{"id":"https://openalex.org/W2618648656","doi":"https://doi.org/10.1186/s12936-017-1837-5","title":"Naturally acquired humoral and cellular immune responses to Plasmodium vivax merozoite surface protein 8 in patients with P. vivax infection","display_name":"Naturally acquired humoral and cellular immune responses to Plasmodium vivax merozoite surface protein 8 in patients with P. vivax infection","publication_year":2017,"publication_date":"2017-05-22","ids":{"openalex":"https://openalex.org/W2618648656","doi":"https://doi.org/10.1186/s12936-017-1837-5","mag":"2618648656","pmid":"https://pubmed.ncbi.nlm.nih.gov/28532483","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5440977"},"language":"en","primary_location":{"id":"doi:10.1186/s12936-017-1837-5","doi":"https://doi.org/10.1186/s12936-017-1837-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12936-017-1837-5","pdf_url":"https://malariajournal.biomedcentral.com/counter/pdf/10.1186/s12936-017-1837-5","source":{"id":"https://openalex.org/S93003929","display_name":"Malaria Journal","issn_l":"1475-2875","issn":["1475-2875"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Malaria Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://malariajournal.biomedcentral.com/counter/pdf/10.1186/s12936-017-1837-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065807103","display_name":"Yang Cheng","orcid":"https://orcid.org/0000-0002-3014-342X","observed_orcids":["https://orcid.org/0000-0002-3014-342X"]},"institutions":[{"id":"https://openalex.org/I111599522","display_name":"Jiangnan University","ror":"https://ror.org/04mkzax54","country_code":"CN","type":"education","lineage":["https://openalex.org/I111599522"]},{"id":"https://openalex.org/I165507594","display_name":"Kangwon National University","ror":"https://ror.org/01mh5ph17","country_code":"KR","type":"education","lineage":["https://openalex.org/I165507594"]}],"countries":["CN","KR"],"is_corresponding":false,"raw_author_name":"Yang Cheng","raw_affiliation_strings":["Department of Medical Environmental Biology and Tropical Medicine, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, 200-701, Republic of Korea","Department of Parasitology, Wuxi Medical School, Jiangnan University, Wuxi, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Environmental Biology and Tropical Medicine, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, 200-701, Republic of Korea","institution_ids":["https://openalex.org/I165507594"]},{"raw_affiliation_string":"Department of Parasitology, Wuxi Medical School, Jiangnan University, Wuxi, Jiangsu, China","institution_ids":["https://openalex.org/I111599522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100408229","display_name":"Bo Wang","orcid":"https://orcid.org/0009-0009-9112-3025","observed_orcids":["https://orcid.org/0009-0009-9112-3025"]},"institutions":[{"id":"https://openalex.org/I165507594","display_name":"Kangwon National University","ror":"https://ror.org/01mh5ph17","country_code":"KR","type":"education","lineage":["https://openalex.org/I165507594"]},{"id":"https://openalex.org/I4210136596","display_name":"First Affiliated Hospital of Anhui Medical University","ror":"https://ror.org/03t1yn780","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136596"]}],"countries":["CN","KR"],"is_corresponding":false,"raw_author_name":"Bo Wang","raw_affiliation_strings":["Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China","Department of Medical Environmental Biology and Tropical Medicine, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, 200-701, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China","institution_ids":["https://openalex.org/I4210136596"]},{"raw_affiliation_string":"Department of Medical Environmental Biology and Tropical Medicine, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, 200-701, Republic of Korea","institution_ids":["https://openalex.org/I165507594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046103584","display_name":"Siriruk Changrob","orcid":"https://orcid.org/0000-0002-1826-4333","observed_orcids":["https://orcid.org/0000-0002-1826-4333"]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Siriruk Changrob","raw_affiliation_strings":["Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok, 10700, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok, 10700, Thailand","institution_ids":["https://openalex.org/I25399158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025058637","display_name":"Jin\u2010Hee Han","orcid":"https://orcid.org/0000-0003-0836-6675","observed_orcids":["https://orcid.org/0000-0003-0836-6675"]},"institutions":[{"id":"https://openalex.org/I165507594","display_name":"Kangwon National University","ror":"https://ror.org/01mh5ph17","country_code":"KR","type":"education","lineage":["https://openalex.org/I165507594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jin-Hee Han","raw_affiliation_strings":["Department of Medical Environmental Biology and Tropical Medicine, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, 200-701, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Environmental Biology and Tropical Medicine, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, 200-701, Republic of Korea","institution_ids":["https://openalex.org/I165507594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036611116","display_name":"Jetsumon