{"id":"https://openalex.org/W2619002073","doi":"https://doi.org/10.18632/oncotarget.17863","title":"Leflunomide/teriflunomide inhibit Epstein-Barr virus (EBV)-induced lymphoproliferative disease and lytic viral replication","display_name":"Leflunomide/teriflunomide inhibit Epstein-Barr virus (EBV)-induced lymphoproliferative disease and lytic viral replication","publication_year":2017,"publication_date":"2017-05-15","ids":{"openalex":"https://openalex.org/W2619002073","doi":"https://doi.org/10.18632/oncotarget.17863","mag":"2619002073","pmid":"https://pubmed.ncbi.nlm.nih.gov/28574826"},"language":"en","primary_location":{"id":"doi:10.18632/oncotarget.17863","doi":"https://doi.org/10.18632/oncotarget.17863","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.17863","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=17863&path%5B%5D=57213","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=17863&path%5B%5D=57213","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042214841","display_name":"Andrea Bilger","orcid":"https://orcid.org/0000-0002-4838-4731","observed_orcids":["https://orcid.org/0000-0002-4838-4731","https://orcid.org/0009-0004-0985-0527"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea Bilger","raw_affiliation_strings":["Department of Oncology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001676700","display_name":"Julie Plowshay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie Plowshay","raw_affiliation_strings":["Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA","Rocky Mountain Infectious Disease Specialists, Aurora, Colorado, USA","Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA; Rocky Mountain Infectious Disease Specialists, Aurora, Colorado, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Rocky Mountain Infectious Disease Specialists, Aurora, Colorado, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA; Rocky Mountain Infectious Disease Specialists, Aurora, Colorado, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074923818","display_name":"Shidong Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shidong Ma","raw_affiliation_strings":["Department of Oncology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA","Sanofi Pharmaceuticals, Cambridge, Massachusetts, USA","Department of Oncology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA; Sanofi Pharmaceuticals, Cambridge, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Sanofi Pharmaceuticals, Cambridge, Massachusetts, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Oncology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA; Sanofi Pharmaceuticals, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050586319","display_name":"Dhananjay M. Nawandar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dhananjay Nawandar","raw_affiliation_strings":["Department Cellular and Molecular Biology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, USA","Department of Cancer Biology and Immunology, Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Cambridge, Massachusetts, USA","Department Cellular and Molecular Biology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, USA; Department of Cancer Biology and Immunology, Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Cambridge, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Cellular and Molecular Biology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Cancer Biology and Immunology, Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department Cellular and Molecular Biology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, USA; Department of Cancer Biology and Immunology, Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082636703","display_name":"Elizabeth A. Barlow","orcid":"https://orcid.org/0000-0002-2269-1629","observed_orcids":["https://orcid.org/0000-0002-2269-1629"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth A. Barlow","raw_affiliation_strings":["Department of Oncology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013916954","display_name":"James C. Romero-Masters","orcid":"https://orcid.org/0000-0001-6871-0568","observed_orcids":["https://orcid.org/0000-0001-6871-0568"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James C. Romero-Masters","raw_affiliation_strings":["Department of Cellular and Molecular Pathology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Pathology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012636364","display_name":"Jillian A. Bristol","orcid":"https://orcid.org/0000-0001-6109-8126","observed_orcids":["https://orcid.org/0000-0001-6109-8126"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jillian A. Bristol","raw_affiliation_strings":["Department of Oncology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100611664","display_name":"Zhe Li","orcid":"https://orcid.org/0000-0002-1106-382X","observed_orcids":["https://orcid.org/0000-0002-1106-382X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE","FR"],"is_corresponding":false,"raw_author_name":"Zhe Li","raw_affiliation_strings":["Joint DKFZ Inserm Unit U1074, German Cancer Center (DKFZ), Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint DKFZ Inserm Unit U1074, German Cancer Center (DKFZ), Heidelberg, Germany","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009245958","display_name":"Ming\u2010Han Tsai","orcid":"https://orcid.org/0000-0001-5563-3057","observed_orcids":["https://orcid.org/0000-0001-5563-3057"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE","FR"],"is_corresponding":false,"raw_author_name":"Ming-Han