah480","country_code":"JP","type":"education","lineage":["https://openalex.org/I200475212"]},{"id":"https://openalex.org/I4210143791","display_name":"Institute for Molecular Science","ror":"https://ror.org/04wqh5h97","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1319490839","https://openalex.org/I199525922","https://openalex.org/I4210143791"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuji Akiyama","raw_affiliation_strings":["Department of Functional Molecular Science, The Graduate University for Advanced Studies (SOKENDAI), 38 Nishigo-Naka, Okazaki 444-8585, Japan","Research Center of Integrative Molecular System (CIMoS), Institute for Molecular Science, National Institute of Natural Sciences, 38 Nishigo-Naka, Myodaiji, Okazaki 444-8585, Japan","Research Center of Integrative Molecular System (CIMoS), Institute for Molecular Science, National Institute of Natural Sciences, 38 Nishigo-Naka, Myodaiji, Okazaki, 444-8585, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Functional Molecular Science, The Graduate University for Advanced Studies (SOKENDAI), 38 Nishigo-Naka, Okazaki 444-8585, Japan","institution_ids":["https://openalex.org/I200475212"]},{"raw_affiliation_string":"Research Center of Integrative Molecular System (CIMoS), Institute for Molecular Science, National Institute of Natural Sciences, 38 Nishigo-Naka, Myodaiji, Okazaki 444-8585, Japan","institution_ids":["https://openalex.org/I199525922","https://openalex.org/I4210143791"]},{"raw_affiliation_string":"Research Center of Integrative Molecular System (CIMoS), Institute for Molecular Science, National Institute of Natural Sciences, 38 Nishigo-Naka, Myodaiji, Okazaki, 444-8585, Japan","institution_ids":["https://openalex.org/I199525922","https://openalex.org/I4210143791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016640043","display_name":"Eriko Nango","orcid":"https://orcid.org/0000-0001-9851-7355","observed_orcids":["https://orcid.org/0000-0001-9851-7355"]},"institutions":[{"id":"https://openalex.org/I4210104871","display_name":"SPring-8","ror":"https://ror.org/01d1kv753","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210104871","https://openalex.org/I4210110652","https://openalex.org/I4210111000"]},{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eriko Nango","raw_affiliation_strings":["RIKEN SPring-8 Center, 1-1-1, Kouto, Hyogo 679-5148, Japan","RIKEN SPring-8 Center, 1-1-1, Kouto, Hyogo, 679-5148, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RIKEN SPring-8 Center, 1-1-1, Kouto, Hyogo 679-5148, Japan","institution_ids":["https://openalex.org/I4210104871","https://openalex.org/I4210110652"]},{"raw_affiliation_string":"RIKEN SPring-8 Center, 1-1-1, Kouto, Hyogo, 679-5148, Japan","institution_ids":["https://openalex.org/I4210104871","https://openalex.org/I4210110652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060363731","display_name":"Yukinari Kato","orcid":"https://orcid.org/0000-0001-5385-8201","observed_orcids":["https://orcid.org/0000-0001-5385-8201"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukinari Kato","raw_affiliation_strings":["Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan","New Industry Creation Hatchery Center, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan","New Industry Creation Hatchery Center, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"New Industry Creation Hatchery Center, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"New Industry Creation Hatchery Center, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060119598","display_name":"Mika  Kato Kaneko","orcid":"https://orcid.org/0000-0002-4158-9208","observed_orcids":["https://orcid.org/0000-0002-4158-9208"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mika K. Kaneko","raw_affiliation_strings":["Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan","Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016321178","display_name":"Junichi Takagi","orcid":"https://orcid.org/0000-0002-1219-475X","observed_orcids":["https://orcid.org/0000-0002-1219-475X"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Junichi Takagi","raw_affiliation_strings":["Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Osaka 565-0871, Japan","Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Osaka, 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Osaka, 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025106618","display_name":"Maiko Hosotani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Maiko Hosotani","raw_affiliation_strings":["Laboratory of Structural Biology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1, Tsushima-naka, Okayama 700-8530, Japan","Laboratory of Structural Biology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1, Tsushima-naka, Okayama, 700-8530, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Structural Biology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1, Tsushima-naka, Okayama 700-8530, Japan","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Laboratory of Structural Biology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1, Tsushima-naka, Okayama, 700-8530, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051185216","display_name":"Atsuko Yamashita","orcid":"https://orcid.org/0000-0002-8001-4642","observed_orcids":["https://orcid.org/0000-0002-8001-4642"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]},{"id":"https://openalex.org/I4210104871","display_name":"SPring-8","ror":"https://ror.org/01d1kv753","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210104871","https://openalex.org/I4210110652","https://openalex.org/I4210111000"]},{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Atsuko Yamashita","raw_affiliation_strings":["Laboratory of Structural