Sattabongkot","orcid":"https://orcid.org/0000-0002-3938-4588","observed_orcids":["https://orcid.org/0000-0002-3938-4588"]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Jetsumon Sattabongkot","raw_affiliation_strings":["Mahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand","institution_ids":["https://openalex.org/I25399158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058101079","display_name":"Kwon\u2010Soo Ha","orcid":"https://orcid.org/0000-0002-4219-1787","observed_orcids":["https://orcid.org/0000-0002-4219-1787"]},"institutions":[{"id":"https://openalex.org/I165507594","display_name":"Kangwon National University","ror":"https://ror.org/01mh5ph17","country_code":"KR","type":"education","lineage":["https://openalex.org/I165507594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kwon-Soo Ha","raw_affiliation_strings":["Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, 200-701, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, 200-701, Republic of Korea","institution_ids":["https://openalex.org/I165507594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029209641","display_name":"Patchanee Chootong","orcid":"https://orcid.org/0000-0001-6892-4494","observed_orcids":["https://orcid.org/0000-0001-6892-4494"]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Patchanee Chootong","raw_affiliation_strings":["Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok, 10700, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok, 10700, Thailand","institution_ids":["https://openalex.org/I25399158"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Feng Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165507594","display_name":"Kangwon National University","ror":"https://ror.org/01mh5ph17","country_code":"KR","type":"education","lineage":["https://openalex.org/I165507594"]},{"id":"https://openalex.org/I4210093078","display_name":"Jiangsu Institute of Parasitic Diseases","ror":"https://ror.org/01d176154","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210093078"]}],"countries":["CN","KR"],"is_corresponding":false,"raw_author_name":"Feng Lu","raw_affiliation_strings":["Department of Medical Environmental Biology and Tropical Medicine, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, 200-701, Republic of Korea","Key Laboratory of Parasitic Disease Control and Prevention (Ministry of Health), and Jiangsu Provincial Key Laboratory of Parasite Molecular Biology, Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu Province, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Environmental Biology and Tropical Medicine, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, 200-701, Republic of Korea","institution_ids":["https://openalex.org/I165507594"]},{"raw_affiliation_string":"Key Laboratory of Parasitic Disease Control and Prevention (Ministry of Health), and Jiangsu Provincial Key Laboratory of Parasite Molecular Biology, Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu Province, People's Republic of China","institution_ids":["https://openalex.org/I4210093078"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001316470","display_name":"Jun Cao","orcid":"https://orcid.org/0000-0001-5298-9234","observed_orcids":["https://orcid.org/0000-0001-5298-9234"]},"institutions":[{"id":"https://openalex.org/I4210093078","display_name":"Jiangsu Institute of Parasitic Diseases","ror":"https://ror.org/01d176154","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210093078"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Cao","raw_affiliation_strings":["Key Laboratory of Parasitic Disease Control and Prevention (Ministry of Health), and Jiangsu Provincial Key Laboratory of Parasite Molecular Biology, Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu Province, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Parasitic Disease Control and Prevention (Ministry of Health), and Jiangsu Provincial Key Laboratory of Parasite Molecular Biology, Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu Province, People's Republic of China","institution_ids":["https://openalex.org/I4210093078"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008154153","display_name":"Myat Htut Nyunt","orcid":"https://orcid.org/0000-0002-2026-8026","observed_orcids":["https://orcid.org/0000-0002-2026-8026"]},"institutions":[{"id":"https://openalex.org/I165507594","display_name":"Kangwon National University","ror":"https://ror.org/01mh5ph17","country_code":"KR","type":"education","lineage":["https://openalex.org/I165507594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Myat Htut Nyunt","raw_affiliation_strings":["Department of Medical Environmental Biology and Tropical Medicine, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, 200-701, Republic of Korea","Department of Medical Research, Yangon, Myanmar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Environmental Biology and Tropical Medicine, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, 200-701, Republic of Korea","institution_ids":["https://openalex.org/I165507594"]},{"raw_affiliation_string":"Department of Medical Research, Yangon, Myanmar","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091654903","display_name":"Won Sun