{"id":"https://openalex.org/W261843657","doi":null,"title":"The Therapeutic Targeting Of Folate Receptor Alpha Positive Tumors Via Folate Receptor Selective Novel 5- And 6- Substituted Pyrrolo [2,3-D]pyrimidine Antifolates\"","display_name":"The Therapeutic Targeting Of Folate Receptor Alpha Positive Tumors Via Folate Receptor Selective Novel 5- And 6- Substituted Pyrrolo [2,3-D]pyrimidine Antifolates\"","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W261843657","mag":"261843657"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.wayne.edu:oa_dissertations-2154","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.wayne.edu/oa_dissertations/1155","pdf_url":null,"source":{"id":"https://openalex.org/S171990522","display_name":"Human Biology","issn_l":"0018-7143","issn":["0018-7143","1534-6617"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316469","host_organization_name":"Wayne State University Press","host_organization_lineage":["https://openalex.org/P4310316469"],"host_organization_lineage_names":["Wayne State University Press"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wayne State University Dissertations","raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033156854","display_name":"Shermaine K. Mitchell-Ryan","orcid":"https://orcid.org/0000-0002-7157-3768","observed_orcids":["https://orcid.org/0000-0002-7157-3768"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Shermaine Mitchell-Ryan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5033156854"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.5913000106811523,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.5913000106811523,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.1462000012397766,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.11990000307559967,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/folate-receptor-alpha","display_name":"folate receptor alpha","score":0.9570000171661377},{"id":"https://openalex.org/keywords/epithelial-ovarian-cancer","display_name":"epithelial ovarian cancer","score":0.8479999899864197},{"id":"https://openalex.org/keywords/reduced-folate-carrier","display_name":"reduced folate carrier","score":0.8199999928474426},{"id":"https://openalex.org/keywords/folate-transport","display_name":"folate transport","score":0.7369999885559082},{"id":"https://openalex.org/keywords/purine-salvage-pathway","display_name":"purine salvage pathway","score":0.8399999737739563},{"id":"https://openalex.org/keywords/membrane-transport","display_name":"membrane transport","score":0.34200000762939453}],"concepts":[{"id":"https://openalex.org/C2780306303","wikidata":"https://www.wikidata.org/wiki/Q24784504","display_name":"Folate receptor","level":4,"score":0.8787729144096375},{"id":"https://openalex.org/C2779321679","wikidata":"https://www.wikidata.org/wiki/Q207722","display_name":"Pyrimidine","level":2,"score":0.6568319797515869},{"id":"https://openalex.org/C2781382166","wikidata":"https://www.wikidata.org/wiki/Q50573407","display_name":"Antifolate","level":4,"score":0.5938844084739685},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5840973854064941},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.538642406463623},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.45522746443748474},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.413968950510025},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.36536091566085815},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.316651314496994},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29337048530578613},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24359694123268127},{"id":"https://openalex.org/C2778397455","wikidata":"https://www.wikidata.org/wiki/Q50429865","display_name":"Antimetabolite","level":3,"score":0.24249178171157837},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.18986248970031738},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.08431598544120789}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.wayne.edu:oa_dissertations-2154","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.wayne.edu/oa_dissertations/1155","pdf_url":null,"source":{"id":"https://openalex.org/S171990522","display_name":"Human Biology","issn_l":"0018-7143","issn":["0018-7143","1534-6617"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316469","host_organization_name":"Wayne State University Press","host_organization_lineage":["https://openalex.org/P4310316469"],"host_organization_lineage_names":["Wayne State University Press"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wayne State University