{"id":"https://openalex.org/W2613730752","doi":null,"title":"Biological functions of microRNA-216 and microRNA-217 during the development of pancreatic cancer","display_name":"Biological functions of microRNA-216 and microRNA-217 during the development of pancreatic cancer","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2613730752","mag":"2613730752"},"language":"en","primary_location":{"id":"pmh:oai:etd.ohiolink.edu:osu1374244806","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1374244806","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1374244806","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1374244806","raw_type":"text"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1374244806","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015560574","display_name":"Ana Clara P. Azevedo\u2010Pouly","orcid":"https://orcid.org/0000-0001-8308-9271","observed_orcids":["https://orcid.org/0000-0001-8308-9271"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ana Clara P. Azevedo\u2010Pouly","raw_affiliation_strings":["the Ohio State University"],"raw_orcid":"https://orcid.org/0000-0001-8308-9271","affiliations":[{"raw_affiliation_string":"the Ohio State University","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5015560574"],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":null,"apc_paid":null,"fwci":0.1166,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.5870084,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.8830000162124634},{"id":"https://openalex.org/keywords/mir-216a","display_name":"miR-216a","score":0.8650000095367432},{"id":"https://openalex.org/keywords/mir-216b","display_name":"miR-216b","score":0.996999979019165},{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"non-coding RNA","score":0.8320000171661377},{"id":"https://openalex.org/keywords/acinar-to-ductal-metaplasia","display_name":"acinar-to-ductal metaplasia","score":0.972000002861023},{"id":"https://openalex.org/keywords/genetically-engineered-mouse-models","display_name":"genetically engineered mouse models","score":0.8320000171661377}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.8625560998916626},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.7734421491622925},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4479128122329712},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3928840160369873},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36895307898521423},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33554282784461975},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2315618097782135},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16287770867347717}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:etd.ohiolink.edu:osu1374244806","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1374244806","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1374244806","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1374244806","raw_type":"text"},{"id":"mag:2613730752","doi":null,"is_oa":false,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1374244806","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:etd.ohiolink.edu:osu1374244806","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1374244806","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1374244806","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1374244806","raw_type":"text"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6600000262260437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2613730752.pdf","grobid_xml":"https://content.openalex.org/works/W2613730752.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1992481702","https://openalex.org/W2026595595","https://openalex.org/W2414743991","https://openalex.org/W2966826412","https://openalex.org/W2331688448","https://openalex.org/W4225255163","https://openalex.org/W1984101390","https://openalex.org/W1976924899","https://openalex.org/W1971691280","https://openalex.org/W2767113052"],"abstract_inverted_index":{"Pancreatic":[0],"cancer":[1,130],"is":[2,19,32,97,226],"among":[3],"the":[4,30,42,65,101,105,121,142,167,175,183,194,201,216,227,270,279,294,302],"most":[5],"lethal":[6],"of":[7,14,29,44,72,104,120,149,182,198,213],"all":[8,262,301],"human":[9],"diseases.With":[10],"a":[11,20,58,89,154,207],"5-year":[12],"survival":[13],"less":[15],"than":[16],"6%,":[17],"there":[18],"dire":[21],"need":[22],"for":[23,239,269,293,300],"new":[24],"therapeutic":[25],"options":[26],"[1].Molecular":[27],"understanding":[28],"disease":[31,66],"vital":[33],"to":[34,37,113,164,177,233,250,260,284],"overcome":[35],"barriers":[36],"effective":[38],"treatment.Here":[39],"we":[40,87],"evaluate":[41],"expression":[43,127,151,185],"noncoding":[45,73],"RNAs":[46,74],"in":[47,52,57,68,100,128,135,137,157,166,189,202,223,253,278],"patient":[48],"tissues,":[49,131],"cell":[50,116,132,180],"lines,":[51],"vitro":[53,138,190,203],"model":[54,62,191],"systems":[55],"and":[56,79,94,111,134,209,247,267,274,290],"genetically":[59],"engineered":[60],"mouse":[61],"that":[63,96,140,147,192],"recapitulates":[64],"progression":[67],"humans.Two":[69],"different":[70,102],"classes":[71],"were":[75],"studied,":[76],"microRNA":[77],"(miRNA)":[78],"transcribed":[80],"ultraconserved":[81],"elements":[82],"(T-UCRs).Corroborating":[83],"previously":[84],"published":[85],"data,":[86],"identify":[88],"miRNA":[90],"cluster":[91],"(miR-216a,":[92],"miR-216b,":[93],"miR-217)":[95],"consistently":[98],"down-regulated":[99],"models":[103],"disease.These":[106],"miRNAs,":[107],"are":[108],"pancreas":[109],"enriched,":[110],"appear":[112],"be":[114,153],"acinar":[115,179],"specific.A":[117],"large":[118],"percentage":[119],"482":[122],"known":[123],"T-UCRs":[124],"had":[125],"increased":[126],"pancreatic":[129,143],"lines":[133],"an":[136,178,188,244],"system":[139],"mimics":[141,193],"desmoplastic":[144],"reaction.We":[145],"hypothesized":[146],"loss":[148],"miR-216/-217":[150],"might":[152],"crucial":[155],"step":[156],"regulating":[158],"acinar-to-ductal":[159],"metaplasia":[160],"(ADM).Although":[161],"historically":[162],"believed":[163],"originate":[165],"ductal":[168],"cells,":[169],"compounding":[170],"evidence":[171],"now":[172],"has":[173],"shifted":[174],"paradigm":[176],"origin":[181],"malignancy.miR-216/-217":[184],"decreases":[186],"using":[187],"ADM":[195],"process.Adenovirus":[196],"overexpression":[197],"miR-217":[199],"during":[200],"have":[204,298],"developed":[205],"as":[206,210],"person":[208],"scientist":[211],"because":[212],"this,":[214],"but":[215],"process":[217],"was":[218],"not":[219],"easy.Dr.":[220],"Schmittgen's":[221],"confidence":[222],"my":[224,254,263],"abilities":[225],"reason":[228],"why":[229],"I":[230,257],"am":[231],"able":[232],"write":[234],"this":[235],"dissertation":[236],"today.Thank":[237],"you":[238],"entrusting":[240],"me":[241,249],"with":[242],"such":[243],"important":[245],"question":[246],"allowing":[248],"grow":[251],"scientifically":[252],"own":[255],"way.Second,":[256],"would":[258,281],"like":[259,283],"thank":[261,285],"lab":[264],"mates,":[265],"past":[266],"present,":[268],"personal":[271],"help,":[272],"friendship":[273],"countless":[275],"shared":[276],"hours":[277],"lab.I":[280],"specially":[282],"Jong-Kook":[286],"Park,":[287],"Dhruvit":[288],"Sutaria":[289],"JinMai":[291],"Jiang":[292],"special":[295],"support":[296],"they":[297],"provided.Jong-Kook":[299],"late":[303],"nigh":[304],"scientific":[305]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-09-09T07:26:56.047234","created_date":"2017-05-19T00:00:00"}