Park","orcid":"https://orcid.org/0000-0001-5868-3797","observed_orcids":["https://orcid.org/0000-0001-5868-3797"]},"institutions":[{"id":"https://openalex.org/I165507594","display_name":"Kangwon National University","ror":"https://ror.org/01mh5ph17","country_code":"KR","type":"education","lineage":["https://openalex.org/I165507594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Won Sun Park","raw_affiliation_strings":["Department of Physiology, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, 200-701, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, 200-701, Republic of Korea","institution_ids":["https://openalex.org/I165507594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072401668","display_name":"Seok\u2010Ho Hong","orcid":"https://orcid.org/0000-0003-3372-442X","observed_orcids":["https://orcid.org/0000-0003-3372-442X"]},"institutions":[{"id":"https://openalex.org/I165507594","display_name":"Kangwon National University","ror":"https://ror.org/01mh5ph17","country_code":"KR","type":"education","lineage":["https://openalex.org/I165507594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seok-Ho Hong","raw_affiliation_strings":["Department of Internal Medicine, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, 200-701, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, 200-701, Republic of Korea","institution_ids":["https://openalex.org/I165507594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069337675","display_name":"Chae Seung Lim","orcid":"https://orcid.org/0000-0002-7765-0840","observed_orcids":["https://orcid.org/0000-0002-7765-0840"]},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chae Seung Lim","raw_affiliation_strings":["Department of Laboratory Medicine, College of Medicine, Korea University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, College of Medicine, Korea University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I197347611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072345714","display_name":"Takafumi Tsuboi","orcid":"https://orcid.org/0000-0002-7415-1325","observed_orcids":["https://orcid.org/0000-0002-7415-1325"]},"institutions":[{"id":"https://openalex.org/I43545212","display_name":"Ehime University","ror":"https://ror.org/017hkng22","country_code":"JP","type":"education","lineage":["https://openalex.org/I43545212"]},{"id":"https://openalex.org/I4405287542","display_name":"Proteo-Science Center, Ehime University","ror":"https://ror.org/05ffb9p90","country_code":"JP","type":"facility","lineage":["https://openalex.org/I43545212","https://openalex.org/I4405287542"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takafumi Tsuboi","raw_affiliation_strings":["Division of Malaria Research, Proteo-Science Center, Ehime University, Matsuyama, Ehime, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Malaria Research, Proteo-Science Center, Ehime University, Matsuyama, Ehime, Japan","institution_ids":["https://openalex.org/I43545212","https://openalex.org/I4405287542"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110608058","display_name":"Eun\u2010Taek Han","orcid":"https://orcid.org/0000-0003-1962-7199","observed_orcids":["https://orcid.org/0000-0003-1962-7199"]},"institutions":[{"id":"https://openalex.org/I165507594","display_name":"Kangwon National University","ror":"https://ror.org/01mh5ph17","country_code":"KR","type":"education","lineage":["https://openalex.org/I165507594"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Eun-Taek Han","raw_affiliation_strings":["Department of Medical Environmental Biology and Tropical Medicine, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, 200-701, Republic of Korea. ethan@kangwon.ac.kr","Department of Medical Environmental Biology and Tropical Medicine, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, 200-701, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Environmental Biology and Tropical Medicine, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, 200-701, Republic of Korea. ethan@kangwon.ac.kr","institution_ids":["https://openalex.org/I165507594"]},{"raw_affiliation_string":"Department of Medical Environmental Biology and Tropical Medicine, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, 200-701, Republic of Korea","institution_ids":["https://openalex.org/I165507594"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5110608058"],"corresponding_institution_ids":["https://openalex.org/I165507594"],"apc_list":{"value":2890,"currency":"USD","value_usd":2890},"apc_paid":{"value":2890,"currency":"USD","value_usd":2890},"fwci":3.074,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.91388454,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"16","issue":"1","first_page":"211","last_page":"211"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12685","display_name":"Phytochemical compounds biological activities","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmodium-vivax","display_name":"Plasmodium vivax","score":1.0},{"id":"https://openalex.org/keywords/humoral-immune-response","display_name":"humoral immune response","score":0.7870000004768372},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.9980000257492065},{"id":"https://openalex.org/keywords/igg2-antibodies","display_name":"IgG2 