{"id":"https://openalex.org/W2617455688","doi":"https://doi.org/10.1146/annurev-pharmtox-010716-105106","title":"Targeting Epigenetics in Cancer","display_name":"Targeting Epigenetics in Cancer","publication_year":2017,"publication_date":"2017-10-09","ids":{"openalex":"https://openalex.org/W2617455688","doi":"https://doi.org/10.1146/annurev-pharmtox-010716-105106","mag":"2617455688","pmid":"https://pubmed.ncbi.nlm.nih.gov/28992434","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5800772"},"language":"en","primary_location":{"id":"doi:10.1146/annurev-pharmtox-010716-105106","doi":"https://doi.org/10.1146/annurev-pharmtox-010716-105106","is_oa":true,"landing_page_url":"https://doi.org/10.1146/annurev-pharmtox-010716-105106","pdf_url":"https://www.annualreviews.org/doi/pdf/10.1146/annurev-pharmtox-010716-105106","source":{"id":"https://openalex.org/S163849586","display_name":"The Annual Review of Pharmacology and Toxicology","issn_l":"0362-1642","issn":["0362-1642","1545-4304"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Pharmacology and Toxicology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.annualreviews.org/doi/pdf/10.1146/annurev-pharmtox-010716-105106","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008754012","display_name":"Richard Lynn Bennett","orcid":"https://orcid.org/0000-0002-0243-2443","observed_orcids":["https://orcid.org/0000-0002-0243-2443"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4390039331","display_name":"UF Health Cancer Center","ror":"https://ror.org/044vhe029","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144","https://openalex.org/I4390039331"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard L. Bennett","raw_affiliation_strings":["Division of Hematology & Oncology, Department of Medicine, University of Florida Health Cancer Center, University of Florida, Gainesville, Florida 32606, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology & Oncology, Department of Medicine, University of Florida Health Cancer Center, University of Florida, Gainesville, Florida 32606, USA;","institution_ids":["https://openalex.org/I33213144","https://openalex.org/I4390039331"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034992183","display_name":"Jonathan D. Licht","orcid":"https://orcid.org/0000-0002-3942-1369","observed_orcids":["https://orcid.org/0000-0002-3942-1369"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4390039331","display_name":"UF Health Cancer Center","ror":"https://ror.org/044vhe029","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144","https://openalex.org/I4390039331"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jonathan D. Licht","raw_affiliation_strings":["Division of Hematology & Oncology, Department of Medicine, University of Florida Health Cancer Center, University of Florida, Gainesville, Florida 32606, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology & Oncology, Department of Medicine, University of Florida Health Cancer Center, University of Florida, Gainesville, Florida 32606, USA;","institution_ids":["https://openalex.org/I33213144","https://openalex.org/I4390039331"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034992183"],"corresponding_institution_ids":["https://openalex.org/I33213144","https://openalex.org/I4390039331"],"apc_list":null,"apc_paid":null,"fwci":2.3024,"has_fulltext":true,"cited_by_count":252,"citation_normalized_percentile":{"value":0.91494083,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"58","issue":"1","first_page":"187","last_page":"207"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.6800000071525574},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9110000133514404},{"id":"https://openalex.org/keywords/histone-modifications","display_name":"histone modifications","score":0.9800000190734863},{"id":"https://openalex.org/keywords/chromatin-structure","display_name":"chromatin structure","score":0.9890000224113464},{"id":"https://openalex.org/keywords/epigenetic-inhibitors","display_name":"epigenetic inhibitors","score":0.8999999761581421},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.8999999761581421},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.9470000267028809},{"id":"https://openalex.org/keywords/epigenetic-therapy","display_name":"epigenetic therapy","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.944282054901123},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.6806346774101257},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6761735677719116},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6204324960708618},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5644243955612183},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5487462282180786},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5128486156463623},{"id":"https://openalex.org/C114691636","wikidata":"https://www.wikidata.org/wiki/Q5031434","display_name":"Cancer epigenetics","level":5,"score":0.5123802423477173},{"id":"https://openalex.org/C179463898","wikidata":"https://www.wikidata.org/wiki/Q10273301","display_name":"Epigenesis","level":5,"score":0.4757663607597351},{"id":"https://openalex.org/C2780737395","wikidata":"https://www.wikidata.org/wiki/Q18353741","display_name":"Epigenetic