{"id":"https://openalex.org/W2613313484","doi":"https://doi.org/10.1113/jp274260","title":"Angiotensin II signalling kicks out p27Kip1: casein kinase 2 augmentation of Cav1.2 L\u2010type Ca2+ channel activity in immature ventricular cardiomyocytes","display_name":"Angiotensin II signalling kicks out p27Kip1: casein kinase 2 augmentation of Cav1.2 L\u2010type Ca2+ channel activity in immature ventricular cardiomyocytes","publication_year":2017,"publication_date":"2017-05-09","ids":{"openalex":"https://openalex.org/W2613313484","doi":"https://doi.org/10.1113/jp274260","mag":"2613313484","pmid":"https://pubmed.ncbi.nlm.nih.gov/28488737","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5491853"},"language":"en","primary_location":{"id":"doi:10.1113/jp274260","doi":"https://doi.org/10.1113/jp274260","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jp274260","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5491853","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071886776","display_name":"Mary C. Horne","orcid":"https://orcid.org/0000-0002-2799-3212","observed_orcids":["https://orcid.org/0000-0002-2799-3212"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mary C. Horne","raw_affiliation_strings":["Department of Pharmacology, University of California, Davis, CA, 95616-8636 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of California, Davis, CA, 95616-8636 USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029091929","display_name":"Johannes Wilhelm Hell","orcid":"https://orcid.org/0000-0001-7960-7531","observed_orcids":["https://orcid.org/0000-0001-7960-7531"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Johannes W. Hell","raw_affiliation_strings":["Department of Pharmacology, University of California, Davis, CA, 95616-8636 USA"],"raw_orcid":"https://orcid.org/0000-0001-7960-7531","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of California, Davis, CA, 95616-8636 USA","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5029091929","https://openalex.org/A5071886776"],"corresponding_institution_ids":["https://openalex.org/I84218800"],"apc_list":{"value":5400,"currency":"USD","value_usd":5400},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.08433098,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"595","issue":"13","first_page":"4131","last_page":"4132"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.7178000211715698,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.7178000211715698,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.22059999406337738,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.02019999921321869,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.9200000166893005},{"id":"https://openalex.org/keywords/cav1-2-l-type-calcium-channel","display_name":"Cav1.2 L-type calcium channel","score":0.8700000047683716},{"id":"https://openalex.org/keywords/p27","display_name":"p27","score":0.9599999785423279},{"id":"https://openalex.org/keywords/casein-kinase-2","display_name":"casein kinase 2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/beta-arrestin-2","display_name":"\u03b2-arrestin2","score":0.9390000104904175},{"id":"https://openalex.org/keywords/angiotensin-ii-type-1-receptor","display_name":"angiotensin II type 1 receptor","score":0.9290000200271606},{"id":"https://openalex.org/keywords/src-family-kinases","display_name":"Src family kinases","score":0.7049999833106995},{"id":"https://openalex.org/keywords/neonatal-heart","display_name":"neonatal heart","score":0.4830000102519989},{"id":"https://openalex.org/keywords/calcium-influx","display_name":"calcium influx","score":0.5720000267028809},{"id":"https://openalex.org/keywords/cardiac-electrophysiology","display_name":"cardiac electrophysiology","score":0.5759999752044678},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.32499998807907104}],"concepts":[{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.6248849630355835},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5002105236053467},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47012150287628174},{"id":"https://openalex.org/C143910341","wikidata":"https://www.wikidata.org/wiki/Q21102140","display_name":"Casein