Tsai","raw_affiliation_strings":["Joint DKFZ Inserm Unit U1074, German Cancer Center (DKFZ), Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint DKFZ Inserm Unit U1074, German Cancer Center (DKFZ), Heidelberg, Germany","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036094965","display_name":"Henri\u2010Jacques Delecluse","orcid":"https://orcid.org/0000-0002-1744-6274","observed_orcids":["https://orcid.org/0000-0002-1744-6274"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE","FR"],"is_corresponding":false,"raw_author_name":"Henri-Jacques Delecluse","raw_affiliation_strings":["Joint DKFZ Inserm Unit U1074, German Cancer Center (DKFZ), Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint DKFZ Inserm Unit U1074, German Cancer Center (DKFZ), Heidelberg, Germany","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I17937529"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028943143","display_name":"Shannon C. Kenney","orcid":"https://orcid.org/0000-0002-9655-6526","observed_orcids":["https://orcid.org/0000-0002-9655-6526"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shannon C. Kenney","raw_affiliation_strings":["Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA","Department of Oncology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Oncology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5962,"has_fulltext":true,"cited_by_count":78,"citation_normalized_percentile":{"value":0.91727266,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"8","issue":"27","first_page":"44266","last_page":"44280"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leflunomide","display_name":"leflunomide","score":0.9959999918937683},{"id":"https://openalex.org/keywords/teriflunomide","display_name":"teriflunomide","score":1.0},{"id":"https://openalex.org/keywords/epstein-barr-virus","display_name":"Epstein-Barr virus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lymphoproliferative-disorders","display_name":"lymphoproliferative disorders","score":0.847000002861023},{"id":"https://openalex.org/keywords/b-cell-lymphoma","display_name":"B-cell lymphoma","score":0.8109999895095825},{"id":"https://openalex.org/keywords/dihydroorotate-dehydrogenase","display_name":"dihydroorotate dehydrogenase","score":0.8140000104904175},{"id":"https://openalex.org/keywords/pyrimidine-synthesis-inhibition","display_name":"pyrimidine synthesis inhibition","score":0.8870000243186951},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.6449999809265137},{"id":"https://openalex.org/keywords/organ-transplant-recipients","display_name":"organ transplant recipients","score":0.746999979019165},{"id":"https://openalex.org/keywords/humanized-mouse-model","display_name":"humanized mice","score":0.7310000061988831},{"id":"https://openalex.org/keywords/antiviral-therapy","display_name":"antiviral therapy","score":0.6179999709129333},{"id":"https://openalex.org/keywords/cytomegalovirus","display_name":"cytomegalovirus","score":0.8159999847412109},{"id":"https://openalex.org/keywords/bk-polyomavirus","display_name":"BK virus","score":0.847000002861023},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.47699999809265137}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6489372849464417},{"id":"https://openalex.org/C2775905006","wikidata":"https://www.wikidata.org/wiki/Q248550","display_name":"Leflunomide","level":3,"score":0.5487736463546753},{"id":"https://openalex.org/C2781375147","wikidata":"https://www.wikidata.org/wiki/Q6900","display_name":"Epstein\u2013Barr virus","level":3,"score":0.4766174852848053},{"id":"https://openalex.org/C2777703276","wikidata":"https://www.wikidata.org/wiki/Q3077133","display_name":"Teriflunomide","level":4,"score":0.4356393814086914},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4036111831665039},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.3343852162361145},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.3299633264541626},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.2618391513824463},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.23620522022247314},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.1393970549106598},{"id":"https://openalex.org/C2776036978","wikidata":"https://www.wikidata.org/wiki/Q425137","display_name":"Fingolimod","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077339","descriptor_name":"Leflunomide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077339","descriptor_name":"Leflunomide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077339","descriptor_name":"Leflunomide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003437","descriptor_name":"Crotonates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003437","descriptor_name":"Crotonates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003437","descriptor_name":"Crotonates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006885","descriptor_name":"Hydroxybutyrates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006885","descriptor_name":"Hydroxybutyrates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006885","descriptor_name":"Hydroxybutyrates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007555","descriptor_name":"Isoxazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007555","descriptor_name":"Isoxazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007555","descriptor_name":"Isoxazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008232","descriptor_name":"Lymphoproliferative Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008232","descriptor_name":"Lymphoproliferative Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008232","descriptor_name":"Lymphoproliferative Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008232","descriptor_name":"Lymphoproliferative Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008232","descriptor_name":"Lymphoproliferative Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008232","descriptor_name":"Lymphoproliferative Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008232","descriptor_name":"Lymphoproliferative