{"id":"https://openalex.org/W2611907031","doi":"https://doi.org/10.1007/s00428-017-2137-8","title":"Liquid biopsy: unlocking the potentials of cell-free DNA","display_name":"Liquid biopsy: unlocking the potentials of cell-free DNA","publication_year":2017,"publication_date":"2017-05-02","ids":{"openalex":"https://openalex.org/W2611907031","doi":"https://doi.org/10.1007/s00428-017-2137-8","mag":"2611907031","pmid":"https://pubmed.ncbi.nlm.nih.gov/28466157"},"language":"en","primary_location":{"id":"doi:10.1007/s00428-017-2137-8","doi":"https://doi.org/10.1007/s00428-017-2137-8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00428-017-2137-8","pdf_url":null,"source":{"id":"https://openalex.org/S47032817","display_name":"Archiv f\u00fcr Pathologische Anatomie und Physiologie und f\u00fcr Klinische Medicin","issn_l":"0945-6317","issn":["0945-6317","1432-2307"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virchows Archiv","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103371405","display_name":"David T. W. Chu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Chu","raw_affiliation_strings":["The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, 1650 Orleans Street, CRBI Room 151, Baltimore, MD, 21287, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, 1650 Orleans Street, CRBI Room 151, Baltimore, MD, 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091723009","display_name":"Ben Ho Park","orcid":"https://orcid.org/0000-0001-8119-2291","observed_orcids":["https://orcid.org/0000-0001-8119-2291"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ben Ho Park","raw_affiliation_strings":["The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, 1650 Orleans Street, CRBI Room 151, Baltimore, MD, 21287, USA. bpark2@jhmi.edu","The Whiting School of Engineering, Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD, USA. bpark2@jhmi.edu","The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, 1650 Orleans Street, CRBI Room 151, Baltimore, MD, 21287, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, 1650 Orleans Street, CRBI Room 151, Baltimore, MD, 21287, USA. bpark2@jhmi.edu","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]},{"raw_affiliation_string":"The Whiting School of Engineering, Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD, USA. bpark2@jhmi.edu","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, 1650 Orleans Street, CRBI Room 151, Baltimore, MD, 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5091723009"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":0.8989,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.69767442,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"471","issue":"2","first_page":"147","last_page":"154"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.984000027179718},{"id":"https://openalex.org/keywords/cell-free-dna","display_name":"cell-free DNA","score":0.8769999742507935},{"id":"https://openalex.org/keywords/circulating-tumor-dna","display_name":"circulating tumor DNA","score":1.0},{"id":"https://openalex.org/keywords/early-cancer-detection","display_name":"early cancer detection","score":0.7720000147819519},{"id":"https://openalex.org/keywords/cancer-prognosis","display_name":"cancer prognosis","score":0.8230000138282776},{"id":"https://openalex.org/keywords/digital-pcr","display_name":"digital PCR","score":0.6060000061988831},{"id":"https://openalex.org/keywords/next-generation-sequencing","display_name":"next-generation sequencing","score":0.8209999799728394},{"id":"https://openalex.org/keywords/variant-calling","display_name":"variant calling","score":0.6690000295639038},{"id":"https://openalex.org/keywords/ctdna-quantification","display_name":"ctDNA quantification","score":0.722000002861023},{"id":"https://openalex.org/keywords/clinical-oncology","display_name":"clinical oncology","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C152110520","wikidata":"https://www.wikidata.org/wiki/Q14225730","display_name":"Cell-free fetal DNA","level":5,"score":0.794921875},{"id":"https://openalex.org/C2779529041","wikidata":"https://www.wikidata.org/wiki/Q22349364","display_name":"Liquid biopsy","level":3,"score":0.5364241003990173},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.5283349752426147},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5223616361618042},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4184156060218811},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3322996497154236},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3152456283569336},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26724863052368164},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16162407398223877},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15116700530052185},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11616382002830505},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0},{"id":"https://openalex.org/C2778258057","wikidata":"https://www.wikidata.org/wiki/Q1136569","display_name":"Prenatal