kinase 2","level":5,"score":0.4685583710670471},{"id":"https://openalex.org/C2776972302","wikidata":"https://www.wikidata.org/wiki/Q14905744","display_name":"Cav1.2","level":4,"score":0.4635075628757477},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.43559014797210693},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4299790561199188},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40689051151275635},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3374853730201721},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3327833116054535},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3286767601966858},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2968156635761261},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.28845828771591187},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2672273814678192},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.2166609764099121},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12086588144302368},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047390","descriptor_name":"Casein Kinase II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050760","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p27","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1113/jp274260","doi":"https://doi.org/10.1113/jp274260","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jp274260","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5491853","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5491853","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},{"id":"pmid:28488737","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28488737","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5491853","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5491853","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000921104","display_name":"Dysregulation of Cav1.2 by beta amyloid peptide","funder_award_id":"R01AG055357","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1524703234","https://openalex.org/W1607183863","https://openalex.org/W2021845530","https://openalex.org/W2032456072","https://openalex.org/W2128705810","https://openalex.org/W2337631524","https://openalex.org/W2596287968"],"related_works":["https://openalex.org/W2596287968","https://openalex.org/W2585454407","https://openalex.org/W2750965103","https://openalex.org/W2246097746","https://openalex.org/W6995737118","https://openalex.org/W83138467","https://openalex.org/W4361218625","https://openalex.org/W2037236942","https://openalex.org/W2106558515","https://openalex.org/W3211343682"],"abstract_inverted_index":{"Ca2+":[0,5],"influx":[1],"via":[2,52,87,533,559],"the":[3,78,88,98,117,129,141,145,165,179,193,196,199,239,244,257,260,295,352,378,386,392,400,403,437,442,450,459,531,537,548,581,590,607,665,687,719,728,750,773,782,785,795,833,843,899,908,913],"L-type":[4],"channel":[6,50,170,532],"Cav1.2":[7,49,86,173,320,371,379,770],"triggers":[8,527],"our":[9],"heartbeat.":[10],"Perinatally":[11],"and":[12,70,91,155,162,246,279,306,350,372,375,394,397,471,554,563,587,613,642,644,650,686,706,766,779,794,836,858,871],"particularly":[13],"at":[14,449],"birth,":[15],"angiotensin":[16,46,83],"II":[17,47,84,634],"is":[18,216,300,406,662,680,702,711,737,808,880],"produced":[19],"to":[20,57,230,317,355,370,377,390,408,485,604,649,664,683,739,791,820,824,842],"augment":[21],"necessary":[22],"physiological":[23],"changes":[24],"in":[25,114,140,164,213,287,321,567,624,697,718,735,772],"blood":[26],"flow":[27],"such":[28],"as":[29,222],"pulmonary":[30],"perfusion.":[31],"In":[32,853],"this":[33,204,214,432,816],"issue":[34],"of":[35,38,144,151,172,188,195,211,217,243,253,259,269,282,291,319,388,399,402,411,440,445,462,467,514,536,561,571,577,585,594,619,629,638,652,677,689,709,723,743