{"id":"https://openalex.org/W2611295065","doi":"https://doi.org/10.1016/j.ctrv.2017.04.007","title":"Treatment decisions in metastatic colorectal cancer \u2013 Beyond first and second line combination therapies","display_name":"Treatment decisions in metastatic colorectal cancer \u2013 Beyond first and second line combination therapies","publication_year":2017,"publication_date":"2017-05-04","ids":{"openalex":"https://openalex.org/W2611295065","doi":"https://doi.org/10.1016/j.ctrv.2017.04.007","mag":"2611295065","pmid":"https://pubmed.ncbi.nlm.nih.gov/28738235"},"language":"en","primary_location":{"id":"doi:10.1016/j.ctrv.2017.04.007","doi":"https://doi.org/10.1016/j.ctrv.2017.04.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ctrv.2017.04.007","pdf_url":"http://www.cancertreatmentreviews.com/article/S0305737217300658/pdf","source":{"id":"https://openalex.org/S49831067","display_name":"Cancer Treatment Reviews","issn_l":"0305-7372","issn":["0305-7372","1532-1967"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Treatment Reviews","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.cancertreatmentreviews.com/article/S0305737217300658/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079645039","display_name":"Arndt Vogel","orcid":"https://orcid.org/0000-0003-0560-5538","observed_orcids":["https://orcid.org/0000-0003-0560-5538"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. Vogel","raw_affiliation_strings":["Department of Gastroenterology, Hepatology and Endocrinology, Hanover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Hepatology and Endocrinology, Hanover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052177007","display_name":"Ralf\u2010Dieter Hofheinz","orcid":"https://orcid.org/0000-0001-5972-8504","observed_orcids":["https://orcid.org/0000-0001-5972-8504"]},"institutions":[{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210156450"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R.D. Hofheinz","raw_affiliation_strings":["Interdisciplinary Tumor Center Mannheim, University Hospital Mannheim, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Tumor Center Mannheim, University Hospital Mannheim, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany","institution_ids":["https://openalex.org/I4210156450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047515302","display_name":"Stefan Kubicka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126891","display_name":"Kreiskliniken Reutlingen","ror":"https://ror.org/030pd1x82","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126891"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S. Kubicka","raw_affiliation_strings":["Cancer Center Reutlingen, District Hospital Reutlingen, Steinenbergstr. 31, 72764 Reutlingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center Reutlingen, District Hospital Reutlingen, Steinenbergstr. 31, 72764 Reutlingen, Germany","institution_ids":["https://openalex.org/I4210126891"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015232096","display_name":"Dirk Arnold","orcid":"https://orcid.org/0000-0002-5325-8182","observed_orcids":["https://orcid.org/0000-0002-5325-8182"]},"institutions":[{"id":"https://openalex.org/I4405256111","display_name":"CUF Infante Santo Hospital","ror":"https://ror.org/03saa3s66","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4405256111"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"D. Arnold","raw_affiliation_strings":["Instituto CUF de Oncologia, c/o Hospital Infante Santo, Tv. Castro 3, Lisboa, Portugal. Electronic address: dirk.arnold@jmellosaude.pt","Instituto CUF de Oncologia, c/o Hospital Infante Santo, Tv. Castro 3, Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto CUF de Oncologia, c/o Hospital Infante Santo, Tv. Castro 3, Lisboa, Portugal. Electronic address: dirk.arnold@jmellosaude.pt","institution_ids":["https://openalex.org/I4405256111"]},{"raw_affiliation_string":"Instituto CUF de Oncologia, c/o Hospital Infante Santo, Tv. Castro 3, Lisboa, Portugal","institution_ids":["https://openalex.org/I4405256111"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5015232096"],"corresponding_institution_ids":["https://openalex.org/I4405256111"],"apc_list":{"value":4910,"currency":"USD","value_usd":4910},"apc_paid":{"value":4910,"currency":"USD","value_usd":4910},"fwci":1.5059,"has_fulltext":true,"cited_by_count":136,"citation_normalized_percentile":{"value":0.84695893,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"59","issue":null,"first_page":"54","last_page":"60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":1.0},{"id":"https://openalex.org/keywords/third-line-therapy","display_name":"third-line