{"id":"https://openalex.org/W2613375729","doi":"https://doi.org/10.18632/oncotarget.17710","title":"WX-132-18B, a novel microtubule inhibitor, exhibits promising anti-tumor effects","display_name":"WX-132-18B, a novel microtubule inhibitor, exhibits promising anti-tumor effects","publication_year":2017,"publication_date":"2017-05-09","ids":{"openalex":"https://openalex.org/W2613375729","doi":"https://doi.org/10.18632/oncotarget.17710","mag":"2613375729","pmid":"https://pubmed.ncbi.nlm.nih.gov/29069746","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5641089"},"language":"en","primary_location":{"id":"doi:10.18632/oncotarget.17710","doi":"https://doi.org/10.18632/oncotarget.17710","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.17710","pdf_url":null,"source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.18632/oncotarget.17710","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Fang Guan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Fang Guan","raw_affiliation_strings":["Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China","State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, 100850, China","Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, 100850, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, 100850, China","institution_ids":[]},{"raw_affiliation_string":"Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, 100850, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083976878","display_name":"Rui Ding","orcid":"https://orcid.org/0000-0001-9730-0744","observed_orcids":["https://orcid.org/0000-0001-9730-0744"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rui Ding","raw_affiliation_strings":["Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China","State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, 100850, China","Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, 100850, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, 100850, China","institution_ids":[]},{"raw_affiliation_string":"Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, 100850, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100360303","display_name":"Qi Zhang","orcid":"https://orcid.org/0000-0002-4549-9760","observed_orcids":["https://orcid.org/0000-0002-4549-9760"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qi Zhang","raw_affiliation_strings":["Beijing Institute of Radiation Medicine, Beijing, 100850, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Radiation Medicine, Beijing, 100850, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052603478","display_name":"Wei Chen","orcid":"https://orcid.org/0000-0002-2339-5741","observed_orcids":["https://orcid.org/0000-0002-2339-5741"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Chen","raw_affiliation_strings":["Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China","State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, 100850, China","Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, 100850, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, 100850, China","institution_ids":[]},{"raw_affiliation_string":"Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, 100850, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100450471","display_name":"Feifei Li","orcid":"https://orcid.org/0009-0007-0254-0368","observed_orcids":["https://orcid.org/0009-0007-0254-0368"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Feifei Li","raw_affiliation_strings":["Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China","State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, 100850, China","Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, 100850, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, 100850, China","institution_ids":[]},{"raw_affiliation_string":"Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, 100850, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003827115","display_name":"Long Long","orcid":"https://orcid.org/0000-0002-0497-9493","observed_orcids":["https://orcid.org/0000-0002-0497-9493"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Long Long","raw_affiliation_strings":["Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China","State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, 100850, China","Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, 100850, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, 100850, China","institution_ids":[]},{"raw_affiliation_string":"Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, 100850, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100318325","display_name":"W\u011bi Li","orcid":"https://orcid.org/0000-0002-9522-4474","observed_orcids":["https://orcid.org/0000-0002-9522-4474","https://orcid.org/0000-0003-4136-3409","https://orcid.org/0009-0009-9141-6389"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":["Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China","State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, 100850, China","Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, 100850, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, 100850, China","institution_ids":[]},{"raw_affiliation_string":"Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, 100850, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102918795","display_name":"Linna