Dissertations","raw_type":"dissertation"},{"id":"mag:261843657","doi":null,"is_oa":false,"landing_page_url":"http://digitalcommons.wayne.edu/cgi/viewcontent.cgi?article=2154&context=oa_dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":125,"referenced_works":["https://openalex.org/W3975443","https://openalex.org/W12421426","https://openalex.org/W153648782","https://openalex.org/W349978335","https://openalex.org/W1494713003","https://openalex.org/W1498168299","https://openalex.org/W1517703555","https://openalex.org/W1548252075","https://openalex.org/W1581503432","https://openalex.org/W1606951277","https://openalex.org/W1849493927","https://openalex.org/W1933750051","https://openalex.org/W1937219356","https://openalex.org/W1940298872","https://openalex.org/W1946365220","https://openalex.org/W1963776452","https://openalex.org/W1968051127","https://openalex.org/W1970285652","https://openalex.org/W1971352608","https://openalex.org/W1971804824","https://openalex.org/W1971894436","https://openalex.org/W1972849029","https://openalex.org/W1977839032","https://openalex.org/W1977866186","https://openalex.org/W1979012566","https://openalex.org/W1979638914","https://openalex.org/W1979745458","https://openalex.org/W1980920372","https://openalex.org/W1985359348","https://openalex.org/W1990493121","https://openalex.org/W1994139792","https://openalex.org/W1994697518","https://openalex.org/W1995980440","https://openalex.org/W1998290168","https://openalex.org/W1998418923","https://openalex.org/W2005830327","https://openalex.org/W2006181515","https://openalex.org/W2009124714","https://openalex.org/W2009881185","https://openalex.org/W2014349480","https://openalex.org/W2015266666","https://openalex.org/W2015589904","https://openalex.org/W2015766239","https://openalex.org/W2016386954","https://openalex.org/W2016548228","https://openalex.org/W2019207861","https://openalex.org/W2020103848","https://openalex.org/W2023452084","https://openalex.org/W2025654312","https://openalex.org/W2025772696","https://openalex.org/W2026755481","https://openalex.org/W2028776386","https://openalex.org/W2033832729","https://openalex.org/W2035104998","https://openalex.org/W2035842529","https://openalex.org/W2037260804","https://openalex.org/W2037359914","https://openalex.org/W2039693127","https://openalex.org/W2040366777","https://openalex.org/W2041526724","https://openalex.org/W2041601692","https://openalex.org/W2042493999","https://openalex.org/W2047073318","https://openalex.org/W2047649594","https://openalex.org/W2047921578","https://openalex.org/W2048652376","https://openalex.org/W2049877455","https://openalex.org/W2055703363","https://openalex.org/W2066469619","https://openalex.org/W2066588182","https://openalex.org/W2067882963","https://openalex.org/W2070002280","https://openalex.org/W2074565179","https://openalex.org/W2077335616","https://openalex.org/W2078267629","https://openalex.org/W2080156186","https://openalex.org/W2081189233","https://openalex.org/W2084092423","https://openalex.org/W2087100009","https://openalex.org/W2089669745","https://openalex.org/W2091903345","https://openalex.org/W2094049846","https://openalex.org/W2096158179","https://openalex.org/W2097637786","https://openalex.org/W2101259585","https://openalex.org/W2105775417","https://openalex.org/W2106727823","https://openalex.org/W2108027463","https://openalex.org/W2108194180","https://openalex.org/W2108879983","https://openalex.org/W2110292480","https://openalex.org/W2119226590","https://openalex.org/W2121346123","https://openalex.org/W2122523179","https://openalex.org/W2126853759","https://openalex.org/W2128921627","https://openalex.org/W2130097072","https://openalex.org/W2133500958","https://openalex.org/W2133806000","https://openalex.org/W2134043074","https://openalex.org/W2135272972","https://openalex.org/W2139204972","https://openalex.org/W2143796272","https://openalex.org/W2144075705","https://openalex.org/W2145178767","https://openalex.org/W2145540789","https://openalex.org/W2145912883","https://openalex.org/W2150920867","https://openalex.org/W2151962624","https://openalex.org/W2152284526","https://openalex.org/W2154744970","https://openalex.org/W2156806290","https://openalex.org/W2158258441","https://openalex.org/W2162259855","https://openalex.org/W2169502489","https://openalex.org/W2171490806","https://openalex.org/W2178306360","https://openalex.org/W2181778736","https://openalex.org/W2290815490","https://openalex.org/W2320588507","https://openalex.org/W2329562209","https://openalex.org/W2501607421","https://openalex.org/W3147703121","https://openalex.org/W4235693170","https://openalex.org/W4293052525"],"related_works":["https://openalex.org/W4