therapy","score":0.753000020980835},{"id":"https://openalex.org/keywords/regorafenib","display_name":"regorafenib","score":0.9789999723434448},{"id":"https://openalex.org/keywords/trifluridine-tipiracil","display_name":"trifluridine/tipiracil","score":0.7879999876022339},{"id":"https://openalex.org/keywords/vegf-inhibitors","display_name":"VEGF inhibitors","score":0.7549999952316284},{"id":"https://openalex.org/keywords/multikinase-inhibitor","display_name":"multikinase inhibitor","score":0.7549999952316284},{"id":"https://openalex.org/keywords/rechallenge","display_name":"drug rechallenge","score":0.6420000195503235},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.4259999990463257},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.5180000066757202},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.4729999899864197},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9338122010231018},{"id":"https://openalex.org/C2776248978","wikidata":"https://www.wikidata.org/wiki/Q3891664","display_name":"Regorafenib","level":4,"score":0.9335732460021973},{"id":"https://openalex.org/C2780259306","wikidata":"https://www.wikidata.org/wiki/Q412197","display_name":"Irinotecan","level":4,"score":0.8820135593414307},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.6921321153640747},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6859517097473145},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6325521469116211},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6162105202674866},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5501400828361511},{"id":"https://openalex.org/C2780962732","wikidata":"https://www.wikidata.org/wiki/Q422327","display_name":"Oxaliplatin","level":4,"score":0.5238663554191589},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4915636479854584},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4685170650482178},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.4449540674686432},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.42716753482818604},{"id":"https://openalex.org/C2776907518","wikidata":"https://www.wikidata.org/wiki/Q1734165","display_name":"Performance status","level":3,"score":0.4159417450428009},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.360650897026062},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08642825484275818},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.06873175501823425},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010671","descriptor_name":"Phenylurea Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014271","descriptor_name":"Trifluridine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017326","descriptor_name":"Clinical Trials, Phase III as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ctrv.2017.04.007","doi":"https://doi.org/10.1016/j.ctrv.2017.04.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ctrv.2017.04.007","pdf_url":"http://www.cancertreatmentreviews.com/article/S0305737217300658/pdf","source":{"id":"https://openalex.org/S49831067","display_name":"Cancer Treatment Reviews","issn_l":"0305-7372","issn":["0305-7372","1532-1967"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Treatment Reviews","raw_type":"journal-article"},{"id":"pmid:28738235","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28738235","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer treatment reviews","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.ctrv.2017.04.007","doi":"https://doi.org/10.1016/j.ctrv.2017.04.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ctrv.2017.04.007","pdf_url":"http://www.cancertreatmentreviews.com/article/S0305737217300658/pdf","source":{"id":"https://openalex.org/S49831067","display_name":"Cancer Treatment Reviews","issn_l":"0305-7372","issn":["0305-7372","1532-1967"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Treatment Reviews","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320333874","display_name":"Bayer Vital","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2611295065.pdf","grobid_xml":"https://content.openalex.org/works/W2611295065.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W124480818","https://openalex.org/W242040007","https://openalex.org/W244746785","https://openalex.org/W1504814099","https://openalex.org/W1799482054","https://openalex.org/W1909809492","https://openalex.org/W1914351667","https://openalex.org/W1922470522","https://openalex.org/W1934094702","https://openalex.org/W1940241680","https://openalex.org/W1952983316","https://openalex.org/W1968476757","https://openalex.org/W1980850901","https://openalex.org/W1987443121","https://openalex.org/W2005348280","https://openalex.org/W2008336143","https://openalex.org/W2019990270","https://openalex.org/W2024734991","https://openalex.org/W2071971507","https://openalex.org/W2086764265","https://openalex.org/W2097121246","https://openalex.org/W2097383839","https://openalex.org/W2103789431","https://openalex.org/W2106789440","https://openalex.org/W2111851685","https://openalex.org/W2115345709","https://openalex.org/W2115790682","https://openalex.org/W2124033094","https://openalex.org/W2129998117","https://openalex.org/W2135403187","https://openalex.org/W2141434947","https://openalex.org/W2141630197","https://openalex.org/W2147834058","https://openalex.org/W2152454229","https://openalex.org/W2155311724","https://openalex.org/W2156229277","https://openalex.org/W2166191933","https://openalex.org/W2172575055","https://openalex.org/W2195700916","https://openalex.org/W2203767631","https://openalex.org/W2336815607","https://openalex.org/W2409420104","https://openalex.org/W2464342550","https://openalex.org/W2470575266","https://openalex.org/W2471825623","https://openalex.org/W2479232428","https://openalex.org/W2528229149","https://openalex.org/W2530590137","https://openalex.org/W2531140887","https://openalex.org/W2569086487","https://openalex.org/W2572024892","https://openalex.org/W2587295933","https://openalex.org/W2588203578","https://openalex.org/W2588737724","https://openalex.org/W2590886028","https://openalex.org/W2591225204","https://openalex.org/W2592898585","https://openalex.org/W2898760131","https://openalex.org/W3012137667","https://openalex.org/W3217688204","https://openalex.org/W4235857807","https://openalex.org/W4237741640","https://openalex.org/W4238105128","https://openalex.org/W4255946219","https://openalex.org/W6609367197","https://openalex.org/W6804491069"],"related_works":["https://openalex.org/W2792663627","https://openalex.org/W2993232042","https://openalex.org/W7214146293","https://openalex.org/W4319592081","https://openalex.org/W4405070709","https://openalex.org/W4399555748","https://openalex.org/W4206559885","https://openalex.org/W3017607167","https://openalex.org/W4390499048","https://openalex.org/W4379282528"],"abstract_inverted_index":{"Median":[0],"overall":[1],"survival":[2],"(OS)":[3],"of":[4,20,59,161,197],"patients":[5,42,89,201],"with":[6,38,184],"metastatic":[7],"colorectal":[8],"cancer":[9],"(mCRC)":[10],"has":[11],"reached":[12],"up":[13],"to":[14,54,117,142,158,193,199],"30months":[15],"in":[16,30,119,127,136,144,153],"recent":[17],"clinical":[18],"trials":[19,123],"first":[21],"line":[22,64],"therapies.":[23],"Following":[24],"disease":[25],"progression":[26],"after":[27],"the":[28,62,77,145],"standard":[29],"both,":[31],"1st":[32],"and":[33,48,98,103,125,168],"2nd":[34],"line,":[35],"combination":[36],"chemotherapy":[37,94],"monoclonal":[39],"antibodies,":[40],"many":[41],"maintain":[43],"a":[44,49,83,154],"good":[45],"performance":[46],"status":[47],"significant":[50],"proportion":[51],"is":[52,82,165,204,212],"motivated":[53],"undergo":[55],"further":[56],"therapy.":[57],"Choices":[58],"treatment":[60,194],"beyond":[61],"second":[63],"setting":[65],"for":[66,87,173,209],"mCRC":[67,88,128],"are":[68],"therefore":[69],"becoming":[70],"increasingly":[71],"important.":[72],"New":[73],"options":[74],"have":[75,91],"entered":[76],"therapeutic":[78],"field":[79],"recently:":[80],"Regorafenib":[81,112],"multikinase":[84],"inhibitor":[85],"approved":[86],"who":[90],"progressed":[92],"on":[93],"(including":[95],"fluoropyrimidines,":[96],"irinotecan,":[97],"oxaliplatin),":[99],"plus":[100],"VEGF":[101],"inhibitor(s)":[102],"-":[104,108],"if":[105,182],"RAS":[106],"wild-type":[107],"an":[109,131],"anti-EGFR":[110],"inhibitor.":[111],"significantly":[113,137],"improved":[114,138],"OS,":[115],"compared":[116,141],"placebo,":[118],"two":[120],"phase":[121,146],"III":[122,147],"(CORRECT":[124],"CONCUR)":[126],"patients.":[129],"Trifluridine/Tipiracil,":[130],"oral":[132],"fluoropyrimidine,":[133],"also":[134,205],"resulted":[135],"OS":[139],"when":[140],"placebo":[143],"RECOURSE":[148],"trial,":[149],"which":[150,176,200],"was":[151],"conducted":[152],"similar":[155],"patient":[156],"population":[157],"CORRECT.":[159],"Reintroduction":[160],"previously":[162],"administered":[163],"therapy":[164],"another":[166],"valid":[167],"commonly":[169],"used":[170],"approach,":[171],"especially":[172],"those":[174],"regimens":[175],"were":[177],"discontinued":[178],"before":[179],"progression,":[180],"e.g.":[181],"associated":[183],"cumulative":[185],"toxicities,":[186],"such":[187],"as":[188],"peripheral":[189],"neuropathy":[190],"or":[191],"due":[192],"breaks.":[195],"Re-challenge":[196],"drugs":[198],"developed":[202],"resistance":[203],"feasible":[206],"although":[207],"evidence":[208],"this":[210],"strategy":[211],"limited.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":22},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2017-05-12T00:00:00"}