{"id":"https://openalex.org/W2612901302","doi":"https://doi.org/10.1186/s13045-017-0470-7","title":"Current status and perspectives of patient-derived xenograft models in cancer research","display_name":"Current status and perspectives of patient-derived xenograft models in cancer research","publication_year":2017,"publication_date":"2017-05-12","ids":{"openalex":"https://openalex.org/W2612901302","doi":"https://doi.org/10.1186/s13045-017-0470-7","mag":"2612901302","pmid":"https://pubmed.ncbi.nlm.nih.gov/28499452","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5427553"},"language":"en","primary_location":{"id":"doi:10.1186/s13045-017-0470-7","doi":"https://doi.org/10.1186/s13045-017-0470-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13045-017-0470-7","pdf_url":"https://jhoonline.biomedcentral.com/track/pdf/10.1186/s13045-017-0470-7","source":{"id":"https://openalex.org/S46507181","display_name":"Journal of Hematology & Oncology","issn_l":"1756-8722","issn":["1756-8722"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hematology & Oncology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2612901302"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jhoonline.biomedcentral.com/track/pdf/10.1186/s13045-017-0470-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040491475","display_name":"Yunxin Lai","orcid":"https://orcid.org/0000-0003-3673-149X","observed_orcids":["https://orcid.org/0000-0003-3673-149X"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2802148028","display_name":"Guangzhou Institutes of Biomedicine and Health","ror":"https://ror.org/02c31t502","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2802148028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunxin Lai","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China","Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2802148028"]},{"raw_affiliation_string":"Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2802148028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112233597","display_name":"Xinru Wei","orcid":"https://orcid.org/0009-0004-5225-5504","observed_orcids":["https://orcid.org/0009-0004-5225-5504"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2802148028","display_name":"Guangzhou Institutes of Biomedicine and Health","ror":"https://ror.org/02c31t502","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2802148028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinru Wei","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China","Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2802148028"]},{"raw_affiliation_string":"Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2802148028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002255727","display_name":"Shouheng Lin","orcid":"https://orcid.org/0000-0002-6248-5926","observed_orcids":["https://orcid.org/0000-0002-6248-5926"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2802148028","display_name":"Guangzhou Institutes of Biomedicine and Health","ror":"https://ror.org/02c31t502","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2802148028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shouheng Lin","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China","Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2802148028"]},{"raw_affiliation_string":"Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2802148028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101441065","display_name":"Le Qin","orcid":"https://orcid.org/0000-0002-8244-8217","observed_orcids":["https://orcid.org/0000-0002-8244-8217"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2802148028","display_name":"Guangzhou Institutes of Biomedicine and Health","ror":"https://ror.org/02c31t502","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2802148028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Le Qin","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China","Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2802148028"]},{"raw_affiliation_string":"Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2802148028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101859218","display_name":"Lin Cheng","orcid":"https://orcid.org/0000-0001-7180-0388","observed_orcids":["https://orcid.org/0000-0001-7180-0388"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2802148028","display_name":"Guangzhou Institutes of Biomedicine and Health","ror":"https://ror.org/02c31t502","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2802148028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Cheng","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China","Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2802148028"]},{"raw_affiliation_string":"Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2802148028"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100432789","display_name":"Peng Li","orcid":"https://orcid.org/0000-0003-4530-2400","observed_orcids":["https://orcid.org/0000-0003-4530-2400"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2802148028","display_name":"Guangzhou