{"id":"https://openalex.org/W2619082986","doi":"https://doi.org/10.1002/wnan.1479","title":"Nanotherapeutic systems for local treatment of brain tumors","display_name":"Nanotherapeutic systems for local treatment of brain tumors","publication_year":2017,"publication_date":"2017-05-24","ids":{"openalex":"https://openalex.org/W2619082986","doi":"https://doi.org/10.1002/wnan.1479","mag":"2619082986","pmid":"https://pubmed.ncbi.nlm.nih.gov/28544801"},"language":"en","primary_location":{"id":"doi:10.1002/wnan.1479","doi":"https://doi.org/10.1002/wnan.1479","is_oa":false,"landing_page_url":"https://doi.org/10.1002/wnan.1479","pdf_url":null,"source":{"id":"https://openalex.org/S132212666","display_name":"Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology","issn_l":"1939-0041","issn":["1939-0041","1939-5116"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"WIREs Nanomedicine and Nanobiotechnology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5701865","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068656421","display_name":"Rami W. Chakroun","orcid":"https://orcid.org/0000-0002-8349-6587","observed_orcids":["https://orcid.org/0000-0002-8349-6587"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rami Walid Chakroun","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering Johns Hopkins University Baltimore MD USA","Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering Johns Hopkins University Baltimore MD USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100365982","display_name":"Pengcheng Zhang","orcid":"https://orcid.org/0000-0002-4546-0022","observed_orcids":["https://orcid.org/0000-0002-4546-0022"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pengcheng Zhang","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering Johns Hopkins University Baltimore MD USA","Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering Johns Hopkins University Baltimore MD USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064904381","display_name":"Ran Lin","orcid":"https://orcid.org/0000-0002-4413-6300","observed_orcids":["https://orcid.org/0000-0002-4413-6300"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ran Lin","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering Johns Hopkins University Baltimore MD USA","Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering Johns Hopkins University Baltimore MD USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074588897","display_name":"Paula V. Schiapparelli","orcid":"https://orcid.org/0000-0003-4551-6337","observed_orcids":["https://orcid.org/0000-0003-4551-6337"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paula Schiapparelli","raw_affiliation_strings":["Department of Neurosurgery Mayo Clinic, Jacksonville FL USA","Department of Neurosurgery, Mayo Clinic, Jacksonville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery Mayo Clinic, Jacksonville FL USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Department of Neurosurgery, Mayo Clinic, Jacksonville, FL, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029294194","display_name":"Alfredo Qui\u00f1ones\u2010Hinojosa","orcid":"https://orcid.org/0000-0003-4262-5968","observed_orcids":["https://orcid.org/0000-0003-4262-5968"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alfredo Quinones\u2010Hinojosa","raw_affiliation_strings":["Department of Neurosurgery Mayo Clinic, Jacksonville FL USA","Department of Neurosurgery, Mayo Clinic, Jacksonville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery Mayo Clinic, Jacksonville FL USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Department of Neurosurgery, Mayo Clinic, Jacksonville, FL, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077586136","display_name":"Honggang Cui","orcid":"https://orcid.org/0000-0002-4684-2655","observed_orcids":["https://orcid.org/0000-0002-4684-2655"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Honggang Cui","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering Johns Hopkins University Baltimore MD USA","Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering Johns Hopkins University Baltimore MD USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5077586136"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":{"value":4730,"currency":"USD","value_usd":4730},"apc_paid":null,"fwci":3.0583,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.92254808,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"10","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.026799999177455902,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.8429999947547913},{"id":"https://openalex.org/keywords/brain-tumors","display_name":"brain tumors","score":0.9010000228881836},{"id":"https://openalex.org/keywords/nanoparticle-drug-delivery","display_name":"nanoparticle drug