,769,775,784,787,797,815,885,901,912],"The":[36,209,308,741],"Journal":[37],"Physiology":[39],"Kashihara":[40,311,363,488,744],"et":[41,65,175,264,312,324,364,382,415,474,489,499,655,745,802,850,893],"al.":[42,66,176,265,313,325,365,383,416,475,490,500,656,746,803,851,894],"now":[43,314,747],"report":[44,309],"that":[45,73,82,186,346,367,421,456,505,511,523,547,749,754,828],"increases":[48],"activity":[51,171,529],"a":[53,108,223,798,825,875],"novel":[54],"pathway":[55],"specific":[56],"immature":[58,700,761],"but":[59,699],"not":[60,481,681],"adult":[61],"ventricular":[62],"cardiomyocytes":[63,322,701,736],"(Kashihara":[64,323,381,498,801],"2017).":[67,326,384,501,804],"Using":[68],"pharmacological":[69],"molecular":[71],"approaches":[72],"elegantly":[74],"complement":[75],"each":[76],"other,":[77],"authors":[79,180],"convincingly":[80],"show":[81],"regulates":[85],"AT1":[89,100,524,757,834,859,914],"receptor":[90,101,525,835,857,860,890],"its":[92,236,298,409,517,578],"binding":[93,241,387,583,648],"partner":[94],"\u03b2-arrestin2":[95,765,810],"rather":[96],"than":[97],"conventional":[99],"coupled":[102],"Gq/11":[103],"signalling.":[104],"\u03b2-Arrestin2":[105],"then":[106],"stimulates":[107,635],"Src-family":[109],"tyrosine":[110,550],"kinase":[111,134,225,245,337],"(SFK),":[112],"which":[113,329,623,732,838,879,917],"turn":[115,625],"phosphorylates":[116,138,512,869],"protein":[118],"p27Kip1":[119],"(p27)":[120],"on":[121,469,573,621,640,760],"Tyr88.":[122],"This":[123,521,658],"phosphorylation":[124,187,466,560,618,637,884],"prevents":[125],"p27":[126,212,228,270,316,374,389,426,463,468,538,557,574,595,620,630,639,647,678,710,733,777,788],"from":[127,670,764],"inhibiting":[128],"otherwise":[130],"constitutively":[131],"active":[132],"casein":[133],"2":[135],"(CK2).":[136],"CK2":[137,353,404,422,867],"Thr1704":[139,189],"proximal":[142,200],"half":[143],"about":[146],"660":[147],"residue":[148],"long":[149],"C-terminus":[150],"Cav1.2.":[152,208],"Nearby":[153],"Arg1696":[154],"Arg1697":[156],"electrostatically":[157],"interact":[158],"with":[159,198,275,343,540,610,673],"Glu2103,":[160],"Glu2106,":[161],"Asp2110":[163],"distal":[166,197],"C-terminus,":[167,201],"thereby":[168,202,250,588,645],"reducing":[169,203,516],"(Hulme":[174],"2006).":[177],"As":[178],"hypothesize,":[181],"it":[182],"thus":[183],"appears":[184],"likely":[185],"acts":[190],"by":[191,310,704,882],"decreasing":[192],"interaction":[194,206,539,609,672,696],"autoinhibitory":[205],"within":[207],"role":[210],"context":[215],"particular":[218],"interest.":[219],"Originally":[220],"identified":[221],"cyclin-dependent":[224],"inhibitor":[226],"(CDKi),":[227],"binds":[229,369],"cyclin\u2013CDK2":[231,412,605],"subunit":[232],"complexes.":[233],"It":[234],"inserts":[235],"310-helix":[237,579],"into":[238,580],"ATP":[240,582],"pocket":[242],"inhibits":[247],"CDK2":[248,586,591,614,671],"activity,":[249,338],"blocking":[251],"progression":[252],"mitotic":[254,684],"cells":[255,293,685],"through":[256,464,691],"G1-phase":[258],"cell":[261,276],"cycle":[262,277],"(Russo":[263,414],"1996).":[266,417],"Thus,":[267],"upregulation":[268],"has":[271,303,759],"been":[272],"mainly":[273],"associated":[274],"inhibition":[278,651],"growth":[280,690,717],"arrest":[281],"proliferating":[283],"cells.":[284],"Its":[285],"function":[286],"tissues":[288],"primarily":[289],"composed":[290],"post-mitotic":[292],"like":[294],"heart,":[296],"where":[297],"expression":[299,722,734,793],"developmentally":[301],"upregulated,":[302],"remained":[304],"enigmatic":[305],"elusive.":[307],"links":[315],"regulation":[318,410,676],"Unlike":[327],"CDKs,":[328],"bind":[330],"positive":[331,659,751],"regulatory":[332],"cyclin":[333,612],"subunits":[334,341,345,396,615,725],"required":[335],"for":[336,714,898,921],"catalytic":[339],"CK2\u03b1/\u03b1\u2019":[340],"associate":[342],"\u03b2":[344,395],"confer":[347],"substrate":[348],"specificity":[349],"target":[351],"holoenzyme":[354,405