diagnosis","level":4,"score":0.0},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000073890","descriptor_name":"Liquid Biopsy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000074141","descriptor_name":"Circulating Tumor DNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008495","descriptor_name":"Medical Oncology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008495","descriptor_name":"Medical Oncology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00428-017-2137-8","doi":"https://doi.org/10.1007/s00428-017-2137-8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00428-017-2137-8","pdf_url":null,"source":{"id":"https://openalex.org/S47032817","display_name":"Archiv f\u00fcr Pathologische Anatomie und Physiologie und f\u00fcr Klinische Medicin","issn_l":"0945-6317","issn":["0945-6317","1432-2307"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virchows Archiv","raw_type":"journal-article"},{"id":"pmid:28466157","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28466157","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virchows Archiv : an international journal of pathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000911005","display_name":"Regional Oncology Research Center","funder_award_id":"P30CA006973","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306109","display_name":"Avon Foundation for Women","ror":"https://ror.org/02eqe7f55"},{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320310226","display_name":"Genomic Health","ror":"https://ror.org/05njgh475"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334037","display_name":"Loxo Oncology","ror":"https://ror.org/03abe5304"},{"id":"https://openalex.org/F4320334461","display_name":"Foundation Medicine","ror":"https://ror.org/02ackr434"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W782403376","https://openalex.org/W1249058925","https://openalex.org/W1492817649","https://openalex.org/W1528629181","https://openalex.org/W1799492544","https://openalex.org/W1849446486","https://openalex.org/W1914351667","https://openalex.org/W1923619280","https://openalex.org/W1934888046","https://openalex.org/W1950887784","https://openalex.org/W1967347815","https://openalex.org/W1981232037","https://openalex.org/W1983466841","https://openalex.org/W1985805774","https://openalex.org/W1993453915","https://openalex.org/W1995795575","https://openalex.org/W2002937040","https://openalex.org/W2015438948","https://openalex.org/W2015631955","https://openalex.org/W2021145743","https://openalex.org/W2027317947","https://openalex.org/W2033344838","https://openalex.org/W2041142042","https://openalex.org/W2043696829","https://openalex.org/W2044191816","https://openalex.org/W2047242786","https://openalex.org/W2054039272","https://openalex.org/W2058440954","https://openalex.org/W2062109911","https://openalex.org/W2065293650","https://openalex.org/W2067904749","https://openalex.org/W2069786312","https://openalex.org/W2073367400","https://openalex.org/W2092479048","https://openalex.org/W2095618958","https://openalex.org/W2099729090","https://openalex.org/W2104641188","https://openalex.org/W2107503225","https://openalex.org/W2111324624","https://openalex.org/W2113945202","https://openalex.org/W2116731538","https://openalex.org/W2116805592","https://openalex.org/W2120869188","https://openalex.org/W2121110176","https://openalex.org/W2124358769","https://openalex.org/W2126773860","https://openalex.org/W2127340110","https://openalex.org/W2128196636","https://openalex.org/W2132388337","https://openalex.org/W2134232003","https://openalex.org/W2134519717","https://openalex.org/W2140575188","https://openalex.org/W2143264090","https://openalex.org/W2146867648","https://openalex.org/W2147292635","https://openalex.org/W2150575159","https://openalex.org/W2154018281","https://openalex.org/W2154220735","https://openalex.org/W2155893084","https://openalex.org/W2161821474","https://openalex.org/W2168803496","https://openalex.org/W2171237493","https://openalex.org/W2177855755","https://openalex.org/W2231747349","https://openalex.org/W2280092090","https://openalex.org/W2415153281","https://openalex.org/W2415372857","https://openalex.org/W2416111151","https://openalex.org/W2417534909","https://openalex.org/W2479773785","https://openalex.org/W2486004214","https://openalex.org/W2579829632","https://openalex.org/W4234746319","https://openalex.org/W4235642752","https://openalex.org/W4235857807","https://openalex.org/W4238448376"],"related_works":["https://openalex.org/W2946988212","https://openalex.org/W2793969139","https://openalex.org/W2601308395","https://openalex.org/W4200418225","https://openalex.org/W2898440027","https://openalex.org/W2808882806","https://openalex.org/W2809420393","https://openalex.org/W3015181340","https://openalex.org/W2903901425","https://openalex.org/W2791076315"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-05-12T00:00:00"}
