{"id":"https://openalex.org/W2618311580","doi":"https://doi.org/10.1038/nrg.2017.32","title":"Associating cellular epigenetic models with human phenotypes","display_name":"Associating cellular epigenetic models with human phenotypes","publication_year":2017,"publication_date":"2017-05-30","ids":{"openalex":"https://openalex.org/W2618311580","doi":"https://doi.org/10.1038/nrg.2017.32","mag":"2618311580","pmid":"https://pubmed.ncbi.nlm.nih.gov/28555657"},"language":"en","primary_location":{"id":"doi:10.1038/nrg.2017.32","doi":"https://doi.org/10.1038/nrg.2017.32","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrg.2017.32","pdf_url":null,"source":{"id":"https://openalex.org/S8553189","display_name":"Nature Reviews Genetics","issn_l":"1471-0056","issn":["1471-0056","1471-0064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Genetics","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064165945","display_name":"Tuuli Lappalainen","orcid":"https://orcid.org/0000-0002-7746-8109","observed_orcids":["https://orcid.org/0000-0002-7746-8109"]},"institutions":[{"id":"https://openalex.org/I4210151462","display_name":"New York Genome Center","ror":"https://ror.org/05wf2ga96","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210151462"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tuuli Lappalainen","raw_affiliation_strings":["New York Genome Center, 101 Avenue of the Americas, New York, New York 10013, USA; and at the Department of Systems Biology, Columbia University, 1130 Street Nicholas Avenue, New York, New York 10032, USA","at the Department of Systems Biology, New York Genome Center, 101 Avenue of the Americas, New York, New York 10013, Columbia University, 1130 Street Nicholas Avenue, New York, New York 10032, USA.,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York Genome Center, 101 Avenue of the Americas, New York, New York 10013, USA; and at the Department of Systems Biology, Columbia University, 1130 Street Nicholas Avenue, New York, New York 10032, USA","institution_ids":["https://openalex.org/I4210151462","https://openalex.org/I78577930"]},{"raw_affiliation_string":"at the Department of Systems Biology, New York Genome Center, 101 Avenue of the Americas, New York, New York 10013, Columbia University, 1130 Street Nicholas Avenue, New York, New York 10032, USA.,","institution_ids":["https://openalex.org/I4210151462","https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048839844","display_name":"John M. Greally","orcid":"https://orcid.org/0000-0001-6069-7960","observed_orcids":["https://orcid.org/0000-0001-6069-7960"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John M. Greally","raw_affiliation_strings":["Departments of Genetics, Medicine and Pediatrics, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx, New York 10461, USA","Departments of Genetics, Medicine and Pediatrics, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx, 10461, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Genetics, Medicine and Pediatrics, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx, New York 10461, USA","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Departments of Genetics, Medicine and Pediatrics, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx, 10461, New York, USA","institution_ids":["https://openalex.org/I129975664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5048839844","https://openalex.org/A5064165945"],"corresponding_institution_ids":["https://openalex.org/I129975664","https://openalex.org/I4210151462","https://openalex.org/I78577930"],"apc_list":null,"apc_paid":null,"fwci":3.3371,"has_fulltext":false,"cited_by_count":271,"citation_normalized_percentile":{"value":0.95224007,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"18","issue":"7","first_page":"441","last_page":"451"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigenome-wide-association-study","display_name":"epigenome-wide association study","score":0.9919999837875366},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.984000027179718},{"id":"https://openalex.org/keywords/cellular-reprogramming","display_name":"cellular reprogramming","score":0.7300000190734863},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.8059999942779541},{"id":"https://openalex.org/keywords/causality","display_name":"causality","score":0.6520000100135803},{"id":"https://openalex.org/keywords/multi-omics-profiling","display_name":"multi-omics profiling","score":0.8270000219345093},{"id":"https://openalex.org/keywords/environmental-perturbations","display_name":"environmental disturbance","score":0.7080000042915344},{"id":"https://openalex.org/keywords/phenotypic-variation","display_name":"phenotypic variability","score":0.8050000071525574},{"id":"https://openalex.org/keywords/functional-genomics","display_name":"functional genomics","score":0.9039999842643738}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.8840048313140869},{"id":"https://openalex.org/C117717151","wikidata":"https://www.wikidata.org/wiki/Q3589155","display_name":"Epigenome","level":5,"score":0.875749945640564},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8157284259796143},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6884906888008118},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.6633225083351135},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.650463342666626},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6355348229408264},{"id":"https://openalex.org/C179463898","wikidata":"https://www.wikidata.org/wiki/Q10273301","display_name":"Epigenesis","level":5,"score":0.5308286547660828},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.48846235871315},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4773454964160919},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.44697368144989014},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.42966610193252563},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.192295104265213},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.18520832061767578},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.08681628108024597},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.07779005169868469},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.06587481498718262}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065150","descriptor_name":"Cellular