{"id":"https://openalex.org/W2618382011","doi":"https://doi.org/10.25135/rnp.2017.1701.002","title":"Cytotoxic Cardenolides from Calotropis Species: A Short Review","display_name":"Cytotoxic Cardenolides from Calotropis Species: A Short Review","publication_year":2017,"publication_date":"2017-05-15","ids":{"openalex":"https://openalex.org/W2618382011","doi":"https://doi.org/10.25135/rnp.2017.1701.002","mag":"2618382011"},"language":"en","primary_location":{"id":"doi:10.25135/rnp.2017.1701.002","doi":"https://doi.org/10.25135/rnp.2017.1701.002","is_oa":true,"landing_page_url":"https://doi.org/10.25135/rnp.2017.1701.002","pdf_url":"https://doi.org/10.25135/rnp.2017.1701.002","source":{"id":"https://openalex.org/S33141064","display_name":"Records of Natural Products","issn_l":"1307-6167","issn":["1307-6167"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310318281","host_organization_name":"ACG Publications","host_organization_lineage":["https://openalex.org/P4310318281"],"host_organization_lineage_names":["ACG Publications"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Records of Natural Products","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.25135/rnp.2017.1701.002","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101972395","display_name":"Eric Wei Chiang Chan","orcid":"https://orcid.org/0000-0002-5513-5207","observed_orcids":["https://orcid.org/0000-0002-5513-5207"]},"institutions":[{"id":"https://openalex.org/I55285296","display_name":"UCSI University","ror":"https://ror.org/019787q29","country_code":"MY","type":"education","lineage":["https://openalex.org/I55285296"]}],"countries":["MY"],"is_corresponding":true,"raw_author_name":"Eric Wei Chiang Chan","raw_affiliation_strings":["Faculty of Applied Sciences, UCSI University, Cheras 56000, Kuala Lumpur, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Applied Sciences, UCSI University, Cheras 56000, Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I55285296"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061182508","display_name":"Nuha I. Sweidan","orcid":"https://orcid.org/0000-0003-0509-4803","observed_orcids":["https://orcid.org/0000-0003-0509-4803"]},"institutions":[{"id":"https://openalex.org/I36622005","display_name":"Petra University","ror":"https://ror.org/039d9es10","country_code":"JO","type":"education","lineage":["https://openalex.org/I36622005"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Nuha I. Sweidan","raw_affiliation_strings":["Department of Chemistry, University of Petra, Amman 961343, Jordan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Petra, Amman 961343, Jordan","institution_ids":["https://openalex.org/I36622005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076763009","display_name":"Siu Kuin Wong","orcid":"https://orcid.org/0000-0002-2289-8910","observed_orcids":["https://orcid.org/0000-0002-2289-8910"]},"institutions":[{"id":"https://openalex.org/I11662577","display_name":"Monash University Malaysia","ror":"https://ror.org/00yncr324","country_code":"MY","type":"education","lineage":["https://openalex.org/I11662577","https://openalex.org/I56590836"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Siu Kuin Wong","raw_affiliation_strings":["School of Science, Monash University Sunway, Petaling Jaya 46150, Selangor, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Science, Monash University Sunway, Petaling Jaya 46150, Selangor, Malaysia","institution_ids":["https://openalex.org/I11662577"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101666177","display_name":"Hung Tuck Chan","orcid":"https://orcid.org/0000-0003-0779-0685","observed_orcids":["https://orcid.org/0000-0003-0779-0685"]},"institutions":[{"id":"https://openalex.org/I4405256572","display_name":"International Society for Mangrove Ecosystems","ror":"https://ror.org/04adnng28","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I4405256572"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hung Tuck Chan","raw_affiliation_strings":["Secretariat, International Society for Mangrove Ecosystems,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Secretariat, International Society for Mangrove