{"id":"https://openalex.org/W2612370158","doi":"https://doi.org/10.1016/j.chest.2017.05.004","title":"Decreased Serum Sirtuin-1 in COPD","display_name":"Decreased Serum Sirtuin-1 in COPD","publication_year":2017,"publication_date":"2017-05-12","ids":{"openalex":"https://openalex.org/W2612370158","doi":"https://doi.org/10.1016/j.chest.2017.05.004","mag":"2612370158","pmid":"https://pubmed.ncbi.nlm.nih.gov/28506610","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5540026"},"language":"en","primary_location":{"id":"doi:10.1016/j.chest.2017.05.004","doi":"https://doi.org/10.1016/j.chest.2017.05.004","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chest.2017.05.004","pdf_url":"http://journal.chestnet.org/article/S0012369217309212/pdf","source":{"id":"https://openalex.org/S76900504","display_name":"CHEST Journal","issn_l":"0012-3692","issn":["0012-3692","1931-3543"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chest","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://journal.chestnet.org/article/S0012369217309212/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050592181","display_name":"Satoru Yanagisawa","orcid":"https://orcid.org/0000-0003-3895-5518","observed_orcids":["https://orcid.org/0000-0003-3895-5518"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Satoru Yanagisawa","raw_affiliation_strings":["Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, England","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010301737","display_name":"Andriana \u0399. Papaioannou","orcid":"https://orcid.org/0000-0001-9708-3241","observed_orcids":["https://orcid.org/0000-0001-9708-3241"]},"institutions":[{"id":"https://openalex.org/I2800888565","display_name":"Sismanoglio General Hospital","ror":"https://ror.org/057cm0m66","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I2800888565"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Andriana I. Papaioannou","raw_affiliation_strings":["Third Respiratory Medicine Department, Sismanogleion General Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Respiratory Medicine Department, Sismanogleion General Hospital, Athens, Greece","institution_ids":["https://openalex.org/I2800888565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029339474","display_name":"Anastasia Papaporfyriou","orcid":"https://orcid.org/0000-0002-5479-4649","observed_orcids":["https://orcid.org/0000-0002-5479-4649"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210166756","display_name":"Sotiria General Hospital","ror":"https://ror.org/05gbdc474","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210166756"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Anastasia Papaporfyriou","raw_affiliation_strings":["First Respiratory Medicine Department, University of Athens, Sotiria Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Respiratory Medicine Department, University of Athens, Sotiria Hospital, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210166756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113917249","display_name":"Jonathan R. Baker","orcid":"https://orcid.org/0000-0002-9694-8001","observed_orcids":["https://orcid.org/0000-0002-9694-8001"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jonathan R. Baker","raw_affiliation_strings":["Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, England","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084578388","display_name":"Chaitanya Vuppusetty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Chaitanya Vuppusetty","raw_affiliation_strings":["Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, England","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057623122","display_name":"Stelios Loukides","orcid":"https://orcid.org/0000-0002-4278-9922","observed_orcids":["https://orcid.org/0000-0002-4278-9922"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Stelios Loukides","raw_affiliation_strings":["Division of Respiratory Diseases I, National and Kapodistrian University of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Respiratory Diseases I, National and Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030258071","display_name":"Peter John Barnes","orcid":"https://orcid.org/0000-0002-5122-4018","observed_orcids":["https://orcid.org/0000-0002-5122-4018","https://orcid.org/0000-0002-6815-1564"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Peter J. Barnes","raw_affiliation_strings":["Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, England","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040751152","display_name":"Kazuhiro Ito","orcid":"https://orcid.org/0000-0001-9320-2717","observed_orcids":["https://orcid.org/0000-0001-9320-2717"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Kazuhiro Ito","raw_affiliation_strings":["Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, England. Electronic address: k.ito@imperial.ac.uk","Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, England. Electronic address: k.ito@imperial.ac.uk","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, England","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5040751152"],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":{"value":4160,"currency":"USD","value_usd":4160},"apc_paid":{"value":3462,"currency":"EUR","value_usd":3733},"fwci":7.3218,"has_fulltext":true,"cited_by_count":66,"citation_normalized_percentile":{"value":0.97479468,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"152","issue":"2","first_page":"343","last_page":"352"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.6362000107765198,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.6362000107765198,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.357699990272522,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirt1","display_name":"SIRT1","score":0.9309999942779541},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9539999961853027},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.9459999799728394},{"id":"https://openalex.org/keywords/protein-deacetylase","display_name":"protein