{"id":"https://openalex.org/W2612899199","doi":null,"title":"Elucidation of UNC-51-like kinase signaling pathways.","display_name":"Elucidation of UNC-51-like kinase signaling pathways.","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2612899199","mag":"2612899199"},"language":"en","primary_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/126092","doi":null,"is_oa":false,"landing_page_url":"https://deepblue.lib.umich.edu/bitstreams/092327bc-232b-4062-b1f4-a3a6e32b107d/download","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052356535","display_name":"Adam W. Avery","orcid":"https://orcid.org/0000-0001-8085-1822","observed_orcids":["https://orcid.org/0000-0001-8085-1822"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Adam W. Avery","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8085-1822","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5052356535"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.5903000235557556,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.5903000235557556,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.13570000231266022,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.02759999968111515,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serine-threonine-kinase","display_name":"serine/threonine kinase","score":0.8019999861717224},{"id":"https://openalex.org/keywords/c-terminal-domain","display_name":"C-terminal domain","score":0.875},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8999999761581421},{"id":"https://openalex.org/keywords/frs2","display_name":"FRS2","score":0.8960000276565552},{"id":"https://openalex.org/keywords/fibroblast-growth-factor-receptor","display_name":"fibroblast growth factor receptor","score":0.8939999938011169},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinase-signaling","display_name":"receptor tyrosine kinase signaling","score":0.921999990940094},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.8349999785423279},{"id":"https://openalex.org/keywords/raf","display_name":"Raf","score":0.628000020980835},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.8209999799728394},{"id":"https://openalex.org/keywords/rab11b","display_name":"Rab11b","score":0.8880000114440918},{"id":"https://openalex.org/keywords/protein-phosphatase-5","display_name":"protein phosphatase 5","score":0.9330000281333923},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.7860000133514404},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.9559999704360962}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46351587772369385},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4355594217777252},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35267627239227295},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3314237594604492}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/126092","doi":null,"is_oa":false,"landing_page_url":"https://deepblue.lib.umich.edu/bitstreams/092327bc-232b-4062-b1f4-a3a6e32b107d/download","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2612899199","doi":null,"is_oa":false,"landing_page_url":"https://deepblue.lib.umich.edu/handle/2027.42/126092","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2093366207","https://openalex.org/W2063650770","https://openalex.org/W2036901614","https://openalex.org/W4386241839","https://openalex.org/W2341169824","https://openalex.org/W3097281467","https://openalex.org/W7011361545","https://openalex.org/W2983061896","https://openalex.org/W2155472936","https://openalex.org/W2110586413"],"abstract_inverted_index":{"Caenorhabditis":[0],"elegans":[1],"UNC-51":[2,18,49,84,142],"and":[3,19,45,50,71,85,158,177,185,245],"mammalian":[4,182],"UNC-51-like":[5],"kinase":[6,64,239],"(ULK)":[7],"1/2":[8],"represent":[9],"an":[10,62,67],"evolutionarily":[11],"conserved":[12],"family":[13],"of":[14,32,83,102,120,141,150,161,195,206,220,253,273],"serine/threonine-specific":[15,237],"protein":[16,173,234,238,266],"kinases:":[17],"ULK1/2":[20,33,41,51,86,103],"have":[21,42,52],"been":[22,132],"shown":[23],"to":[24,112,134,209,262],"regulate":[25,211,264],"neuronal":[26],"differentiation.":[27],"However,":[28],"the":[29,99,117,123,138,159,164,186,236,271],"expression":[30],"pattern":[31],"in":[34,93,148,181,250],"adult":[35],"mice":[36],"is":[37,87,208,230],"ubiquitous,":[38],"suggesting":[39,227],"that":[40,80,192,203,228,243,279],"both":[43],"neural":[44],"non-neural":[46],"regulatory":[47],"roles.":[48],"a":[53,72,108,204,231,274],"characteristic":[54],"domain":[55,82,119,140,155],"structure":[56],"defined":[57],"by":[58],"primary":[59],"sequence":[60],"homology:":[61],"amino-terminal":[63],"catalytic":[65],"domain,":[66],"intermediate":[68],"proline/serine-rich":[69],"region":[70],"carboxy-terminal":[73,81,118,139,154],"domain.":[74],"Evidence":[75],"including":[76],"evolutionary":[77],"conservation":[78],"suggests":[79],"functionally":[88,248],"important.":[89],"The":[90,145],"work":[91,269],"presented":[92],"this":[94,125],"dissertation":[95],"sheds":[96],"light":[97],"on":[98],"molecular":[100],"mechanism":[101],"signal":[104],"transduction.":[105],"We":[106,201,241],"performed":[107],"yeast":[109],"two-hybrid":[110],"screen":[111,126,146],"identify":[113],"interacting":[114,156,233],"proteins":[115,130,191],"for":[116,235],"ULK2.":[121],"At":[122],"time":[124],"was":[127,179],"performed,":[128],"no":[129],"had":[131],"reported":[133],"specifically":[135],"interact":[136],"with":[137,163],"or":[143],"ULK1/2.":[144],"resulted":[147],"identification":[149],"eleven":[151],"unique":[152],"ULK2":[153,162,207,229,246,265],"proteins,":[157],"interaction":[160],"isolates":[165],"fibroblast":[166,212],"growth":[167,213],"factor":[168,214],"receptor":[169,198,215],"substrate":[170],"2":[171],"(FRS2),":[172],"phosphatase":[174],"5":[175],"(PP5)":[176],"Rab11b":[178],"confirmed":[180],"cells.":[183],"FRS2,":[184],"homolog":[187],"FRS3,":[188],"are":[189,247],"adaptor":[190],"mediate":[193],"signaling":[194,277],"multiple":[196],"different":[197],"tyrosine":[199],"kinases.":[200],"demonstrate":[202,242],"function":[205,261],"negatively":[210],"(FGFR)":[216],"mediated":[217,255,282],"tyrosyl":[218,257],"phosphorylation":[219],"FRS2/3.":[221],"In":[222],"addition":[223],"we":[224],"present":[225],"data":[226],"novel":[232,275],"Raf.":[240],"Raf":[244,259],"linked":[249],"negative":[251],"regulation":[252],"FGFR":[254,281],"FRS3":[256],"phosphorylation.":[258,284],"may":[260],"positively":[263],"stability.":[267],"This":[268],"supports":[270],"existence":[272],"Raf/ULK":[276],"pathway":[278],"regulates":[280],"FRS2/3":[283]},"counts_by_year":[],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2017-05-19T00:00:00"}
