{"id":"https://openalex.org/W2613240297","doi":"https://doi.org/10.1200/jco.2014.32.15_suppl.10016","title":"The impact of initial cerebrospinal fluid (CSF) findings on outcome among patients with NCI standard (SR) and high-risk (HR) B-lymphoblastic leukemia (ALL): A report from the Children\u2019s Oncology Group (COG) Studies AALL0331 and AALL0232.","display_name":"The impact of initial cerebrospinal fluid (CSF) findings on outcome among patients with NCI standard (SR) and high-risk (HR) B-lymphoblastic leukemia (ALL): A report from the Children\u2019s Oncology Group (COG) Studies AALL0331 and AALL0232.","publication_year":2014,"publication_date":"2014-05-20","ids":{"openalex":"https://openalex.org/W2613240297","doi":"https://doi.org/10.1200/jco.2014.32.15_suppl.10016","mag":"2613240297"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2014.32.15_suppl.10016","doi":"https://doi.org/10.1200/jco.2014.32.15_suppl.10016","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2014.32.15_suppl.10016","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056916024","display_name":"Naomi Joan Winick","orcid":"https://orcid.org/0000-0002-6636-3870","observed_orcids":["https://orcid.org/0000-0002-6636-3870"]},"institutions":[{"id":"https://openalex.org/I1297463080","display_name":"Children's Medical Center","ror":"https://ror.org/02ndk3y82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1297463080"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naomi Joan Winick","raw_affiliation_strings":["The University of Texas Southwestern Medical Center;  Center for Cancer and Blood Disorders, Children's Medical Center Dallas, Dallas, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas Southwestern Medical Center;  Center for Cancer and Blood Disorders, Children's Medical Center Dallas, Dallas, TX","institution_ids":["https://openalex.org/I1297463080","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085010022","display_name":"Meenakshi Devidas","orcid":"https://orcid.org/0000-0002-1099-3478","observed_orcids":["https://orcid.org/0000-0002-1099-3478"]},"institutions":[{"id":"https://openalex.org/I4210134079","display_name":"Children's Oncology Group","ror":"https://ror.org/03yyg2352","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210134079"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meenakshi Devidas","raw_affiliation_strings":["Children's Oncology Group, Gainesville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Oncology Group, Gainesville, FL","institution_ids":["https://openalex.org/I4210134079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079420293","display_name":"Kelly W. Maloney","orcid":"https://orcid.org/0000-0002-3711-9529","observed_orcids":["https://orcid.org/0000-0002-3711-9529"]},"institutions":[{"id":"https://openalex.org/I4210096275","display_name":"Children's Hospital Colorado","ror":"https://ror.org/00mj9k629","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210096275"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly W. Maloney","raw_affiliation_strings":["Children's Hospital Colorado, Aurora, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Colorado, Aurora, CO","institution_ids":["https://openalex.org/I4210096275"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015357573","display_name":"Eric C. Larsen","orcid":"https://orcid.org/0000-0002-4783-5975","observed_orcids":["https://orcid.org/0000-0002-4783-5975"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric Larsen","raw_affiliation_strings":["Maine Children's Cancer Program, Scarborough, ME"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maine Children's Cancer Program, Scarborough, ME","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069008480","display_name":"Leonard A. Mattano","orcid":"https://orcid.org/0000-0002-8409-0589","observed_orcids":["https://orcid.org/0000-0002-8409-0589"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leonard A. Mattano","raw_affiliation_strings":["MSU/KCMS, Kalamazoo, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MSU/KCMS, Kalamazoo, MI","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109198501","display_name":"Michael J. Borowitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Borowitz","raw_affiliation_strings":["The Johns Hopkins University School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Johns Hopkins University School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074089943","display_name":"Andrew J. Carroll","orcid":"https://orcid.org/0000-0001-9844-730X","observed_orcids":["https://orcid.org/0000-0001-9844-730X"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J Carroll","raw_affiliation_strings":["The University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076362342","display_name":"Julie M. Gastier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie M Gastier-Foster","raw_affiliation_strings":["Nationwide Children's Hospital, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nationwide Children's