{"id":"https://openalex.org/W2614945779","doi":"https://doi.org/10.1002/jssc.201700185","title":"High\u2010performance liquid chromatographic cartridge with gradient elution capability coupled with UV absorbance detector and mass spectrometer for peptide and protein analysis","display_name":"High\u2010performance liquid chromatographic cartridge with gradient elution capability coupled with UV absorbance detector and mass spectrometer for peptide and protein analysis","publication_year":2017,"publication_date":"2017-05-17","ids":{"openalex":"https://openalex.org/W2614945779","doi":"https://doi.org/10.1002/jssc.201700185","mag":"2614945779","pmid":"https://pubmed.ncbi.nlm.nih.gov/28514057"},"language":"en","primary_location":{"id":"doi:10.1002/jssc.201700185","doi":"https://doi.org/10.1002/jssc.201700185","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jssc.201700185","pdf_url":null,"source":{"id":"https://openalex.org/S45406943","display_name":"Journal of Separation Science","issn_l":"1615-9306","issn":["1615-9306","1615-9314"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Separation Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061694686","display_name":"Kyle B. Lynch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8692664","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83","country_code":"US","type":"education","lineage":["https://openalex.org/I8692664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle B. Lynch","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK, USA","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK, USA","institution_ids":["https://openalex.org/I8692664"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053330465","display_name":"Apeng Chen","orcid":"https://orcid.org/0000-0002-1936-2007","observed_orcids":["https://orcid.org/0000-0002-1936-2007"]},"institutions":[{"id":"https://openalex.org/I8692664","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83","country_code":"US","type":"education","lineage":["https://openalex.org/I8692664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Apeng Chen","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK, USA","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK, USA","institution_ids":["https://openalex.org/I8692664"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000483207","display_name":"Yang Yu","orcid":"https://orcid.org/0000-0002-3373-9536","observed_orcids":["https://orcid.org/0000-0002-3373-9536"]},"institutions":[{"id":"https://openalex.org/I8692664","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83","country_code":"US","type":"education","lineage":["https://openalex.org/I8692664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Yang","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK, USA","institution_ids":["https://openalex.org/I8692664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102475615","display_name":"Joann Juan Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8692664","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83","country_code":"US","type":"education","lineage":["https://openalex.org/I8692664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joann J. Lu","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK, USA","institution_ids":["https://openalex.org/I8692664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084467442","display_name":"Shaorong Liu","orcid":"https://orcid.org/0000-0002-4602-0483","observed_orcids":["https://orcid.org/0000-0002-4602-0483"]},"institutions":[{"id":"https://openalex.org/I8692664","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83","country_code":"US","type":"education","lineage":["https://openalex.org/I8692664"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shaorong Liu","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK, USA"],"raw_orcid":"https://orcid.org/0000-0002-4602-0483","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK, USA","institution_ids":["https://openalex.org/I8692664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5084467442"],"corresponding_institution_ids":["https://openalex.org/I8692664"],"apc_list":{"value":4030,"currency":"USD","value_usd":4030},"apc_paid":null,"fwci":1.3126,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.74641435,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"40","issue":"13","first_page":"2752","last_page":"2758"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.475600004196167,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.475600004196167,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.42089998722076416,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.05739999935030937,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gradient-elution","display_name":"gradient elution","score":0.972000002861023},{"id":"https://openalex.org/keywords/peptide-separation","display_name":"peptide separation","score":0.6639999747276306},{"id":"https://openalex.org/keywords/protein-separation","display_name":"protein separation","score":0.9800000190734863},{"id":"https://openalex.org/keywords/uv-absorbance-detection","display_name":"UV absorbance detection","score":0.7390000224113464},{"id":"https://openalex.org/keywords/mass-spectrometry-coupling","display_name":"mass spectrometry coupling","score":0.890999972820282},{"id":"https://openalex.org/keywords/electrochemical-detection","display_name":"electrochemical detection","score":0.7139999866485596},{"id":"https://openalex.org/keywords/laser-induced-fluorescence-detection","display_name":"laser-induced