deacetylase","score":0.8259999752044678},{"id":"https://openalex.org/keywords/emphysema","display_name":"emphysema","score":0.8109999895095825},{"id":"https://openalex.org/keywords/acute-exacerbation-of-copd","display_name":"COPD exacerbations","score":0.9010000228881836},{"id":"https://openalex.org/keywords/airway-obstruction","display_name":"airway obstruction","score":0.8420000076293945},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8420000076293945},{"id":"https://openalex.org/keywords/lung-function","display_name":"lung function","score":0.4819999933242798},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.5920000076293945},{"id":"https://openalex.org/keywords/diffusing-capacity-for-carbon-monoxide","display_name":"diffusing capacity for carbon monoxide","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.8835047483444214},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.7298105955123901},{"id":"https://openalex.org/C2780561631","wikidata":"https://www.wikidata.org/wiki/Q421331","display_name":"Sirtuin","level":4,"score":0.6149778962135315},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5789589881896973},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5754382014274597},{"id":"https://openalex.org/C2776536020","wikidata":"https://www.wikidata.org/wiki/Q21113719","display_name":"Sirtuin 1","level":4,"score":0.5619480609893799},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5420907139778137},{"id":"https://openalex.org/C165637977","wikidata":"https://www.wikidata.org/wiki/Q11067835","display_name":"Diffusing capacity","level":4,"score":0.5270932912826538},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.49126309156417847},{"id":"https://openalex.org/C27101514","wikidata":"https://www.wikidata.org/wiki/Q206120","display_name":"Lung volumes","level":3,"score":0.415653795003891},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4134158790111542},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4085841476917267},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38382488489151},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3414439857006073},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2762207090854645},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14157703518867493},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.11718717217445374},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0717674195766449},{"id":"https://openalex.org/C3018587741","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung function","level":3,"score":0.06888774037361145},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005541","descriptor_name":"Forced Expiratory Volume","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014797","descriptor_name":"Vital Capacity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D056564","descriptor_name":"Sirtuin 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.chest.2017.05.004","doi":"https://doi.org/10.1016/j.chest.2017.05.004","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chest.2017.05.004","pdf_url":"http://journal.chestnet.org/article/S0012369217309212/pdf","source":{"id":"https://openalex.org/S76900504","display_name":"CHEST Journal","issn_l":"0012-3692","issn":["0012-3692","1931-3543"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chest","raw_type":"journal-article"},{"id":"pmid:28506610","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28506610","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chest","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5540026","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5540026/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chest","raw_type":"Text"},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/48398","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10044/1/48398","pdf_url":null,"source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"352","raw_type":"Journal Article"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:1a8e44d9-8176-4a8d-a4c8-80f1fcf4fefd","doi":null,"is_oa":true,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:1a8e44d9-8176-4a8d-a4c8-80f1fcf4fefd","pdf_url":"https://ora.ox.ac.uk/objects/uuid:1a8e44d9-8176-4a8d-a4c8-80f1fcf4fefd/files/me6ac6636b5503d0935dec766a6c97159","source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Symplectic Elements at Oxford","raw_type":"Journal article"}],"best_oa_location":{"id":"doi:10.1016/j.chest.2017.05.004","doi":"https://doi.org/10.1016/j.chest.2017.05.004","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chest.2017.05.004","pdf_url":"http://journal.chestnet.org/article/S0012369217309212/pdf","source":{"id":"https://openalex.org/S76900504","display_name":"CHEST Journal","issn_l":"0012-3692","issn":["0012-3692","1931-3543"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chest","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G144908002","display_name":"Oxidative stress-induced inflammatory gene expression and ageing in COPD: role of sirtuin-1 and histone methylation","funder_award_id":"093080/Z/10/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G3916691092","display_name":null,"funder_award_id":"093080/Z/10/","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G959482419","display_name":"NIHR Senior Investigator Award","funder_award_id":"NF-SI-0611-10148","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2612370158.pdf","grobid_xml":"https://content.openalex.org/works/W2612370158.