delivery","score":0.8489999771118164},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.8949999809265137},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.968999981880188},{"id":"https://openalex.org/keywords/controlled-drug-release","display_name":"controlled drug release","score":0.8629999756813049},{"id":"https://openalex.org/keywords/local-tumor-treatment","display_name":"local tumor treatment","score":0.550000011920929},{"id":"https://openalex.org/keywords/brain-tumor-treatment","display_name":"brain tumor therapy","score":0.4620000123977661},{"id":"https://openalex.org/keywords/nanomedicine","display_name":"nanomedicine","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47167736291885376},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.322751522064209},{"id":"https://openalex.org/C55587333","wikidata":"https://www.wikidata.org/wiki/Q1133029","display_name":"Engineering ethics","level":1,"score":0.322541207075119}],"mesh":[{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018481","descriptor_name":"Convection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018481","descriptor_name":"Convection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018481","descriptor_name":"Convection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020100","descriptor_name":"Hydrogels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020100","descriptor_name":"Hydrogels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020100","descriptor_name":"Hydrogels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050997","descriptor_name":"Nanomedicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D050997","descriptor_name":"Nanomedicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D050997","descriptor_name":"Nanomedicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/wnan.1479","doi":"https://doi.org/10.1002/wnan.1479","is_oa":false,"landing_page_url":"https://doi.org/10.1002/wnan.1479","pdf_url":null,"source":{"id":"https://openalex.org/S132212666","display_name":"Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology","issn_l":"1939-0041","issn":["1939-0041","1939-5116"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"WIREs Nanomedicine and Nanobiotechnology","raw_type":"journal-article"},{"id":"pmid:28544801","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28544801","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5281501","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5701865","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5701865","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5701865","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wiley Interdiscip Rev Nanomed Nanobiotechnol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5701865","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5701865","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wiley Interdiscip Rev Nanomed Nanobiotechnol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8799999952316284,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2295583845","display_name":null,"funder_award_id":"R21 CA191740","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7388469624","display_name":"CAREER: Self-Assembly of Anti-Cancer Drugs into Well-Defined Supramolecular Nanostructures","funder_award_id":"1255281","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G9000353983","display_name":null,"funder_award_id":"NIH/R21CA191740","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320307856","display_name":"World Health Organization","ror":"https://ror.org/01f80g185"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":239,"referenced_works":["https://openalex.org/W1087259","https://openalex.org/W67670358","https://openalex.org/W760546722","https://openalex.org/W1470598344","https://openalex.org/W1474295733","https://openalex.org/W1485411688","https://openalex.org/W1516518029","https://openalex.org/W1538902372","https://openalex.org/W1551978591","https://openalex.org/W1570195799","https://openalex.org/W1575993552","https://openalex.org/W1624957772","https://openalex.org/W1655997880","https://openalex.org/W1750998545","https://openalex.org/W1790847442","https://openalex.org/W1801242987","https://openalex.org/W1821415384","https://openalex.org/W1838570471","https://openalex.org/W1864485862","https://openalex.org/W1895781480","https://openalex.org/W1937235214","https://openalex.org/W1964979091","https://openalex.org/W1965642226","https://openalex.org/W1965709929","https://openalex.org/W1965894523","https://openalex.org/W1966463392","https://openalex.org/W1966597723","https://openalex.org/W1966611280","https://openalex.org/W1969757222","https://openalex.org/W1970030334","https://openalex.org/W1972248948","https://openalex.org/W1973544766","https://openalex.org/W1973652084","https://openalex.org/W1974000574","https://openalex.org/W1974847420","https://openalex.org/W1976797458","https://openalex.org/W1976970322","https://openalex.org/W1977779892","https://openalex.org/W1982471389","https://