Li","orcid":"https://orcid.org/0000-0003-3930-9243","observed_orcids":["https://orcid.org/0000-0003-3930-9243"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Linna Li","raw_affiliation_strings":["Beijing Institute of Radiation Medicine, Beijing, 100850, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Radiation Medicine, Beijing, 100850, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101146568","display_name":"Dexuan Yang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dexuan Yang","raw_affiliation_strings":["Beijing Institute of Radiation Medicine, Beijing, 100850, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Radiation Medicine, Beijing, 100850, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100741336","display_name":"Lan Xie","orcid":"https://orcid.org/0000-0001-5831-8730","observed_orcids":["https://orcid.org/0000-0001-5831-8730"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lan Xie","raw_affiliation_strings":["Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China","State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, 100850, China","Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, 100850, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, 100850, China","institution_ids":[]},{"raw_affiliation_string":"Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, 100850, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103388600","display_name":"Shoujun Yuan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shoujun Yuan","raw_affiliation_strings":["Beijing Institute of Radiation Medicine, Beijing, 100850, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Radiation Medicine, Beijing, 100850, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5115594091","display_name":"Lili Wang","orcid":"https://orcid.org/0000-0001-7886-0180","observed_orcids":["https://orcid.org/0000-0001-7886-0180"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lili Wang","raw_affiliation_strings":["Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China","State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, 100850, China","Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, 100850, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, 100850, China","institution_ids":[]},{"raw_affiliation_string":"Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, 100850, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5083976878"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2791,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.8719644,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"8","issue":"42","first_page":"71782","last_page":"71796"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.021400000900030136,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.013700000010430813,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microtubule-inhibitors","display_name":"microtubule inhibitors","score":0.9210000038146973},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7789999842643738},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.9240000247955322},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.6919999718666077},{"id":"https://openalex.org/keywords/redox-homeostasis","display_name":"redox homeostasis","score":0.6380000114440918},{"id":"https://openalex.org/keywords/paclitaxel-resistance","display_name":"paclitaxel resistance","score":0.6980000138282776},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7649999856948853},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.6650000214576721},{"id":"https://openalex.org/keywords/angiogenesis-inhibition","display_name":"angiogenesis inhibition","score":0.6740000247955322},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.5680000185966492},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor-receptor","display_name":"vascular endothelial growth factor receptor","score":0.5540000200271606}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5461576581001282},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.4712308645248413},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.43365049362182617},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4195297360420227},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2542649507522583},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.20424750447273254}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.18632/oncotarget.17710","doi":"https://doi.org/10.18632/oncotarget.17710","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.17710","pdf_url":null,"source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5641089","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5641089","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Text"},{"id":"pmid:29069746","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29069746","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.18632/oncotarget.17710","doi":"https://doi.org/10.18632/oncotarget.17710","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.17710","pdf_url":null,"source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1574056173","https://openalex.org/W1965278529","https://openalex.org/W1971579914","https://openalex.org/W1979790654","https://openalex.org/W1982502422","https://openalex.org/W1990378170","https://openalex.org/W1991959240","https://openalex.org/W1992313984","https://openalex.org/W1998108152","https://openalex.org/W1999142756