{"id":"https://openalex.org/W2615366256","doi":null,"title":"The role of pattern recognition receptors in amyloid-beta-induced inflammation","display_name":"The role of pattern recognition receptors in amyloid-beta-induced inflammation","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2615366256","mag":"2615366256"},"language":"en","primary_location":{"id":"pmh:oai:https://orca.cardiff.ac.uk:100532","doi":null,"is_oa":false,"landing_page_url":"https://orca.cardiff.ac.uk/100532/13/2017LoizouF%20PhD%20DPR.pdf","pdf_url":"https://orca.cardiff.ac.uk/100532/13/2017LoizouF%20PhD%20DPR.pdf","source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044891234","display_name":"Florentia Loizou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Florentia Loizou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5044891234"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.6772000193595886,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.6772000193595886,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.30250000953674316,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9909999966621399},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.9919999837875366},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.972000002861023},{"id":"https://openalex.org/keywords/pattern-recognition-receptors","display_name":"pattern recognition receptors","score":0.9879999756813049},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.8659999966621399},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.9190000295639038},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.8999999761581421},{"id":"https://openalex.org/keywords/c5ar1","display_name":"C5aR1","score":0.8849999904632568},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.8379999995231628},{"id":"https://openalex.org/keywords/tlr2","display_name":"TLR2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8700000047683716},{"id":"https://openalex.org/keywords/nik","display_name":"NIK","score":0.5260000228881836},{"id":"https://openalex.org/keywords/endosomal-trafficking","display_name":"endosomal trafficking","score":0.5870000123977661},{"id":"https://openalex.org/keywords/anti-inflammatory-agents","display_name":"anti-inflammatory agents","score":0.3580000102519989},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.45399999618530273},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.3310000002384186}],"concepts":[{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.8304966688156128},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.6173191070556641},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5910205841064453},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.5868604779243469},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5441738963127136},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.5364433526992798},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.47525498270988464},{"id":"https://openalex.org/C111289621","wikidata":"https://www.wikidata.org/wiki/Q418772","display_name":"Pattern recognition receptor","level":4,"score":0.4676384925842285},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.4657946825027466},{"id":"https://openalex.org/C2779499704","wikidata":"https://www.wikidata.org/wiki/Q5008266","display_name":"C5a receptor","level":4,"score":0.43502047657966614},{"id":"https://openalex.org/C2776156579","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid beta","level":3,"score":0.43024998903274536},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.414041131734848},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3699615001678467},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3685324192047119},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3676092028617859},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2864909768104553},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2633521556854248},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.074644535779953}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:https://orca.cardiff.ac.uk:100532","doi":null,"is_oa":false,"landing_page_url":"https://orca.cardiff.ac.uk/100532/13/2017LoizouF%20PhD%20DPR.pdf","pdf_url":"https://orca.cardiff.ac.uk/100532/13/2017LoizouF%20PhD%20DPR.pdf","source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2615366256","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.715993","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2043679754","https://openalex.org/W3019520705","https://openalex.org/W4396792971","https://openalex.org/W2545305028","https://openalex.org/W2799815156","https://openalex.org/W3109691907","https://openalex.org/W2277120524","https://openalex.org/W7167833838","https://openalex.org/W1974305753","https://openalex.org/W3044896953"],"abstract_inverted_index":{"Alzheimer\u2019s":[0,88],"disease":[1,14,72,89],"(AD)":[2],"is":[3,15,118,129,326,381,415],"the":[4,11,37,85,96,139,155,161,164,169,172,175,183,188,192,198,211,250,287,296,303,345,375,382,408,416,422,425,428,433,447,474,487,518,526,548,558,564,568,581],"most":[5,417],"common":[6],"form":[7],"of":[8,24,33,41,71,78,87,98,116,134,163,168,177,194,200,207,213,237,252,289,298,308,324,377,403,410,424,430,520,529,550,557,567,583],"dementia":[9],"among":[10],"elderly.":[12],"The":[13,31,306,333,441,514],"characterized":[16],"by":[17,468],"amyloid-\u03b2":[18],"(A\u03b2)":[19],"plaques,":[20],"neurofibrillary":[21],"tangles,":[22],"loss":[23,109],"synapses":[25],"and":[26,28,39,48,54,150,174,182,187,205,219