openalex.org/W1983067875","https://openalex.org/W1983766005","https://openalex.org/W1984341909","https://openalex.org/W1984955359","https://openalex.org/W1985684473","https://openalex.org/W1985800624","https://openalex.org/W1987480442","https://openalex.org/W1989250261","https://openalex.org/W1992983740","https://openalex.org/W1995586545","https://openalex.org/W1996293069","https://openalex.org/W1996507796","https://openalex.org/W1997146974","https://openalex.org/W1997160008","https://openalex.org/W1997302075","https://openalex.org/W1998000193","https://openalex.org/W2000915705","https://openalex.org/W2001215365","https://openalex.org/W2003736464","https://openalex.org/W2003926924","https://openalex.org/W2004048765","https://openalex.org/W2007988355","https://openalex.org/W2008055481","https://openalex.org/W2008435693","https://openalex.org/W2010618825","https://openalex.org/W2014356856","https://openalex.org/W2014537537","https://openalex.org/W2015504271","https://openalex.org/W2016983859","https://openalex.org/W2018473726","https://openalex.org/W2018522439","https://openalex.org/W2018556794","https://openalex.org/W2019163583","https://openalex.org/W2020246410","https://openalex.org/W2024514018","https://openalex.org/W2024754897","https://openalex.org/W2026332644","https://openalex.org/W2027147390","https://openalex.org/W2028560023","https://openalex.org/W2028917956","https://openalex.org/W2030141189","https://openalex.org/W2034365540","https://openalex.org/W2036304264","https://openalex.org/W2036932527","https://openalex.org/W2037798920","https://openalex.org/W2038613867","https://openalex.org/W2038624271","https://openalex.org/W2038850485","https://openalex.org/W2039202448","https://openalex.org/W2039759758","https://openalex.org/W2040283668","https://openalex.org/W2040882015","https://openalex.org/W2041780028","https://openalex.org/W2042778784","https://openalex.org/W2043563039","https://openalex.org/W2044013857","https://openalex.org/W2045052963","https://openalex.org/W2045451897","https://openalex.org/W2046606679","https://openalex.org/W2052057182","https://openalex.org/W2054077061","https://openalex.org/W2055881439","https://openalex.org/W2056475298","https://openalex.org/W2056476092","https://openalex.org/W2056730157","https://openalex.org/W2057691996","https://openalex.org/W2058213249","https://openalex.org/W2060432355","https://openalex.org/W2061225714","https://openalex.org/W2062144350","https://openalex.org/W2062643170","https://openalex.org/W2063538683","https://openalex.org/W2063800774","https://openalex.org/W2065527895","https://openalex.org/W2066616656","https://openalex.org/W2066671159","https://openalex.org/W2067991861","https://openalex.org/W2068121152","https://openalex.org/W2068586723","https://openalex.org/W2070248960","https://openalex.org/W2070378483","https://openalex.org/W2071926235","https://openalex.org/W2072229818","https://openalex.org/W2072687605","https://openalex.org/W2077556340","https://openalex.org/W2077819013","https://openalex.org/W2080086992","https://openalex.org/W2082097131","https://openalex.org/W2082292403","https://openalex.org/W2083120527","https://openalex.org/W2083336965","https://openalex.org/W2086393160","https://openalex.org/W2087236473","https://openalex.org/W2088473419","https://openalex.org/W2089028118","https://openalex.org/W2089117567","https://openalex.org/W2091324614","https://openalex.org/W2091690481","https://openalex.org/W2091736771","https://openalex.org/W2091857781","https://openalex.org/W2092307209","https://openalex.org/W2093418985","https://openalex.org/W2093807603","https://openalex.org/W2095512576","https://openalex.org/W2096287682","https://openalex.org/W2096456517","https://openalex.org/W2097128649","https://openalex.org/W2097402711","https://openalex.org/W2097943048","https://openalex.org/W2099431752","https://openalex.org/W2101099825","https://openalex.org/W2101782398","https://openalex.org/W2104251127","https://openalex.org/W2104572811","https://openalex.org/W2106364535","https://openalex.org/W2109818109","https://openalex.org/W2111217091","https://openalex.org/W2111814792","https://openalex.org/W2115362657","https://openalex.org/W2116191565","https://openalex.org/W2116956138","https://openalex.org/W2117553516","https://openalex.org/W2117993260","https://openalex.org/W2118471749","https://openalex.org/W2120100866","https://openalex.org/W2120919579","https://openalex.org/W2127154566","https://openalex.org/W2127256767","https://openalex.org/W2128610705","https://openalex.org/W2128923622","https://openalex.org/W2129263071","https://openalex.org/W2131082444","https://openalex.org/W2131659761","https://openalex.org/W2131950300","https://openalex.org/W2133885408","https://openalex.org/W2133953251","https://openalex.org/W2134886995","https://openalex.org/W2136610170","https://openalex.org/W2139187462","https://openalex.org/W2140898147","https://openalex.org/W2