{"id":"https://openalex.org/W2617866595","doi":null,"title":"Determining Lineage Fate, Survival and Proliferation of Differentiating Thymocytes: Interplay between Notch, TCR, PI3K and MAPK Pathways","display_name":"Determining Lineage Fate, Survival and Proliferation of Differentiating Thymocytes: Interplay between Notch, TCR, PI3K and MAPK Pathways","publication_year":2013,"publication_date":"2013-03-04","ids":{"openalex":"https://openalex.org/W2617866595","mag":"2617866595"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/35084","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/35084","pdf_url":"https://utoronto.scholaris.ca/bitstreams/532b1b7e-f37b-4943-b8c9-2b4655293275/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/532b1b7e-f37b-4943-b8c9-2b4655293275/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102487175","display_name":"Gladys W. Wong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Gladys W. Wong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5102487175"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.052000001072883606,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gamma-delta-t-cells","display_name":"\u03b3\u03b4 T cells","score":0.7620000243186951},{"id":"https://openalex.org/keywords/alpha-beta-t-cells","display_name":"alpha beta T cells","score":0.9179999828338623},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.9890000224113464},{"id":"https://openalex.org/keywords/t-cell-receptor-signaling","display_name":"T cell receptor signaling","score":0.9539999961853027},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9179999828338623},{"id":"https://openalex.org/keywords/mapk-erk-pathway","display_name":"MAPK/ERK pathway","score":0.8130000233650208},{"id":"https://openalex.org/keywords/id3-algorithm","display_name":"ID3","score":0.9570000171661377},{"id":"https://openalex.org/keywords/hes1","display_name":"Hes1","score":0.9129999876022339},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.9900000095367432},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9819999933242798},{"id":"https://openalex.org/keywords/pre-t-cell-receptor","display_name":"pre-T cell receptor","score":0.7760000228881836},{"id":"https://openalex.org/keywords/interferon-gamma-production","display_name":"IFN-gamma production","score":0.722000002861023}],"concepts":[{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.7856054306030273},{"id":"https://openalex.org/C161879069","wikidata":"https://www.wikidata.org/wiki/Q904082","display_name":"Notch signaling pathway","level":3,"score":0.663784921169281},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6497234106063843},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6405282616615295},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.6145753860473633},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5649403929710388},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49245771765708923},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36381617188453674},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32824698090553284},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.32021400332450867},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.2728012502193451},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16630366444587708},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.07325345277786255},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06955179572105408}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/35084","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/35084","pdf_url":"https://utoronto.scholaris.ca/bitstreams/532b1b7e-f37b-4943-b8c9-2b4655293275/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:collectionscanada.gc.ca:OTU.1807/35084","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1807/35084","pdf_url":null,"source":{"id":"https://openalex.org/S4306402307","display_name":"Library and Archives Canada (Government of Canada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802286613","host_organization_name":"Government of