{"id":"https://openalex.org/W2617419085","doi":"https://doi.org/10.1038/s41598-017-01737-w","title":"In silico analyses of deleterious missense SNPs of human apolipoprotein E3","display_name":"In silico analyses of deleterious missense SNPs of human apolipoprotein E3","publication_year":2017,"publication_date":"2017-05-24","ids":{"openalex":"https://openalex.org/W2617419085","doi":"https://doi.org/10.1038/s41598-017-01737-w","mag":"2617419085","pmid":"https://pubmed.ncbi.nlm.nih.gov/28559539","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5449402"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-017-01737-w","doi":"https://doi.org/10.1038/s41598-017-01737-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-017-01737-w","pdf_url":"https://www.nature.com/articles/s41598-017-01737-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2617419085"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-017-01737-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086375606","display_name":"\u00c1llan S. Pires","orcid":"https://orcid.org/0000-0002-5633-3838","observed_orcids":["https://orcid.org/0000-0002-5633-3838"]},"institutions":[{"id":"https://openalex.org/I24871856","display_name":"Universidade Cat\u00f3lica de Bras\u00edlia","ror":"https://ror.org/0058wy590","country_code":"BR","type":"education","lineage":["https://openalex.org/I24871856"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Allan S. Pires","raw_affiliation_strings":["Centro de An\u00e1lises Prote\u00f4micas e Bioqu\u00edmicas, P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Gen\u00f4micas e Biotecnologia, Universidade Cat\u00f3lica de Bras\u00edlia, Bras\u00edlia-DF, Brazil","Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Gen\u00f4micas e Biotecnologia, Universidade Cat\u00f3lica de Bras\u00edlia, Bras\u00edlia-DF, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de An\u00e1lises Prote\u00f4micas e Bioqu\u00edmicas, P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Gen\u00f4micas e Biotecnologia, Universidade Cat\u00f3lica de Bras\u00edlia, Bras\u00edlia-DF, Brazil","institution_ids":["https://openalex.org/I24871856"]},{"raw_affiliation_string":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Gen\u00f4micas e Biotecnologia, Universidade Cat\u00f3lica de Bras\u00edlia, Bras\u00edlia-DF, Brazil","institution_ids":["https://openalex.org/I24871856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074236037","display_name":"William Farias Porto","orcid":"https://orcid.org/0000-0002-4739-8250","observed_orcids":["https://orcid.org/0000-0002-4739-8250"]},"institutions":[{"id":"https://openalex.org/I24871856","display_name":"Universidade Cat\u00f3lica de Bras\u00edlia","ror":"https://ror.org/0058wy590","country_code":"BR","type":"education","lineage":["https://openalex.org/I24871856"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"William F. Porto","raw_affiliation_strings":["Centro de An\u00e1lises Prote\u00f4micas e Bioqu\u00edmicas, P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Gen\u00f4micas e Biotecnologia, Universidade Cat\u00f3lica de Bras\u00edlia, Bras\u00edlia-DF, Brazil","Porto Reports, Bras\u00edlia-DF, Brazil","Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Gen\u00f4micas e Biotecnologia, Universidade Cat\u00f3lica de Bras\u00edlia, Bras\u00edlia-DF, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de An\u00e1lises Prote\u00f4micas e Bioqu\u00edmicas, P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Gen\u00f4micas e Biotecnologia, Universidade Cat\u00f3lica de Bras\u00edlia, Bras\u00edlia-DF, Brazil","institution_ids":["https://openalex.org/I24871856"]},{"raw_affiliation_string":"Porto Reports, Bras\u00edlia-DF, Brazil","institution_ids":[]},{"raw_affiliation_string":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Gen\u00f4micas e Biotecnologia, Universidade Cat\u00f3lica de Bras\u00edlia, Bras\u00edlia-DF, Brazil","institution_ids":["https://openalex.org/I24871856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036861140","display_name":"Oct\u00e1vio Luiz Franco","orcid":"https://orcid.org/0000-0001-9546-0525","observed_orcids":["https://orcid.org/0000-0001-9546-0525"]},"institutions":[{"id":"https://openalex.org/I24871856","display_name":"Universidade Cat\u00f3lica de Bras\u00edlia","ror":"https://ror.org/0058wy590","country_code":"BR","type":"education","lineage":["https://openalex.org/I24871856"]},{"id":"https://openalex.org/I44839336","display_name":"Universidade Cat\u00f3lica Dom