{"id":"https://openalex.org/W26112641","doi":"https://doi.org/10.1080/00015458.2009.11680466","title":"Clinicopathologic Features and Prognostic Significance of Lung Tumours with Mixed Histologic Patterns","display_name":"Clinicopathologic Features and Prognostic Significance of Lung Tumours with Mixed Histologic Patterns","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W26112641","doi":"https://doi.org/10.1080/00015458.2009.11680466","mag":"26112641","pmid":"https://pubmed.ncbi.nlm.nih.gov/19803261"},"language":"en","primary_location":{"id":"doi:10.1080/00015458.2009.11680466","doi":"https://doi.org/10.1080/00015458.2009.11680466","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00015458.2009.11680466","pdf_url":null,"source":{"id":"https://openalex.org/S4393917737","display_name":"Acta chirurgica Belgica","issn_l":"0001-5458","issn":["0001-5458","1784-3421","2577-0160"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","jufo-1","medline","poland-20","russia-white-list-3","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Chirurgica Belgica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"E. Cakir","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Cakir","raw_affiliation_strings":["Department of Pathology, Ataturk Chest Diseases and Chest Surgery Education and Research Hospital","Department of Pathology, Ataturk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Ataturk Chest Diseases and Chest Surgery Education and Research Hospital","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology, Ataturk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, Turkey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054269555","display_name":"Funda Demira\u011f","orcid":"https://orcid.org/0000-0003-4790-8369","observed_orcids":["https://orcid.org/0000-0003-4790-8369"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. Demirag","raw_affiliation_strings":["Department of Pathology, Ataturk Chest Diseases and Chest Surgery Education and Research Hospital","Department of Pathology, Ataturk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Ataturk Chest Diseases and Chest Surgery Education and Research Hospital","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology, Ataturk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, Turkey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028982645","display_name":"Mehtap Ayd\u0131n","orcid":"https://orcid.org/0000-0003-4044-9366","observed_orcids":["https://orcid.org/0000-0003-4044-9366"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Aydin","raw_affiliation_strings":["Department of Chest Diseases, Ataturk Chest Diseases and Chest Surgery Education and Research Hospital","Department of Chest Diseases, Ataturk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chest Diseases, Ataturk Chest Diseases and Chest Surgery Education and Research Hospital","institution_ids":[]},{"raw_affiliation_string":"Department of Chest Diseases, Ataturk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, Turkey","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007669056","display_name":"Ebru \u00dcnsal","orcid":"https://orcid.org/0000-0002-1879-7922","observed_orcids":["https://orcid.org/0000-0002-1879-7922"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Unsal","raw_affiliation_strings":["Department of Pathology, Ataturk Chest Diseases and Chest Surgery Education and Research Hospital","Department of Pathology, Ataturk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Ataturk Chest Diseases and Chest Surgery Education and Research Hospital","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology, Ataturk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, Turkey","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6829,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.84526362,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"109","issue":"4","first_page":"489","last_page":"493"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.5259000062942505,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.5259000062942505,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.39430001378059387,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12992","display_name":"Metastasis and carcinoma case studies","score":0.05139999836683273,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.7419999837875366},{"id":"https://openalex.org/keywords/adenosquamous-carcinoma","display_name":"adenosquamous carcinoma","score":0.9919999837875366},{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":0.8510000109672546},{"id":"https://openalex.org/keywords/large-cell-neuroendocrine-carcinoma","display_name":"large cell neuroendocrine carcinoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/vascular-invasion","display_name":"vascular invasion","score":0.7260000109672546},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.9520000219345093},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.7490000128746033},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.8943020701408386},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8484448194503784},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6785422563552856},{"id":"https://openalex.org/C2776512503","wikidata":"https://www.wikidata.org/wiki/Q3658380","display_name":"Adenosquamous carcinoma","level":4,"score":0.6577883362770081},{"id":"https://openalex.org/C2778911148","wikidata":"https://www.wikidata.org/wiki/Q15979047","display_name":"Large