Reprogramming","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/nrg.2017.32","doi":"https://doi.org/10.1038/nrg.2017.32","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrg.2017.32","pdf_url":null,"source":{"id":"https://openalex.org/S8553189","display_name":"Nature Reviews Genetics","issn_l":"1471-0056","issn":["1471-0056","1471-0064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Genetics","raw_type":"journal-article"},{"id":"pmid:28555657","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28555657","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature reviews. Genetics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":104,"referenced_works":["https://openalex.org/W1591423336","https://openalex.org/W1608345078","https://openalex.org/W1963970354","https://openalex.org/W1964372737","https://openalex.org/W1969499463","https://openalex.org/W1973639800","https://openalex.org/W1974747095","https://openalex.org/W1975528145","https://openalex.org/W1984996540","https://openalex.org/W1985987855","https://openalex.org/W1988142188","https://openalex.org/W1989643947","https://openalex.org/W1992068823","https://openalex.org/W1993616000","https://openalex.org/W1998603632","https://openalex.org/W2001681640","https://openalex.org/W2006488092","https://openalex.org/W2014359105","https://openalex.org/W2014377267","https://openalex.org/W2014852291","https://openalex.org/W2017782636","https://openalex.org/W2023155906","https://openalex.org/W2024818056","https://openalex.org/W2028951414","https://openalex.org/W2029033394","https://openalex.org/W2029874395","https://openalex.org/W2032602115","https://openalex.org/W2033202128","https://openalex.org/W2035877973","https://openalex.org/W2039053594","https://openalex.org/W2040630204","https://openalex.org/W2041674913","https://openalex.org/W2051406511","https://openalex.org/W2052314258","https://openalex.org/W2054750734","https://openalex.org/W2056546931","https://openalex.org/W2061076014","https://openalex.org/W2061425021","https://openalex.org/W2061891352","https://openalex.org/W2064846815","https://openalex.org/W2065103652","https://openalex.org/W2067245109","https://openalex.org/W2069089843","https://openalex.org/W2069433314","https://openalex.org/W2070339716","https://openalex.org/W2071010503","https://openalex.org/W2074174832","https://openalex.org/W2079667206","https://openalex.org/W2083225704","https://openalex.org/W2084377709","https://openalex.org/W2085499593","https://openalex.org/W2086085458","https://openalex.org/W2086702905","https://openalex.org/W2091151146","https://openalex.org/W2091576663","https://openalex.org/W2094248448","https://openalex.org/W2096192437","https://openalex.org/W2099166697","https://openalex.org/W2100156547","https://openalex.org/W2100552707","https://openalex.org/W2101526557","https://openalex.org/W2102309722","https://openalex.org/W2102818272","https://openalex.org/W2107337799","https://openalex.org/W2112655992","https://openalex.org/W2117757143","https://openalex.org/W2119215188","https://openalex.org/W2121417064","https://openalex.org/W2124359985","https://openalex.org/W2125700595","https://openalex.org/W2125987139","https://openalex.org/W2130523009","https://openalex.org/W2130736113","https://openalex.org/W2136680615","https://openalex.org/W2136691282","https://openalex.org/W2148187752","https://openalex.org/W2149955384","https://openalex.org/W2151574084","https://openalex.org/W2152426658","https://openalex.org/W2153848323","https://openalex.org/W2155538826","https://openalex.org/W2162395131","https://openalex.org/W2166310590","https://openalex.org/W2169556367","https://openalex.org/W2169719363","https://openalex.org/W2170324063","https://openalex.org/W2173095331","https://openalex.org/W2177432730","https://openalex.org/W2179299562","https://openalex.org/W2219596071","https://openalex.org/W2280718773","https://openalex.org/W2284785012","https://openalex.org/W2346071487","https://openalex.org/W2364603449","https://openalex.org/W2409532517","https://openalex.org/W2467067181","https://openalex.org/W2474212100","https://openalex.org/W2518828632","https://openalex.org/W2553059833","https://openalex.org/W2560630567","https://openalex.org/W2561301122","https://openalex.org/W2592211960","https://openalex.org/W2951214768","https://openalex.org/W4240859691"],"related_works":["https://openalex.org/W2055303513","https://openalex.org/W1988142188","https://openalex.org/W2795223073","https://openalex.org/W2474212100","https://openalex.org/W1546737260","https://openalex.org/W4200382074","https://openalex.org/W2790563050","https://openalex.org/W2551476694","https://openalex.org/W2920386893","https://openalex.org/W2169012852"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":28},{"year":2022,"cited_by_count":34},{"year":2021,"cited_by_count":37},{"year":2020,"cited_by_count":37},{"year":2019,"cited_by_count":46},{"year":2018,"cited_by_count":37},{"year":2017,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-06-05T00:00:00"}