Canada","host_organization_lineage":["https://openalex.org/I2802286613"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2617866595","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/handle/1807/35084","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/35084","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/35084","pdf_url":"https://utoronto.scholaris.ca/bitstreams/532b1b7e-f37b-4943-b8c9-2b4655293275/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2617866595.pdf","grobid_xml":"https://content.openalex.org/works/W2617866595.grobid-xml"},"referenced_works_count":364,"referenced_works":["https://openalex.org/W2858831","https://openalex.org/W14592976","https://openalex.org/W37384269","https://openalex.org/W62563637","https://openalex.org/W74305253","https://openalex.org/W97158386","https://openalex.org/W148638240","https://openalex.org/W258316223","https://openalex.org/W1452565297","https://openalex.org/W1484859051","https://openalex.org/W1486421511","https://openalex.org/W1488144685","https://openalex.org/W1498420538","https://openalex.org/W1499586736","https://openalex.org/W1500113424","https://openalex.org/W1501500713","https://openalex.org/W1505521705","https://openalex.org/W1507372361","https://openalex.org/W1509163238","https://openalex.org/W1510860702","https://openalex.org/W1516581843","https://openalex.org/W1518606375","https://openalex.org/W1524005671","https://openalex.org/W1527612372","https://openalex.org/W1542406910","https://openalex.org/W1558245619","https://openalex.org/W1558515869","https://openalex.org/W1565044685","https://openalex.org/W1568605582","https://openalex.org/W1574902133","https://openalex.org/W1574918102","https://openalex.org/W1585517331","https://openalex.org/W1589576417","https://openalex.org/W1590871522","https://openalex.org/W1595064677","https://openalex.org/W1598239336","https://openalex.org/W1663019954","https://openalex.org/W1668774261","https://openalex.org/W1672865967","https://openalex.org/W1761846133","https://openalex.org/W1775427038","https://openalex.org/W1806127905","https://openalex.org/W1814149446","https://openalex.org/W1849720919","https://openalex.org/W1863038493","https://openalex.org/W1871851255","https://openalex.org/W1887724877","https://openalex.org/W1905394267","https://openalex.org/W1905760657","https://openalex.org/W1920024920","https://openalex.org/W1925809477","https://openalex.org/W1936405794","https://openalex.org/W1937347519","https://openalex.org/W1939083266","https://openalex.org/W1947563713","https://openalex.org/W1963058400","https://openalex.org/W1963932077","https://openalex.org/W1964077677","https://openalex.org/W1966374669","https://openalex.org/W1966411920","https://openalex.org/W1966828612","https://openalex.org/W1966949361","https://openalex.org/W1969544207","https://openalex.org/W1969968701","https://openalex.org/W1970531910","https://openalex.org/W1972044265","https://openalex.org/W1972736348","https://openalex.org/W1973035870","https://openalex.org/W1974168822","https://openalex.org/W1974659740","https://openalex.org/W1975087118","https://openalex.org/W1976620258","https://openalex.org/W1978686705","https://openalex.org/W1979530431","https://openalex.org/W1980026279","https://openalex.org/W1980212327","https://openalex.org/W1980746867","https://openalex.org/W1981238156","https://openalex.org/W1981611424","https://openalex.org/W1982070877","https://openalex.org/W1982130774","https://openalex.org/W1982311631","https://openalex.org/W1983507527","https://openalex.org/W1983570871","https://openalex.org/W1984159955","https://openalex.org/W1984695968","https://openalex.org/W1985094563","https://openalex.org/W1985470462","https://openalex.org/W1987716978","https://openalex.org/W1991552247","https://openalex.org/W1992048975","https://openalex.org/W1992438206","https://openalex.org/W1993090087","https://openalex.org/W1993641677","https://openalex.org/W1994183260","https://openalex.org/W1994511844","https://openalex.org/W1994581518","https://openalex.org/W1994957003","https://openalex.org/W1995297089","https://openalex.org/W1995421851","https://openalex.org/W1996253034","https://openalex.org/W1998038367","https://openalex.org/W1999278480","https://openalex.org/W2000550532","https://openalex.org/W2000927180","https://openalex.org/W2001193776","https://openalex.org/W2002404925","https://openalex.org/W2002573132","https://openalex.org/W2002999573","https://openalex.org/W2004289105","https://openalex.org/W2004500300","https://openalex.org/W2004603629","https://openalex.org/W2007896376","https://openalex.org/W2008065206","https://openalex.org/W2008313660","https://openalex.