fluorescence detection","score":0.9900000095367432}],"concepts":[{"id":"https://openalex.org/C34381374","wikidata":"https://www.wikidata.org/wiki/Q37144","display_name":"Cartridge","level":2,"score":0.9470701217651367},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.8370420336723328},{"id":"https://openalex.org/C94915269","wikidata":"https://www.wikidata.org/wiki/Q1834857","display_name":"Detector","level":2,"score":0.6524271965026855},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.639774739742279},{"id":"https://openalex.org/C33390570","wikidata":"https://www.wikidata.org/wiki/Q188463","display_name":"Spectrometer","level":2,"score":0.6359115839004517},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.633653998374939},{"id":"https://openalex.org/C98015330","wikidata":"https://www.wikidata.org/wiki/Q907315","display_name":"Absorbance","level":2,"score":0.5980455875396729},{"id":"https://openalex.org/C73826308","wikidata":"https://www.wikidata.org/wiki/Q684907","display_name":"Elution","level":2,"score":0.5877113342285156},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.5280718803405762},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.5203137397766113},{"id":"https://openalex.org/C110084920","wikidata":"https://www.wikidata.org/wiki/Q381624","display_name":"Chromatography detector","level":3,"score":0.4250243604183197},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2661057710647583},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0953778326511383},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D013056","descriptor_name":"Spectrophotometry, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053841","descriptor_name":"Electroosmosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jssc.201700185","doi":"https://doi.org/10.1002/jssc.201700185","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jssc.201700185","pdf_url":null,"source":{"id":"https://openalex.org/S45406943","display_name":"Journal of Separation Science","issn_l":"1615-9306","issn":["1615-9306","1615-9314"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Separation Science","raw_type":"journal-article"},{"id":"pmid:28514057","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28514057","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of separation science","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2986155719","display_name":"Polymer monolith-based high-pressure electroosmotic micropump","funder_award_id":"AR14-015","funder_id":"https://openalex.org/F4320310627","funder_display_name":"Oklahoma Center for the Advancement of Science and Technology"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320310627","display_name":"Oklahoma Center for the Advancement of Science and Technology","ror":"https://ror.org/02q578v20"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W941833992","https://openalex.org/W1112645305","https://openalex.org/W1155114829","https://openalex.org/W1971536928","https://openalex.org/W1975075532","https://openalex.org/W1979027012","https://openalex.org/W1988796421","https://openalex.org/W2011820097","https://openalex.org/W2014011029","https://openalex.org/W2014155474","https://openalex.org/W2021172854","https://openalex.org/W2023375068","https://openalex.org/W2025670719","https://openalex.org/W2046693173","https://openalex.org/W2059688150","https://openalex.org/W2190551284","https://openalex.org/W2195292868","https://openalex.org/W2289937625","https://openalex.org/W2314983988","https://openalex.org/W2316495912","https://openalex.org/W2470197561"],"related_works":["https://openalex.org/W1155114829","https://openalex.org/W1971536928","https://openalex.org/W2066210710","https://openalex.org/W2047040498","https://openalex.org/W1963881477","https://openalex.org/W2094664551","https://openalex.org/W7057117851","https://openalex.org/W6959207910","https://openalex.org/W2071167552","https://openalex.org/W2043722137"],"abstract_inverted_index":{"We":[0,23,82],"discuss":[1],"the":[2,51,86],"construction":[3],"and":[4,38,54,77,93,114],"performance":[5],"of":[6,20,41],"a":[7,18,39,71,80,94],"high-performance":[8,72],"liquid":[9,73],"chromatography":[10,74],"cartridge":[11,75,87,103],"that":[12,15],"we":[13,68],"developed":[14,26],"resulted":[16],"from":[17],"culmination":[19],"previous":[21],"research.":[22],"have":[24,69,83],"recently":[25],"an":[27,89],"innovative":[28],"approach":[29],"to":[30,49,60],"creating":[31],"gradient":[32],"elutions":[33],"using":[34],"dual":[35],"electroosmotic":[36],"pumps":[37],"series":[40],"three":[42],"valves.":[43],"This":[44],"method":[45],"has":[46],"been":[47],"proved":[48],"be":[50],"most":[52],"reproducible":[53],"robust":[55],"in":[56],"producing":[57],"gradients":[58],"compared":[59],"our":[61],"previously":[62],"tested":[63],"methods.":[64],"Using":[65],"this":[66],"approach,":[67],"assembled":[70],"powered":[76],"controlled":[78],"via":[79],"computer.":[81],"successfully":[84],"coupled":[85,106],"with":[88,107],"ultraviolet":[90],"absorbance":[91],"detector":[92,113],"mass":[95],"spectrometer":[96],"for":[97],"separating":[98],"complex":[99],"protein/peptide":[100],"samples.":[101],"The":[102],"is":[104],"readily":[105],"other":[108],"detectors":[109],"such":[110],"as":[111],"electrochemical":[112],"laser-induced":[115],"fluorescence":[116],"detector.":[117]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-05-26T00:00:00"}