Disorders","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008232","descriptor_name":"Lymphoproliferative Disorders","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008232","descriptor_name":"Lymphoproliferative Disorders","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014052","descriptor_name":"Toluidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014052","descriptor_name":"Toluidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014052","descriptor_name":"Toluidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014775","descriptor_name":"Virus Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014775","descriptor_name":"Virus Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014775","descriptor_name":"Virus Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016259","descriptor_name":"Genes, myc","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016259","descriptor_name":"Genes, myc","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016259","descriptor_name":"Genes, myc","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019927","descriptor_name":"Cyclin E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019927","descriptor_name":"Cyclin E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019927","descriptor_name":"Cyclin E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.18632/oncotarget.17863","doi":"https://doi.org/10.18632/oncotarget.17863","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.17863","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=17863&path%5B%5D=57213","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},{"id":"pmid:28574826","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28574826","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4460694","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5546479","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5546479","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5546479","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Oncotarget","raw_type":"Text"},{"id":"pmh:oai:dash.harvard.edu:1/34375187","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:34375187","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.18632/oncotarget.17863","doi":"https://doi.org/10.18632/oncotarget.17863","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.17863","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=17863&path%5B%5D=57213","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6600000262260437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G42679306","display_name":null,"funder_award_id":"P30CA014520","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7505140584","display_name":null,"funder_award_id":"P01-CA022443","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G858431382","display_name":null,"funder_award_id":"R01 CA174462","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000029774","display_name":null,"funder_award_id":"P01 CA22443","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000058898","display_name":null,"funder_award_id":"R01CA174462","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000265189","display_name":null,"funder_award_id":"P30CA014520","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000352744","display_name":null,"funder_award_id":"CA014520","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2619002073.pdf","grobid_xml":"https://content.openalex.org/works/W2619002073.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W1502688016","https://openalex.org/W1531385547","https://openalex.org/W1531490664","https://openalex.org/W1547532383","https://openalex.org/W1578954095","https://openalex.org/W1963973972","https://openalex.org/W1968923103","https://openalex.org/W1976400658","https://openalex.org/W1977809195","https://openalex.org/W1981692602","https://openalex.org/W1981785841","https://openalex.org/W1987512032","https://openalex.org/W1994524871","https://openalex.org/W2000614504","https://openalex.org/W2008511202","https://openalex.org/W2009561614","https://openalex.org/W2015616819","https://openalex.org/W2019728262","https://openalex.org/W2024991882","https://openalex.org/W2026094543","https://openalex.org/W2047214508","https://openalex.org/W2054213118","https://openalex.org/W2055892558","https://openalex.org/W2062816809","https://openalex.org/W2071833051","https://openalex.org/W2074479811","https://openalex.org/W2075494258","https://openalex.org/W2083202616","https://openalex.org/W2087638002","https://openalex.org/W2092911406","https://openalex.org/W2095517704","https://openalex.org/W2097787479","https://openalex.org/W2100161576","https://openalex.org/W2100870126","https://openalex.org/W2107060734","https://openalex.org/W2108385487","https://openalex.org/W2119423337","https://openalex.org/W2126805876","https://openalex.org/W2133247083","https://openalex.org/W2138234417","https://openalex.org/W2140058638","https://