{"id":"https://openalex.org/W2616987446","doi":"https://doi.org/10.1080/00016489.2017.1328743","title":"Molecular mechanisms underlying the protective effects of hydrogen-saturated saline on noise-induced hearing loss","display_name":"Molecular mechanisms underlying the protective effects of hydrogen-saturated saline on noise-induced hearing loss","publication_year":2017,"publication_date":"2017-05-26","ids":{"openalex":"https://openalex.org/W2616987446","doi":"https://doi.org/10.1080/00016489.2017.1328743","mag":"2616987446","pmid":"https://pubmed.ncbi.nlm.nih.gov/28549396"},"language":"en","primary_location":{"id":"doi:10.1080/00016489.2017.1328743","doi":"https://doi.org/10.1080/00016489.2017.1328743","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00016489.2017.1328743","pdf_url":null,"source":{"id":"https://openalex.org/S198335345","display_name":"Acta Oto-Laryngologica","issn_l":"0001-6489","issn":["0001-6489","1651-2251","1651-2553"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Oto-Laryngologica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035557178","display_name":"Li\u2010Wei Chen","orcid":"https://orcid.org/0000-0001-8805-2275","observed_orcids":["https://orcid.org/0000-0001-8805-2275"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liwei Chen","raw_affiliation_strings":["Department of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, China;","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064339428","display_name":"Mingkun Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingkun Han","raw_affiliation_strings":["Department of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, China;","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102943213","display_name":"Yan Lu","orcid":"https://orcid.org/0000-0003-3952-2343","observed_orcids":["https://orcid.org/0000-0003-3952-2343"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210121761","display_name":"First Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/030e09f60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Lu","raw_affiliation_strings":["Department of Otolaryngology Head and Neck Surgery, Affiliated Fuzhou First Hospital of Fujian Medical University, Fujian, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery, Affiliated Fuzhou First Hospital of Fujian Medical University, Fujian, China;","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017777201","display_name":"Daishi Chen","orcid":"https://orcid.org/0000-0002-6143-5732","observed_orcids":["https://orcid.org/0000-0002-6143-5732"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]},{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN","DE"],"is_corresponding":false,"raw_author_name":"Daishi Chen","raw_affiliation_strings":["Department of Neurosurgery Erlangen, Medical Faculty of the Friedrich Alexander University of Erlangen-Numberg, Erlangen, Germany;","Department of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery Erlangen, Medical Faculty of the Friedrich Alexander University of Erlangen-Numberg, Erlangen, Germany;","institution_ids":["https://openalex.org/I181369854"]},{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, China;","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100680897","display_name":"Xuejun Sun","orcid":"https://orcid.org/0000-0003-2387-5531","observed_orcids":["https://orcid.org/0000-0003-2387-5531"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuejun Sun","raw_affiliation_strings":["Department of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, China;","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083382074","display_name":"Shiming Yang","orcid":"https://orcid.org/0000-0002-7808-2566","observed_orcids":["https://orcid.org/0000-0002-7808-2566"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shiming Yang","raw_affiliation_strings":["Department of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, China;","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101579243","display_name":"Wei Sun","orcid":"https://orcid.org/0000-0002-7958-6117","observed_orcids":["https://orcid.org/0000-0002-7958-6117"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Sun","raw_affiliation_strings":["Department of Communicative Disorders and Sciences, University at Buffalo The State University of New York, Buffalo, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Communicative Disorders and Sciences, University at Buffalo The State University of New York, Buffalo, NY, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013993748","display_name":"Ning Yu","orcid":"https://orcid.org/0000-0001-6596-9216","observed_orcids":["https://orcid.org/0000-0001-6596-9216"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ning Yu","raw_affiliation_strings":["Department of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, China;","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100944027","display_name":"Suoqiang Zhai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Suoqiang Zhai","raw_affiliation_strings":["Department of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, China;","institution_ids":["https://openalex.org/I2802939634"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5013993748","https://openalex.org/A5100944027"],"corresponding_institution_ids":["https://openalex.org/I2802939634"],"apc_list":null,"apc_paid":null,"fwci":0.84,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.73956571,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"137","issue":"10","first_page":"1063","last_page":"1068"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":0.8378999829292297,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":0.8378999829292297,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.16130000352859497,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10283","display_name":"Hearing Loss and Rehabilitation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/noise-induced-hearing-loss","display_name":"noise-induced hearing loss","score":0.8700000047683716},{"id":"https://openalex.org/keywords/hydrogen-therapy","display_name":"hydrogen treatment","score":0.7820000052452087},{"id":"https://openalex.org/keywords/cochlear-protection","display_name":"cochlear protection","score":0.7670000195503235},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9390000104904175},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8700000047683716},{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.824999988079071},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9750000238418579},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9670000076293945},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9700000286102295},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.890999972820282},{"id":"https://openalex.org/keywords/hmgb1","display_name":"HMGB1","score":0.9309999942779541},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.871893584728241},{"id":"https://openalex.org/C2779356876","wikidata":"https://www.wikidata.org/wiki/Q1475712","display_name":"Noise-induced