Bosco","ror":"https://ror.org/02q070r42","country_code":"BR","type":"education","lineage":["https://openalex.org/I44839336"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Octavio L. Franco","raw_affiliation_strings":["Centro de An\u00e1lises Prote\u00f4micas e Bioqu\u00edmicas, P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Gen\u00f4micas e Biotecnologia, Universidade Cat\u00f3lica de Bras\u00edlia, Bras\u00edlia-DF, Brazil","Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Gen\u00f4micas e Biotecnologia, Universidade Cat\u00f3lica de Bras\u00edlia, Bras\u00edlia-DF, Brazil","S-Inova Biotech, P\u00f3s-gradua\u00e7\u00e3o em Biotecnologia, Universidade Cat\u00f3lica Dom Bosco, Campo Grande, MS, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de An\u00e1lises Prote\u00f4micas e Bioqu\u00edmicas, P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Gen\u00f4micas e Biotecnologia, Universidade Cat\u00f3lica de Bras\u00edlia, Bras\u00edlia-DF, Brazil","institution_ids":["https://openalex.org/I24871856"]},{"raw_affiliation_string":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Gen\u00f4micas e Biotecnologia, Universidade Cat\u00f3lica de Bras\u00edlia, Bras\u00edlia-DF, Brazil","institution_ids":["https://openalex.org/I24871856"]},{"raw_affiliation_string":"S-Inova Biotech, P\u00f3s-gradua\u00e7\u00e3o em Biotecnologia, Universidade Cat\u00f3lica Dom Bosco, Campo Grande, MS, Brazil","institution_ids":["https://openalex.org/I44839336"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017926034","display_name":"S\u00e9rgio Amorim de Alencar","orcid":"https://orcid.org/0000-0001-8236-6468","observed_orcids":["https://orcid.org/0000-0001-8236-6468"]},"institutions":[{"id":"https://openalex.org/I24871856","display_name":"Universidade Cat\u00f3lica de Bras\u00edlia","ror":"https://ror.org/0058wy590","country_code":"BR","type":"education","lineage":["https://openalex.org/I24871856"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"S\u00e9rgio A. Alencar","raw_affiliation_strings":["Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Gen\u00f4micas e Biotecnologia, Universidade Cat\u00f3lica de Bras\u00edlia, Bras\u00edlia-DF, Brazil. sergiodealencar@gmail.com","Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Gen\u00f4micas e Biotecnologia, Universidade Cat\u00f3lica de Bras\u00edlia, Bras\u00edlia-DF, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Gen\u00f4micas e Biotecnologia, Universidade Cat\u00f3lica de Bras\u00edlia, Bras\u00edlia-DF, Brazil. sergiodealencar@gmail.com","institution_ids":["https://openalex.org/I24871856"]},{"raw_affiliation_string":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Gen\u00f4micas e Biotecnologia, Universidade Cat\u00f3lica de Bras\u00edlia, Bras\u00edlia-DF, Brazil","institution_ids":["https://openalex.org/I24871856"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5017926034"],"corresponding_institution_ids":["https://openalex.org/I24871856"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":1.132,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.74751043,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"7","issue":"1","first_page":"2509","last_page":"2509"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.8701000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.8701000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.05090000107884407,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.02879999950528145,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-e3","display_name":"apolipoprotein E3","score":0.9480000138282776},{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.8690000176429749},{"id":"https://openalex.org/keywords/missense-single-nucleotide-polymorphisms","display_name":"missense single nucleotide polymorphisms","score":0.9399999976158142},{"id":"https://openalex.org/keywords/deleterious-mutations","display_name":"deleterious mutations","score":0.9240000247955322},{"id":"https://openalex.org/keywords/protein-structure","display_name":"protein structure","score":0.47699999809265137},{"id":"https://openalex.org/keywords/molecular-dynamics-simulation","display_name":"molecular dynamics simulation","score":0.6949999928474426},{"id":"https://openalex.org/keywords/computational-prediction-tools","display_name":"computational prediction tools","score":0.6100000143051147},{"id":"https://openalex.org/keywords/hydrogen-bonding","display_name":"hydrogen bonding","score":0.7829999923706055},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8769999742507935},{"id":"https://openalex.org/keywords/type-iii-hyperlipoproteinemia","display_name":"type