{"id":"https://openalex.org/W2613293232","doi":"https://doi.org/10.1183/13993003.congress-2016.pa4016","title":"Evidence of renal and pulmonary endothelial dysfunction in chronic obstructive pulmonary disease (COPD)","display_name":"Evidence of renal and pulmonary endothelial dysfunction in chronic obstructive pulmonary disease (COPD)","publication_year":2016,"publication_date":"2016-09-01","ids":{"openalex":"https://openalex.org/W2613293232","doi":"https://doi.org/10.1183/13993003.congress-2016.pa4016","mag":"2613293232"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2016.pa4016","doi":"https://doi.org/10.1183/13993003.congress-2016.pa4016","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2016.pa4016","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"3.3 Mechanisms of Lung Injury and Repair","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037733639","display_name":"Francesca Polverino","orcid":"https://orcid.org/0000-0001-9686-5698","observed_orcids":["https://orcid.org/0000-0001-9686-5698"]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1305258596","display_name":"Lovelace Respiratory Research Institute","ror":"https://ror.org/038qbqz41","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1305258596"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Francesca Polverino","raw_affiliation_strings":["COPD Group, Lovelace Respiratory Research Institute","Medicine, Brigham and Women's, Harvard Medical School","Medicine, University of Parma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"COPD Group, Lovelace Respiratory Research Institute","institution_ids":["https://openalex.org/I1305258596"]},{"raw_affiliation_string":"Medicine, Brigham and Women's, Harvard Medical School","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Medicine, University of Parma","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019402145","display_name":"Maria Eugenia Laucho-Contreras","orcid":"https://orcid.org/0000-0002-7611-0498","observed_orcids":["https://orcid.org/0000-0002-7611-0498"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Laucho-Conttreras","raw_affiliation_strings":["Medicine, Brigham and Women's, Harvard Medical School","Medicine, University of Caracas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Brigham and Women's, Harvard Medical School","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Medicine, University of Caracas","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112934231","display_name":"Vanesa Bijol","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vanesa Bijol","raw_affiliation_strings":["Pathology, Brigham and Women's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Brigham and Women's Hospital","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053025512","display_name":"V\u00edctor Pinto-Plata","orcid":"https://orcid.org/0000-0002-8038-1952","observed_orcids":["https://orcid.org/0000-0002-8038-1952"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor Pinto-Plata","raw_affiliation_strings":["Medicine, Brigham and Women's, Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Brigham and Women's, Harvard Medical School","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042518391","display_name":"Miguel J. Divo","orcid":"https://orcid.org/0000-0002-0770-7653","observed_orcids":["https://orcid.org/0000-0002-0770-7653"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miguel Divo","raw_affiliation_strings":["Medicine, Brigham and Women's, Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Brigham and Women's, Harvard Medical School","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020032238","display_name":"Mary E. Choi","orcid":"https://orcid.org/0000-0002-6853-336X","observed_orcids":["https://orcid.org/0000-0002-6853-336X"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Choi","raw_affiliation_strings":["Medicine, Weill Cornell University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Weill Cornell University","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090956629","display_name":"Lynette Marie Sholl","orcid":"https://orcid.org/0000-0002-9532-9735","observed_orcids":["https://orcid.org/0000-0002-9532-9735"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lynette Sholl","raw_affiliation_strings":["Pathology, Brigham and Women's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Brigham and Women's Hospital","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020012431","display_name":"Hans V. Petersen","orcid":"https://orcid.org/0000-0002-6703-9730","observed_orcids":["https://orcid.org/0000-0002-6703-9730"]},"institutions":[{"id":"https://openalex.org/I1305258596","display_name":"Lovelace