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1241013975","https://openalex.org/W1522380508","https://openalex.org/W1553938284","https://openalex.org/W1933395080","https://openalex.org/W1934899628","https://openalex.org/W1935872874","https://openalex.org/W1963982942","https://openalex.org/W1964059126","https://openalex.org/W1979504051","https://openalex.org/W1980244548","https://openalex.org/W1985002063","https://openalex.org/W1988226846","https://openalex.org/W1993700011","https://openalex.org/W1995095187","https://openalex.org/W1995898214","https://openalex.org/W2000445173","https://openalex.org/W2001686534","https://openalex.org/W2002726093","https://openalex.org/W2004008756","https://openalex.org/W2008166785","https://openalex.org/W2015361145","https://openalex.org/W2022970298","https://openalex.org/W2026152516","https://openalex.org/W2028003302","https://openalex.org/W2028178274","https://openalex.org/W2041756621","https://openalex.org/W2041959419","https://openalex.org/W2042419649","https://openalex.org/W2048196082","https://openalex.org/W2051806959","https://openalex.org/W2077523026","https://openalex.org/W2085720633","https://openalex.org/W2092728526","https://openalex.org/W2094509696","https://openalex.org/W2097948853","https://openalex.org/W2100080030","https://openalex.org/W2101720365","https://openalex.org/W2117980988","https://openalex.org/W2127938597","https://openalex.org/W2130374023","https://openalex.org/W2134580583","https://openalex.org/W2135002409","https://openalex.org/W2139347600","https://openalex.org/W2143982567","https://openalex.org/W2170498202","https://openalex.org/W2216303098","https://openalex.org/W2227693155","https://openalex.org/W2536788911","https://openalex.org/W2606215428","https://openalex.org/W4245666729"],"related_works":["https://openalex.org/W2554434967","https://openalex.org/W2802664683","https://openalex.org/W4387169127","https://openalex.org/W2777357832","https://openalex.org/W2123193437","https://openalex.org/W2543068196","https://openalex.org/W2357225350","https://openalex.org/W2563817821","https://openalex.org/W2153303662","https://openalex.org/W1992216140"],"abstract_inverted_index":{"Background":[0],"The":[1],"protein":[2,46,58],"deacetylase":[3],"sirtuin-1":[4],"(SIRT1)":[5],"is":[6,11],"an":[7],"antiaging":[8],"molecule":[9],"that":[10],"decreased":[12,98,208,265],"in":[13,16,27,39,99,112,250,258,266],"the":[14,56,93,105,183,267,275],"lung":[15,184,213],"patients":[17,40,100,268],"with":[18,41,65,101,104,121,134,169,209,224,269],"COPD.":[19,42,297],"Recently,":[20],"SIRT1":[21,31,45,57,246,277],"was":[22,50,96,131,205,247,264],"reported":[23,38],"to":[24],"be":[25,288],"detectable":[26],"serum,":[28],"but":[29],"serum":[30],"(s120S)":[32],"levels":[33],"have":[34],"not":[35,248],"yet":[36],"been":[37],"Methods":[43],"Serum":[44],"of":[47,72,182,212,228,252,283,296],"all":[48],"samples":[49],"measured":[51,149],"by":[52,87,150,274],"Western":[53,88],"blot,":[54],"and":[55,63,79,82,130,179,223,254,286],"band":[59],"densities":[60],"were":[61,85],"calculated":[62],"compared":[64,103],"clinical":[66,226],"parameters.":[67],"Results":[68],"Several":[69],"molecular":[70],"sizes":[71],"SIRT1,":[73],"including":[74],"120":[75],"kDa":[76],"(actual":[77],"size)":[78],"fragments":[80],"(102":[81],"75":[83],"kDa)":[84],"quantified":[86],"blot.":[89],"Among":[90],"them,":[91],"only":[92],"120-kDa":[94],"s120S":[95,163,263],"significantly":[97,207],"COPD":[102,109,122,230],"control":[106],"subjects":[107,114],"without":[108],"(s120S":[110],"ratio":[111],"healthy":[113],"=":[115,123,128,141,145,157,161,173,177,198,202,217,221,244],"0.90":[116],"\u00b1":[117,125,236,240],"0.34":[118],"vs":[119,233,238],"those":[120],"0.68":[124],"0.24;":[126],"P":[127,144,160,176,201,220,243],".014)":[129],"positively":[132],"correlated":[133],"airway":[135],"obstruction":[136],"(FEV":[137],"1":[138,152],"/FVC,":[139],"r":[140,156,172,197,216],"0.31":[142],";":[143,159,175,200,219,242],".020);":[146],"its":[147],"severity":[148,211],"FEV":[151],"%":[153],"predicted":[154],"(":[155,171,196,215],"0.29":[158],".029).":[162],"also":[164,206],"showed":[165],"a":[166,225,281,289],"positive":[167],"correlation":[168],"BMI":[170],"0.36":[174],".0077)":[178],"diffusing":[180],"capacity":[181],"per":[185],"unit":[186],"volume":[187],"(the":[188],"carbon":[189],"monoxide":[190],"transfer":[191],"coefficient:":[192],"K":[193],"CO":[194],"%)":[195],"0.32":[199],".025).":[203],"It":[204],"increasing":[210],"emphysema":[214],"\u20130.40":[218],".027)":[222],"history":[227],"frequent":[229],"exacerbations":[231],"(infrequent":[232],"frequent,":[234],"0.76":[235],"0.20":[237],"0.56":[239],"0.26":[241],".027).":[245],"detected":[249],"supernatant":[251],"A549":[253],"primary":[255],"epithelial":[256],"cells":[257,279],"normal":[259],"culture":[260],"conditions.":[261],"Conclusions":[262],"COPD,":[270],"potentially":[271],"as":[272,280],"reflected":[273],"reduced":[276],"within":[278],"result":[282],"oxidative":[284],"stress,":[285],"might":[287],"potential":[290],"biomarker":[291],"for":[292],"certain":[293],"disease":[294],"characteristics":[295]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2017-05-19T00:00:00"}