III hyperlipoproteinemia","score":0.9039999842643738},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.8149999976158142},{"id":"https://openalex.org/keywords/telomere-shortening","display_name":"telomere shortening","score":0.9470000267028809}],"concepts":[{"id":"https://openalex.org/C75563809","wikidata":"https://www.wikidata.org/wiki/Q2656896","display_name":"Missense mutation","level":4,"score":0.7675250172615051},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.7408190965652466},{"id":"https://openalex.org/C35794970","wikidata":"https://www.wikidata.org/wiki/Q5243761","display_name":"dbSNP","level":5,"score":0.7366254329681396},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.555708110332489},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5526596903800964},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47561198472976685},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.4541747272014618},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4434365928173065},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.42634958028793335},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.41200608015060425},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40055081248283386},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.38193070888519287},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3253532648086548},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32473793625831604},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2855684459209442},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.2802492082118988},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.2605527639389038},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.25372445583343506},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2528127431869507},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.15777185559272766}],"mesh":[{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053318","descriptor_name":"Apolipoprotein E3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053318","descriptor_name":"Apolipoprotein E3","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-017-01737-w","doi":"https://doi.org/10.1038/s41598-017-01737-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-017-01737-w","pdf_url":"https://www.nature.com/articles/s41598-017-01737-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4305980","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC5449402","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:28559539","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28559539","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5449402","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5449402/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:43e3c748c0db48c28f20a0cab69056a9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/43e3c748c0db48c28f20a0cab69056a9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-017-01737-w","doi":"https://doi.org/10.1038/s41598-017-01737-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-017-01737-w","pdf_url":"https://www.nature.com/articles/s41598-017-01737-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320323350","display_name":"Funda\u00e7\u00e3o de Apoio \u00e0 Pesquisa do Distrito Federal","ror":"https://ror.org/04djvx395"},{"id":"https://openalex.org/F4320323354","display_name":"Funda\u00e7\u00e3o de Apoio ao Desenvolvimento do Ensino, Ci\u00eancia e Tecnologia do Estado de Mato Grosso do Sul","ror":"https://ror.org/05jtrt935"},{"id":"https://openalex.org/F4320324689","display_name":"Universidade Cat\u00f3lica de Bras\u00edlia","ror":"https://ror.org/0058wy590"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2617419085.pdf","grobid_xml":"https://content.openalex.org/works/W2617419085.grobid-xml"},"referenced_works_count":83,"referenced_works":["https://openalex.org/W98152484","https://openalex.org/W134453782","https://openalex.org/W148236777","https://openalex.org/W1491824558","https://openalex.org/W1546262989","https://openalex.org/W1585939084","https://openalex.org/W1595347157","https://openalex.org/W1925637678","https://openalex.org/W1966078827","https://openalex.org/W1968866732","https://openalex.org/W1973035681","https://openalex.org/W1978763597","https://openalex.org/W1979447150","https://openalex.org/W1980717122","https://openalex.org/W1980740976","https://openalex.org/W1980888617","https://openalex.org/W1986191025","https://openalex.org/W1987507232","https://openalex.org/W1990016625","https://openalex.org/W1991306495","https