{"id":"https://openalex.org/W2611091509","doi":"https://doi.org/10.1111/bdi.12490","title":"Systematic assessment of environmental risk factors for bipolar disorder: an umbrella review of systematic reviews and meta\u2010analyses","display_name":"Systematic assessment of environmental risk factors for bipolar disorder: an umbrella review of systematic reviews and meta\u2010analyses","publication_year":2017,"publication_date":"2017-03-01","ids":{"openalex":"https://openalex.org/W2611091509","doi":"https://doi.org/10.1111/bdi.12490","mag":"2611091509","pmid":"https://pubmed.ncbi.nlm.nih.gov/28470927"},"language":"en","primary_location":{"id":"doi:10.1111/bdi.12490","doi":"https://doi.org/10.1111/bdi.12490","is_oa":true,"landing_page_url":"https://doi.org/10.1111/bdi.12490","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bdi.12490","source":{"id":"https://openalex.org/S58085280","display_name":"Bipolar Disorders","issn_l":"1398-5647","issn":["1398-5647","1399-5618"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bipolar Disorders","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bdi.12490","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109268792","display_name":"Beatrice Bortolato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Beatrice Bortolato","raw_affiliation_strings":["Institute for clinical Research and Education in Medicine, I.R.E.M., Padova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for clinical Research and Education in Medicine, I.R.E.M., Padova, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013298138","display_name":"Cristiano Andr\u00e9 K\u00f6hler","orcid":"https://orcid.org/0000-0003-0503-5264","observed_orcids":["https://orcid.org/0000-0003-0503-5264"]},"institutions":[{"id":"https://openalex.org/I243754102","display_name":"Universidade Federal do Cear\u00e1","ror":"https://ror.org/03srtnf24","country_code":"BR","type":"education","lineage":["https://openalex.org/I243754102"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Cristiano A. K\u00f6hler","raw_affiliation_strings":["Department of Clinical Medicine and Translational Psychiatry Research Group Faculty of Medicine Federal University of Cear\u00e1  Fortaleza Cear\u00e1 Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine and Translational Psychiatry Research Group Faculty of Medicine Federal University of Cear\u00e1  Fortaleza Cear\u00e1 Brazil","institution_ids":["https://openalex.org/I243754102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057413062","display_name":"\u0395vangelos \u0395vangelou","orcid":"https://orcid.org/0000-0002-5488-2999","observed_orcids":["https://orcid.org/0000-0002-5488-2999","https://orcid.org/0000-0002-8818-7193"]},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB","GR"],"is_corresponding":false,"raw_author_name":"Evangelos Evangelou","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK","Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072831235","display_name":"Jordi Le\u00f3n Caballero","orcid":"https://orcid.org/0000-0003-0138-7289","observed_orcids":["https://orcid.org/0000-0003-0138-7289"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I4210090703","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental","ror":"https://ror.org/009byq155","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210090703","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210133106","display_name":"Parc de Salut","ror":"https://ror.org/032exky44","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210133106"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jordi Le\u00f3n\u2010Caballero","raw_affiliation_strings":["Bipolar Unit, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain","Institut de Neuropsiquiatria i Addiccions, Parc de Salut Mar, CIBERSAM, Universidad Autonoma de Barcelona, Barcelona, Catalonia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bipolar Unit, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain","institution_ids":["https://openalex.org/I4210090703","https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I71999127"]},{"raw_affiliation_string":"Institut de Neuropsiquiatria i Addiccions, Parc de Salut Mar, CIBERSAM, Universidad Autonoma de Barcelona, Barcelona, Catalonia, Spain","institution_ids":["https://openalex.org/I123044942","https://openalex.org/I4210090703","https://openalex.org/I4210133106"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083734796","display_name":"Marco Solmi","orcid":"https://orcid.org/0000-0003-4877-7233","observed_orcids":["https://orcid.org/0000-0003-4877-7233"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Solmi","raw_affiliation_strings":["Department of Medicine, DIMED, Geriatrics Division, University of Padova, Padova, Italy","Department of Neurosciences, University of Padova, Padova, Italy","Institute for clinical Research and Education in Medicine, I.R.E.M., Padova, Italy","Local Health Unit 17 ULSS 17, Mental Health