Biology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1, Tsushima-naka, Okayama 700-8530, Japan","RIKEN SPring-8 Center, 1-1-1, Kouto, Hyogo 679-5148, Japan","RIKEN SPring-8 Center, 1-1-1, Kouto, Hyogo, 679-5148, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Structural Biology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1, Tsushima-naka, Okayama 700-8530, Japan","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"RIKEN SPring-8 Center, 1-1-1, Kouto, Hyogo 679-5148, Japan","institution_ids":["https://openalex.org/I4210104871","https://openalex.org/I4210110652"]},{"raw_affiliation_string":"RIKEN SPring-8 Center, 1-1-1, Kouto, Hyogo, 679-5148, Japan","institution_ids":["https://openalex.org/I4210104871","https://openalex.org/I4210110652"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5051185216"],"corresponding_institution_ids":["https://openalex.org/I163770644","https://openalex.org/I4210104871","https://openalex.org/I4210110652"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":8.1439,"has_fulltext":true,"cited_by_count":161,"citation_normalized_percentile":{"value":0.9833925,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"8","issue":"1","first_page":"15530","last_page":"15530"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ligand-binding-domain","display_name":"ligand-binding domain","score":0.7670000195503235},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.652999997138977},{"id":"https://openalex.org/keywords/amino-acid-identification","display_name":"amino acid recognition","score":0.6740000247955322},{"id":"https://openalex.org/keywords/umami-taste","display_name":"umami taste","score":0.7680000066757202},{"id":"https://openalex.org/keywords/sweet-taste","display_name":"sweet taste","score":0.9309999942779541},{"id":"https://openalex.org/keywords/taste-perception","display_name":"taste perception","score":0.4959999918937683},{"id":"https://openalex.org/keywords/aromatic-residues","display_name":"aromatic residues","score":0.5870000123977661},{"id":"https://openalex.org/keywords/receptor-heterodimerization","display_name":"receptor heterodimerization","score":0.5070000290870667}],"concepts":[{"id":"https://openalex.org/C2776946002","wikidata":"https://www.wikidata.org/wiki/Q202637","display_name":"Umami","level":3,"score":0.9218594431877136},{"id":"https://openalex.org/C8868529","wikidata":"https://www.wikidata.org/wiki/Q124794","display_name":"Taste","level":2,"score":0.7943037748336792},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.714584469795227},{"id":"https://openalex.org/C178006227","wikidata":"https://www.wikidata.org/wiki/Q3454532","display_name":"Taste receptor","level":3,"score":0.666465163230896},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.5169912576675415},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.5019991397857666},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5001347064971924},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.48529237508773804},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4291188418865204}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009990","descriptor_name":"Oryzias","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009990","descriptor_name":"Oryzias","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009990","descriptor_name":"Oryzias","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013649","descriptor_name":"Taste","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013649","descriptor_name":"Taste","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013649","descriptor_name":"Taste","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013650","descriptor_name":"Taste Buds","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013650","descriptor_name":"Taste Buds","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013650","descriptor_name":"Taste Buds","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013650","descriptor_name":"Taste Buds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013650","descriptor_name":"Taste Buds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013650","descriptor_name":"Taste Buds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/ncomms15530","doi":"https://doi.org/10.1038/ncomms15530","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ncomms15530","pdf_url":"https://www.nature.com/articles/ncomms15530.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmid:28534491","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28534491","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4313179","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5457512","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5457512","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5457512","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmh:oai:RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15530","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/ncomms15530","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:f22496cabba74436b0d2faf93634c069","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f22496cabba74436b0d2faf93634c069","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/ncomms15530","doi":"https://doi.org/10.1038/ncomms15530","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ncomms15530","pdf_url":"https://www.nature.com/articles/ncomms15530.