{"id":"https://openalex.org/W2611136309","doi":"https://doi.org/10.1093/annonc/mdx213","title":"Immune checkpoint-associated cardiotoxicity: case report with systematic review of literature","display_name":"Immune checkpoint-associated cardiotoxicity: case report with systematic review of literature","publication_year":2017,"publication_date":"2017-05-01","ids":{"openalex":"https://openalex.org/W2611136309","doi":"https://doi.org/10.1093/annonc/mdx213","mag":"2611136309","pmid":"https://pubmed.ncbi.nlm.nih.gov/28472223"},"language":"en","primary_location":{"id":"doi:10.1093/annonc/mdx213","doi":"https://doi.org/10.1093/annonc/mdx213","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdx213","pdf_url":"https://academic.oup.com/annonc/article-pdf/28/8/2034/19388805/mdx213.pdf","source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/annonc/article-pdf/28/8/2034/19388805/mdx213.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051388864","display_name":"Aman Chauhan","orcid":"https://orcid.org/0009-0003-0136-1983","observed_orcids":["https://orcid.org/0009-0003-0136-1983","https://orcid.org/0000-0002-4183-2116"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I2802239656","display_name":"Markey Cancer Center","ror":"https://ror.org/01dhvva97","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285210727","https://openalex.org/I143302722","https://openalex.org/I2802239656"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A. Chauhan","raw_affiliation_strings":["Department of Internal Medicine, Markey Cancer Center, University of Kentucky, Lexington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Markey Cancer Center, University of Kentucky, Lexington","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2802239656"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044995812","display_name":"Grant Burkeen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I2802239656","display_name":"Markey Cancer Center","ror":"https://ror.org/01dhvva97","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285210727","https://openalex.org/I143302722","https://openalex.org/I2802239656"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Burkeen","raw_affiliation_strings":["Department of Internal Medicine, Markey Cancer Center, University of Kentucky, Lexington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Markey Cancer Center, University of Kentucky, Lexington","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2802239656"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077133739","display_name":"Jenna Houranieh","orcid":"https://orcid.org/0009-0007-8378-0899","observed_orcids":["https://orcid.org/0009-0007-8378-0899"]},"institutions":[{"id":"https://openalex.org/I2801733747","display_name":"Lexington VA Health Care System","ror":"https://ror.org/01dm04760","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801733747","https://openalex.org/I4210112672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Houranieh","raw_affiliation_strings":["Lexington Veterans Affairs Medical Center, Lexington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lexington Veterans Affairs Medical Center, Lexington, USA","institution_ids":["https://openalex.org/I2801733747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030064179","display_name":"Susanne M. Arnold","orcid":"https://orcid.org/0000-0001-6542-9551","observed_orcids":["https://orcid.org/0000-0001-6542-9551"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I2802239656","display_name":"Markey Cancer Center","ror":"https://ror.org/01dhvva97","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285210727","https://openalex.org/I143302722","https://openalex.org/I2802239656"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Arnold","raw_affiliation_strings":["Department of Internal Medicine, Markey Cancer Center, University of Kentucky, Lexington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Markey Cancer Center, University of Kentucky, Lexington","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2802239656"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005448318","display_name":"Lowell Brian Anthony","orcid":"https://orcid.org/0000-0001-7348-7874","observed_orcids":["https://orcid.org/0000-0001-7348-7874"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I2802239656","display_name":"Markey Cancer Center","ror":"https://ror.org/01dhvva97","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285210727","https://openalex.org/I143302722","https://openalex.org/I2802239656"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Anthony","raw_affiliation_strings":["Department of Internal Medicine, Markey Cancer Center, University of Kentucky, Lexington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Markey Cancer Center, University of Kentucky, Lexington","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2802239656"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5051388864"],"corresponding_institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2802239656"],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":0.4872,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.49072279,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"28","issue":"8","first_page":"2034","last_page":"2038"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.01759999990463257,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11638","display_name":"Cardiac tumors and thrombi","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.9380000233650208},{"id":"https://openalex.org/keywords/immune-related-adverse-events","display_name":"immune-related adverse events","score":0.796999990940094},{"id":"https://openalex.org/keywords/ipilimumab","display_name":"ipilimumab","score":0.925000011920929},{"id":"https://openalex.org/keywords/nivolumab","display_name":"nivolumab","score":1.0},{"id":"https://openalex.org/keywords/pembrolizumab","display_name":"pembrolizumab","score":1.0},{"id":"https://openalex.org/keywords/atezolizumab","display_name":"atezolizumab","score":0.9909999966621399},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.5979999899864197},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9120000004768372},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.8309999704360962},{"id":"https://openalex.org/keywords/kidney-cancer","display_name":"kidney cancer","score":0.9480000138282776},{"id":"https://openalex.org/keywords/hodgkin-lymphoma","display_name":"Hodgkin's disease","score":0.9480000138282776}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9488773345947266},{"id":"https://openalex.org/C2778233292","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiotoxicity","level":3,"score":0.8747203350067139},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.47405216097831726},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.42238619923591614},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31342488527297974},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.21842211484909058},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21545487642288208}],"mesh":[{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077594","descriptor_name":"Nivolumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066126","descriptor_name":"Cardiotoxicity","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D066126","descriptor_name":"Cardiotoxicity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/annonc/mdx213","doi":"https://doi.org/10.1093/annonc/mdx213","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdx213","pdf_url":"https://academic.oup.com/annonc/article-pdf/28/8/2034/19388805/mdx213.pdf","source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},{"id":"pmid:28472223","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28472223","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of oncology : official journal of the European Society for Medical Oncology","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.1093/annonc/mdx213","doi":"https://doi.org/10.1093/annonc/mdx213","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdx213","pdf_url":"https://academic.oup.com/annonc/article-pdf/28/8/2034/19388805/mdx213.pdf","source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2611136309.pdf","grobid_xml":"https://content.openalex.org/works/W2611136309.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W1992987036","https://openalex.org/W2000222100","https://openalex.org/W2338423971","https://openalex.org/W2338693579","https://openalex.org/W2466250207","https://openalex.org/W2478478625","https://openalex.org/W2502471875","https://openalex.org/W2522075115","https://openalex.org/W2547133566"],"related_works":["https://openalex.org/W2767828983","https://openalex.org/W7215476464","https://openalex.org/W2969488286","https://openalex.org/W4403474603","https://openalex.org/W3174148304","https://openalex.org/W4388824945","https://openalex.org/W3006834131","https://openalex.org/W2478478625","https://openalex.org/W2766565264","https://openalex.org/W3097542144"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-05-12T00:00:00"}