cell","level":4,"score":0.534697949886322},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.5256125926971436},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.4645967185497284},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.45005038380622864},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.43982255458831787},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.37224847078323364},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3129873275756836},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.23802676796913147},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.06450366973876953}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002283","descriptor_name":"Carcinoma, Bronchogenic","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002283","descriptor_name":"Carcinoma, Bronchogenic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002283","descriptor_name":"Carcinoma, Bronchogenic","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011013","descriptor_name":"Pneumonectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018196","descriptor_name":"Carcinoma, Adenosquamous","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D018196","descriptor_name":"Carcinoma, Adenosquamous","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018196","descriptor_name":"Carcinoma, Adenosquamous","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D018278","descriptor_name":"Carcinoma, Neuroendocrine","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D018278","descriptor_name":"Carcinoma, Neuroendocrine","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018278","descriptor_name":"Carcinoma, Neuroendocrine","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1080/00015458.2009.11680466","doi":"https://doi.org/10.1080/00015458.2009.11680466","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00015458.2009.11680466","pdf_url":null,"source":{"id":"https://openalex.org/S4393917737","display_name":"Acta chirurgica Belgica","issn_l":"0001-5458","issn":["0001-5458","1784-3421","2577-0160"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","jufo-1","medline","poland-20","russia-white-list-3","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Chirurgica Belgica","raw_type":"journal-article"},{"id":"pmid:19803261","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19803261","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta chirurgica Belgica","raw_type":"Journal Article"},{"id":"pmh:9c825a67-6b3f-413a-9b55-449875eef00f","doi":null,"is_oa":false,"landing_page_url":"https://avesis.aybu.edu.tr/publication/details/9c825a67-6b3f-413a-9b55-449875eef00f/oai","pdf_url":null,"source":{"id":"https://openalex.org/S7407055213","display_name":"AYBU AVESIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W154120697","https://openalex.org/W1964681864","https://openalex.org/W1965419248","https://openalex.org/W2025095579","https://openalex.org/W2027925037","https://openalex.org/W2037088166","https://openalex.org/W2038819632","https://openalex.org/W2049004574","https://openalex.org/W2089767548","https://openalex.org/W2105933823","https://openalex.org/W2169411097","https://openalex.org/W4255980705"],"related_works":["https://openalex.org/W2105933823","https://openalex.org/W7100587932","https://openalex.org/W2065916082","https://openalex.org/W2043709536","https://openalex.org/W1485425038","https://openalex.org/W2612573757","https://openalex.org/W2016092796","https://openalex.org/W2091895816","https://openalex.org/W3011710214","https://openalex.org/W277528249"],"abstract_inverted_index":{"Lung":[0],"tumours":[1,18,27,75,82,114,239,245],"with":[2,19,25,39,52,112,228,253],"a":[3,40,45,53,254],"mixed":[4,20,41,229],"histologic":[5,42],"pattern":[6,43],"are":[7,231],"rare.":[8],"We":[9],"evaluated":[10,108],"the":[11,26,57,62,113,135,172,196,207,213,219,235],"clinicopathologic":[12],"features":[13],"and":[14,22,44,76,98,104,110,131,137,159,185,216,242],"prognosis":[15],"of":[16,36,49,67],"lung":[17],"histology":[21,55,174,198,209,230],"compared":[23,111],"them":[24],"which":[28],"have":[29],"single":[30,54,116,173,197,208,255],"histology.":[31,117,256],"The":[32,79],"study":[33,63,136],"group":[34,47,64,215,223],"consisted":[35,48],"39":[37],"patients":[38,51],"control":[46,138],"41":[50],"on":[56],"consecutive":[58],"surgical":[59],"specimens.":[60],"In":[61],"three":[65],"types":[66],"tumour":[68,132,222],"were":[69,83,107,191,204],"identified:":[70],"adenosquamous":[71,144,214,240],"carcinoma,":[72],"combined":[73,80,177,220,243],"neuro-endocrine":[74,81,95,178,221,244],"biphasic":[77],"tumours.":[78],"further":[84],"divided":[85],"into":[86],"small":[87],"cell":[88,94],"carcinoma":[89,91,96,241],"(SCLC)+non-neuro-endocrine":[90],"(NNEC),":[92],"SCLC+large":[93],"(LCNEC)":[97],"LCNEC":[99],"+NNEC.":[100],"Clinicopathologic":[101],"characteristics,":[102],"stage":[103,147],"survival":[105,202],"rates":[106,203],"retrospectively":[109],"showing":[115],"There":[118],"was":[119,166],"no":[120],"significant":[121],"difference":[122],"in":[123,171,195,234],"mean":[124],"age,":[125],"sex,":[126],"smoking":[127],"history,":[128],"asbestos":[129],"exposure":[130],"size":[133],"between":[134],"groups":[139],"(p":[140,151,156,163,182,188,224],">":[141],"0.05).":[142],"Among":[143,176,237],"carcinomas":[145],"advanced":[146,180],"(IIIa":[148],"or":[149],"IIIb)":[150],"=":[152,157,164,183,189,225],"0.004),":[153],"vascular":[154,186],"invasion":[155,187],"0.04)":[158],"parietal":[160],"pleural":[161],"involvement":[162],"0.012)":[165],"significantly":[167],"more":[168,192,247],"evident":[169,193],"than":[170,194,251],"group.":[175,199],"tumours,":[179],"stages":[181],"0.002)":[184],"0.003)":[190],"Two-":[200],"year":[201],"60%":[205],"for":[206,212,218],"group,":[210],"39%":[211],"25%":[217],"0.0002).":[226],"Tumours":[227],"rarely":[232],"seen":[233],"lung.":[236],"these":[238],"present":[246],"aggressive":[248],"clinico-pathologic":[249],"behaviour":[250],"tumors":[252]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}