://openalex.org/W1991397623","https://openalex.org/W1992192767","https://openalex.org/W2006599070","https://openalex.org/W2009182898","https://openalex.org/W2013028402","https://openalex.org/W2016443299","https://openalex.org/W2019757163","https://openalex.org/W2024396347","https://openalex.org/W2025299147","https://openalex.org/W2031553026","https://openalex.org/W2031727884","https://openalex.org/W2036362108","https://openalex.org/W2040465648","https://openalex.org/W2048212555","https://openalex.org/W2051394059","https://openalex.org/W2052288531","https://openalex.org/W2058487877","https://openalex.org/W2059145105","https://openalex.org/W2059802803","https://openalex.org/W2061530946","https://openalex.org/W2062089093","https://openalex.org/W2063192890","https://openalex.org/W2067174909","https://openalex.org/W2069197202","https://openalex.org/W2071436876","https://openalex.org/W2074109912","https://openalex.org/W2076048958","https://openalex.org/W2086164560","https://openalex.org/W2088697165","https://openalex.org/W2089335658","https://openalex.org/W2089863534","https://openalex.org/W2092387745","https://openalex.org/W2094201044","https://openalex.org/W2094364456","https://openalex.org/W2102124048","https://openalex.org/W2103945336","https://openalex.org/W2109293787","https://openalex.org/W2111326065","https://openalex.org/W2114886480","https://openalex.org/W2116099439","https://openalex.org/W2121101037","https://openalex.org/W2122732537","https://openalex.org/W2124088653","https://openalex.org/W2127018534","https://openalex.org/W2128572087","https://openalex.org/W2128995100","https://openalex.org/W2129883875","https://openalex.org/W2136769627","https://openalex.org/W2138870569","https://openalex.org/W2149580316","https://openalex.org/W2156125289","https://openalex.org/W2159091343","https://openalex.org/W2165071259","https://openalex.org/W2168223461","https://openalex.org/W2169243280","https://openalex.org/W2169892526","https://openalex.org/W2179425537","https://openalex.org/W2285849357","https://openalex.org/W2387073917","https://openalex.org/W4210767115","https://openalex.org/W4249458466","https://openalex.org/W4254547023","https://openalex.org/W4300196896"],"related_works":["https://openalex.org/W4413926316","https://openalex.org/W4412954828","https://openalex.org/W4387383606","https://openalex.org/W2087788439","https://openalex.org/W2034724732","https://openalex.org/W4319916529","https://openalex.org/W1981437877","https://openalex.org/W2901592770","https://openalex.org/W2119291357"],"abstract_inverted_index":{"ApoE3":[0,26,140],"is":[1],"the":[2,46,64,114,137,148,151],"major":[3],"chylomicron":[4],"apolipoprotein,":[5],"binding":[6],"in":[7,25,51,82,113,127],"a":[8,111,144],"specific":[9],"liver":[10],"peripheral":[11],"cell":[12],"receptor,":[13],"allowing":[14],"transport":[15],"and":[16,39,61,89,95,121,142],"normal":[17],"catabolism":[18],"of":[19,48,67,92,116,139,150,153],"triglyceride-rich":[20],"lipoprotein":[21],"constituents.":[22],"Point":[23],"mutations":[24],"have":[27,78],"been":[28],"associated":[29,99],"with":[30,100],"Alzheimer's":[31],"disease,":[32],"type":[33],"III":[34],"hyperlipoproteinemia,":[35],"atherosclerosis,":[36],"telomere":[37],"shortening":[38],"impaired":[40],"cognitive":[41],"function.":[42],"Here,":[43],"we":[44],"evaluate":[45,63],"impact":[47,66,152],"missense":[49],"SNPs":[50],"APOE":[52,156],"retrieved":[53],"from":[54],"dbSNP":[55],"through":[56],"16":[57],"computational":[58],"prediction":[59],"tools,":[60],"further":[62],"structural":[65,80],"convergent":[68],"deleterious":[69],"changes":[70,81],"using":[71],"100":[72],"ns":[73],"molecular":[74],"dynamics":[75],"simulations.":[76],"We":[77],"found":[79],"four":[83],"analyzed":[84],"variants":[85],"(Pro102Arg,":[86],"Arg132Ser,":[87],"Arg176Cys":[88],"Trp294Cys),":[90],"two":[91],"them":[93],"(Pro102Arg":[94],"Arg176Cys)":[96],"being":[97],"previously":[98],"human":[101],"diseases.":[102],"In":[103,130],"all":[104],"cases,":[105],"except":[106],"for":[107,147],"Trp294Cys,":[108],"there":[109],"was":[110],"loss":[112],"number":[115],"hydrogen":[117],"bonds":[118],"between":[119],"CT":[120],"NT":[122],"domains":[123],"that":[124],"could":[125,135],"result":[126],"their":[128],"detachment.":[129],"conclusion,":[131],"data":[132],"presented":[133],"here":[134],"increase":[136],"knowledge":[138],"activity":[141],"be":[143],"starting":[145],"point":[146],"study":[149],"variations":[154],"on":[155],"gene.":[157]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2017-06-05T00:00:00"}