org/W2008737860","https://openalex.org/W2010315866","https://openalex.org/W2010435020","https://openalex.org/W2010997554","https://openalex.org/W2011717162","https://openalex.org/W2013587414","https://openalex.org/W2014548832","https://openalex.org/W2014913358","https://openalex.org/W2015331792","https://openalex.org/W2016293652","https://openalex.org/W2017105911","https://openalex.org/W2017191360","https://openalex.org/W2017493275","https://openalex.org/W2017719081","https://openalex.org/W2018216682","https://openalex.org/W2018322294","https://openalex.org/W2019216667","https://openalex.org/W2019985217","https://openalex.org/W2020617877","https://openalex.org/W2021680927","https://openalex.org/W2021766626","https://openalex.org/W2021820438","https://openalex.org/W2023029824","https://openalex.org/W2023403245","https://openalex.org/W2023865101","https://openalex.org/W2025346006","https://openalex.org/W2025491149","https://openalex.org/W2025804504","https://openalex.org/W2026708020","https://openalex.org/W2027971163","https://openalex.org/W2028275698","https://openalex.org/W2028669354","https://openalex.org/W2028735719","https://openalex.org/W2028942940","https://openalex.org/W2029350186","https://openalex.org/W2029393400","https://openalex.org/W2030624761","https://openalex.org/W2030688963","https://openalex.org/W2031141836","https://openalex.org/W2032013475","https://openalex.org/W2032275687","https://openalex.org/W2032406291","https://openalex.org/W2033222990","https://openalex.org/W2035543586","https://openalex.org/W2036216798","https://openalex.org/W2037736150","https://openalex.org/W2037760821","https://openalex.org/W2038181944","https://openalex.org/W2039748263","https://openalex.org/W2040112038","https://openalex.org/W2041211388","https://openalex.org/W2042531263","https://openalex.org/W2042777921","https://openalex.org/W2042831411","https://openalex.org/W2043395027","https://openalex.org/W2043521345","https://openalex.org/W2044001333","https://openalex.org/W2044174672","https://openalex.org/W2044874211","https://openalex.org/W2044915747","https://openalex.org/W2046928493","https://openalex.org/W2047137615","https://openalex.org/W2047816695","https://openalex.org/W2049272122","https://openalex.org/W2050700188","https://openalex.org/W2052249831","https://openalex.org/W2052305285","https://openalex.org/W2052965357","https://openalex.org/W2053444110","https://openalex.org/W2055003617","https://openalex.org/W2056256651","https://openalex.org/W2056429839","https://openalex.org/W2056462157","https://openalex.org/W2057091891","https://openalex.org/W2057654378","https://openalex.org/W2057725997","https://openalex.org/W2058203815","https://openalex.org/W2058734213","https://openalex.org/W2058858066","https://openalex.org/W2058924545","https://openalex.org/W2059257370","https://openalex.org/W2059846307","https://openalex.org/W2060579010","https://openalex.org/W2060710804","https://openalex.org/W2061149209","https://openalex.org/W2061307900","https://openalex.org/W2061631515","https://openalex.org/W2064018023","https://openalex.org/W2065388713","https://openalex.org/W2065601509","https://openalex.org/W2065980555","https://openalex.org/W2066255742","https://openalex.org/W2066893530","https://openalex.org/W2067131315","https://openalex.org/W2067707046","https://openalex.org/W2067717074","https://openalex.org/W2068012172","https://openalex.org/W2068425472","https://openalex.org/W2068427129","https://openalex.org/W2068510450","https://openalex.org/W2069330945","https://openalex.org/W2070015044","https://openalex.org/W2070190414","https://openalex.org/W2070451931","https://openalex.org/W2070829001","https://openalex.org/W2071287590","https://openalex.org/W2071632799","https://openalex.org/W2071686558","https://openalex.org/W2071894403","https://openalex.org/W2072321096","https://openalex.org/W2073933067","https://openalex.org/W2074183372","https://openalex.org/W2075514051","https://openalex.org/W2075556460","https://openalex.org/W2075566981","https://openalex.org/W2076674503","https://openalex.org/W2077548707","https://openalex.org/W2078126797","https://openalex.org/W2078191138","https://openalex.org/W2079279013","https://openalex.org/W2079339500","https://openalex.org/W2080181628","https://openalex.org/W2080809922","https://openalex.org/W2082670705","https://openalex.org/W2083