{"id":"https://openalex.org/W261350843","doi":"https://doi.org/10.1161/circ.128.suppl_22.a327","title":"Abstract 327: Impaired Mitochondrial Function Following The Metabolic Phase Of Cardiac Arrest And Resuscitation: Differences In Tissue Vulnerability, Site And Severity Of Dysfunction","display_name":"Abstract 327: Impaired Mitochondrial Function Following The Metabolic Phase Of Cardiac Arrest And Resuscitation: Differences In Tissue Vulnerability, Site And Severity Of Dysfunction","publication_year":2013,"publication_date":"2013-11-26","ids":{"openalex":"https://openalex.org/W261350843","doi":"https://doi.org/10.1161/circ.128.suppl_22.a327","mag":"261350843"},"language":"en","primary_location":{"id":"doi:10.1161/circ.128.suppl_22.a327","doi":"https://doi.org/10.1161/circ.128.suppl_22.a327","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.128.suppl_22.a327","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053812510","display_name":"Joshua W. Lampe","orcid":"https://orcid.org/0000-0001-6036-535X","observed_orcids":["https://orcid.org/0000-0001-6036-535X"]},"institutions":[{"id":"https://openalex.org/I4210143392","display_name":"University of Pennsylvania Health System","ror":"https://ror.org/04h81rw26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua W Lampe","raw_affiliation_strings":["Emergency Medicine, Univ of Pennsylvania Health System, Cntr for Resuscitation Science, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emergency Medicine, Univ of Pennsylvania Health System, Cntr for Resuscitation Science, Philadelphia, PA","institution_ids":["https://openalex.org/I4210143392","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056027440","display_name":"Mary A. Selak","orcid":"https://orcid.org/0000-0003-3029-0021","observed_orcids":["https://orcid.org/0000-0003-3029-0021"]},"institutions":[{"id":"https://openalex.org/I4210143392","display_name":"University of Pennsylvania Health System","ror":"https://ror.org/04h81rw26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary A Selak","raw_affiliation_strings":["Univ of Pennsylvania Health System, Cntr for Resuscitation Science, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Pennsylvania Health System, Cntr for Resuscitation Science, Philadelphia, PA","institution_ids":["https://openalex.org/I4210143392","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tong Da","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143392","display_name":"University of Pennsylvania Health System","ror":"https://ror.org/04h81rw26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tong Da","raw_affiliation_strings":["Univ of Pennsylvania Health System, Cntr for Resuscitation Science, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Pennsylvania Health System, Cntr for Resuscitation Science, Philadelphia, PA","institution_ids":["https://openalex.org/I4210143392","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wei Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Zhang","raw_affiliation_strings":["Second Affiliation Hosp of Wenzhou Med College, Zhejing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Affiliation Hosp of Wenzhou Med College, Zhejing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029762084","display_name":"Ming Yin","orcid":"https://orcid.org/0000-0003-4585-8732","observed_orcids":["https://orcid.org/0000-0003-4585-8732"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming Yin","raw_affiliation_strings":["General Hosp of PLA, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General Hosp of PLA, Beijing, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048698351","display_name":"Chih\u2010Hsien Wang","orcid":"https://orcid.org/0000-0003-3214-6867","observed_orcids":["https://orcid.org/0000-0003-3214-6867"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chih-Hsien Wang","raw_affiliation_strings":["National Taiwan Univ Hosp, Hsin Chu Branch, Hsin Chu City, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Taiwan Univ Hosp, Hsin Chu Branch, Hsin Chu City, Taiwan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004688395","display_name":"Meagan