Hospital, Columbus, OH","institution_ids":["https://openalex.org/I1314135232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110114990","display_name":"Nyla A. Heerema","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nyla A. Heerema","raw_affiliation_strings":["The Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061732223","display_name":"Cheryl L. Willman","orcid":"https://orcid.org/0000-0002-1524-2622","observed_orcids":["https://orcid.org/0000-0002-1524-2622"]},"institutions":[{"id":"https://openalex.org/I4390039284","display_name":"UNM Comprehensive Cancer Center","ror":"https://ror.org/05kx2e072","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I169521973","https://openalex.org/I4390039284"]}],"countries":["MX","US"],"is_corresponding":false,"raw_author_name":"Cheryl L. Willman","raw_affiliation_strings":["University of New Mexico Cancer Center, Albuquerque, NM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of New Mexico Cancer Center, Albuquerque, NM","institution_ids":["https://openalex.org/I4390039284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013754928","display_name":"Brent Lee Wood","orcid":"https://orcid.org/0000-0001-7414-3969","observed_orcids":["https://orcid.org/0000-0001-7414-3969"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brent L. Wood","raw_affiliation_strings":["University of Washington, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010840699","display_name":"Mignon L. Loh","orcid":"https://orcid.org/0000-0003-4099-4700","observed_orcids":["https://orcid.org/0000-0003-4099-4700"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mignon L. Loh","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024573751","display_name":"Elizabeth A. Raetz","orcid":"https://orcid.org/0000-0002-8547-1658","observed_orcids":["https://orcid.org/0000-0002-8547-1658"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth A. Raetz","raw_affiliation_strings":["University of Utah Huntsman Cancer Institute, Salt Lake City, UT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utah Huntsman Cancer Institute, Salt Lake City, UT","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023214494","display_name":"Stephen P. Hunger","orcid":"https://orcid.org/0000-0002-5492-3957","observed_orcids":["https://orcid.org/0000-0002-5492-3957"]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Hunger","raw_affiliation_strings":["University of Colorado Denver Health Science Center, Aurora, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Denver Health Science Center, Aurora, CO","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080485119","display_name":"William L. Carroll","orcid":"https://orcid.org/0000-0003-1550-4167","observed_orcids":["https://orcid.org/0000-0003-1550-4167"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William L. Carroll","raw_affiliation_strings":["NYU Cancer Institute, New York University Langone Medical Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NYU Cancer Institute, New York University Langone Medical Center, New York, NY","institution_ids":["https://openalex.org/I4210086933"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":16,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":"15_suppl","first_page":"10016","last_page":"10016"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12212","display_name":"CNS Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/b-cell-acute-lymphoblastic-leukemia","display_name":"B-cell acute lymphoblastic leukemia","score":0.8980000019073486},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.7749999761581421},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-findings","display_name":"cerebrospinal fluid findings","score":0.8539999723434448},{"id":"https://openalex.org/keywords/cns-leukemia","display_name":"CNS leukemia","score":0.675000011920929},{"id":"https://openalex.org/keywords/cns-relapse","display_name":"central nervous system relapse","score":0.7760000228881836},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8450000286102295},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.7160000205039978},{"id":"https://openalex.org/keywords/cranial-irradiation","display_name":"cranial irradiation","score":0.7390000224113464},{"id":"https://openalex.org/keywords/cns-directed-therapy","display_name":"CNS-directed therapy","score":0.6370000243186951},{"id":"https://openalex.org/keywords/event-free-survival","display_name":"event-free survival","score":0.7919999957084656},{"id":"https://openalex.org/keywords/pediatric-leukemia","display_name":"pediatric leukemia","score":0.4790000021457672},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9116485118865967},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7194929718971252},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6092065572738647},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.5893459916114807},{"id":"https://openalex.org/C2778488018","wikidata":"https://www.wikidata.org/wiki/Q42395","display_name":"White blood