404112304","https://openalex.org/W7165356093","https://openalex.org/W2316860190","https://openalex.org/W4386329606","https://openalex.org/W2910693133","https://openalex.org/W3205182906","https://openalex.org/W7133235660","https://openalex.org/W4394797858","https://openalex.org/W2955142397","https://openalex.org/W2312907617"],"abstract_inverted_index":{"Ovarian":[0,17],"Cancer":[1,18],"is":[2,51,68],"the":[3,13,25,46,87,108,147,152,159,166,187,238,284,288,295,314,317,330,340,346,349,368,374],"fifth":[4],"leading":[5],"cause":[6],"of":[7,10,22,31,73,89,110,149,154,168,178,189,197,205,225,244,265,297,316,319,332,348,370,376],"cancer-related":[8],"death":[9],"women":[11],"in":[12,85,228,231,241,262,272],"United":[14],"States.":[15],"Epithelial":[16],"(EOC)":[19],"constitutes":[20],"85-90%":[21],"malignancies":[23],"within":[24,146],"ovary,":[26],"with":[27,60,140,186,193],"an":[28],"alarming":[29],"majority":[30],"these":[32],"cases":[33],"diagnosed":[34],"at":[35],"advanced":[36],"stage.":[37],"While":[38],"most":[39,247],"patients":[40,245],"are":[41,129,138,144,180,202,276,360],"initially":[42],"highly":[43],"responsive":[44],"to":[45,107,131,222,278],"current":[47],"treatment":[48,153,260],"standard,":[49],"there":[50,67],"a":[52,61,93,203,210,242,263,324,333],"very":[53],"high":[54,117],"probability":[55],"that":[56,113,128,275,300,352,359],"they":[57,268],"will":[58,236],"recur":[59],"drug":[62],"resistant":[63],"fatal":[64],"disease.":[65,198],"Currently":[66],"no":[69],"validated":[70],"comprehensive":[71],"model":[72],"disease":[74,91,230],"progression":[75],"for":[76,161],"ovarian":[77,155],"cancer,":[78],"although":[79],"tremendous":[80],"progress":[81,104],"has":[82,97,105,157],"been":[83,98,270],"made":[84],"understanding":[86],"origin":[88],"this":[90,141,223,310],"and":[92,143,171,195,255,327,342,366],"putative":[94],"precursor":[95],"lesion":[96],"identified":[99],"via":[100,362],"molecular":[101,111,150],"profiling.":[102],"This":[103,293],"led":[106],"identification":[109],"signatures":[112],"not":[114],"only":[115],"distinguish":[116],"grade":[118,121,196],"from":[119,214,280],"low":[120],"tumors,":[122],"but":[123],"it":[124,344],"also":[125],"highlights":[126],"mutations":[127],"unique":[130],"each":[132],"histological":[133],"type.":[134],"Even":[135],"though":[136],"we":[137,312],"armed":[139],"information":[142],"well":[145],"age":[148],"targeting,":[151],"cancer":[156],"remained":[158],"same":[160],"over":[162,307],"40":[163],"years,":[164],"when":[165],"use":[167],"platinum-based":[169],"therapies":[170,201],"taxanes":[172],"were":[173],"introduced.":[174],"Approximately":[175],"90":[176],"percent":[177],"EOC":[179],"folate":[181,290,304],"receptor":[182,190,226],"alpha":[183],"(FR\u03b1)":[184],"positive":[185],"extent":[188],"over-expression":[191],"corresponding":[192],"stage":[194],"FR\u03b1":[199,219,363],"based":[200],"subject":[204],"increasing":[206],"interest":[207],"warranted":[208],"by":[209,283],"growing":[211],"number":[212,264],"malignancies,":[213,266],"various":[215,320],"tissue":[216],"types,":[217],"showing":[218],"expression.":[220],"Due":[221],"increase":[224],"expression":[227],"advance":[229],"EOC,":[232],"designing":[233],"FR\u03b1-targeted":[234],"agents":[235],"enhance":[237],"therapeutic":[239],"window":[240],"population":[243],"where":[246],"treatments":[248],"fail.":[249],"The":[250],"clinically":[251],"approved":[252],"antifolates,":[253],"MTX":[254],"PMX,":[256],"have":[257,269],"greatly":[258],"improved":[259],"outcomes":[261],"however":[267],"implicated":[271],"dose-limiting":[273],"toxicities":[274],"thought":[277],"arise":[279],"uptake":[281],"mediated":[282,361],"ubiquitously":[285],"express":[286],"protein,":[287],"reduced":[289],"carrier":[291],"(RFC).":[292],"encourages":[294],"development":[296],"novel":[298,353,377],"antifolates":[299],"utilize":[301],"other":[302],"available":[303],"transport":[305],"mechanisms":[306],"RFC.":[308],"In":[309],"study":[311],"explored":[313],"impact":[315,369],"addition":[318],"structural":[321],"components":[322],"on":[323,339,373],"pyrrolo[2,3-d]pyrimidine":[325],"scaffold":[326,341],"demonstrated:":[328],"(1)":[329],"significance":[331],"5":[334],"vs":[335],"6":[336],"position":[337],"substitution":[338],"how":[343],"impacts":[345],"pharmacology":[347],"compound;":[350],"(2)":[351],"6-substituted":[354],"pyrrolo[2,3-d]pyrimidines":[355],"show":[356],"remarkable":[357],"potencies":[358],"membrane":[364],"transport;":[365],"(3)":[367],"purine":[371],"salvage":[372],"efficacy":[375],"antifolates.":[378]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}