141137181","https://openalex.org/W2141960867","https://openalex.org/W2145021735","https://openalex.org/W2145238798","https://openalex.org/W2145550995","https://openalex.org/W2146804964","https://openalex.org/W2146845803","https://openalex.org/W2147535764","https://openalex.org/W2148977460","https://openalex.org/W2149145595","https://openalex.org/W2149768128","https://openalex.org/W2150558027","https://openalex.org/W2159821105","https://openalex.org/W2162872529","https://openalex.org/W2163011235","https://openalex.org/W2164475208","https://openalex.org/W2164615905","https://openalex.org/W2164788523","https://openalex.org/W2166649262","https://openalex.org/W2168339179","https://openalex.org/W2180223963","https://openalex.org/W2213504946","https://openalex.org/W2222811352","https://openalex.org/W2231446594","https://openalex.org/W2235523093","https://openalex.org/W2240084039","https://openalex.org/W2264721780","https://openalex.org/W2275318246","https://openalex.org/W2281496323","https://openalex.org/W2284436064","https://openalex.org/W2288772615","https://openalex.org/W2289697279","https://openalex.org/W2291461503","https://openalex.org/W2299786462","https://openalex.org/W2308170743","https://openalex.org/W2319797080","https://openalex.org/W2326103518","https://openalex.org/W2328665600","https://openalex.org/W2405462404","https://openalex.org/W2406913770","https://openalex.org/W2419048121","https://openalex.org/W2431592911","https://openalex.org/W2461509262","https://openalex.org/W2462551729","https://openalex.org/W2479806620","https://openalex.org/W2503365563","https://openalex.org/W2520212767","https://openalex.org/W2530494509","https://openalex.org/W2531640839","https://openalex.org/W2560367415","https://openalex.org/W2568159634","https://openalex.org/W2572376937","https://openalex.org/W2731279912","https://openalex.org/W3022598401","https://openalex.org/W3148120625","https://openalex.org/W4210310956","https://openalex.org/W4230908322","https://openalex.org/W4242403727","https://openalex.org/W4243543845","https://openalex.org/W6600058893"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725"],"abstract_inverted_index":{"Malignant":[0],"brain":[1,72,110,137],"tumor,":[2],"including":[3,29],"the":[4,17,35,64,76,86,90,98,109,115,125,131,134,140,161],"most":[5,18],"common":[6],"type":[7],"glioblastoma,":[8],"are":[9,157],"histologically":[10],"heterogeneous":[11],"and":[12,24,33,39,55,68,142,194,199,203],"invasive":[13],"tumors":[14,73],"known":[15],"as":[16],"devastating":[19],"neoplasms":[20],"with":[21],"high":[22],"morbidity":[23],"mortality.":[25],"Despite":[26],"multimodal":[27],"treatment":[28,53],"surgery,":[30],"radiotherapy,":[31],"chemotherapy,":[32],"immunotherapy,":[34],"disease":[36],"inevitably":[37],"recurs":[38],"is":[40,189],"fatal.":[41],"This":[42,187],"lack":[43],"of":[44,71,78,92,105,124,136,144,153],"curative":[45],"options":[46],"has":[47],"motivated":[48],"researchers":[49],"to":[50,56,96,159],"explore":[51],"new":[52,58],"strategies":[54],"develop":[57],"drug":[59],"delivery":[60],"systems":[61,155],"(DDSs);":[62],"however,":[63],"unique":[65],"anatomical,":[66],"physiological,":[67],"pathological":[69],"features":[70],"greatly":[74],"limit":[75],"effectiveness":[77,141],"conventional":[79],"chemotherapy.":[80],"In":[81],"this":[82],"context,":[83],"we":[84],"review":[85,152],"recent":[87],"progress":[88],"in":[89,101,130,176],"development":[91],"nanoparticle-based":[93],"DDSs":[94],"aiming":[95],"address":[97],"key":[99],"challenges":[100],"transporting":[102],"sufficient":[103],"amount":[104],"therapeutic":[106,174],"agents":[107,175],"into":[108],"tumor":[111],"areas":[112],"while":[113],"minimizing":[114],"potential":[116],"side":[117],"effects.":[118],"We":[119,147],"first":[120],"provide":[121,149],"an":[122,150],"overview":[123],"standard":[126],"treatments":[127],"currently":[128],"used":[129],"clinic":[132],"for":[133,208],"management":[135],"cancers,":[138],"discussing":[139],"limitations":[143],"each":[145],"therapy.":[146],"then":[148],"in-depth":[151],"nanotherapeutic":[154],"that":[156],"intended":[158],"bypass":[160],"blood-brain":[162],"barrier,":[163],"overcome":[164],"multidrug":[165],"resistance,":[166],"infiltrate":[167],"larger":[168],"tumorous":[169],"tissue":[170],"areas,":[171],"and/or":[172],"release":[173],"a":[177],"controlled":[178],"manner.":[179],"WIREs":[180],"Nanomed":[181],"Nanobiotechnol":[182],"2018,":[183],"10:e1479.":[184],"doi:":[185],"10.1002/wnan.1479":[186],"article":[188],"categorized":[190],"under:":[191],"Implantable":[192],"Materials":[193],"Surgical":[195],"Technologies":[196],">":[197,206],"Nanomaterials":[198],"Implants":[200],"Therapeutic":[201],"Approaches":[202],"Drug":[204],"Discovery":[205],"Nanomedicine":[207],"Oncologic":[209],"Disease.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":4}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