cell","level":2,"score":0.511699914932251},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.41998475790023804},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4178132712841034},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.4131825566291809},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.23403170704841614},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2014.32.15_suppl.10016","doi":"https://doi.org/10.1200/jco.2014.32.15_suppl.10016","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2014.32.15_suppl.10016","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.75,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2060257772","https://openalex.org/W2058773221","https://openalex.org/W2003001535","https://openalex.org/W2081363855","https://openalex.org/W3032178137","https://openalex.org/W3022272789","https://openalex.org/W2127866346","https://openalex.org/W2050449486","https://openalex.org/W4206599988","https://openalex.org/W2358105114"],"abstract_inverted_index":{"10016":[0],"Background:":[1],"To":[2],"determine":[3],"the":[4,52,141,179,186,219,241,255,271],"prognostic":[5],"significance":[6],"of":[7,10,23,125,181,185,188,198,204,221,236,240,243,257,262,273,278,368],"variable":[8],"numbers":[9],"white":[11],"cells":[12,17],"(WBC),":[13],"blasts":[14,68,77,99,110],"and/or":[15],"red":[16],"(RBC)":[18],"in":[19,218,226,254,264],"diagnostic":[20],"CSF":[21,34,56,182,189,274],"samples":[22],"ALL":[24],"patients,":[25],"COG":[26],"protocols,":[27],"AALL0331":[28],"(SR)/AALL0232":[29],"(HR)":[30],"incorporated":[31],"a":[32,215,248],"uniform":[33],"and":[35,157,169,173,208,251],"risk":[36,143],"group":[37],"classification":[38,53],"schema":[39],"for":[40,200,284],"all":[41],"newly":[42],"diagnosed":[43],"patients.":[44,210],"Methods:":[45],"Patients,":[46],"1-31":[47],"years,":[48],"were":[49],"enrolled":[50],"on":[51],"protocol,":[54],"AALL03B1.":[55],"status":[57,146],"was":[58],"designated":[59],"as:":[60],"CNS1-no":[61],"blasts;":[62],"CNS2a-":[63],"<":[64,70,101,177,334,364,395],"5":[65,74,84,96,107,307,311,315],"WBC":[66,75,85,90,97,108,117,170,190],"+":[67,69,76,78,86,98,100,109,111],"10":[71,80,102,113],"RBC/ml;":[72,81,103],"CNS2b-<":[73],">":[79,83,95,106,112],"CNS2c-":[82],"blasts,":[87,183],"with":[88,115,247,286],"excess":[89,116],"proportional":[91,119],"to":[92,120,140],"RBC;":[93,121],"CNS3a-":[94],"CNS3b":[104],"-":[105],"RBC/ml,":[114],"not":[118,148,223,269],"CNS3c-":[122],"clinical":[123],"signs":[124],"CNS":[126,237,258,279,294,296,301,384],"leukemia":[127],"(e.g.":[128],"cranial":[129,160],"nerve":[130],"deficits,":[131],"hypothalamic":[132],"disease).":[133],"Only":[134],"CNS1":[135],"patients":[136,153,229,267,285],"could":[137],"be":[138],"allocated":[139],"SR-low":[142],"arm.":[144],"CNS2":[145],"did":[147,268],"impact":[149,272],"therapy":[150,156,281],"but":[151],"CNS3":[152],"received":[154,206],"augmented":[155],"1800":[158],"cGY":[159],"radiation.":[161],"Results:":[162],"In":[163],"multivariate":[164],"analysis":[165],"that":[166],"includes":[167],"age":[168],"at":[171],"diagnosis":[172],"Day":[174],"29":[175],"MRD":[176],"0.1%,":[178],"presence":[180],"regardless":[184,239],"number":[187,242],"or":[191],"RBC":[192],"is":[193,282],"an":[194,252],"independent":[195],"adverse":[196],"predictor":[197],"outcome":[199],"NCI":[201,265,320,336,351],"SR":[202,266],"(all":[203],"whom":[205],"dexamethasone)":[207],"HR":[209],"The":[211,260],"EFS":[212,309,313,317],"difference":[213,217],"reflects":[214],"significant":[216],"incidence":[220],"CNS,":[222],"marrow":[224],"relapse":[225,370,385],"CNS1vs":[227],"CNS2/3":[228,287],"(see":[230],"Table).":[231],"Conclusion:":[232],"Even":[233],"low":[234],"levels":[235],"leukemia,":[238],"RBCs,":[244],"are":[245],"associated":[246],"lower":[249],"EFS/OS":[250],"increase":[253],"likelihood":[256],"relapse.":[259],"use":[261],"dexamethasone":[263],"negate":[270],"blasts.":[275],"Further":[276],"augmentation":[277],"directed":[280],"needed":[283],"disease.":[288],"Clinical":[289],"trial":[290],"information:":[291],"NCY00482352.":[292],"Cohort":[293],"1":[295],"2":[297],"a,":[298,303],"b,":[299,304],"c":[300,305],"3":[302],"p-value":[306],"yr":[308,312,316],"N":[310,314,318],"Overall":[319],"SR/HR":[321],"85.3":[322],"\u00b1":[323,327,331,339,343,347,354,361,372,376,380,387,390,393],".56%":[324],"7214":[325],"76":[326],"2%":[328],"836":[329],"75.7":[330],"5.2%":[332],"124":[333],"0.0001":[335,365,396],"SR-AALL0331":[337],"89.9%":[338],".59%":[340],"4721":[341],"85":[342],"2.3%":[344],"415":[345],"82":[346],"7.1%":[348],"52":[349],"0.0003":[350],"HR-AALL0232":[352],"76.5":[353],"1.2%":[355],"2493":[356],"67.1\u00b1":[357],"3%":[358],"421":[359],"70.5":[360],"7.2%":[362],"72":[363],"Cumulative":[366],"Incidence":[367],"Marrow":[369],"6.3":[371],".3%":[373],"7395":[374],"7.1":[375],".9%":[377],"857":[378],"9.3":[379],"2.9%":[381],"127":[382],"0.18":[383],"2.9":[386],".21%":[388],"7.8":[389],"1%":[391],"5.9":[392],"2.2%":[394]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}