],"selected":[356],"proteins":[357],"(Montenarh":[358,427],"&":[359,428],"Goetz,":[360,429],"2013).":[361,430],"Importantly,":[362,721],"determined":[366],"CK2\u03b2":[368],"recruits":[373],"CK2\u03b1\u2019":[376,393,486,636,724,792],"complex":[380,800,827,848],"Here":[385],"both":[391,611],"blockage":[398],"activation":[401,768,900],"akin":[407],"complexes":[413],"Earlier":[418],"work":[419,454],"showed":[420],"itself":[423],"can":[424],"phosphorylate":[425],"Although":[431,599],"CK2-mediated":[433,707],"modification":[434],"apparently":[435],"altered":[436],"secondary":[438],"structure":[439],"p27,":[441,515],"biological":[443],"significance":[444],"these":[446,478,492],"findings":[447,503,742],"was":[448],"time":[451,910],"unclear.":[452],"Later":[453],"indicated":[455],"AngII":[457,506,705,755],"induces":[458,811],"proteasomal":[460],"degradation":[461,628],"CK2\u03b1\u2019-dependent":[465],"Ser83":[470,641],"Thr187":[472,643],"(Hauck":[473,654],"2008).":[476,657],"However,":[477],"studies":[479,544],"did":[480],"resolve":[482],"what":[483],"leads":[484],"activation.":[487,813],"take":[491],"earlier":[493,543],"observations":[494],"several":[495,919],"steps":[496],"further":[497],"Their":[502],"indicate":[504,748],"signalling":[507,526,826,861,891,904],"activates":[508],"an":[509],"SFK":[510],"Tyr88":[513,572],"CK2\u03b1\u2019\u03b2":[518,528,767],"inhibitory":[519,592],"effect.":[520],"suggests":[522],"towards":[530,781],"SFK-mediated":[534],"alteration":[535],"CK2\u03b1\u2019\u03b2.":[541],"Indeed,":[542],"have":[545],"shown":[546],"non-receptor":[549],"kinases":[551],"Lyn,":[552],"Abl,":[553],"Src":[555,812,822],"regulate":[556],"stability":[558,679],"Tyr74":[562],"Tyr":[564],"88":[565],"(reviewed":[566],"Kaldis,":[568],"2007).":[569,598,632],"Phosphorylation":[570],"hinders":[575],"insertion":[576],"site":[584],"impairs":[589],"action":[593],"10-fold":[596],"(Kaldis,":[597,631],"pTyr88-p27":[600],"initially":[601],"remains":[602],"bound":[603],"complexes,":[606],"intermolecular":[608],"facilitates":[616],"CDK2-mediated":[617],"Thr187,":[622],"promotes":[626],"ubiquitin-mediated":[627],"Angiotensin":[633],"antagonizes":[646],"CK2\u03b1'":[653],"feedback":[660,667],"mechanism":[661,817],"analogous":[663,841],"above":[666],"loop":[668],"arising":[669],"pTyr88\u2013p27.":[674],"Thus":[675],"restricted":[682],"promotion":[688],"cellular":[692],"proliferation.":[693],"Rather":[694],"p27\u2013CK2\u03b1\u2019":[695],"differentiated":[698],"regulated":[703],"inactivation":[708],"clearly":[712],"critical":[713],"cardiac":[715],"hypertrophic":[716],"neonate.":[720],"decreases":[726],"during":[727,731,887],"postnatal":[729],"period":[730],"known":[738],"increase.":[740],"inotropic":[752],"effect":[753],"stimulated":[756],"receptors":[758],"heart":[762],"results":[763],"channels":[771],"absence":[774],"high":[776],"levels":[778,789],"points":[780],"importance":[783],"balance":[786],"relative":[790],"pre-assembly":[796],"p27\u2013CK2\u2013Cav1.2":[799],"One":[805],"open":[806],"question":[807],"how":[809],"Part":[814],"could":[818,829,906],"be":[819,830,840],"move":[821],"close":[823],"formed":[831],"between":[832],"Cav1.2,":[837],"would":[839],"\u03b22":[844,855,888],"adrenergic":[845,856,889],"receptor\u2013Gs\u2013adenylyl":[846],"cyclase\u2013PKA\u2013Cav1.2":[847],"(Patriarchi":[849,892],"2016).":[852,895],"fact,":[854],"might":[862],"very":[863],"well":[864],"intersect":[865],"because":[866],"typically":[868],"serine":[870],"threonine":[872],"residues":[873],"near":[874],"negatively":[876],"charged":[877],"residue,":[878],"created":[881],"PKA-mediated":[883],"Ser1700":[886],"Perhaps":[896],"requirement":[897],"two":[902],"different":[903],"cascades":[905],"explain":[907],"slow":[909],"course":[911],"receptor\u2013Thr1704":[915],"signalling,":[916],"requires":[918],"hours":[920],"optimal":[922],"phosphorylation.":[923],"None":[924],"declared.":[925]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-05-19T00:00:00"}
