{"id":"https://openalex.org/W2615517513","doi":"https://doi.org/10.1007/s13361-017-1676-1","title":"Subcritical Water Hydrolysis of Peptides: Amino Acid Side-Chain Modifications","display_name":"Subcritical Water Hydrolysis of Peptides: Amino Acid Side-Chain Modifications","publication_year":2017,"publication_date":"2017-05-17","ids":{"openalex":"https://openalex.org/W2615517513","doi":"https://doi.org/10.1007/s13361-017-1676-1","mag":"2615517513","pmid":"https://pubmed.ncbi.nlm.nih.gov/28516297","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5556142"},"language":"en","primary_location":{"id":"doi:10.1007/s13361-017-1676-1","doi":"https://doi.org/10.1007/s13361-017-1676-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13361-017-1676-1","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/jasms.8b05630","source":{"id":"https://openalex.org/S60743949","display_name":"Journal of the American Society for Mass Spectrometry","issn_l":"1044-0305","issn":["1044-0305","1879-1123"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society for Mass Spectrometry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/jasms.8b05630","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030932889","display_name":"Thomas Powell","orcid":"https://orcid.org/0000-0002-8308-6510","observed_orcids":["https://orcid.org/0000-0002-8308-6510"]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Thomas Powell","raw_affiliation_strings":["School of Biosciences, University of Birmingham, Edgbaston, B15 2TT, Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biosciences, University of Birmingham, Edgbaston, B15 2TT, Birmingham, UK","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088085378","display_name":"Steve Bowra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steve Bowra","raw_affiliation_strings":["Phytatec (UK) Ltd., Plas Gogerddan, SY23 3EB, Aberystwyth, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Phytatec (UK) Ltd., Plas Gogerddan, SY23 3EB, Aberystwyth, UK","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014883632","display_name":"Helen J. Cooper","orcid":"https://orcid.org/0000-0003-4590-9384","observed_orcids":["https://orcid.org/0000-0003-4590-9384"]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Helen J. Cooper","raw_affiliation_strings":["School of Biosciences, University of Birmingham, Edgbaston, B15 2TT, Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biosciences, University of Birmingham, Edgbaston, B15 2TT, Birmingham, UK","institution_ids":["https://openalex.org/I79619799"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014883632"],"corresponding_institution_ids":["https://openalex.org/I79619799"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":0.509,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.53829565,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":97},"biblio":{"volume":"28","issue":"9","first_page":"1775","last_page":"1786"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.5952000021934509,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.5952000021934509,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.2433999925851822,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12706","display_name":"Subcritical and Supercritical Water Processes","score":0.1006999984383583,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subcritical-water-hydrolysis","display_name":"subcritical water hydrolysis","score":0.9710000157356262},{"id":"https://openalex.org/keywords/peptide-hydrolysis","display_name":"peptide hydrolysis","score":0.8519999980926514},{"id":"https://openalex.org/keywords/amino-acid-side-chain-modification","display_name":"amino acid side chain modification","score":0.9570000171661377},{"id":"https://openalex.org/keywords/bottom-up-proteomics","display_name":"shotgun proteomics","score":0.8410000205039978},{"id":"https://openalex.org/keywords/cysteine-oxidation","display_name":"cysteine oxidation","score":0.7940000295639038},{"id":"https://openalex.org/keywords/methionine-oxidation","display_name":"methionine oxidation","score":0.875},{"id":"https://openalex.org/keywords/tryptophan-oxidation","display_name":"tryptophan oxidation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/c-terminal-amidation","display_name":"C-terminal amidation","score":0.9710000157356262},{"id":"https://openalex.org/keywords/model-peptides","display_name":"model peptides","score":0.7599999904632568}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9448263645172119},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.652334451675415},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.6276817917823792},{"id":"https://openalex.org/C2777109674","wikidata":"https://www.wikidata.org/wiki/Q3710342","display_name":"Electron-transfer dissociation","level":4,"score":0.5732493996620178},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.5678975582122803},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5674233436584473},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.5622121691703796},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.49860596656799316},{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.4830194413661957},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4751850664615631},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.4739770293235779},{"id":"https://openalex.org/C2780912031","wikidata":"https://www.wikidata.org/wiki/Q180341","display_name":"Methionine","level":3,"score":0.4733576774597168},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.4619377851486206},{"id":"https://openalex.org/C204921945","wikidata":"https://www.wikidata.org/wiki/Q899689","display_name":"Side chain","level":3,"score":0.4314758777618408},{"id":"https://openalex.org/C31684184","wikidata":"https://www.wikidata.org/wiki/Q33293","display_name":"Peptide bond","level":3,"score":0.41413414478302},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.3191131353378296},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2659342586994171},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1651184856891632},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1007/s13361-017-1676-1","doi":"https://doi.org/10.1007/s13361-017-1676-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13361-017-1676-1","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/jasms.8b05630","source":{"id":"https://openalex.org/S60743949","display_name":"Journal