antibodies","score":0.5230000019073486},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7350000143051147},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":1.0},{"id":"https://openalex.org/keywords/food-vacuoles","display_name":"food vacuoles","score":0.7329999804496765},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.8709999918937683},{"id":"https://openalex.org/keywords/epitopes","display_name":"antigenic determinants","score":0.5910000205039978},{"id":"https://openalex.org/keywords/vaccine-targets","display_name":"vaccine targets","score":0.4790000021457672},{"id":"https://openalex.org/keywords/blood-stage-malaria","display_name":"blood-stage malaria","score":0.5669999718666077},{"id":"https://openalex.org/keywords/protective-immunity","display_name":"protective immunity","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C2779997623","wikidata":"https://www.wikidata.org/wiki/Q311376","display_name":"Plasmodium vivax","level":4,"score":0.8605450391769409},{"id":"https://openalex.org/C2777023991","wikidata":"https://www.wikidata.org/wiki/Q83138168","display_name":"Merozoite surface protein","level":5,"score":0.7946352958679199},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7815483808517456},{"id":"https://openalex.org/C2779026604","wikidata":"https://www.wikidata.org/wiki/Q4774742","display_name":"Antigenicity","level":3,"score":0.7152056694030762},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6610658764839172},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6418166160583496},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6364347338676453},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.6145114898681641},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5978434085845947},{"id":"https://openalex.org/C2776548049","wikidata":"https://www.wikidata.org/wiki/Q1142875","display_name":"Humoral immunity","level":3,"score":0.5735694766044617},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.47754013538360596},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.46517157554626465},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.4026884436607361},{"id":"https://openalex.org/C2781034427","wikidata":"https://www.wikidata.org/wiki/Q6741353","display_name":"Malaria vaccine","level":4,"score":0.3847513794898987},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35548096895217896},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.1479770541191101}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000953","descriptor_name":"Antigens, Protozoan","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000953","descriptor_name":"Antigens, Protozoan","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002052","descriptor_name":"Myanmar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010966","descriptor_name":"Plasmodium vivax","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010966","descriptor_name":"Plasmodium vivax","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013785","descriptor_name":"Thailand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016780","descriptor_name":"Malaria, Vivax","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016780","descriptor_name":"Malaria, Vivax","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056724","descriptor_name":"Immunity, Humoral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056910","descriptor_name":"Republic of Korea","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12936-017-1837-5","doi":"https://doi.org/10.1186/s12936-017-1837-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12936-017-1837-5","pdf_url":"https://malariajournal.biomedcentral.com/counter/pdf/10.1186/s12936-017-1837-5","source":{"id":"https://openalex.org/S93003929","display_name":"Malaria Journal","issn_l":"1475-2875","issn":["1475-2875"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Malaria Journal","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4291762","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5440977","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5440977","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5440977","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Malar J","raw_type":"Text"},{"id":"pmid:28532483","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28532483","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Malaria journal","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c4252c00a1004e2488833bd550477c6b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c4252c00a1004e2488833bd550477c6b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Malaria Journal, Vol 16, Iss 1, Pp 1-12 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12936-017-1837-5","doi":"https://doi.org/10.1186/s12936-017-1837-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12936-017-1837-5","pdf_url":"https://malariajournal.biomedcentral.com/counter/pdf/10.1186/s12936-017-1837-5","source":{"id":"https://openalex.org/S93003929","display_name":"Malaria Journal","issn_l":"1475-2875","issn":["1475-2875"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Malaria Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3497167089","display_name":null,"funder_award_id":"2015-R1A4A1038666","funder_id":"https://openalex.org/F4320322030","funder_display_name":"Ministry of Science, ICT and Future Planning"},{"id":"https://openalex.org/G4534225278","display_name":null,"funder_award_id":"2014R1A2A1A11052079","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G6962367781","display_name":null,"funder_award_id":"2015-R1A4A1038666","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G7966536266","display_name":null,"funder_award_id":"NRF-2014R1A2A1A11052079","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322030","display_name":"Ministry of Science, ICT and Future Planning","ror":"https://ror.org/032e49973"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2618648656.pdf","grobid_xml":"https://content.openalex.org/works/W2618648656.