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.75,"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2171970672","display_name":"Reconstitution of private chaperone systems using synthetic binding proteins","funder_award_id":"15H05370","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3129865373","display_name":"Structural mechanism of the Wnt-receptor interaction","funder_award_id":"17H01420","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6015386423","display_name":"Generation and characterization of monoclonal antibodies against the extracellular regions of taste receptors","funder_award_id":"25891017","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7226847385","display_name":"Construction of evaluation method of sweet-taste response for newly-produced rice starch pastes","funder_award_id":"15K00796","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320317111","display_name":"Urakami Foundation for Food and Food Culture Promotion","ror":"https://ror.org/03j186m48"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320325855","display_name":"Council for Science and Technology Policy","ror":null},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2619083483.pdf","grobid_xml":"https://content.openalex.org/works/W2619083483.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W1136490972","https://openalex.org/W1506907307","https://openalex.org/W1539796472","https://openalex.org/W1945680072","https://openalex.org/W1965270719","https://openalex.org/W1965875043","https://openalex.org/W1968759975","https://openalex.org/W1969133910","https://openalex.org/W1969547178","https://openalex.org/W1969672293","https://openalex.org/W1970250202","https://openalex.org/W1980823413","https://openalex.org/W1991197347","https://openalex.org/W1992956599","https://openalex.org/W1993003691","https://openalex.org/W1993684492","https://openalex.org/W1996099759","https://openalex.org/W2002984932","https://openalex.org/W2004264351","https://openalex.org/W2019182153","https://openalex.org/W2022096033","https://openalex.org/W2023343746","https://openalex.org/W2023939486","https://openalex.org/W2024011576","https://openalex.org/W2029582401","https://openalex.org/W2029854492","https://openalex.org/W2030640567","https://openalex.org/W2038573621","https://openalex.org/W2038840577","https://openalex.org/W2042475399","https://openalex.org/W2048707877","https://openalex.org/W2066088601","https://openalex.org/W2067388704","https://openalex.org/W2068322437","https://openalex.org/W2069847094","https://openalex.org/W2073115006","https://openalex.org/W2074473216","https://openalex.org/W2085794257","https://openalex.org/W2088924256","https://openalex.org/W2092322873","https://openalex.org/W2092387745","https://openalex.org/W2093826299","https://openalex.org/W2099666647","https://openalex.org/W2100292354","https://openalex.org/W2100822781","https://openalex.org/W2111523314","https://openalex.org/W2111658605","https://openalex.org/W2115366624","https://openalex.org/W2121145363","https://openalex.org/W2122060463","https://openalex.org/W2124026197","https://openalex.org/W2130060890","https://openalex.org/W2131417105","https://openalex.org/W2131777290","https://openalex.org/W2132067013","https://openalex.org/W2133135629","https://openalex.org/W2143815085","https://openalex.org/W2146972650","https://openalex.org/W2154197653","https://openalex.org/W2157393167","https://openalex.org/W2162327153","https://openalex.org/W2163341755","https://openalex.org/W2163833204","https://openalex.org/W2165565773","https://openalex.org/W2168706542","https://openalex.org/W2172011217","https://openalex.org/W2201150409","https://openalex.org/W2408576125","https://openalex.org/W2415039239","https://openalex.org/W4249590403"],"related_works":["https://openalex.org/W3122144785","https://openalex.org/W2986018130","https://openalex.org/W2115903163","https://openalex.org/W1520955230","https://openalex.org/W2485236155","https://openalex.org/W2156849060","https://openalex.org/W3190679906","https://openalex.org/W2318771561","https://openalex.org/W2990791507","https://openalex.org/W3210218061"],"abstract_inverted_index":{"The":[0,72],"taste":[1,59,109,147],"receptor":[2],"type":[3],"1":[4],"(T1r)":[5],"family":[6],"perceives":[7],"'palatable'":[8],"tastes.":[9],"These":[10],"receptors":[11],"function":[12],"as":[13],"T1r2-T1r3":[14,65],"and":[15,25,31,83],"T1r1-T1r3":[16],"heterodimers":[17],"to":[18,68],"recognize":[19],"a":[20,97,121,138],"wide":[21],"array":[22],"of":[23,52,62,108,146],"sweet":[24],"umami":[26],"(savory)":[27],"tastes":[28,40],"in":[29,75,79,116],"sugars":[30],"amino":[32,70,125],"acids.":[33,71],"Nonetheless,":[34],"it":[35],"is":[36,77,94,118],"unclear":[37],"how":[38],"diverse":[39],"are":[41],"recognized":[42],"by":[43,96,120],"so":[44],"few":[45],"receptors.":[46,148],"Here":[47],"we":[48,136],"present":[49],"crystal":[50],"structures":[51],"the":[53,58,63,105,113,129,143],"extracellular":[54],"ligand-binding":[55,73],"domains":[56],"(LBDs),":[57],"recognition":[60],"regions":[61],"fish":[64],"heterodimer,":[66],"bound":[67,124],"different":[69],"pocket":[74,115],"T1r2LBD":[76],"rich":[78],"aromatic":[80],"residues,":[81],"spacious":[82],"accommodates":[84],"hydrated":[85],"percepts.":[86],"Biophysical":[87],"studies":[88],"show":[89],"that":[90,128],"this":[91],"binding":[92],"site":[93],"characterized":[95],"broad":[98],"yet":[99],"discriminating":[100],"chemical":[101,144],"recognition,":[102],"contributing":[103],"for":[104,141],"particular":[106],"trait":[107],"perception.":[110],"In":[111],"contrast,":[112],"analogous":[114],"T1r3LBD":[117],"occupied":[119],"rather":[122],"loosely":[123],"acid,":[126],"suggesting":[127],"T1r3":[130],"has":[131],"an":[132],"auxiliary":[133],"role.":[134],"Overall,":[135],"provide":[137],"structural":[139],"basis":[140],"understanding":[142],"perception":[145]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":28},{"year":2024,"cited_by_count":22},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":22},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":4}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}