Ecosystems,","institution_ids":["https://openalex.org/I4405256572"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5101972395"],"corresponding_institution_ids":["https://openalex.org/I55285296"],"apc_list":null,"apc_paid":null,"fwci":0.3571,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.45726605,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"11","issue":"4","first_page":"334","last_page":"344"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13185","display_name":"Phytochemistry and Bioactive Compounds","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13185","display_name":"Phytochemistry and Bioactive Compounds","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardenolides","display_name":"cardenolides","score":0.9850000143051147},{"id":"https://openalex.org/keywords/calotropis-gigantea","display_name":"Calotropis gigantea","score":0.9729999899864197},{"id":"https://openalex.org/keywords/calotropis-procera","display_name":"Calotropis procera","score":1.0},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9179999828338623},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.9480000138282776},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8820000290870667},{"id":"https://openalex.org/keywords/sodium-pump-inhibition","display_name":"sodium pump inhibition","score":0.8830000162124634},{"id":"https://openalex.org/keywords/non-apoptotic-cell-death","display_name":"non-apoptotic cell death","score":0.9610000252723694},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.8109999895095825},{"id":"https://openalex.org/keywords/steroidal-lactones","display_name":"steroidal lactones","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C2780257055","wikidata":"https://www.wikidata.org/wiki/Q423910","display_name":"Cardenolide","level":3,"score":0.7456434965133667},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5469052195549011},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5439093708992004},{"id":"https://openalex.org/C2779406593","wikidata":"https://www.wikidata.org/wiki/Q948690","display_name":"Calotropis procera","level":2,"score":0.4926608204841614},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4722936451435089},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3854076564311981},{"id":"https://openalex.org/C194671627","wikidata":"https://www.wikidata.org/wiki/Q192639","display_name":"Glycoside","level":2,"score":0.3758811950683594},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.3389180898666382},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2653772830963135},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20414134860038757},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1755024492740631}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.25135/rnp.2017.1701.002","doi":"https://doi.org/10.25135/rnp.2017.1701.002","is_oa":true,"landing_page_url":"https://doi.org/10.25135/rnp.2017.1701.002","pdf_url":"https://doi.org/10.25135/rnp.2017.1701.002","source":{"id":"https://openalex.org/S33141064","display_name":"Records of Natural Products","issn_l":"1307-6167","issn":["1307-6167"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310318281","host_organization_name":"ACG Publications","host_organization_lineage":["https://openalex.org/P4310318281"],"host_organization_lineage_names":["ACG Publications"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Records of Natural Products","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.25135/rnp.2017.1701.002","doi":"https://doi.org/10.25135/rnp.2017.1701.002","is_oa":true,"landing_page_url":"https://doi.org/10.25135/rnp.2017.1701.002","pdf_url":"https://doi.org/10.25135/rnp.2017.1701.002","source":{"id":"https://openalex.org/S33141064","display_name":"Records of Natural Products","issn_l":"1307-6167","issn":["1307-6167"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310318281","host_organization_name":"ACG Publications","host_organization_lineage":["https://openalex.org/P4310318281"],"host_organization_lineage_names":["ACG Publications"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Records of Natural Products","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2618382011.pdf","grobid_xml":"https://content.openalex.org/works/W2618382011.