{"id":"https://openalex.org/W2612837282","doi":null,"title":"Cross-sectional analysis of cortical thickness across the lifespan","display_name":"Cross-sectional analysis of cortical thickness across the lifespan","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2612837282","mag":"2612837282"},"language":"en","primary_location":{"id":"pmh:oai:digitalrepository.trincoll.edu:theses-1666","doi":null,"is_oa":true,"landing_page_url":"https://digitalrepository.trincoll.edu/theses/651","pdf_url":"https://digitalrepository.trincoll.edu/theses/651","source":{"id":"https://openalex.org/S4306402599","display_name":"Trinity College Digital Repository (Trinity College, Hartford CT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I56722557","host_organization_name":"Trinity College","host_organization_lineage":["https://openalex.org/I56722557"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Senior Theses and Projects","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalrepository.trincoll.edu/theses/651","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045383606","display_name":"Thomas J Hum-Hyder","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Thomas J Hum-Hyder","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5045383606"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cortical-thickness","display_name":"cortical thickness","score":0.9990000128746033},{"id":"https://openalex.org/keywords/brain-aging","display_name":"brain aging","score":0.9240000247955322},{"id":"https://openalex.org/keywords/lifespan","display_name":"lifespan","score":0.49000000953674316},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.8500000238418579},{"id":"https://openalex.org/keywords/age-effects","display_name":"age effects","score":0.5619999766349792},{"id":"https://openalex.org/keywords/sensorimotor-cortex","display_name":"sensorimotor cortex","score":0.859000027179718},{"id":"https://openalex.org/keywords/parietal-lobe","display_name":"parietal lobe","score":0.9940000176429749},{"id":"https://openalex.org/keywords/frontal-lobe","display_name":"frontal lobe","score":1.0},{"id":"https://openalex.org/keywords/cingulate-gyrus","display_name":"cingulate gyrus","score":0.996999979019165},{"id":"https://openalex.org/keywords/alzheimer-s-dementia","display_name":"Alzheimer's dementia","score":0.6859999895095825},{"id":"https://openalex.org/keywords/vascular-dementia","display_name":"vascular dementia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/accelerated-aging","display_name":"accelerated aging","score":0.6850000023841858},{"id":"https://openalex.org/keywords/human-connectome-project","display_name":"Human Connectome Project","score":0.7929999828338623},{"id":"https://openalex.org/keywords/mayo-clinic-study-of-aging","display_name":"Mayo Clinic Study of Aging","score":1.0}],"concepts":[{"id":"https://openalex.org/C142052008","wikidata":"https://www.wikidata.org/wiki/Q954027","display_name":"Cross-sectional study","level":2,"score":0.45240503549575806},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.19993731379508972},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.18621167540550232}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalrepository.trincoll.edu:theses-1666","doi":null,"is_oa":true,"landing_page_url":"https://digitalrepository.trincoll.edu/theses/651","pdf_url":"https://digitalrepository.trincoll.edu/theses/651","source":{"id":"https://openalex.org/S4306402599","display_name":"Trinity College Digital Repository (Trinity College, Hartford CT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I56722557","host_organization_name":"Trinity College","host_organization_lineage":["https://openalex.org/I56722557"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Senior Theses and Projects","raw_type":"text"},{"id":"mag:2612837282","doi":null,"is_oa":false,"landing_page_url":"http://digitalrepository.trincoll.edu/cgi/viewcontent.cgi?article=1666&context=theses","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalrepository.trincoll.edu:theses-1666","doi":null,"is_oa":true,"landing_page_url":"https://digitalrepository.trincoll.edu/theses/651","pdf_url":"https://digitalrepository.trincoll.edu/theses/651","source":{"id":"https://openalex.org/S4306402599","display_name":"Trinity College Digital Repository (Trinity College, Hartford CT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I56722557","host_organization_name":"Trinity College","host_organization_lineage":["https://openalex.org/I56722557"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Senior Theses and Projects","raw_type":"text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2612837282.pdf","grobid_xml":"https://content.openalex.org/works/W2612837282.