Institutes of Biomedicine and Health","ror":"https://ror.org/02c31t502","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2802148028"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Peng Li","raw_affiliation_strings":["Department of Abdominal Surgery, Affiliated Cancer Hospital & Institute of Guangzhou Medical University of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, 510095, China. li_peng@gibh.ac.cn","Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China. li_peng@gibh.ac.cn","Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China. li_peng@gibh.ac.cn","Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Abdominal Surgery, Affiliated Cancer Hospital & Institute of Guangzhou Medical University of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, 510095, China. li_peng@gibh.ac.cn","institution_ids":["https://openalex.org/I92039509"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China. li_peng@gibh.ac.cn","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2802148028"]},{"raw_affiliation_string":"Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China. li_peng@gibh.ac.cn","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2802148028"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2802148028"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100432789"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2802148028","https://openalex.org/I92039509"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":4.1974,"has_fulltext":true,"cited_by_count":314,"citation_normalized_percentile":{"value":0.97037915,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"10","issue":"1","first_page":"106","last_page":"106"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.8920000195503235},{"id":"https://openalex.org/keywords/patient-derived-orthotopic-xenograft","display_name":"patient-derived orthotopic xenograft","score":0.902999997138977},{"id":"https://openalex.org/keywords/immunodeficient-mice","display_name":"immunodeficient mice","score":0.8629999756813049},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6959999799728394},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9950000047683716},{"id":"https://openalex.org/keywords/anticancer-drug-screening","display_name":"anticancer drug screening","score":0.718999981880188},{"id":"https://openalex.org/keywords/preclinical-cancer-research","display_name":"preclinical cancer research","score":0.7480000257492065},{"id":"https://openalex.org/keywords/tumor-initiation","display_name":"tumor initiation","score":0.3149999976158142}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6988334655761719},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6445002555847168},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.5777140855789185},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5621234178543091},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5157015919685364},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4830965995788574},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4627869427204132},{"id":"https://openalex.org/C2993043200","wikidata":"https://www.wikidata.org/wiki/Q7239206","display_name":"Preclinical research","level":2,"score":0.45770904421806335},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4404159188270569},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.42844754457473755},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.41051971912384033},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36337482929229736},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.293997585773468},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1713070273399353},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.11903589963912964}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D016042","descriptor_name":"Transplantation, Heterotopic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016688","descriptor_name":"Mice, Inbred NOD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018183","descriptor_name":"Transplantation Chimera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018941","descriptor_name":"Antigens, CD19","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s13045-017-0470-7","doi":"https://doi.org/10.1186/s13045-017-0470-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13045-017-0470-7","pdf_url":"https://jhoonline.biomedcentral.com/track/pdf/10.1186/s13045-017-0470-7","source":{"id":"https://openalex.org/S46507181","display_name":"Journal of Hematology & Oncology","issn_l":"1756-8722","issn":["1756-8722"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hematology & Oncology","raw_type":"journal-article"},{"id":"pmid:28499452","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28499452","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of hematology & oncology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5427553","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5427553/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Hematol