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W214384120","https://openalex.org/W837407662","https://openalex.org/W1142027947","https://openalex.org/W1488879331","https://openalex.org/W1537292529","https://openalex.org/W1540141616","https://openalex.org/W1971854514","https://openalex.org/W1981724227","https://openalex.org/W1991659408","https://openalex.org/W1997287496","https://openalex.org/W2002479547","https://openalex.org/W2002666431","https://openalex.org/W2004631970","https://openalex.org/W2022272763","https://openalex.org/W2030913496","https://openalex.org/W2033450100","https://openalex.org/W2038344425","https://openalex.org/W2043260309","https://openalex.org/W2052435665","https://openalex.org/W2052643634","https://openalex.org/W2053387930","https://openalex.org/W2054405945","https://openalex.org/W2068225939","https://openalex.org/W2070195852","https://openalex.org/W2070358111","https://openalex.org/W2076624473","https://openalex.org/W2080066296","https://openalex.org/W2082736445","https://openalex.org/W2088547946","https://openalex.org/W2106957556","https://openalex.org/W2162228607","https://openalex.org/W2178526851","https://openalex.org/W2189620630","https://openalex.org/W2219068525","https://openalex.org/W2346454747","https://openalex.org/W2412518506","https://openalex.org/W2415025034","https://openalex.org/W2531964534","https://openalex.org/W2538771905","https://openalex.org/W2559283289","https://openalex.org/W2590292977","https://openalex.org/W2952110960","https://openalex.org/W2985624949","https://openalex.org/W4231849797","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2162228607","https://openalex.org/W3138209804","https://openalex.org/W1971854514","https://openalex.org/W2085753859","https://openalex.org/W2070195852","https://openalex.org/W2068225939","https://openalex.org/W3204062199","https://openalex.org/W1142027947","https://openalex.org/W3036847918","https://openalex.org/W6939366158"],"abstract_inverted_index":{"From":[0],"different":[1],"plant":[2],"parts":[3],"of":[4,13,34,50,66,71,86,128,137,147,155,176],"Calotropis":[5],"species":[6],"(C.gigantea":[7],"and":[8,21,59,82,167,174],"C.":[9,148],"procera),":[10],"various":[11],"classes":[12],"compounds":[14],"such":[15],"as":[16,32,77],"oxypregnanes,":[17],"terpenoids,":[18],"sterols,":[19],"cardenolides":[20,29,67],"flavonoids":[22],"have":[23,36,74,91,105],"been":[24,75],"isolated.Of":[25],"these":[26],"compounds,":[27],"the":[28,69,84,126,144,153],"stand":[30],"out":[31],"many":[33],"them":[35],"anticancer":[37],"properties.Cardenolides":[38],"are":[39],"C":[40],"23":[41],"steroids":[42],"with":[43,99,112],"a":[44,51,54,60,129,139,169],"five-membered":[45,113],"unsaturated":[46],"butyrolactone":[47],"ring":[48,101,114],"consisting":[49],"steroid":[52],"nucleus,":[53],"lactone":[55],"moiety":[56,62],"at":[57,63,121],"C-17":[58],"sugar":[61,102,115],"C-3.The":[64],"roles":[65],"in":[68,182],"treatment":[70],"human":[72],"cancer":[73,87],"established":[76],"they":[78],"can":[79],"induce":[80],"apoptosis":[81],"inhibit":[83],"growth":[85],"cells.Structure-activity":[88],"relationship":[89],"analyses":[90],"yielded":[92],"some":[93],"interesting":[94],"findings":[95],"on":[96],"their":[97],"cytotoxicity.Compounds":[98],"six-membered":[100],"groups":[103],"generally":[104],"significantly":[106],"stronger":[107],"inhibitory":[108],"activity":[109],"than":[110],"those":[111],"groups.A":[116],"formyl":[117],"or":[118,131],"methyl-hydroxyl":[119],"group":[120,133],"C-10":[122],"enhances":[123],"cytotoxicity":[124],"while":[125],"presence":[127],"4\u00b4-OH":[130],"16-OH":[132],"decreases":[134],"cytotoxicity.Chemical":[135],"modification":[136],"2\"-oxovoruscharin,":[138],"novel":[140],"cardenolide":[141],"extracted":[142],"from":[143],"root":[145],"bark":[146],"procera,":[149],"has":[150],"led":[151],"to":[152],"synthesis":[154],"UNBS1450.The":[156],"compound":[157],"is":[158,168,180],"characterized":[159],"by":[160],"more":[161],"potent":[162],"antiproliferative":[163],"activity,":[164],"lower":[165],"toxicity,":[166],"strong":[170],"sodium":[171],"pump":[172],"inhibitor":[173],"inducer":[175],"non-apoptotic":[177],"cell":[178],"death.UNBS1450":[179],"currently":[181],"Phase":[183],"I":[184],"clinical":[185],"trials.":[186]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-06-05T00:00:00"}