","https://openalex.org/W2011157682","https://openalex.org/W2014636427","https://openalex.org/W2021914983","https://openalex.org/W2023063172","https://openalex.org/W2027542963","https://openalex.org/W2027595591","https://openalex.org/W2041929141","https://openalex.org/W2048938594","https://openalex.org/W2069199584","https://openalex.org/W2084889020","https://openalex.org/W2088494127","https://openalex.org/W2090555034","https://openalex.org/W2093855538","https://openalex.org/W2094756868","https://openalex.org/W2095072642","https://openalex.org/W2104029891","https://openalex.org/W2108432488","https://openalex.org/W2109689528","https://openalex.org/W2112302256","https://openalex.org/W2124514746","https://openalex.org/W2128362969","https://openalex.org/W2128380808","https://openalex.org/W2128560067","https://openalex.org/W2131895751","https://openalex.org/W2136136735","https://openalex.org/W2147051864","https://openalex.org/W2158139588","https://openalex.org/W2238071320","https://openalex.org/W2322103588","https://openalex.org/W2334969290","https://openalex.org/W4406057120"],"related_works":["https://openalex.org/W4407573721","https://openalex.org/W2040611118","https://openalex.org/W2960271283","https://openalex.org/W4312125591","https://openalex.org/W7133001198","https://openalex.org/W1966508867","https://openalex.org/W6977386101","https://openalex.org/W3202442635","https://openalex.org/W1989799657","https://openalex.org/W4319655899"],"abstract_inverted_index":{"//":[0],"Fang":[1],"Guan":[2],"1,":[3,9,19,24,29,34,47,56],"2,":[4,10],"*":[5,11,89],",":[6,12,16,21,26,31,36,40,44,49],"Rui":[7],"Ding":[8],"Qi":[13],"Zhang":[14],"3":[15,39,43,52,80],"Wei":[17,32],"Chen":[18],"2":[20,25,30,35,48,57,68],"Feifei":[22],"Li":[23,33,38],"Long":[27,28],"Linna":[37],"Dexuan":[41],"Yang":[42],"Lan":[45],"Xie":[46],"Shoujun":[50,104],"Yuan":[51],"and":[53,63,74,145,174,194,217,250,272,277,303,308,319],"Lili":[54,100],"Wang":[55],"1":[58],"Beijing":[59,81],"Institute":[60,82],"of":[61,72,83,244,253,280,301],"Pharmacology":[62],"Toxicology,":[64],"Beijing,":[65,77,86],"100850,":[66,78,87],"China":[67,79,88],"State":[69],"Key":[70],"Laboratory":[71],"Toxicology":[73],"Medical":[75],"Countermeasures,":[76],"Radiation":[84],"Medicine,":[85],"These":[90,313],"authors":[91],"have":[92,136],"contributed":[93],"equally":[94],"to":[95,163],"this":[96],"work":[97],"Correspondence":[98],"to:":[99],"Wang,":[101],"email:":[102,106],"wangll63@126.com":[103],"Yuan,":[105],"yuansj@nic.bmi.ac.cn":[107],"Keywords:":[108],"tubulin":[109,168,302],"inhibitor,":[110],"anti-tumor":[111,311,327],"effects,":[112],"high":[113],"content":[114,178],"assay,":[115],"cellular":[116,185],"phenotype,":[117],"colchicine-binding":[118,165,299],"site":[119,166,300],"Received:":[120],"November":[121],"16,":[122],"2016":[123],"Accepted:":[124],"April":[125],"24,":[126],"2017":[127,131],"Published:":[128],"May":[129],"09,":[130],"ABSTRACT":[132],"Cancer":[133],"drug":[134,328],"researchers":[135],"been":[137],"seeking":[138],"microtubule-inhibiting":[139],"agents":[140],"(MIAs)":[141],"with":[142,316],"higher":[143],"bioactivity":[144,230],"lower":[146],"toxicity":[147],"than":[148,170,235],"currently":[149],"marketed":[150],"drugs.":[151],"WX-132-18B,":[152],"a":[153,290,325],"novel":[154,291],"structural":[155],"compound":[156],"synthesized":[157],"at":[158,201],"our":[159],"institute,":[160],"specifically":[161],"bound":[162],"the":[164,171,183,189,202,219,237,242,258,278,298],"on":[167,297],"rather":[169],"vinblastine":[172],"site,":[173],"concentration-dependently":[175],"reduced":[176],"microtubule":[177],"via":[179],"depolymerization.":[180],"It":[181],"exhibited":[182],"same":[184],"phenotypic":[186],"profiles":[187],"as":[188],"classic":[190,238],"MIAs":[191],"(colchicine,":[192],"vincristine,":[193],"taxol),":[195],"including":[196],"inducing":[197],"cell":[198,207],"cycle":[199],"arrest":[200],"G2/M":[203],"phase,":[204],"triggering":[205],"tumor":[206,255,281],"apoptosis,":[208],"promoting":[209],"nuclear":[210],"membrane":[211,215],"permeability,":[212],"reducing":[213],"mitochondrial":[214],"potential,":[216],"disrupting":[218],"redox":[220],"system":[221],"balance.":[222],"Importantly,":[223],"WX-132-18B":[224,264,288,324],"displayed":[225],"more":[226],"potent":[227,305],"in":[228,284,306,309],"vitro":[229,307],"(IC":[231],"50":[232],"0.45\u20130.99":[233],"nM)":[234],"did":[236],"MIAs;":[239],"it":[240],"inhibited":[241,267],"proliferation":[243],"human":[245,254,270],"umbilical":[246],"vein":[247],"endothelial":[248],"cells":[249,262],"seven":[251],"types":[252],"cells,":[256],"especially":[257],"taxol-resistant":[259],"breast":[260],"cancer":[261,274],"MX-1/T.":[263],"also":[265],"dose-dependently":[266],"mice":[268],"sarcoma,":[269],"lung,":[271],"gastric":[273],"xenograft":[275],"tumors":[276],"formation":[279],"blood":[282],"vessels":[283],"mice.":[285],"In":[286],"conclusion,":[287],"is":[289],"microtubule-depolymerizing":[292],"agent":[293],"that":[294],"selectively":[295],"acts":[296],"exerts":[304],"vivo":[310],"effects.":[312],"characteristics,":[314],"along":[315],"its":[317],"anti-angiogenesis":[318],"anti-drug":[320],"resistance":[321],"properties,":[322],"make":[323],"promising":[326],"candidate.":[329]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-05-19T00:00:00"}
