{"id":"https://openalex.org/W2616516632","doi":"https://doi.org/10.1080/17474124.2017.1330150","title":"New insights into the earliest stages of colorectal tumorigenesis","display_name":"New insights into the earliest stages of colorectal tumorigenesis","publication_year":2017,"publication_date":"2017-05-15","ids":{"openalex":"https://openalex.org/W2616516632","doi":"https://doi.org/10.1080/17474124.2017.1330150","mag":"2616516632","pmid":"https://pubmed.ncbi.nlm.nih.gov/28503955","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5859121"},"language":"en","primary_location":{"id":"doi:10.1080/17474124.2017.1330150","doi":"https://doi.org/10.1080/17474124.2017.1330150","is_oa":false,"landing_page_url":"https://doi.org/10.1080/17474124.2017.1330150","pdf_url":null,"source":{"id":"https://openalex.org/S175204640","display_name":"Expert Review of Gastroenterology & Hepatology","issn_l":"1747-4124","issn":["1747-4124","1747-4132"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Gastroenterology & Hepatology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC5859121","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047282786","display_name":"Chelsie K. Sievers","orcid":"https://orcid.org/0000-0003-0088-753X","observed_orcids":["https://orcid.org/0000-0003-0088-753X"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"funder","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chelsie K. Sievers","raw_affiliation_strings":["Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA","Division of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"]},{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068477057","display_name":"William M. Grady","orcid":"https://orcid.org/0000-0002-0129-7809","observed_orcids":["https://orcid.org/0000-0002-0129-7809"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William M. Grady","raw_affiliation_strings":["Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA","Department of Medicine, University of Washington Medical School, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Department of Medicine, University of Washington Medical School, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026680523","display_name":"Richard B. Halberg","orcid":"https://orcid.org/0000-0001-6886-1534","observed_orcids":["https://orcid.org/0000-0001-6886-1534"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"funder","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard B. Halberg","raw_affiliation_strings":["Carbone Cancer Center, University of Wisconsin - Madison, Madison, WI, USA","Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA","Division of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carbone Cancer Center, University of Wisconsin - Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"]},{"raw_affiliation_string":"Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"]},{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079022788","display_name":"Perry Joseph Pickhardt","orcid":"https://orcid.org/0000-0002-5534-8202","observed_orcids":["https://orcid.org/0000-0002-5534-8202"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Perry J. Pickhardt","raw_affiliation_strings":["Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5079022788"],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":null,"apc_paid":null,"fwci":0.7857,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.60492611,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"11","issue":"8","first_page":"723","last_page":"729"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.7167999744415283,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.7167999744415283,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.12999999523162842,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.07569999992847443,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-carcinogenesis","display_name":"colorectal carcinogenesis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/tumor-evolution","display_name":"tumor evolution","score":0.6700000166893005},{"id":"https://openalex.org/keywords/colorectal-polyps","display_name":"colorectal polyps","score":0.9300000071525574},{"id":"https://openalex.org/keywords/polyp-regression","display_name":"polyp regression","score":0.7730000019073486},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.7509999871253967},{"id":"https://openalex.org/keywords/tumor-initiation","display_name":"tumor initiation","score":0.6069999933242798},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5630000233650208},{"id":"https://openalex.org/keywords/ct-colonography","display_name":"CT colonography","score":0.6830000281333923},{"id":"https://openalex.org/keywords/lineage-tracing","display_name":"lineage tracing","score":0.4560000002384186}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7873345613479614},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6197490692138672},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5155960917472839},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35951322317123413},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.271945059299469},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.18712633848190308}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003111","descriptor_name":"Colonic Polyps","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D003111","descriptor_name":"Colonic Polyps","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003111","descriptor_name":"Colonic Polyps","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047368","descriptor_name":"Tumor Burden","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1080/17474124.2017.1330150","doi":"https://doi.org/10.1080/17474124.2017.1330150","is_oa":false,"landing_page_url":"https://doi.org/10.1080/17474124.2017.1330150","pdf_url":null,"source":{"id":"https://openalex.org/S175204640","display_name":"Expert Review of Gastroenterology & Hepatology","issn_l":"1747-4124","issn":["1747-4124","1747-4132"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Gastroenterology & Hepatology","raw_type":"journal-article"},{"id":"pmid:28503955","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28503955","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert review of gastroenterology & hepatology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5020425","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5859121","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5859121","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5859121","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Expert Rev Gastroenterol Hepatol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5020425","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5859121","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3002731596","display_name":"Training in Cancer Biology Training Grant","funder_award_id":"T32CA009135","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4259426110","display_name":null,"funder_award_id":"UO1 CA152756","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4261609826","display_name":null,"funder_award_id":"RO1 CA194663","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4475416948","display_name":"(PQC1) Accelerated biological aging and colon polyp to cancer progression","funder_award_id":"R01CA194663","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6094902270","display_name":"Biomarkers for Reducing Mortality of Cancers of the Colon and Esophagus","funder_award_id":"U01CA152756","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000870050","display_name":"UW Comprehensive Cancer Center Support","funder_award_id":"P30CA014520","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320309434","display_name":"University of Wisconsin-Madison","ror":"https://ror.org/01y2jtd41"},{"id":"https://openalex.org/F4320332976","display_name":"Department of Radiology, University of Wisconsin-Madison","ror":"https://ror.org/01y2jtd41"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1594235143","https://openalex.org/W1842792112","https://openalex.org/W1950966508","https://openalex.org/W1964154017","https://openalex.org/W1969373767","https://openalex.org/W1978711255","https://openalex.org/W2010873488","https://openalex.org/W2011957420","https://openalex.org/W2021194737","https://openalex.org/W2027518809","https://openalex.org/W2036541245","https://openalex.org/W2039725154","https://openalex.org/W2041993682","https://openalex.org/W2043539979","https://openalex.org/W2064054320","https://openalex.org/W2069377300","https://openalex.org/W2084118031","https://openalex.org/W2086282272","https://openalex.org/W2089779525","https://openalex.org/W2091723114","https://openalex.org/W2093144236","https://openalex.org/W2093540186","https://openalex.org/W2100594643","https://openalex.org/W2107539126","https://openalex.org/W2109948920","https://openalex.org/W2110725213","https://openalex.org/W2116116569","https://openalex.org/W2121772402","https://openalex.org/W2126228632","https://openalex.org/W2126903025","https://openalex.org/W2131474316","https://openalex.org/W2131829779","https://openalex.org/W2138051779","https://openalex.org/W2140080780","https://openalex.org/W2147354890","https://openalex.org/W2154974159","https://openalex.org/W2156506674","https://openalex.org/W2163235555","https://openalex.org/W2169895148","https://openalex.org/W2171080110","https://openalex.org/W2177689130","https://openalex.org/W2196214471","https://openalex.org/W2260951263","https://openalex.org/W2284361446","https://openalex.org/W2309995842","https://openalex.org/W2317639164","https://openalex.org/W2399870834","https://openalex.org/W2402960337","https://openalex.org/W2406334358","https://openalex.org/W2414805863","https://openalex.org/W2515742449"],"related_works":["https://openalex.org/W2284361446","https://openalex.org/W2478931942","https://openalex.org/W2515742449","https://openalex.org/W2740171345","https://openalex.org/W7154717986","https://openalex.org/W2086282272","https://openalex.org/W6904898047","https://openalex.org/W2775933724","https://openalex.org/W2050265193","https://openalex.org/W2081684577"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Tumors":[1],"in":[2,27,89,141,146,157,191],"the":[3,42,58,74,90,105,113,162,192,196],"large":[4],"intestine":[5],"have":[6,129,133],"been":[7,130],"postulated":[8,175],"to":[9,22,132,170],"arise":[10],"via":[11],"a":[12,17,61,81],"stepwise":[13],"accumulation":[14],"of":[15,45,57,64,84,100,112,195],"mutations,":[16],"process":[18],"that":[19,39,164],"takes":[20],"up":[21],"20":[23],"years.":[24],"Recent":[25],"advances":[26],"lineage":[28],"tracing":[29],"and":[30,49,77,87,109,115,143,160,178,188],"DNA":[31],"sequencing,":[32],"however,":[33],"are":[34],"revealing":[35],"new":[36,151],"evolutionary":[37],"models":[38],"better":[40,103],"explain":[41],"vast":[43],"amount":[44],"heterogeneity":[46],"observed":[47],"within":[48,108],"across":[50,110],"colorectal":[51,65,118],"tumors.":[52],"Areas":[53],"covered:":[54],"A":[55],"review":[56],"literature":[59],"supporting":[60,80],"novel":[62],"model":[63,99,152],"tumor":[66,85,101,186],"evolution":[67,102],"was":[68],"conducted.":[69],"The":[70,94],"following":[71],"commentary":[72],"examines":[73],"basic":[75],"science":[76],"clinical":[78],"evidence":[79],"modified":[82],"view":[83],"initiation":[86],"progression":[88],"colon.":[91],"Expert":[92],"commentary:":[93],"proposed":[95],"'cancer":[96],"punctuated":[97],"equilibrium'":[98],"explains":[104],"variability":[106,156],"seen":[107],"polyps":[111,119],"colon":[114],"rectum.":[116],"Small":[117],"(6-9mm)":[120],"followed":[121],"longitudinally":[122],"by":[123,176],"interval":[124],"imaging":[125],"with":[126,180],"CT":[127],"colonography":[128],"reported":[131],"multiple":[134],"fates:":[135],"some":[136,138,165],"growing,":[137],"remaining":[139],"static":[140],"size,":[142],"others":[144],"regressing":[145],"size":[147],"over":[148],"time.":[149],"This":[150],"allows":[153],"for":[154],"this":[155],"growth":[158,189],"behavior":[159,190],"supports":[161],"hypothesis":[163],"tumors":[166],"can":[167],"be":[168,171],"'born":[169],"bad'":[172],"as":[173],"originally":[174],"Sottoriva":[177],"colleagues,":[179],"very":[181],"early":[182],"molecular":[183],"events":[184],"impacting":[185],"fitness":[187],"later":[193],"stages":[194],"disease":[197],"process.":[198]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-05-26T00:00:00"}