Respiratory Research Institute","ror":"https://ror.org/038qbqz41","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1305258596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hans Petersen","raw_affiliation_strings":["COPD Group, Lovelace Respiratory Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"COPD Group, Lovelace Respiratory Research Institute","institution_ids":["https://openalex.org/I1305258596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052246328","display_name":"Yohannes Tesfaigzi","orcid":"https://orcid.org/0000-0002-3997-5839","observed_orcids":["https://orcid.org/0000-0002-3997-5839"]},"institutions":[{"id":"https://openalex.org/I1305258596","display_name":"Lovelace Respiratory Research Institute","ror":"https://ror.org/038qbqz41","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1305258596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yohannes Tesfaigzi","raw_affiliation_strings":["COPD Group, Lovelace Respiratory Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"COPD Group, Lovelace Respiratory Research Institute","institution_ids":["https://openalex.org/I1305258596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008555938","display_name":"Bartolom\u00e9 R. Celli","orcid":"https://orcid.org/0000-0002-7266-8371","observed_orcids":["https://orcid.org/0000-0002-7266-8371"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1305258596","display_name":"Lovelace Respiratory Research Institute","ror":"https://ror.org/038qbqz41","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1305258596"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bartolome Celli","raw_affiliation_strings":["COPD Group, Lovelace Respiratory Research Institute","Medicine, Brigham and Women's, Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"COPD Group, Lovelace Respiratory Research Institute","institution_ids":["https://openalex.org/I1305258596"]},{"raw_affiliation_string":"Medicine, Brigham and Women's, Harvard Medical School","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022680952","display_name":"Caroline Ann Owen","orcid":"https://orcid.org/0000-0003-4377-3591","observed_orcids":["https://orcid.org/0000-0003-4377-3591"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1305258596","display_name":"Lovelace Respiratory Research Institute","ror":"https://ror.org/038qbqz41","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1305258596"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caroline Owen","raw_affiliation_strings":["COPD Group, Lovelace Respiratory Research Institute","Medicine, Brigham and Women's, Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"COPD Group, Lovelace Respiratory Research Institute","institution_ids":["https://openalex.org/I1305258596"]},{"raw_affiliation_string":"Medicine, Brigham and Women's, Harvard Medical School","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA4016","last_page":"PA4016"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":1.0},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.9890000224113464},{"id":"https://openalex.org/keywords/microalbuminuria","display_name":"microalbuminuria","score":0.9150000214576721},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7580000162124634},{"id":"https://openalex.org/keywords/advanced-glycation-end-products","display_name":"advanced glycation end products","score":0.9919999837875366},{"id":"https://openalex.org/keywords/rage","display_name":"RAGE","score":0.871999979019165},{"id":"https://openalex.org/keywords/kidney-injury","display_name":"kidney injury","score":0.8270000219345093},{"id":"https://openalex.org/keywords/pulmonary-endothelial-cells","display_name":"pulmonary endothelial cells","score":0.6309999823570251},{"id":"https://openalex.org/keywords/cigarette-smoke","display_name":"cigarette smoke","score":0.5609999895095825},{"id":"https://openalex.org/keywords/glomerulosclerosis","display_name":"glomerulosclerosis","score":0.7300000190734863},{"id":"https://openalex.org/keywords/interstitial-fibrosis","display_name":"interstitial fibrosis","score":0.9269999861717224},{"id":"https://openalex.org/keywords/endothelial-cell-apoptosis","display_name":"endothelial cell apoptosis","score":0.8149999976158142},{"id":"https://openalex.org/keywords/lung-function-decline","display_name":"lung function decline","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8835921883583069},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7128655910491943},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.6856827139854431},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5326399803161621},{"id":"https://openalex.org/C2778857457","wikidata":"https://www.wikidata.org/wiki/Q153641","display_name":"Rage (emotion)","level":2,"score":0.5261449813842773},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5075656175613403},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5058967471122742},{"id":"https://openalex.org/C2776174234","wikidata":"https://www.wikidata.org/wiki/Q974792","display_name":"Albuminuria","level":3,"score":0.49811625480651855},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.4915054738521576},{"id":"https://openalex.org/C2779922275","wikidata":"https://www.wikidata.org/wiki/Q1129105","display_name":"Diabetic nephropathy","level":3,"score":0.4821869432926178},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.470418244600296},{"id":"https://openalex.org/C147990577","wikidata":"https://www.wikidata.org/wiki/Q25790","display_name":"Glycation","level":3,"score":0.4542078375816345},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4448770582675934},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.43191248178482056},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.061810076236724854},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2016.pa4016","doi":"https://doi.org/10.1183/13993003.congress-2016.pa4016","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2016.pa4016","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"3.3 Mechanisms of Lung Injury and Repair","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8799999952316284,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2587650424","https://openalex.org/W7161606689","https://openalex.org/W2591807816","https://openalex.org/W3029823206","https://openalex.org/W2793849010","https://openalex.org/W7105795456","https://openalex.org/W7119073759","https://openalex.org/W3097725463","https://openalex.org/W4416809721","https://openalex.org/W3082323218"],"abstract_inverted_index":{"Background:":[0],"About":[1],"25%":[2],"of":[3,13,118,152],"COPD":[4,26,65,156,184,212,241],"patients":[5,54,66,185,242],"have":[6,27,67],"microalbuminuria":[7],"(MAB;":[8],"which":[9,38,147],"is":[10,23,32],"a":[11],"marker":[12],"endothelial":[14,50],"dysfunction":[15],"[ED])":[16],"associated":[17],"with":[18,55,150,224,243],"increased":[19,35,145,179,191,227],"mortality,":[20],"but":[21],"it":[22],"unknown":[24],"whether":[25],"underlying":[28],"renal":[29,68,82,119,209],"lesions.":[30],"ED":[31,220],"linked":[33,232],"to":[34,79,102,233],"oxidative":[36,73,128,192,235],"stress":[37,129,193],"induces":[39],"advanced":[40],"end":[41],"glycation":[42],"products":[43],"(AGE)":[44],"and":[45,58,70,81,97,126,133,137,139,169,181,197,199,204,208,215,221,226],"their":[46],"receptor":[47],"(RAGE)":[48],"in":[49,53,76,84,93,195,206,238],"cells":[51],"(EC)":[52],"diabetes":[56],"mellitus":[57],"cardiovascular":[59],"diseases.":[60],"We":[61],"hypothesize":[62],"that:":[63],"1)":[64,115],"injury;":[69],"2)":[71,124],"the":[72,234],"stress-AGE-RAGE":[74,236],"axis":[75,237],"EC":[77,135],"contributes":[78],"pulmonary":[80,207],"injury":[83,120,223],"COPD.":[85],"Methods:":[86],"Urinary":[87],"albumin:creatinine":[88],"ratios":[89],"(UACRs)":[90],"were":[91],"measured":[92],"smoker":[94],"controls":[95],"(SC)":[96],"wild":[98],"type":[99],"mice":[100,177,188,217],"exposed":[101],"air":[103],"or":[104],"CS":[105],"for":[106,201],"1-6":[107],"months.":[108],"In":[109],"these":[110],"groups":[111],"we":[112],"also":[113,189],"examined:":[114],"ultrastructural":[116],"(evidence":[117],"using":[121],"electron":[122],"microscopy);":[123],"lung":[125,132,153],"kidney":[127,134,222],"levels;":[130],"3)":[131],"apoptosis":[136,205],"AGEs":[138],"RAGE":[140],"levels.":[141],"Results:":[142],"SC":[143],"had":[144,158,178,190],"UACRs":[146,180,228],"correlated":[148],"directly":[149],"rate":[151],"function":[154],"decline.":[155],"kidneys":[157,173],"greater":[159],"subcapsular":[160],"scarring,":[161],"glomerulo-sclerosis,":[162],"interstitial":[163],"fibrosis,":[164],"tubular":[165],"atrophy,":[166],"arterial":[167],"sclerosis,":[168],"mesangial":[170],"expansion":[171],"than":[172],"from":[174,247],"SC.":[175],"CS-exposed":[176,187,216],"shrunken":[182],"glomeruli.":[183],"and/or":[186],"levels":[194],"lungs":[196],"kidneys,":[198],"staining":[200],"AGES,":[202],"RAGE,":[203],"EC.":[210,239],"Conclusions:":[211],"patients,":[213],"SC,":[214],"develop":[218],"generalized":[219],"MAB":[225,244],"that":[229],"may":[230,245],"be":[231],"Thus,":[240],"benefit":[246],"therapies":[248],"targeting":[249],"ED.":[250]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2017-05-19T00:00:00"}