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1257538669","https://openalex.org/W1958597028","https://openalex.org/W1965989845","https://openalex.org/W1966378897","https://openalex.org/W1975821649","https://openalex.org/W1983355263","https://openalex.org/W1992562869","https://openalex.org/W1997459925","https://openalex.org/W2004293194","https://openalex.org/W2004371621","https://openalex.org/W2018726584","https://openalex.org/W2019911531","https://openalex.org/W2020519533","https://openalex.org/W2020780341","https://openalex.org/W2022224852","https://openalex.org/W2033085283","https://openalex.org/W2035079822","https://openalex.org/W2036162736","https://openalex.org/W2039752037","https://openalex.org/W2039792380","https://openalex.org/W2042853608","https://openalex.org/W2045388585","https://openalex.org/W2045794894","https://openalex.org/W2045892248","https://openalex.org/W2049398775","https://openalex.org/W2052104903","https://openalex.org/W2056965030","https://openalex.org/W2057164916","https://openalex.org/W2060684078","https://openalex.org/W2061082762","https://openalex.org/W2065338300","https://openalex.org/W2078790263","https://openalex.org/W2079872795","https://openalex.org/W2091036612","https://openalex.org/W2096508529","https://openalex.org/W2102405898","https://openalex.org/W2110208125","https://openalex.org/W2117102945","https://openalex.org/W2118421222","https://openalex.org/W2124648012","https://openalex.org/W2127324977","https://openalex.org/W2134591652","https://openalex.org/W2138728868","https://openalex.org/W2151130155","https://openalex.org/W2162686834","https://openalex.org/W2167840686","https://openalex.org/W2309687825","https://openalex.org/W2319500822","https://openalex.org/W2460653397","https://openalex.org/W2499800833","https://openalex.org/W2569175784","https://openalex.org/W2580655159","https://openalex.org/W4233552088"],"related_works":["https://openalex.org/W4389376346","https://openalex.org/W2205275466","https://openalex.org/W4319224411","https://openalex.org/W2054104751","https://openalex.org/W2124648012","https://openalex.org/W2888567776","https://openalex.org/W7099556450","https://openalex.org/W2085892093","https://openalex.org/W2089788984","https://openalex.org/W2082939309"],"abstract_inverted_index":{"An":[0],"understanding":[1,15],"of":[2,61,86,92,105,109,139,151],"the":[3,8,16,57,70,75,82,96,125,135,147,157],"normal":[4],"aging":[5,23],"process":[6],"across":[7,95],"lifespan":[9],"is":[10,175],"important":[11],"for":[12,49],"gaining":[13],"an":[14],"pathophysiological":[17],"changes":[18],"that":[19,189],"occur":[20],"in":[21,102,131,156,171,182],"accelerated":[22],"diseases,":[24],"such":[25],"as":[26],"Alzheimer\u2019s":[27],"Disease":[28],"Dementia":[29,33],"(ADD)":[30],"and":[31,56,74,117],"Vascular":[32],"(VaD).":[34],"The":[35,63],"present":[36],"study":[37],"cross-sectionally":[38],"analyzed":[39],"cortical":[40],"thickness":[41],"values":[42],"derived":[43],"from":[44,69,81,134],"T1-weighted":[45],"magnetic":[46],"resonance":[47],"images":[48],"two":[50],"large":[51],"cohorts:":[52],"Human":[53,71,158],"Connectome":[54,72,159],"Project":[55,73],"Mayo":[58,83,136,148],"Clinic":[59,84,137,149],"Study":[60,85,138,150],"Aging.":[62,140],"897":[64],"participants":[65,77],"aged":[66,78],"between":[67,79,120],"22-36":[68],"801":[76],"52-92":[80],"Aging":[87,152],"created":[88],"a":[89,177,186],"robust":[90],"cohort":[91],"non-demented":[93],"individuals":[94,133,168],"lifespan.":[97],"We":[98],"found":[99],"age":[100,126,180],"effects":[101,127,145,165],"four":[103],"out":[104],"five":[106],"composite":[107],"regions":[108],"interest":[110],"(Sensorimotor":[111],"Cortex,":[112],"Parietal":[113],"Lobe,":[114,116],"Frontal":[115],"Cingulate":[118],"Gyrus)":[119],"both":[121],"cohorts.":[122],"As":[123],"expected,":[124],"were":[128,142],"more":[129],"significant":[130,163],"older":[132,167],"There":[141],"additionally":[143],"sex":[144,164],"within":[146,166],"cohort,":[153],"but":[154,169],"not":[155,170],"Project.":[160],"By":[161],"showing":[162],"younger":[172],"individuals,":[173],"there":[174,184],"likely":[176],"point":[178],"beyond":[179],"36":[181],"which":[183],"exists":[185],"transitional":[187],"period":[188],"sparks":[190],"future":[191],"sex-specific":[192],"decline.":[193]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-05-19T00:00:00"}
