{"id":"https://openalex.org/W2612522158","doi":"https://doi.org/10.1038/nrgastro.2017.51","title":"Non-conventional features of peripheral serotonin signalling \u2014 the gut and beyond","display_name":"Non-conventional features of peripheral serotonin signalling \u2014 the gut and beyond","publication_year":2017,"publication_date":"2017-05-10","ids":{"openalex":"https://openalex.org/W2612522158","doi":"https://doi.org/10.1038/nrgastro.2017.51","mag":"2612522158","pmid":"https://pubmed.ncbi.nlm.nih.gov/28487547","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5672796"},"language":"en","primary_location":{"id":"doi:10.1038/nrgastro.2017.51","doi":"https://doi.org/10.1038/nrgastro.2017.51","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrgastro.2017.51","pdf_url":null,"source":{"id":"https://openalex.org/S120397320","display_name":"Nature Reviews Gastroenterology & Hepatology","issn_l":"1759-5045","issn":["1759-5045","1759-5053"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Gastroenterology & Hepatology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5672796","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013788326","display_name":"Stephanie N. Spohn","orcid":"https://orcid.org/0000-0002-9667-9956","observed_orcids":["https://orcid.org/0000-0002-9667-9956"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie N. Spohn","raw_affiliation_strings":["Department of Internal Medicine, Division of Infectious Disease, 1518 Medical Science Research Building 1, 1150 W. Medical Center Drive, University of Michigan, Ann Arbor, Michigan, 48109, USA","Department of Neurological Sciences, D403A Given Building, University of Vermont, Vermont, 05405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Infectious Disease, 1518 Medical Science Research Building 1, 1150 W. Medical Center Drive, University of Michigan, Ann Arbor, Michigan, 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Neurological Sciences, D403A Given Building, University of Vermont, Vermont, 05405, USA","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085753911","display_name":"Gary M. Mawe","orcid":"https://orcid.org/0000-0001-8876-8468","observed_orcids":["https://orcid.org/0000-0001-8876-8468"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gary M. Mawe","raw_affiliation_strings":["Department of Neurological Sciences, D403A Given Building, University of Vermont, Vermont, 05405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Sciences, D403A Given Building, University of Vermont, Vermont, 05405, USA","institution_ids":["https://openalex.org/I111236770"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5085753911"],"corresponding_institution_ids":["https://openalex.org/I111236770"],"apc_list":null,"apc_paid":null,"fwci":3.2836,"has_fulltext":false,"cited_by_count":291,"citation_normalized_percentile":{"value":0.95416079,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"14","issue":"7","first_page":"412","last_page":"420"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.7250000238418579},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.7829999923706055},{"id":"https://openalex.org/keywords/enterochromaffin-cells","display_name":"enterochromaffin cells","score":0.9210000038146973},{"id":"https://openalex.org/keywords/serotonin-receptors","display_name":"serotonin receptors","score":0.625},{"id":"https://openalex.org/keywords/5-ht7-receptor","display_name":"5-HT7 receptor","score":0.9070000052452087},{"id":"https://openalex.org/keywords/5-ht4-receptor","display_name":"5-HT4 receptor","score":1.0},{"id":"https://openalex.org/keywords/gastrointestinal-inflammation","display_name":"gastrointestinal inflammation","score":0.800000011920929},{"id":"https://openalex.org/keywords/colitis","display_name":"colitis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/hematopoiesis","display_name":"hematopoiesis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/metabolic-homeostasis","display_name":"metabolic homeostasis","score":0.8659999966621399},{"id":"https://openalex.org/keywords/bone-remodeling","display_name":"bone remodeling","score":0.9449999928474426},{"id":"https://openalex.org/keywords/enteric-reflexes","display_name":"enteric reflexes","score":0.7149999737739563},{"id":"https://openalex.org/keywords/gut-brain-axis","display_name":"gut-brain axis","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C90423213","wikidata":"https://www.wikidata.org/wiki/Q568290","display_name":"Enterochromaffin cell","level":4,"score":0.9407230615615845},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.8446792364120483},{"id":"https://openalex.org/C53910766","wikidata":"https://www.wikidata.org/wiki/Q238516","display_name":"5-HT receptor","level":4,"score":0.6024677753448486},{"id":"https://openalex.org/C2780512811","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Gastrointestinal tract","level":2,"score":0.5159853100776672},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.48815256357192993},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48556849360466003},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.4657016396522522},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38540947437286377},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33185479044914246},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3026859164237976},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2414001226425171}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016723","descriptor_name":"Bone