therapy","level":5,"score":0.4387405812740326},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4086237847805023},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3906140923500061},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3774165213108063},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.33751118183135986},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3149909973144531},{"id":"https://openalex.org/C150425827","wikidata":"https://www.wikidata.org/wiki/Q2560317","display_name":"Histone methyltransferase","level":4,"score":0.1343289017677307}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1146/annurev-pharmtox-010716-105106","doi":"https://doi.org/10.1146/annurev-pharmtox-010716-105106","is_oa":true,"landing_page_url":"https://doi.org/10.1146/annurev-pharmtox-010716-105106","pdf_url":"https://www.annualreviews.org/doi/pdf/10.1146/annurev-pharmtox-010716-105106","source":{"id":"https://openalex.org/S163849586","display_name":"The Annual Review of Pharmacology and Toxicology","issn_l":"0362-1642","issn":["0362-1642","1545-4304"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Pharmacology and Toxicology","raw_type":"journal-article"},{"id":"pmid:28992434","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28992434","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of pharmacology and toxicology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5291456","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5800772","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5800772","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5800772","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Annu Rev Pharmacol Toxicol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1146/annurev-pharmtox-010716-105106","doi":"https://doi.org/10.1146/annurev-pharmtox-010716-105106","is_oa":true,"landing_page_url":"https://doi.org/10.1146/annurev-pharmtox-010716-105106","pdf_url":"https://www.annualreviews.org/doi/pdf/10.1146/annurev-pharmtox-010716-105106","source":{"id":"https://openalex.org/S163849586","display_name":"The Annual Review of Pharmacology and Toxicology","issn_l":"0362-1642","issn":["0362-1642","1545-4304"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Pharmacology and Toxicology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G333824044","display_name":"Spatio-Temporal Organization of Chromatin and Information Transfer in Cancer","funder_award_id":"U54CA193419","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G35251022","display_name":"UTX, MLL AND PATHOGENIC DEREGULATION OF HISTONE METHYLATION IN MULTIPLE MYELOMA","funder_award_id":"R01CA180475","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5470963091","display_name":"The Role of MMSET in the Pathogenesis and Progression of Lymphoid Malignancy","funder_award_id":"R01CA195732","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2617455688.pdf","grobid_xml":"https://content.openalex.org/works/W2617455688.grobid-xml"},"referenced_works_count":160,"referenced_works":["https://openalex.org/W122353466","https://openalex.org/W235826207","https://openalex.org/W603336398","https://openalex.org/W633990065","https://openalex.org/W1484293540","https://openalex.org/W1533942477","https://openalex.org/W1565539350","https://openalex.org/W1610516579","https://openalex.org/W1754355975","https://openalex.org/W1905278501","https://openalex.org/W1919687837","https://openalex.org/W1921071413","https://openalex.org/W1963736125","https://openalex.org/W1968677867","https://openalex.org/W1968761707","https://openalex.org/W1976033223","https://openalex.org/W1977706798","https://openalex.org/W1988373809","https://openalex.org/W1990711772","https://openalex.org/W1993295257","https://openalex.org/W1994672948","https://openalex.org/W1995675594","https://openalex.org/W1996487270","https://openalex.org/W1997087919","https://openalex.org/W1999952815","https://openalex.org/W2002788005","https://openalex.org/W2004380688","https://openalex.org/W2004499293","https://openalex.org/W2005629927","https://openalex.org/W2005829971","https://openalex.org/W2009826707","https://openalex.org/W2010429928","https://openalex.org/W2010437331","https://openalex.org/W2011376261","https://openalex.org/W2013571070","https://openalex.org/W2013799496","https://openalex.org/W2013810007","https://openalex.org/W2015416439","https://openalex.org/W2017492512","https://openalex.org/W2018508414","https://openalex.org/W2020520804","https://openalex.org/W2022240113","https://openalex.org/W2024373518","https://openalex.org/W2024985626","https://openalex.org/W2025193307","https://openalex.org/W2029402659","https://openalex.org/W2029457245","https://openalex.org/W2030337250","https://openalex.org/W2030754208","https://openalex.org/W2033027341","https://openalex.org/W2033078160","https://openalex.org/W2033247628","https://openalex.org/W2034519672","https://openalex.org/W2034619626","https://openalex.org/W2036777838","https://openalex.org/W2037548653","https://openalex.org/W2040257851","https://openalex.org/W2040393829","https://openalex.org/W2041336616","https://openalex.org/W2041535798","https://openalex.org/W2044352858","https://openalex.org/W2053116646","https://openalex.org/W2054301876","https://openalex.org/W2054621094","https://openalex.org/W2054643318","https://openalex.org/W2056369410","https://openalex.org/W2060446375","https://openalex.org/W2061891352","https://openalex.org/W2063296278","https://openalex.org/W2065367918","https://openalex.org/W2068473772","https://openalex.org/W2069918359","https://openalex.org/W2071576183","https://openalex.org/W2072191008","https://openalex.org/W2074329146","https://openalex.org/W2078972833","https://openalex.org/W2080029028","https://openalex.org/W2081279521","https://openalex.org/W2082592723","https://openalex.org/W2084295010","https://openalex.org/W2086857599","https://openalex.org/W2087507084","https://openalex.org/W2087719423","https://openalex.org/W2088260828","https://openalex.org/W2095026025","https://openalex.org/W2096796171","https://openalex.org/W2097589930","https://openalex.org/W2097743943","https://openalex.org/W2099129819","https://openalex.org/W2100365251","https://openalex.org/W2100618837","https://openalex.org/W2100630390","https://openalex.org/W2104425103","https://openalex.org/W2104954848","https://openalex.org/W2105085478","https://openalex.org/W2106584820","https://openalex.org/W2107337799","https://openalex.org/W2107661677","https://openalex.org/W2110957729","https://openalex.org/W2112259312","https://openalex.org/W2112725925","https://openalex.org/W2113634596","https://openalex.org/W2114031931","https://openalex.org/W2116739152","https://openalex.org/W2117305571","https://openalex.org/W2118428599","https://openalex.org/W2119079421","https://openalex.org/W2121356384","https://openalex.org/W2121369682","https://openalex.org/W2122277359","https://openalex.org/W2123564569","https://openalex.org/W2124877193","https://openalex.org/W2126817554","https://openalex.org/W2127352480","https://openalex.org/W2129129812","https://openalex.org/W2130808015","https://openalex.org/W2131072337","https://openalex.org/W2132310381","https://openalex.org/W2136905998","https://openalex.org/W2137505881","https://openalex.org/W2140929811","https://openalex.org/W2141476381","https://openalex.org/W2142745453","https://openalex.org/W2144792857","https://openalex.org/W2147516356","https://openalex.org/W2148429447","https://openalex.org/W2152258603","https://openalex.org/W2154313451","https://openalex.org/W2160234594","https://openalex.org/W2162619595","https://openalex.org/W2163583950","https://openalex.org/W2164166000","https://openalex.org/W2164969543","https://openalex.org/W2166907165","https://openalex.org/W2167118090","https://openalex.org/W2169690426","https://openalex.org/W2169724454","https://openalex.org/W2183418069","https://openalex.org/W2185127129","https://openalex.org/W2190015925","https://openalex.org/W2234360948","https://openalex.org/W2238488506","https://openalex.org/W2239956464","https://openalex.org/W2275197865","https://openalex.org/W2318281771","https://openalex.org/W2319549623","https://openalex.org/W2320983896","https://openalex.org/W2329063786","https://openalex.org/W2331846333","https://openalex.org/W2341775915","https://openalex.org/W2484616545","https://openalex.org/W2513480194","https://openalex.org/W2520340383","https://openalex.org/W2525145186","https://openalex.org/W2555849466","https://openalex.org/W2588321737","https://openalex.org/W2590039001","https://openalex.org/W2793845487","https://openalex.org/W2890678836","https://openalex.org/W4212766227"],"related_works":["https://openalex.org/W3012964494","https://openalex.org/W2995898384","https://openalex.org/W2909403547","https://openalex.org/W2129253231","https://openalex.org/W3107092934","https://openalex.org/W2077719546","https://openalex.org/W1599509467","https://openalex.org/W2911313508","https://openalex.org/W3199306263","https://openalex.org/W2920068846"],"abstract_inverted_index":{"Alterations":[0],"of":[1,17,30,34,38,61,84,95],"genes":[2],"regulating":[3],"epigenetic":[4,39,52,85],"processes":[5,44],"are":[6,45,64,87],"frequently":[7],"found":[8],"as":[9],"cancer":[10,90],"drivers":[11],"and":[12,58,70,82,91],"may":[13],"cause":[14],"widespread":[15],"alterations":[16],"DNA":[18],"methylation,":[19],"histone":[20],"modification":[21],"patterns,":[22],"or":[23],"chromatin":[24],"structure":[25],"that":[26],"disrupt":[27],"normal":[28],"patterns":[29],"gene":[31],"expression.":[32],"Because":[33],"the":[35,79,93],"inherent":[36],"reversibility":[37],"changes,":[40],"inhibitors":[41],"targeting":[42,51,97],"these":[43,62,98],"promising":[46],"anticancer":[47],"strategies.":[48],"Small":[49],"molecules":[50],"regulators":[53],"have":[54],"been":[55],"developed":[56],"recently,":[57],"clinical":[59],"trials":[60],"agents":[63],"under":[65],"way":[66],"for":[67],"hematologic":[68],"malignancies":[69],"solid":[71],"tumors.":[72],"In":[73],"this":[74],"review,":[75],"we":[76],"describe":[77],"how":[78],"writers,":[80],"readers,":[81],"erasers":[83],"marks":[86],"dysregulated":[88],"in":[89],"summarize":[92],"development":[94],"therapies":[96],"mechanisms.":[99]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":26},{"year":2024,"cited_by_count":26},{"year":2023,"cited_by_count":24},{"year":2022,"cited_by_count":31},{"year":2021,"cited_by_count":43},{"year":2020,"cited_by_count":41},{"year":2019,"cited_by_count":30},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-06-05T00:00:00"}