hearing loss","level":4,"score":0.524197518825531},{"id":"https://openalex.org/C2780130748","wikidata":"https://www.wikidata.org/wiki/Q317857","display_name":"Cochlea","level":2,"score":0.47618332505226135},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43512290716171265},{"id":"https://openalex.org/C3018332767","wikidata":"https://www.wikidata.org/wiki/Q4117845","display_name":"Noise exposure","level":3,"score":0.38842615485191345},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3743043541908264},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31892913579940796},{"id":"https://openalex.org/C2780493683","wikidata":"https://www.wikidata.org/wiki/Q16035842","display_name":"Hearing loss","level":2,"score":0.2546933889389038},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.16836589574813843},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.15364795923233032}],"mesh":[{"descriptor_ui":"D000080242","descriptor_name":"8-Hydroxy-2'-Deoxyguanosine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003051","descriptor_name":"Cochlea","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003051","descriptor_name":"Cochlea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003849","descriptor_name":"Deoxyguanosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003849","descriptor_name":"Deoxyguanosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006317","descriptor_name":"Hearing Loss, Noise-Induced","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006317","descriptor_name":"Hearing Loss, Noise-Induced","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006317","descriptor_name":"Hearing Loss, Noise-Induced","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006859","descriptor_name":"Hydrogen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016057","descriptor_name":"Evoked Potentials, Auditory, Brain Stem","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/00016489.2017.1328743","doi":"https://doi.org/10.1080/00016489.2017.1328743","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00016489.2017.1328743","pdf_url":null,"source":{"id":"https://openalex.org/S198335345","display_name":"Acta Oto-Laryngologica","issn_l":"0001-6489","issn":["0001-6489","1651-2251","1651-2553"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Oto-Laryngologica","raw_type":"journal-article"},{"id":"pmid:28549396","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28549396","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta oto-laryngologica","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4619355161","display_name":null,"funder_award_id":"973 Program, No.2012CB967900, No.2014CB943002","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G5479648467","display_name":null,"funder_award_id":"No.2012CB967900","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G8414328109","display_name":null,"funder_award_id":"No.2014CB943002","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G891906045","display_name":null,"funder_award_id":"\u201c973\u201d Program","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W2012271814","https://openalex.org/W2065663588","https://openalex.org/W2073384616","https://openalex.org/W2076966678","https://openalex.org/W2091261755","https://openalex.org/W2104720406","https://openalex.org/W2109257509","https://openalex.org/W2125948531","https://openalex.org/W2130719735","https://openalex.org/W2143016221","https://openalex.org/W2143692885","https://openalex.org/W2144565298","https://openalex.org/W2159054927","https://openalex.org/W2162942329"],"related_works":["https://openalex.org/W3147426749","https://openalex.org/W2073384616","https://openalex.org/W4406343501","https://openalex.org/W2012271814","https://openalex.org/W2076966678","https://openalex.org/W2162942329","https://openalex.org/W3168676717","https://openalex.org/W7162322649","https://openalex.org/W2773501283","https://openalex.org/W3143542153"],"abstract_inverted_index":{"OBJECTIVES:":[0],"This":[1,191],"study":[2,192],"aimed":[3],"to":[4,55,153,211],"explore":[5],"the":[6,10,35,88,117,123,130,139,145,156,167,178,195,198,213],"molecular":[7],"mechanism":[8],"of":[9,13,62,110,132,141,162,201],"protective":[11,199],"effects":[12,200],"hydrogen-saturated":[14,26,100,118,146,168,202],"saline":[15,33,101,119,125,147,158,169,180,203],"on":[16,204],"NIHL.":[17],"METHODS:":[18],"Guinea":[19],"pigs":[20,37,143],"were":[21,38,53,90,149,171],"divided":[22],"into":[23],"three":[24],"groups:":[25],"saline;":[27,29],"normal":[28,124,157,179],"and":[30,46,80,136,164,183,216],"control.":[31],"For":[32],"administration,":[34],"guinea":[36,142],"given":[39],"daily":[40],"abdominal":[41],"injections":[42],"3":[43],"d":[44,186],"before":[45,49],"1":[47],"h":[48],"noise":[50,128,188],"exposure.":[51,189],"ABR":[52],"tested":[54],"examine":[56],"cochlear":[57],"physiology":[58],"changes.":[59],"The":[60,94,108,160],"changes":[61],"8-hydroxy-desoxyguanosine":[63],"(8-HOdG),":[64],"interleukin-1":[65],"(IL-1),":[66],"interleukin-6":[67],"(IL-6),":[68],"interleukin-10":[69],"(IL-10),":[70],"tumor":[71],"necrosis":[72],"factor-\u03b1":[73],"(TNF-\u03b1),":[74],"intercellular":[75],"cell":[76],"adhesion":[77],"molecule-1":[78],"(ICAM-1)":[79],"high":[81],"mobility":[82],"group":[83,120,148,170,181],"box-1":[84],"protein":[85],"(HMGB1)":[86],"in":[87,116,138,144,155,166,175,177],"cochlea":[89,140],"also":[91,113],"examined.":[92],"RESULTS:":[93],"results":[95],"showed":[96],"that":[97],"pre-treatment":[98],"with":[99,122],"could":[102],"significantly":[103,114,172],"attenuate":[104],"noise-induced":[105,205],"hearing":[106,206],"loss.":[107],"concentration":[109],"8-HOdG":[111],"was":[112],"decreased":[115],"compared":[121,152],"group.":[126,159],"After":[127],"exposure,":[129],"concentrations":[131,161],"IL-1,":[133],"IL-6,":[134],"TNF-\u03b1,":[135],"ICAM-1":[137],"dramatically":[150],"reduced":[151],"those":[154,176],"HMGB-1":[163],"IL-10":[165],"higher":[173],"than":[174],"immediately":[182],"at":[184],"7":[185],"after":[187],"CONCLUSIONS:":[190],"revealed":[193],"for":[194],"first":[196],"time":[197],"loss":[207],"(NIHL)":[208],"are":[209],"related":[210],"both":[212],"anti-oxidative":[214],"activity":[215],"anti-inflammatory":[217],"activity.":[218]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-06-05T00:00:00"}