802827","https://openalex.org/W2084104947","https://openalex.org/W2084228983","https://openalex.org/W2084659477","https://openalex.org/W2085555998","https://openalex.org/W2087021490","https://openalex.org/W2087832707","https://openalex.org/W2090456065","https://openalex.org/W2091111894","https://openalex.org/W2092354039","https://openalex.org/W2093115609","https://openalex.org/W2093931465","https://openalex.org/W2095666604","https://openalex.org/W2096364704","https://openalex.org/W2096632716","https://openalex.org/W2097910692","https://openalex.org/W2098272219","https://openalex.org/W2098977954","https://openalex.org/W2099546426","https://openalex.org/W2099687001","https://openalex.org/W2099735892","https://openalex.org/W2099878990","https://openalex.org/W2099965304","https://openalex.org/W2100111497","https://openalex.org/W2100668150","https://openalex.org/W2103731094","https://openalex.org/W2104259190","https://openalex.org/W2104593525","https://openalex.org/W2104624966","https://openalex.org/W2106248746","https://openalex.org/W2106319246","https://openalex.org/W2108490725","https://openalex.org/W2108491220","https://openalex.org/W2108715505","https://openalex.org/W2110464252","https://openalex.org/W2111763240","https://openalex.org/W2113701895","https://openalex.org/W2113724558","https://openalex.org/W2113840114","https://openalex.org/W2114492564","https://openalex.org/W2114700924","https://openalex.org/W2115419666","https://openalex.org/W2118233929","https://openalex.org/W2118329157","https://openalex.org/W2119042271","https://openalex.org/W2119709204","https://openalex.org/W2120908143","https://openalex.org/W2121355298","https://openalex.org/W2121655252","https://openalex.org/W2121955940","https://openalex.org/W2122512547","https://openalex.org/W2123122060","https://openalex.org/W2123836839","https://openalex.org/W2126283955","https://openalex.org/W2126393916","https://openalex.org/W2126464081","https://openalex.org/W2128106363","https://openalex.org/W2128292585","https://openalex.org/W2130227763","https://openalex.org/W2130594577","https://openalex.org/W2131443076","https://openalex.org/W2131795672","https://openalex.org/W2131799581","https://openalex.org/W2132884452","https://openalex.org/W2133334405","https://openalex.org/W2133440148","https://openalex.org/W2133885516","https://openalex.org/W2135332805","https://openalex.org/W2135341184","https://openalex.org/W2138147017","https://openalex.org/W2138421443","https://openalex.org/W2139885427","https://openalex.org/W2140489687","https://openalex.org/W2141231618","https://openalex.org/W2141666411","https://openalex.org/W2141898641","https://openalex.org/W2143900459","https://openalex.org/W2144470070","https://openalex.org/W2144579631","https://openalex.org/W2145144126","https://openalex.org/W2147114673","https://openalex.org/W2147309283","https://openalex.org/W2147373929","https://openalex.org/W2148853426","https://openalex.org/W2149557024","https://openalex.org/W2149627687","https://openalex.org/W2151313755","https://openalex.org/W2151468959","https://openalex.org/W2152994600","https://openalex.org/W2153485112","https://openalex.org/W2154054797","https://openalex.org/W2154852791","https://openalex.org/W2154861644","https://openalex.org/W2155696890","https://openalex.org/W2157023326","https://openalex.org/W2157969772","https://openalex.org/W2158169658","https://openalex.org/W2159046946","https://openalex.org/W2159511823","https://openalex.org/W2160262946","https://openalex.org/W2160272188","https://openalex.org/W2160922815","https://openalex.org/W2161046164","https://openalex.org/W2161132784","https://openalex.org/W2161810908","https://openalex.org/W2161823671","https://openalex.org/W2161913720","https://openalex.org/W2162332365","https://openalex.org/W2163577434","https://openalex.org/W2163579392","https://openalex.org/W2163747337","https://openalex.org/W2163846766","https://openalex.org/W2163965017","https://openalex.org/W2164823776","https://openalex.org/W2164932894","https://openalex.org/W2165023381","https://openalex.org/W2167230971","https://openalex.org/W2168842568","https://openalex.org/W2183322892","https://openalex.org/W2245006846","https://openalex.org/W2316037107","https://openalex.org/W2322711897","https://openalex.org/W2328777842","https://openalex.org/W2330995965","https://openalex.org/W2410953773