,232,244,266,291,300,310,322,340,348,395,453,470,492,501,577],"neurons,":[27],"chronic":[29],"neuroinflammation.":[30,413],"significance":[32],"neuroinflammatory":[34],"processes":[35],"in":[36,80,171,180,202,226,233,286,312,344,356,370,388,391,407,432,438,478,480,511,525,552,572],"on-set":[38],"progression":[40],"AD":[42,60,181,481,588],"have":[43],"been":[44],"debated,":[45],"as":[46,93,114,257],"activated":[47,451],"reactive":[49],"glial":[50],"cells":[51],"demonstrated":[52,65,197,335,364,443,516],"protective":[53],"damaging":[55],"properties.":[56],"However,":[57],"patients":[58,238],"with":[59,62,216,230,239,278,338,538],"treated":[61],"anti-inflammatory":[63],"drugs":[64],"a":[66,272,330,357,400,404,458,507,534,543],"lesser":[67],"than":[68],"average":[69],"extent":[70],"development,":[73],"indicating":[74],"an":[75,101,367,411],"important":[76],"role":[77,162,429],"neuroinflammation":[79],"AD.":[81,240],"Current":[82],"strategies":[83],"for":[84,328,587],"treatment":[86,120,528,545],"are":[90],"minimally":[91],"effective,":[92],"we":[94,158],"lack":[95],"methods":[97],"diagnosis":[99,112],"at":[100],"early":[102],"stage.":[103],"Numerous":[104],"cases":[105],"present":[106,559],"significant":[107],"neuronal":[108,126],"prior":[110],"to":[111,276,294,318,353,365,384,393,483,505,546,563,580],"and,":[113],"restoration":[115],"function":[117],"unlikely,":[119],"options":[121],"focus":[122],"on":[123,160,302,562],"limiting":[124],"further":[125,316,523],"loss.":[127],"It":[128],"my":[130],"hypothesis":[131],"that":[132,444,517],"deposition":[133],"A\u03b2":[135,203,214,231,292,311,325,339,434,551,575],"peptide":[136],"can":[137],"activate":[138,366],"innate":[140,165],"immune":[141],"system":[142,167],"via":[143],"pattern":[144],"recognition":[145,435],"receptors":[146,196],"(PRRs),":[147],"including":[148],"complement,":[149],"evoke":[151],"Alzheimer's":[152],"pathology.":[153],"In":[154,280,456],"current":[156,565],"study,":[157],"focused":[159],"immunity":[166],"brain":[170,234],"initiation":[173],"propagation":[176],"inflammatory":[178],"process":[179],"interplay":[184],"between":[185],"TLRs/NLRs":[186],"complement":[189,220,290,342,394],"system.":[190],"\\nSilencing":[191],"expression":[193],"various":[195],"involvement":[199],"NLRP3":[201],"recognition,":[204],"use":[206],"confocal":[208],"microscopy":[209],"confirmed":[210,225],"association":[212],"interactions":[215,297],"this":[217,380],"inflammasome":[218],"receptors.":[221],"These":[222,397],"results":[223,334,398,442,515,556],"were":[224,263,268,284,362,503],"human":[227,242,313,371,439,512,553],"astrocytes":[228,243,314],"stimulated":[229],"tissue":[235],"slides":[236],"Using":[241],"fluorescence":[245],"resonance":[246],"energy":[247],"transfer":[248],"(FRET),":[249],"associations":[251],"cell":[253,304],"surface":[254],"TLRs":[255],"(such":[256],"TLR2,":[258],"TLR4)with":[259],"CRs":[260],"(C5aR1,":[261],"C3aR)":[262],"investigated;":[264],"TLR2":[265],"TLR4":[267,299],"\\n6":[269],"|":[270,532],"P":[271,533],"g":[273,535],"e":[274,536],"\\nfound":[275],"interact":[277],"C5aR1.":[279],"addition,":[281,457],"A\u03b2-induced":[282,412,448],"responses":[283],"augmented":[285,446],"presence":[288],"appeared":[293],"induce":[295],"C5aR1":[301,498],"surface.":[305],"trafficking":[307,323],"PRRs":[309],"was":[315,436,454,462,522],"investigated":[317,437],"determine":[319],"whether":[320],"internalization":[321],"crucial":[327],"triggering":[329],"proinflammatory":[331],"response.":[332],"that,":[336],"along":[337],"TLR4,":[341],"internalized":[343],"Rab5+":[346,389],"endosomes,":[347],"recruited":[349],"NF-kB-inducing":[350],"kinase":[351],"(NIK)":[352],"these":[354],"endosomes":[355,390],"complement-dependent":[358],"manner.":[359],"MAC":[360],"complexes":[361],"previously":[363],"Akt+NIK+":[368],"signalosome":[369],"endothelial":[372],"cells.":[373,554],"To":[374],"best":[376],"our":[378],"knowledge,":[379],"first":[383],"identify":[385,506],"such":[386],"signalosomes":[387],"response":[392],"A\u03b2.":[396],"suggest":[399],"novel":[401],"possibility":[402],"therapeutic":[405,509,585],"target":[406],"case":[409],"\\nC5a":[414],"potent":[418],"anaphylatoxin,":[419],"thus":[420],"upon":[421],"identification":[423],"complement-inflammasome":[426],"interactions,":[427],"C5a":[431,445],"astrocytes.":[440,513],"IL-1\u03b2":[449,460,521],"production,":[450],"pro-IL-1\u03b2":[452],"caspase-1-dependent.":[455],"C5a-induced":[459],"release":[461],"observed":[463],"following":[464],"Signal":[465],"2":[466],"stimulation":[467],"Ca2+":[469],"lysosomal":[471],"damage.":[472],"Since":[473],"signal":[475],"activation":[476],"resulting":[477],"inflammation":[479],"appears":[482],"involve":[484],"multiple":[485],"receptors,":[486],"therapy":[488],"should":[489],"be":[490],"combinational":[491],"not":[493],"targeting":[494],"single":[495,540],"molecules.":[496],"Thus,":[497],"blocking":[499],"antibodies":[500],"PMX53":[502],"utilized":[504],"combinatory":[508,527,544],"approach":[510],"secretion":[519],"reduced":[524],"PMX53+MCC950":[530],"\\n7":[531],"\\ncompared":[537],"their":[539],"treatments,":[541],"suggesting":[542],"tackle":[547],"effect":[549],"\\nThe":[555],"study":[560],"add":[561],"knowledge":[566],"molecular":[569],"mechanisms":[570],"involved":[571],"AD,":[573],"regarding":[574],"association,":[576],"may":[578],"lead":[579],"design":[582],"targeted":[584],"interventions":[586]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-05-26T00:00:00"}