J. McManus","orcid":"https://orcid.org/0000-0001-6064-0665","observed_orcids":["https://orcid.org/0000-0001-6064-0665"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meagan J McManus","raw_affiliation_strings":["The Children\u2019s Hosp of Philadelphia, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Children\u2019s Hosp of Philadelphia, Philadelphia, PA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085274471","display_name":"Douglas C. Wallace","orcid":"https://orcid.org/0000-0002-7480-8278","observed_orcids":["https://orcid.org/0000-0002-7480-8278"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas C Wallace","raw_affiliation_strings":["The Children\u2019s Hosp of Philadelphia, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Children\u2019s Hosp of Philadelphia, Philadelphia, PA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083278720","display_name":"Lance B. Becker","orcid":"https://orcid.org/0000-0001-7051-8778","observed_orcids":["https://orcid.org/0000-0001-7051-8778"]},"institutions":[{"id":"https://openalex.org/I4210143392","display_name":"University of Pennsylvania Health System","ror":"https://ror.org/04h81rw26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lance B Becker","raw_affiliation_strings":["Univ of Pennsylvania Health System, Cntr for Resuscitation Science, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Pennsylvania Health System, Cntr for Resuscitation Science, Philadelphia, PA","institution_ids":["https://openalex.org/I4210143392","https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"128","issue":"suppl_22","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10645","display_name":"Cardiac Arrest and Resuscitation","score":0.5615000128746033,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10645","display_name":"Cardiac Arrest and Resuscitation","score":0.5615000128746033,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.2727000117301941,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.15330000221729279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.7919999957084656},{"id":"https://openalex.org/keywords/prolonged-cardiac-arrest","display_name":"prolonged cardiac arrest","score":0.8519999980926514},{"id":"https://openalex.org/keywords/cardiopulmonary-bypass","display_name":"cardiopulmonary bypass","score":0.7789999842643738},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.9309999942779541},{"id":"https://openalex.org/keywords/electron-transport-chain","display_name":"electron transport chain","score":0.6359999775886536},{"id":"https://openalex.org/keywords/respiratory-control-ratio","display_name":"respiratory control ratio","score":0.8009999990463257},{"id":"https://openalex.org/keywords/oxygen-consumption","display_name":"oxygen consumption","score":0.7960000038146973},{"id":"https://openalex.org/keywords/heart","display_name":"heart","score":0.4350000023841858},{"id":"https://openalex.org/keywords/brain","display_name":"brain","score":0.9559999704360962},{"id":"https://openalex.org/keywords/kidney","display_name":"kidney","score":1.0},{"id":"https://openalex.org/keywords/nadh-oxidase","display_name":"NADH oxidase","score":0.7179999947547913},{"id":"https://openalex.org/keywords/energy-coupling","display_name":"energy coupling","score":0.492000013589859},{"id":"https://openalex.org/keywords/emergency-resuscitation","display_name":"emergency resuscitation","score":0.40799999237060547}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9333505630493164},{"id":"https://openalex.org/C2778165595","wikidata":"https://www.wikidata.org/wiki/Q5491454","display_name":"Resuscitation","level":2,"score":0.6919795274734497},{"id":"https://openalex.org/C2993469949","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Cardiac