openalex.org/W2146784451","https://openalex.org/W2146853742","https://openalex.org/W2148588361","https://openalex.org/W2153094795","https://openalex.org/W2154147815","https://openalex.org/W2155610307","https://openalex.org/W2160369223","https://openalex.org/W2166043441","https://openalex.org/W2221626926","https://openalex.org/W2228301361","https://openalex.org/W2285594441","https://openalex.org/W2318894243","https://openalex.org/W2331216044","https://openalex.org/W2401113962","https://openalex.org/W2416873769","https://openalex.org/W2467918292","https://openalex.org/W2517490587","https://openalex.org/W2520159331","https://openalex.org/W2529651453","https://openalex.org/W2955504961"],"related_works":["https://openalex.org/W2127459073","https://openalex.org/W3019329228","https://openalex.org/W1862311627","https://openalex.org/W4292851307","https://openalex.org/W1704233276","https://openalex.org/W2047566464","https://openalex.org/W4255185496","https://openalex.org/W2006470888","https://openalex.org/W4283764963","https://openalex.org/W3171595980"],"abstract_inverted_index":{"//":[0],"Andrea":[1],"Bilger":[2],"1":[3,23,33,52],",":[4,9,14,19,24,29,34,38,42],"Julie":[5],"Plowshay":[6],"2,":[7],"6":[8,126],"Shidong":[10],"Ma":[11],"1,":[12,50],"5":[13,120],"Dhananjay":[15],"Nawandar":[16],"3,":[17],"7":[18,135],"Elizabeth":[20],"A.":[21,31],"Barlow":[22],"James":[25],"C.":[26,48,170],"Romero-Masters":[27],"4":[28,101],"Jillian":[30],"Bristol":[32],"Zhe":[35],"Li":[36],"8":[37,41,45,155],"Ming-Han":[39],"Tsai":[40],"Henri-Jacques":[43],"Delecluse":[44],"and":[46,59,75,87,93,105,111,140,145,200,237,270,277,281,315,344,366],"Shannon":[47,169],"Kenney":[49],"2":[51,68],"Department":[53,69,85,102,136,146],"of":[54,57,63,70,73,79,91,97,103,109,115,137,147,206,268,335,362],"Oncology,":[55],"School":[56,72,90,108],"Medicine":[58,74,92,110],"Public":[60,76,94,112],"Health,":[61,77,95,113],"University":[62,78,96,114],"Wisconsin-Madison,":[64,80,98,116],"Madison,":[65,81,99,117],"Wisconsin,":[66,82,118],"USA":[67,83,100,119,125,134,154],"Medicine,":[71,148],"3":[84],"Cellular":[86,104],"Molecular":[88,106],"Biology,":[89],"Pathology,":[107],"Sanofi":[121],"Pharmaceuticals,":[122],"Cambridge,":[123,152],"Massachusetts,":[124,153],"Rocky":[127],"Mountain":[128],"Infectious":[129],"Disease":[130],"Specialists,":[131],"Aurora,":[132],"Colorado,":[133],"Cancer":[138,143,162],"Biology":[139],"Immunology,":[141],"Dana-Farber":[142],"Institute":[144],"Harvard":[149],"Medical":[150],"School,":[151],"Joint":[156],"DKFZ":[157],"Inserm":[158],"Unit":[159],"U1074,":[160],"German":[161],"Center":[163],"(DKFZ),":[164],"Heidelberg,":[165],"Germany":[166],"Correspondence":[167],"to:":[168],"Kenney,":[171],"email:":[172],"skenney@wisc.edu":[173],"Keywords:":[174],"therapy,":[175],"lymphoma,":[176],"lymphoproliferative":[177,222],"disease,":[178],"humanized":[179,341],"mouse":[180,342],"model,":[181],"FDA-approved":[182],"Received:":[183],"March":[184],"17,":[185],"2017":[186,190,194],"Accepted:":[187],"April":[188],"27,":[189],"Published:":[191],"May":[192],"15,":[193],"ABSTRACT":[195],"EBV":[196,297,352,388],"infection":[197,353],"causes":[198],"mononucleosis":[199],"is":[201,282,305],"associated":[202],"with":[203],"specific":[204],"subsets":[205],"B":[207,302,320],"cell":[208,261,303],"lymphomas.":[209],"Immunosuppressed":[210],"patients":[211,384],"such":[212],"as":[213],"organ":[214,290],"transplant":[215,291],"recipients":[216],"are":[217],"particularly":[218],"susceptible":[219],"to":[220,233,243,285],"EBV-induced":[221,336,381],"disease":[223],"(LPD),":[224],"which":[225],"can":[226],"be":[227,376],"fatal.":[228],"Leflunomide":[229,263],"(a":[230],"drug":[231],"used":[232,284],"treat":[234,244,286],"rheumatoid":[235],"arthritis)":[236],"its":[238],"active":[239],"metabolite":[240],"teriflunomide":[241,311,331,349],"(used":[242],"multiple":[245],"sclerosis)":[246],"inhibit":[247,300],"de":[248],"novo":[249],"pyrimidine":[250],"synthesis":[251],"by":[252,357,367],"targeting":[253],"the":[254,266,333,359],"cellular":[255,313],"dihydroorotate":[256],"dehydrogenase,":[257],"thereby":[258],"decreasing":[259],"T":[260],"proliferation.":[262],"also":[264],"inhibits":[265,312,350],"replication":[267,298],"cytomegalovirus":[269],"BK":[271],"virus":[272],"via":[273],"both":[274,339,356],"\u201con":[275],"target\u201d":[276,279],"\u201coff":[278],"mechanisms":[280],"increasingly":[283],"these":[287],"viruses":[288],"in":[289,318,322,338,354,383],"recipients.":[292],"However,":[293],"whether":[294],"leflunomide/teriflunomide":[295],"block":[296],"or":[299],"EBV-mediated":[301],"transformation":[304],"currently":[306],"unknown.":[307],"We":[308],"show":[309],"that":[310],"proliferation,":[314],"promotes":[316],"apoptosis,":[317],"EBV-transformed":[319],"cells":[321],"vitro":[323,355],"at":[324],"a":[325,340,345],"clinically":[326,377],"relevant":[327],"dose.":[328],"In":[329],"addition,":[330],"prevents":[332],"development":[334],"lymphomas":[337],"model":[343],"xenograft":[346],"model.":[347],"Furthermore,":[348],"lytic":[351,363,369],"preventing":[358,380],"initial":[360],"steps":[361],"viral":[364,370],"reactivation,":[365],"blocking":[368],"DNA":[371],"replication.":[372],"Leflunomide/teriflunomide":[373],"might":[374],"therefore":[375],"useful":[378],"for":[379],"LPD":[382],"who":[385],"have":[386],"high":[387],"loads":[389],"yet":[390],"require":[391],"continued":[392],"immunosuppression.":[393]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}