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W190349426","https://openalex.org/W1965546880","https://openalex.org/W1976570057","https://openalex.org/W1977922844","https://openalex.org/W1980084408","https://openalex.org/W1996377313","https://openalex.org/W2004622806","https://openalex.org/W2025693404","https://openalex.org/W2026483075","https://openalex.org/W2027979502","https://openalex.org/W2028939384","https://openalex.org/W2033090330","https://openalex.org/W2042874001","https://openalex.org/W2058668072","https://openalex.org/W2072816037","https://openalex.org/W2090632234","https://openalex.org/W2106541447","https://openalex.org/W2117485436","https://openalex.org/W2118330433","https://openalex.org/W2120356605","https://openalex.org/W2128378359","https://openalex.org/W2129414015","https://openalex.org/W2136303908","https://openalex.org/W2146994826","https://openalex.org/W2147817480","https://openalex.org/W2151383900","https://openalex.org/W2167965520","https://openalex.org/W2318448254","https://openalex.org/W2403511123"],"related_works":["https://openalex.org/W2947617297","https://openalex.org/W7136054866","https://openalex.org/W2750778878","https://openalex.org/W2058668072","https://openalex.org/W2747600376","https://openalex.org/W1985608210","https://openalex.org/W2602536180","https://openalex.org/W7100390545","https://openalex.org/W1904762770","https://openalex.org/W4395682851"],"abstract_inverted_index":{"BACKGROUND:":[0],"Thirty-one":[1],"glycosylphosphatidylinositol":[2],"(GPI)-anchored":[3],"proteins":[4,36],"of":[5,25,60,75,92,98,124,180,217,257,275],"Plasmodium":[6,26],"vivax,":[7],"merozoite":[8,50],"surface":[9,51],"protein":[10,52,133,277],"1":[11],"(MSP1),":[12],"MSP1":[13],"paralogue,":[14],"MSP4,":[15],"MSP5,":[16],"MSP8,":[17],"and":[18,70,77,85,95,109,141,170,219,244],"MSP10":[19],"have":[20],"been":[21],"reported":[22],"from":[23],"homologs":[24],"falciparum":[27],"by":[28],"gene":[29],"annotation":[30],"with":[31,127,148,250,264],"bioinformatics":[32],"tools.":[33],"These":[34],"GPI-anchored":[35],"contain":[37],"two":[38,196],"epidermal":[39],"growth":[40],"factor":[41],"(EGF)-like":[42],"domains":[43],"at":[44],"its":[45],"C-terminus.":[46],"Here,":[47],"P.":[48,82,149,211,251,284],"vivax":[49,252,285],"8":[53],"(PvMSP8)":[54],"are":[55],"considered":[56],"as":[57,111,114],"potential":[58,239],"targets":[59],"protective":[61],"immunity.":[62],"METHODS:":[63],"Recombinant":[64],"PvMSP8":[65,99,117,164,222,235,258],"(rPvMSP8)":[66],"was":[67,100,106,118,154,183,262],"expressed,":[68],"purified,":[69],"used":[71],"for":[72,281],"the":[73,89,121,128,155,202,265],"assessment":[74],"humoral":[76,243],"cellular":[78,207,245],"immune":[79,86,208,246],"responses":[80,157,247],"in":[81,139,143,145,210,225,230,248,269],"vivax-infected":[83],"patients":[84,146,249],"mice.":[87],"Moreover,":[88],"target":[90],"epitope":[91],"ant-PvMSP8":[93],"antibodies":[94,194],"subcellular":[96,255],"localization":[97,256],"also":[101],"determined.":[102],"RESULTS:":[103],"The":[104,131,178,206,254],"rPvMSP8":[105,132],"successfully":[107],"expressed":[108],"purified":[110],"soluble":[112],"form":[113],"~55":[115],"kDa.":[116],"localized":[119],"to":[120,158,163,167,187,240],"outer":[122],"circle":[123],"pigments":[125],"associated":[126,263],"food":[129,267],"vacuole.":[130],"had":[134],"a":[135,176,238],"high":[136,215],"antigenicity":[137],"(73.2%":[138],"sensitivity":[140],"96.2%":[142],"specificity)":[144],"infected":[147],"vivax.":[150],"IgG2":[151],"antibody":[152,182],"subtype":[153],"predominantly":[156],"this":[159,231,276],"antigen.":[160],"Antibody":[161],"response":[162,209],"increased":[165],"up":[166,186],"day":[168],"7":[169],"after":[171],"that":[172,198,234,260],"slightly":[173],"decreased":[174],"within":[175],"month.":[177],"longevity":[179],"anti-PvMSP8":[181,193],"stably":[184],"sustained":[185],"12-year":[188],"recovery":[189],"patient":[190],"samples.":[191],"Most":[192],"recognized":[195],"epitopes":[197],"were":[199],"located":[200],"outside":[201],"C-terminal":[203],"EGF-like":[204],"domain.":[205],"vivax-exposed":[212],"individuals":[213],"produced":[214],"levels":[216],"IFN-\u03b3":[218],"IL-10":[220],"upon":[221],"antigen":[223,236],"stimulation":[224],"vitro.":[226],"CONCLUSIONS:":[227],"All":[228],"data":[229],"study":[232],"suggest":[233],"has":[237],"induce":[241],"both":[242],"infection.":[253],"confirmed":[259],"it":[261],"parasite":[266],"vacuole":[268],"blood-stage":[270],"parasites.":[271],"A":[272],"further":[273],"characterization":[274],"will":[278],"be":[279],"useful":[280],"blood":[282],"stage":[283],"vaccine":[286],"development.":[287]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-06-05T00:00:00"}