dysfunction","level":3,"score":0.5782170295715332},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5104609727859497},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4929482936859131},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.16989099979400635},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.1308862268924713}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.128.suppl_22.a327","doi":"https://doi.org/10.1161/circ.128.suppl_22.a327","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.128.suppl_22.a327","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1910515873","https://openalex.org/W2998518850","https://openalex.org/W7096919290","https://openalex.org/W142424139","https://openalex.org/W3161349458","https://openalex.org/W3163646841","https://openalex.org/W2889542328","https://openalex.org/W2016346542","https://openalex.org/W146534183","https://openalex.org/W2068049473"],"abstract_inverted_index":{"Introduction:":[0],"Mitochondrial":[1],"dysfunction":[2,22,225],"may":[3,312],"be":[4,313],"critical":[5],"to":[6,264,270,310,315],"reperfusion":[7,121,241,290],"injury":[8],"following":[9],"the":[10,62,165,185,195,265,268,291,298,306],"metabolic":[11,36],"phase":[12,37],"of":[13,21,38,48,57,72,81,89,129,253,267,283,289,305],"prolonged":[14,39,73,238],"cardiac":[15,40,74,111],"arrest.":[16],"However,":[17],"specific":[18,46,245],"intra-mitochondrial":[19,249],"sites":[20],"remain":[23],"uncertain":[24],"and":[25,42,54,60,65,96,123,137,143,171,177,190,193,201,213,240,246,259,293,308,318],"differential":[26],"tissue":[27,244,269],"vulnerabilities":[28],"have":[29],"not":[30,301],"been":[31],"well":[32],"characterized.":[33],"HYPOTHESIS:":[34],"The":[35,303],"arrest":[41,75,84,112,116,126],"resuscitation":[43],"will":[44],"provoke":[45],"patterns":[47,205],"fixed":[49],"localized":[50],"defects":[51,235],"in":[52,226],"respiratory":[53,138,215,277],"phosphorylating":[55],"activities":[56,252],"mitochondrial":[58,234,316],"function":[59],"impact":[61],"heart,":[63],"brain,":[64],"kidney":[66,186,256,292],"differently.":[67],"METHODS:":[68],"A":[69],"rodent":[70],"model":[71],"was":[76,173,197],"employed":[77],"with":[78,286],"30":[79,108,114,281],"min":[80,88,109,115,119,125,282,288],"untreated":[82,110],"axphyxial":[83],"followed":[85],"by":[86],"60":[87,118,287],"emergency":[90],"cardiopulmonary":[91],"bypass":[92],"(ECPB).":[93],"Electron":[94],"transport":[95,146],"energy":[97],"coupling":[98],"were":[99,154,218],"analyzed":[100],"under":[101],"four":[102],"experimental":[103],"conditions:":[104],"no":[105],"treatment":[106],"(NORM),":[107],"(CA30),":[113],"plus":[117],"ECPB":[120],"(CA30R60)":[122],"90":[124],"(CA90).":[127],"Measurements":[128],"O":[130,159],"2":[131,160],"consumption":[132,161,212],"(states":[133],"3":[134,158,210],"&":[135,152],"4,":[136],"control":[139,216,278],"ratio),":[140],"NADH":[141],"oxidase,":[142],"partial":[144,221],"electron":[145],"reactions":[147],"(for":[148],"Complex":[149],"I+III,":[150],"II+III,":[151],"IV)":[153],"performed.":[155],"Results:":[156],"State":[157,209],"(glutamate/malate)":[162],"for:":[163],"(a)":[164],"heart":[166,229,254,309],"at":[167],"NORM,":[168],"CA30,":[169],"CA30R60":[170],"CA90":[172],"153\u00b128,":[174],"90\u00b113,":[175],"136\u00b122,":[176],"118\u00b120,":[178],"respectively":[179],"(mean\u00b1s.d.,":[180],"nanoatoms":[181],"oxygen/min/mg":[182],"protein);":[183],"(b)":[184],"was128\u00b132,":[187],"82\u00b112,":[188],"114\u00b118,":[189],"53\u00b18":[191],"respectively;":[192],"(c)":[194],"brain":[196,227,258,294,299,307],"68\u00b15,":[198],"57\u00b14,":[199],"49\u00b116,":[200],"33\u00b16":[202],"respectively.":[203],"Similar":[204],"for":[206,214,321],"succinate":[207],"nourished":[208],"O2":[211],"ratios":[217,279],"seen.":[219],"ETC":[220],"complex":[222],"measures":[223],"revealed":[224],">":[228,230,255,257],"kidney.":[231],"CONCLUSION:":[232],"Distinct":[233],"develops":[236],"after":[237,280],"ischemia":[239,311],"that":[242],"are":[243],"show":[247],"unique":[248],"sites.":[250],"Respiratory":[251],"this":[260],"is":[261],"inversely":[262],"related":[263],"sensitivity":[266],"ischemia/reperfusion":[271],"injury.":[272],"All":[273],"tissues":[274],"demonstrate":[275],"poor":[276],"ischemia.":[284],"However":[285],"recover":[295],"significantly":[296],"while":[297],"does":[300],"improve.":[302],"vulnerability":[304],"linked":[314],"pathways":[317],"a":[319],"target":[320],"new":[322],"therapies.":[323]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}