Remodeling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017615","descriptor_name":"Enteric Nervous System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1038/nrgastro.2017.51","doi":"https://doi.org/10.1038/nrgastro.2017.51","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrgastro.2017.51","pdf_url":null,"source":{"id":"https://openalex.org/S120397320","display_name":"Nature Reviews Gastroenterology & Hepatology","issn_l":"1759-5045","issn":["1759-5045","1759-5053"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Gastroenterology & Hepatology","raw_type":"journal-article"},{"id":"pmid:28487547","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28487547","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature reviews. Gastroenterology & hepatology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5672796","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5672796","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nat Rev Gastroenterol Hepatol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5672796","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5672796","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nat Rev Gastroenterol Hepatol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3294863796","display_name":"Neuronal Excitability and Motility in Colitis","funder_award_id":"R01DK062267","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":90,"referenced_works":["https://openalex.org/W1487053105","https://openalex.org/W1576727246","https://openalex.org/W1920498927","https://openalex.org/W1965734178","https://openalex.org/W1971641444","https://openalex.org/W1972167761","https://openalex.org/W1972348334","https://openalex.org/W1973660081","https://openalex.org/W1974684474","https://openalex.org/W1976476429","https://openalex.org/W1979264182","https://openalex.org/W1981316102","https://openalex.org/W1982898849","https://openalex.org/W1986767459","https://openalex.org/W1996234987","https://openalex.org/W1997066133","https://openalex.org/W1997608252","https://openalex.org/W1998807018","https://openalex.org/W2004399138","https://openalex.org/W2006501629","https://openalex.org/W2007225280","https://openalex.org/W2007824990","https://openalex.org/W2011985298","https://openalex.org/W2018930439","https://openalex.org/W2024321527","https://openalex.org/W2029614004","https://openalex.org/W2029963792","https://openalex.org/W2033253360","https://openalex.org/W2033386838","https://openalex.org/W2035663126","https://openalex.org/W2036062643","https://openalex.org/W2047554789","https://openalex.org/W2050608961","https://openalex.org/W2051567027","https://openalex.org/W2051692635","https://openalex.org/W2053893399","https://openalex.org/W2054502691","https://openalex.org/W2055466946","https://openalex.org/W2061085865","https://openalex.org/W2064975938","https://openalex.org/W2073052871","https://openalex.org/W2074331062","https://openalex.org/W2082422505","https://openalex.org/W2085139899","https://openalex.org/W2086694435","https://openalex.org/W2087566569","https://openalex.org/W2088684629","https://openalex.org/W2093666272","https://openalex.org/W2099872645","https://openalex.org/W2106848510","https://openalex.org/W2107044225","https://openalex.org/W2107215516","https://openalex.org/W2108400677","https://openalex.org/W2108730634","https://openalex.org/W2110109947","https://openalex.org/W2113571486","https://openalex.org/W2114589447","https://openalex.org/W2114627400","https://openalex.org/W2119011821","https://openalex.org/W2119413986","https://openalex.org/W2123649103","https://openalex.org/W2135190897","https://openalex.org/W2135444798","https://openalex.org/W2136232392","https://openalex.org/W2138071306","https://openalex.org/W2138897311","https://openalex.org/W2140544512","https://openalex.org/W2145135755","https://openalex.org/W2155285827","https://openalex.org/W2155948158","https://openalex.org/W2156244933","https://openalex.org/W2162816738","https://openalex.org/W2162851453","https://openalex.org/W2168678503","https://openalex.org/W2171519074","https://openalex.org/W2215050524","https://openalex.org/W2282011912","https://openalex.org/W2287682542","https://openalex.org/W2288494735","https://openalex.org/W2310558151","https://openalex.org/W2328714619","https://openalex.org/W2343547480","https://openalex.org/W2395731002","https://openalex.org/W2419417676","https://openalex.org/W2460164747","https://openalex.org/W2465288450","https://openalex.org/W2485997503","https://openalex.org/W2552097201","https://openalex.org/W3144964960","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2808227016","https://openalex.org/W4214504529","https://openalex.org/W2611159081","https://openalex.org/W2976395376","https://openalex.org/W2904584572","https://openalex.org/W7043257279","https://openalex.org/W3032722136","https://openalex.org/W4283593836","https://openalex.org/W3160558990","https://openalex.org/W2085139899"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":22},{"year":2025,"cited_by_count":27},{"year":2024,"cited_by_count":56},{"year":2023,"cited_by_count":31},{"year":2022,"cited_by_count":33},{"year":2021,"cited_by_count":36},{"year":2020,"cited_by_count":28},{"year":2019,"cited_by_count":26},{"year":2018,"cited_by_count":26},{"year":2017,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-05-19T00:00:00"}