{"id":"https://openalex.org/W26117985","doi":"https://doi.org/10.1007/978-1-59259-326-2_19","title":"Homologies Between the Genetic Etiology and Pathogenesis of the Synucleinopathies and Tauopathies","display_name":"Homologies Between the Genetic Etiology and Pathogenesis of the Synucleinopathies and Tauopathies","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W26117985","doi":"https://doi.org/10.1007/978-1-59259-326-2_19","mag":"26117985"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-59259-326-2_19","doi":"https://doi.org/10.1007/978-1-59259-326-2_19","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-1-59259-326-2_19","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mental and Behavioral Dysfunction in Movement Disorders","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W245966451","display_name":"Mental and Behavioral Dysfunction in Movement Disorders"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1007/978-1-59259-326-2_19","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020514779","display_name":"John Hardy","orcid":"https://orcid.org/0000-0002-3122-0423","observed_orcids":["https://orcid.org/0000-0002-3122-0423"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"John Hardy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5020514779"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1982,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.7354759,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"255","last_page":"258"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.8384000062942505,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.8384000062942505,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.15710000693798065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synucleinopathies","display_name":"synucleinopathies","score":0.9919999837875366},{"id":"https://openalex.org/keywords/tauopathy","display_name":"tauopathy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.8859999775886536},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.9760000109672546},{"id":"https://openalex.org/keywords/lewy-bodies","display_name":"Lewy bodies","score":0.9350000023841858},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.9580000042915344},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.921999990940094},{"id":"https://openalex.org/keywords/dementia-with-lewy-bodies","display_name":"dementia with Lewy bodies","score":0.8920000195503235},{"id":"https://openalex.org/keywords/progressive-supranuclear-palsy","display_name":"progressive supranuclear palsy","score":1.0},{"id":"https://openalex.org/keywords/corticobasal-degeneration","display_name":"corticobasal degeneration","score":1.0},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9629999995231628},{"id":"https://openalex.org/keywords/prion-disease","display_name":"prion disease","score":0.906000018119812},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.8040000200271606},{"id":"https://openalex.org/keywords/genetic-etiology","display_name":"genetic etiology","score":0.828000009059906},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.7319999933242798},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C2776477761","wikidata":"https://www.wikidata.org/wiki/Q945930","display_name":"Progressive supranuclear palsy","level":3,"score":0.9190433621406555},{"id":"https://openalex.org/C2777440831","wikidata":"https://www.wikidata.org/wiki/Q2376264","display_name":"Synucleinopathies","level":5,"score":0.9109049439430237},{"id":"https://openalex.org/C2776936178","wikidata":"https://www.wikidata.org/wiki/Q1755684","display_name":"Corticobasal degeneration","level":4,"score":0.8937228918075562},{"id":"https://openalex.org/C2778548049","wikidata":"https://www.wikidata.org/wiki/Q101245788","display_name":"Dementia with Lewy bodies","level":4,"score":0.8106560707092285},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5626381635665894},{"id":"https://openalex.org/C2779097696","wikidata":"https://www.wikidata.org/wiki/Q1822234","display_name":"Lewy body","level":4,"score":0.5503520369529724},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.5448089838027954},{"id":"https://openalex.org/C2777739294","wikidata":"https://www.wikidata.org/wiki/Q2397106","display_name":"Tauopathy","level":4,"score":0.5378614664077759},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5271220803260803},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4987318515777588},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.47622185945510864},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.4638766050338745},{"id":"https://openalex.org/C68026918","wikidata":"https://www.wikidata.org/wiki/Q1970256","display_name":"Senile