of the American Society for Mass Spectrometry","issn_l":"1044-0305","issn":["1044-0305","1879-1123"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society for Mass Spectrometry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4465824","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5556142","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5556142","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5556142","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Am Soc Mass Spectrom","raw_type":"Text"},{"id":"pmid:28516297","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28516297","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society for Mass Spectrometry","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/9dc80a39-b5b8-4e15-b17c-cf1381cbad93","doi":null,"is_oa":true,"landing_page_url":"https://research.birmingham.ac.uk/en/publications/9dc80a39-b5b8-4e15-b17c-cf1381cbad93","pdf_url":null,"source":{"id":"https://openalex.org/S4306402634","display_name":"University of Birmingham Research Portal (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Powell, T, Bowra, S & Cooper, H 2017, 'Sub-critical water hydrolysis of peptides : Amino acid side-chain modifications', Journal of the American Society for Mass Spectrometry, vol. 28, no. 9, pp. 1775\u20131786. https://doi.org/10.1007/s13361-017-1676-1","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1007/s13361-017-1676-1","doi":"https://doi.org/10.1007/s13361-017-1676-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13361-017-1676-1","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/jasms.8b05630","source":{"id":"https://openalex.org/S60743949","display_name":"Journal of the American Society for Mass Spectrometry","issn_l":"1044-0305","issn":["1044-0305","1879-1123"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society for Mass Spectrometry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5327360545","display_name":"NISA: Novel approaches for in situ analysis of biomolecules","funder_award_id":"EP/L023490/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320315024","display_name":"Advantage West Midlands","ror":"https://ror.org/013b36x77"},{"id":"https://openalex.org/F4320320339","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2615517513.pdf","grobid_xml":"https://content.openalex.org/works/W2615517513.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W123103318","https://openalex.org/W1954241683","https://openalex.org/W1965403325","https://openalex.org/W1973416818","https://openalex.org/W1986032394","https://openalex.org/W1992064752","https://openalex.org/W2009897062","https://openalex.org/W2034084833","https://openalex.org/W2037116841","https://openalex.org/W2038599593","https://openalex.org/W2043503349","https://openalex.org/W2053335584","https://openalex.org/W2060992649","https://openalex.org/W2076367848","https://openalex.org/W2081157778","https://openalex.org/W2081736950","https://openalex.org/W2105556779","https://openalex.org/W2110194449","https://openalex.org/W2141823153","https://openalex.org/W2353971722"],"related_works":["https://openalex.org/W2353971722","https://openalex.org/W6908155133","https://openalex.org/W2247065968","https://openalex.org/W4320180814","https://openalex.org/W2911013605","https://openalex.org/W4322753651","https://openalex.org/W2333937104","https://openalex.org/W4327747816","https://openalex.org/W4281684958","https://openalex.org/W2113423648"],"abstract_inverted_index":{"Previously":[0],"we":[1],"have":[2],"shown":[3,30],"that":[4,42,74],"subcritical":[5,69,83,122,204],"water":[6,25,84,123,192,205],"may":[7],"be":[8],"used":[9],"as":[10],"an":[11],"alternative":[12],"to":[13,31,41,77,93,169],"enzymatic":[14],"digestion":[15,45],"in":[16,33,75,87,202],"the":[17,49,56,80,125,179],"proteolysis":[18],"of":[19,27,51,79,95,127,167,176,181,186],"proteins":[20,28],"for":[21,55,65],"bottom-up":[22],"proteomics.":[23],"Subcritical":[24],"hydrolysis":[26,89,136],"was":[29,188],"result":[32],"protein":[34],"sequence":[35],"coverages":[36],"greater":[37,63],"than":[38,64],"or":[39,150],"equal":[40],"obtained":[43],"following":[44],"with":[46,59,68,121,124],"trypsin;":[47],"however,":[48],"percentage":[50],"peptide":[52,81,103],"spectral":[53],"matches":[54],"samples":[57],"treated":[58,67,120],"trypsin":[60],"were":[61,119,138,200],"consistently":[62],"those":[66],"water.":[70],"This":[71],"observation":[72],"suggests":[73],"addition":[76],"cleavage":[78],"bond,":[82],"treatment":[85],"results":[86,163],"other":[88],"products,":[90],"possibly":[91],"due":[92],"modifications":[94],"amino":[96,107,131],"acid":[97,108,132,196],"side":[98],"chains.":[99],"Here,":[100],"a":[101],"model":[102,114],"comprising":[104],"all":[105],"common":[106],"residues":[109],"(VQSIKCADFLHYMENPTWGR)":[110],"and":[111,117,154,171,174,183,197],"two":[112],"further":[113],"peptides":[115],"(VCFQYMDRGDR":[116],"VQSIKADFLHYENPTWGR)":[118],"aim":[126],"probing":[128],"any":[129],"induced":[130],"side-chain":[133],"modifications.":[134],"The":[135,162],"products":[137],"analyzed":[139],"by":[140],"direct":[141],"infusion":[142],"electrospray":[143],"tandem":[144,159],"mass":[145,160],"spectrometry,":[146],"either":[147],"collision-induced":[148,157],"dissociation":[149,158],"electron":[151],"transfer":[152],"dissociation,":[153],"liquid":[155],"chromatography":[156],"spectrometry.":[161],"show":[164],"preferential":[165],"oxidation":[166,175,185],"cysteine":[168,182],"sulfinic":[170],"sulfonic":[172],"acid,":[173],"methionine.":[177],"In":[178,190],"absence":[180],"methionine,":[184],"tryptophan":[187],"observed.":[189],"addition,":[191],"loss":[193],"from":[194],"aspartic":[195],"C-terminal":[198],"amidation":[199],"observed":[201],"harsher":[203],"conditions.":[206],"Graphical":[207],"Abstract":[208],"\u115f.":[209]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-05-26T00:00:00"}