"],"related_works":["https://openalex.org/W1997516537","https://openalex.org/W2163846766","https://openalex.org/W2403387840","https://openalex.org/W2945169310","https://openalex.org/W7133055977","https://openalex.org/W1590048328","https://openalex.org/W1879256105","https://openalex.org/W2283868499","https://openalex.org/W2024607835","https://openalex.org/W4313349923"],"abstract_inverted_index":{"A":[0],"common":[1],"bipotent":[2],"thymocyte":[3],"precursor":[4],"gives":[5],"rise":[6],"to":[7,40,93,107,111,166,168,230,333],"both":[8,103,133,268],"lineages":[9],"of":[10,71,82,96,114,135,147,173,183,197,225,234,250,264,289,315,329],"T":[11,24,175],"cells,":[12],"\u03b1\u03b2":[13,174],"and":[14,29,36,42,105,117,139,195,215,270,280,282,327,344],"\u03b3\u03b4.":[15],"This":[16],"thesis":[17,310],"addresses":[18],"how":[19],"the":[20,72,97,136,143,169,181,184,204,210,213,232,235,262,273,285,306,316,337,340],"interplay":[21,338],"between":[22,212,339],"intrinsic":[23],"cell":[25,30,176],"receptor":[26],"(TCR)":[27],"signals":[28,32,160,179],"extrinsic":[31],"provided":[33],"by":[34],"Notch":[35,115,148,159,178,214,223],"TCR":[37,57],"ligands":[38],"help":[39],"assign":[41],"support":[43],"a":[44,52,128,312],"final":[45],"lineage":[46,66,278,324],"fate":[47,138],"decision.":[48],"Emerging":[49],"data":[50],"supports":[51],"model":[53,276],"in":[54,64,142,150,241,322],"which":[55,187,240],"differential":[56],"signaling":[58,116,149,346],"capacity":[59],"plays":[60],"an":[61],"instructional":[62],"role":[63],"specifying":[65],"fate,":[67,325],"particularly":[68],"through":[69,292],"induction":[70,224],"ERK":[73],"-":[74,80],"early":[75],"growth":[76],"response":[77],"gene":[78],"(Egr)":[79],"inhibitor":[81],"DNA":[83],"binding":[84],"3":[85],"(Id3)":[86],"pathway.":[87],"In":[88],"particular,":[89],"Id3":[90,101,126,297],"expression":[91,227,233],"serves":[92],"regulate":[94],"adoption":[95,134],"\u03b3\u03b4":[98,137],"fate.":[99],"Moreover,":[100],"is":[102,188,228,252,336],"necessary":[104,229],"sufficient":[106],"enable":[108],"\u03b3\u03b4-lineage":[109],"cells":[110,154,165,266],"differentiate":[112],"independently":[113],"become":[118],"competent":[119],"interferon":[120],"(IFN)-\u03b3-producing":[121],"effectors.":[122],"These":[123],"findings":[124],"identify":[125,203],"as":[127],"central":[129],"player":[130],"that":[131,261,319],"controls":[132],"their":[140],"maturation":[141],"thymus.":[144],"While":[145],"loss":[146],"\u03b3\u03b4TCR-expressing":[151],"CD4-CD8-":[152],"(DN)3":[153],"does":[155],"not":[156],"affect":[157,180],"development,":[158,279],"are":[161,320],"critical":[162,220,248],"for":[163,190,209,254,277],"pre-TCR-bearing":[164],"transition":[167],"CD4+CD8+":[170],"(DP)":[171],"stage":[172],"development.":[177],"activation":[182],"PI3K/Akt":[185,236],"pathway,":[186],"required":[189,253],"pT\u03b1/TCR\u03b2":[191],"(pre-TCR)-induced":[192],"survival,":[193,326],"differentiation":[194],"proliferation":[196,255,328],"developing":[198],"\u03b1\u03b2-lineage":[199],"thymocytes.":[200,331],"Here,":[201],"I":[202,259],"key":[205],"molecular":[206,317],"players":[207],"responsible":[208],"interaction":[211],"PI3K":[216],"pathways":[217],"at":[218],"this":[219,301,309],"developmental":[221],"stage.":[222],"Hes1":[226],"repress":[231],"pathway":[237],"inhibitor,":[238],"PTEN,":[239],"turn":[242],"facilitates":[243],"pre-TCR-induced":[244],"differentiation.":[245],"c-Myc,":[246],"another":[247],"target":[249],"Notch,":[251,341],"during":[256],"\u03b2-selection.":[257],"Lastly,":[258],"find":[260],"majority":[263],"DN3":[265],"expressing":[267],"pre-TCR":[269],"\u03b3\u03b4TCR":[271,293],"follow":[272],"signal":[274,290],"strength":[275],"commit":[281],"mature":[283],"along":[284],"\u03b3\u03b4-lineage.":[286],"However,":[287],"manipulation":[288],"strength,":[291],"ligand":[294],"availability":[295],"or":[296],"expression,":[298],"can":[299],"skew":[300],"development":[302],"outcome.":[303],"Taken":[304],"together,":[305],"results":[307],"from":[308],"provide":[311],"detailed":[313],"examination":[314],"mechanisms":[318],"instrumental":[321],"determining":[323],"differentiating":[330],"Central":[332],"these":[334],"outcomes":[335],"TCR,":[342],"PI3K,":[343],"MAPK":[345],"pathways.":[347]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2017-06-05T00:00:00"}