plaques","level":4,"score":0.4205184876918793},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.4112168550491333},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39324280619621277},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3553330600261688},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.3392750024795532},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.31382912397384644},{"id":"https://openalex.org/C2781449126","wikidata":"https://www.wikidata.org/wiki/Q288591","display_name":"Alpha-synuclein","level":4,"score":0.30602920055389404},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.26923349499702454}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1007/978-1-59259-326-2_19","doi":"https://doi.org/10.1007/978-1-59259-326-2_19","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-1-59259-326-2_19","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mental and Behavioral Dysfunction in Movement Disorders","raw_type":"book-chapter"},{"id":"doi:10.1385/1-59259-326-7:255","doi":"https://doi.org/10.1385/1-59259-326-7:255","is_oa":false,"landing_page_url":"http://doi.org/10.1385/1-59259-326-7:255","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mental and Behavioral Dysfunction in Movement Disorders","raw_type":"book-chapter"},{"id":"mag:26117985","doi":null,"is_oa":false,"landing_page_url":"https://link.springer.com/content/pdf/10.1007%2F978-1-59259-326-2_19.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1007/978-1-59259-326-2_19","doi":"https://doi.org/10.1007/978-1-59259-326-2_19","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-1-59259-326-2_19","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mental and Behavioral Dysfunction in Movement Disorders","raw_type":"book-chapter"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1482580692","https://openalex.org/W1511517753","https://openalex.org/W1527671059","https://openalex.org/W1561023982","https://openalex.org/W1600934558","https://openalex.org/W1985131940","https://openalex.org/W1992589625","https://openalex.org/W2004212414","https://openalex.org/W2029205666","https://openalex.org/W2029380977","https://openalex.org/W2039294533","https://openalex.org/W2045671840","https://openalex.org/W2055937609","https://openalex.org/W2056127416","https://openalex.org/W2066155243","https://openalex.org/W2088949968","https://openalex.org/W2091265794","https://openalex.org/W2111567107","https://openalex.org/W2119998182","https://openalex.org/W2129975909","https://openalex.org/W2141839336","https://openalex.org/W2143604549","https://openalex.org/W2150656456","https://openalex.org/W2153348456","https://openalex.org/W2172007938"],"related_works":["https://openalex.org/W1855549631","https://openalex.org/W2134121616","https://openalex.org/W4393196689","https://openalex.org/W2035355411","https://openalex.org/W1991403218","https://openalex.org/W2163708990","https://openalex.org/W2096180119","https://openalex.org/W2890448347","https://openalex.org/W1973752139","https://openalex.org/W2035661230"],"abstract_inverted_index":{"Two":[0],"major":[1],"classes":[2,54],"of":[3,24,36,55,80],"neurodegenerative":[4],"disease":[5,58,103,107],"are":[6,20,32,72,111],"those":[7,13],"in":[8,14,74,101,120,126],"which":[9,15,75],"tangles":[10,89],"occur":[11,100],"and":[12,29,43,49,68,86,94,105,122],"Lewy":[16,30,83],"bodies":[17,31,84],"occur.":[18],"Tangles":[19],"made":[21,33],"up":[22,34],"largely":[23,35],"the":[25,37,114],"protein":[26,38,92],"tau":[27,91],"(1)":[28],"\u03b1-synuclein":[39],"(2).":[40],"Recent":[41],"genetic":[42],"pathological":[44],"data":[45],"show":[46],"many":[47],"relationships":[48],"similarities":[50],"between":[51],"these":[52],"two":[53],"disease.":[56],"Parkinson\u2019s":[57],"(PD),":[59],"lewy":[60],"body":[61],"dementia":[62],"(LBD),":[63],"progressive":[64],"supranuclear":[65],"palsy":[66],"(PSP),":[67],"corticobasal":[69],"degeneration":[70],"(CBD)":[71],"diseases":[73],"there":[76],"is":[77],"intracellular":[78],"inclusions":[79],"synuclein":[81],"containing":[82,90],"(PD":[85],"LBD)":[87],"or":[88],"(PSP":[93],"CBD).":[95],"These":[96],"same":[97],"lesions":[98,116],"can":[99],"Alzheimer\u2019s":[102],"(AD)":[104],"prion":[106,123],"(PrD)":[108],"when":[109],"they":[110],"secondary":[112],"to":[113],"initiating":[115],"(amyloid":[117],"\u03b2":[118],"[A\u03b2]":[119],"AD":[121],"proteins":[124],"Sc":[125],"PrD).":[127]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