Oncol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:9b185c927e9148a18af17812b891acdb","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9b185c927e9148a18af17812b891acdb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-14 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13045-017-0470-7","doi":"https://doi.org/10.1186/s13045-017-0470-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13045-017-0470-7","pdf_url":"https://jhoonline.biomedcentral.com/track/pdf/10.1186/s13045-017-0470-7","source":{"id":"https://openalex.org/S46507181","display_name":"Journal of Hematology & Oncology","issn_l":"1756-8722","issn":["1756-8722"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hematology & Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1426026581","display_name":null,"funder_award_id":"2016B030229006","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3120228992","display_name":null,"funder_award_id":"81522002","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6184089725","display_name":null,"funder_award_id":"XDB19030205","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G7362019066","display_name":null,"funder_award_id":"2014B020225005","funder_id":"https://openalex.org/F4320324202","funder_display_name":"Guangdong Science and Technology Department"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320324202","display_name":"Guangdong Science and Technology Department","ror":"https://ror.org/00tjzgn92"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2612901302.pdf","grobid_xml":"https://content.openalex.org/works/W2612901302.grobid-xml"},"referenced_works_count":171,"referenced_works":["https://openalex.org/W249545773","https://openalex.org/W347202097","https://openalex.org/W1173391493","https://openalex.org/W1505154631","https://openalex.org/W1505421350","https://openalex.org/W1531424639","https://openalex.org/W1541739901","https://openalex.org/W1547880281","https://openalex.org/W1569875761","https://openalex.org/W1576745000","https://openalex.org/W1587362156","https://openalex.org/W1596453879","https://openalex.org/W1602965390","https://openalex.org/W1603797292","https://openalex.org/W1619537825","https://openalex.org/W1753684754","https://openalex.org/W1784889530","https://openalex.org/W1792291729","https://openalex.org/W1823100676","https://openalex.org/W1834626755","https://openalex.org/W1835915349","https://openalex.org/W1836607032","https://openalex.org/W1854239124","https://openalex.org/W1913709492","https://openalex.org/W1939861246","https://openalex.org/W1952112347","https://openalex.org/W1952297410","https://openalex.org/W1962994287","https://openalex.org/W1969705513","https://openalex.org/W1972265973","https://openalex.org/W1972953754","https://openalex.org/W1975570973","https://openalex.org/W1976023782","https://openalex.org/W1981421409","https://openalex.org/W1983384475","https://openalex.org/W1986380308","https://openalex.org/W1992252639","https://openalex.org/W1995093204","https://openalex.org/W1998238577","https://openalex.org/W2000302922","https://openalex.org/W2001544973","https://openalex.org/W2004142027","https://openalex.org/W2006077720","https://openalex.org/W2009282514","https://openalex.org/W2010023860","https://openalex.org/W2012987872","https://openalex.org/W2014881369","https://openalex.org/W2017236031","https://openalex.org/W2018288777","https://openalex.org/W2020579083","https://openalex.org/W2021525020","https://openalex.org/W2022899908","https://openalex.org/W2024253911","https://openalex.org/W2024446294","https://openalex.org/W2025835234","https://openalex.org/W2029345191","https://openalex.org/W2034148273","https://openalex.org/W2037225246","https://openalex.org/W2037830708","https://openalex.org/W2038626045","https://openalex.org/W2044098649","https://openalex.org/W2045750272","https://openalex.org/W2049225010","https://openalex.org/W2049541774","https://openalex.org/W2052975116","https://openalex.org/W2057706355","https://openalex.org/W2058761715","https://openalex.org/W2059542621","https://openalex.org/W2061271065","https://openalex.org/W2066417528","https://openalex.org/W2067482979","https://openalex.org/W2068812984","https://openalex.org/W2073827381","https://openalex.org/W2080686146","https://openalex.org/W2081410358","https://openalex.org/W2082015682","https://openalex.org/W2083590898","https://openalex.org/W2087734794","https://openalex.org/W2088020377","https://openalex.org/W2093221289","https://openalex.org/W2094383506","https://openalex.org/W2096088010","https://openalex.org/W2102339709","https://openalex.org/W2103276552","https://openalex.org/W2103875073","https://openalex.org/W2106545303","https://openalex.org/W2116069435","https://openalex.org/W2118238803","https://openalex.org/W2119504728","https://openalex.org/W2122624950","https://openalex.org/W2123395438","https://openalex.org/W2126185716","https://openalex.org/W2126404583","https://openalex.org/W2135031820","https://openalex.org/W2135523574","https://openalex.org/W2137906256","https://openalex.org/W2137969630","https://openalex.org/W2145254159","https://openalex.org/W2146041593","https://openalex.org/W2149576348","https://openalex.org/W2150701651","https://openalex.org/W2153869482","https://openalex.org/W2155206211","https://openalex.org/W2156739666","https://openalex.org/W2158155247","https://openalex.org/W2161419307","https://openalex.org/W2162997635","https://openalex.org/W2164723344","https://openalex.org/W2165593729","https://openalex.org/W2169876627","https://openalex.org/W2172077519","https://openalex.org/W2207864075","https://openalex.org/W2217340753","https://openalex.org/W2254902182","https://openalex.org/W2257452128","https://openalex.org/W2259127997","https://openalex.org/W2262334224","https://openalex.org/W2271606669","https://openalex.org/W2282550179","https://openalex.org/W2286013914","https://openalex.org/W2291650052","https://openalex.org/W2298244478","https://openalex.org/W2299045691","https://openalex.org/W2306887830","https://openalex.org/W2311921258","https://openalex.org/W2314906371","https://openalex.org/W2320523858","https://openalex.org/W2320548571","https://openalex.org/W2334045973","https://openalex.org/W2339384409","https://openalex.org/W2340559906","https://openalex.org/W2395507246","https://openalex.org/W2396853932","https://openalex.org/W2400940566","https://openalex.org/W2403462736","https://openalex.org/W2418418689","https://openalex.org/W2419598620","https://openalex.org/W2425507331","https://openalex.org/W2426328976","https://openalex.org/W2465973558","https://openalex.org/W2468923062","https://openalex.org/W2473878031","https://openalex.org/W2495603617","https://openalex.org/W2506418499","https://openalex.org/W2510824538","https://openalex.org/W2513249090","https://openalex.org/W2516251801","https://openalex.org/W2518696212","https://openalex.org/W2520159331","https://openalex.org/W2521186123","https://openalex.org/W2522225554","https://openalex.org/W2524803430","https://openalex.org/W2524917460","https://openalex.org/W2534121389","https://openalex.org/W2549681699","https://openalex.org/W2550296259","https://openalex.org/W2557535757","https://openalex.org/W2559934670","https://openalex.org/W2560396365","https://openalex.org/W2562451460","https://openalex.org/W2566871225","https://openalex.org/W2570331434","https://openalex.org/W2570618306","https://openalex.org/W2571353014","https://openalex.org/W2574695762","https://openalex.org/W2583745495","https://openalex.org/W2588450835","https://openalex.org/W2588648082","https://openalex.org/W2589235955","https://openalex.org/W2589417329","https://openalex.org/W7214153157"],"related_works":["https://openalex.org/W4406595472","https://openalex.org/W3043818142","https://openalex.org/W4386530063","https://openalex.org/W4365148379","https://openalex.org/W6960174424","https://openalex.org/W2725526255","https://openalex.org/W4395698892","https://openalex.org/W2754871120","https://openalex.org/W4406160656","https://openalex.org/W4410718684"],"abstract_inverted_index":{"Cancers":[0],"remain":[1],"a":[2],"major":[3],"public":[4],"health":[5],"problem":[6],"worldwide,":[7],"which":[8,47],"still":[9],"require":[10],"profound":[11],"research":[12,105],"in":[13,45,52,102,119],"both":[14],"the":[15,62,85,107,135],"basic":[16,103],"and":[17,67,91,97,115,118,126,129],"preclinical":[18,120],"fields.":[19],"Patient-derived":[20],"xenograft":[21,76],"(PDX)":[22],"models":[23,90,101],"are":[24,35],"created":[25],"when":[26],"cancerous":[27],"cells":[28],"or":[29],"tissues":[30],"from":[31],"patients'":[32],"primary":[33],"tumors":[34],"implanted":[36],"into":[37],"immunodeficient":[38],"mice":[39],"to":[40,60,87],"simulate":[41],"human":[42],"tumor":[43,116],"biology":[44],"vivo,":[46],"have":[48],"been":[49,70],"extensively":[50],"used":[51],"cancer":[53,104,110],"research.":[54],"The":[55],"routes":[56],"of":[57,64,73,99,109,122,138],"implantation":[58],"appeared":[59],"affect":[61],"outcome":[63],"PDX":[65,89,100,139],"research,":[66],"there":[68],"has":[69],"increasing":[71],"applications":[72],"patient-derived":[74],"orthotopic":[75],"(PDOX)":[77],"models.":[78,140],"In":[79],"this":[80],"review,":[81],"we":[82],"firstly":[83],"summarize":[84],"methodology":[86],"establish":[88],"then":[92],"go":[93],"over":[94],"recent":[95],"application":[96],"function":[98],"on":[106,134],"areas":[108],"characterization,":[111],"initiation,":[112],"proliferation,":[113],"metastasis,":[114],"microenvironment":[117],"explorations":[121],"anti-cancer":[123],"targets,":[124],"drugs,":[125],"therapeutic":[127],"strategies":[128],"finally":[130],"give":[131],"our":[132],"perspectives":[133],"future":[136],"prospects":[137]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":21},{"year":2024,"cited_by_count":39},{"year":2023,"cited_by_count":30},{"year":2022,"cited_by_count":43},{"year":2021,"cited_by_count":35},{"year":2020,"cited_by_count":43},{"year":2019,"cited_by_count":50},{"year":2018,"cited_by_count":32},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2017-05-19T00:00:00"}