Department, Padova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, DIMED, Geriatrics Division, University of Padova, Padova, Italy","institution_ids":["https://openalex.org/I138689650"]},{"raw_affiliation_string":"Department of Neurosciences, University of Padova, Padova, Italy","institution_ids":["https://openalex.org/I138689650"]},{"raw_affiliation_string":"Institute for clinical Research and Education in Medicine, I.R.E.M., Padova, Italy","institution_ids":["https://openalex.org/I138689650"]},{"raw_affiliation_string":"Local Health Unit 17 ULSS 17, Mental Health Department, Padova, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005008571","display_name":"Brendon Stubbs","orcid":"https://orcid.org/0000-0001-7387-3791","observed_orcids":["https://orcid.org/0000-0001-7387-3791"]},"institutions":[{"id":"https://openalex.org/I125671874","display_name":"National Health Service","ror":"https://ror.org/02wnqcb97","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I125671874","https://openalex.org/I1311074006"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I200323923","display_name":"South London and Maudsley NHS Foundation Trust","ror":"https://ror.org/015803449","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200323923"]},{"id":"https://openalex.org/I4210115181","display_name":"Maudsley Hospital","ror":"https://ror.org/02788t795","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200323923","https://openalex.org/I4210115181"]},{"id":"https://openalex.org/I51216347","display_name":"Anglia Ruskin University","ror":"https://ror.org/0009t4v78","country_code":"GB","type":"education","lineage":["https://openalex.org/I51216347"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Brendon Stubbs","raw_affiliation_strings":["Faculty of Health, Social care and Education, Anglia Ruskin University, Chelmsford, UK","Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK","Physiotherapy Department, South London and Maudsley NHS Foundation Trust, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health, Social care and Education, Anglia Ruskin University, Chelmsford, UK","institution_ids":["https://openalex.org/I51216347"]},{"raw_affiliation_string":"Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"Physiotherapy Department, South London and Maudsley NHS Foundation Trust, London, UK","institution_ids":["https://openalex.org/I125671874","https://openalex.org/I200323923","https://openalex.org/I4210115181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072332157","display_name":"Lazaros Belbasis","orcid":"https://orcid.org/0000-0002-2334-6974","observed_orcids":["https://orcid.org/0000-0002-2334-6974"]},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Lazaros Belbasis","raw_affiliation_strings":["Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083379480","display_name":"Isabella Pacchiarotti","orcid":"https://orcid.org/0000-0002-7822-0367","observed_orcids":["https://orcid.org/0000-0002-7822-0367"]},"institutions":[{"id":"https://openalex.org/I4210090703","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental","ror":"https://ror.org/009byq155","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210090703","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Isabella Pacchiarotti","raw_affiliation_strings":["Bipolar Unit, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bipolar Unit, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain","institution_ids":["https://openalex.org/I4210090703","https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074715169","display_name":"Lars Vedel Kessing","orcid":"https://orcid.org/0000-0001-9377-9436","observed_orcids":["https://orcid.org/0000-0001-9377-9436"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Lars V. Kessing","raw_affiliation_strings":["Psychiatric Centre Copenhagen, Rigshospitalet, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":"https://orcid.org/0000-0001-9377-9436","affiliations":[{"raw_affiliation_string":"Psychiatric Centre Copenhagen, Rigshospitalet, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Berk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132157203","display_name":"Barwon Health","ror":"https://ror.org/00my0hg66","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I132157203"]},{"id":"https://openalex.org/I149704539","display_name":"Deakin University","ror":"https://ror.org/02czsnj07","country_code":"AU","type":"education","lineage":["https://openalex.org/I149704539"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Michael Berk","raw_affiliation_strings":["Florey Institute for Neuroscience and Mental Health, Department of Psychiatry, University of Melbourne, Melbourne, Australia","IMPACT Strategic Research Centre (Barwon Health), School of Medicine, Deakin University, Geelong, VIC, Australia","Orygen, The National Centre of Excellence in Youth Mental Health, University of Melbourne, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Florey Institute for Neuroscience and Mental Health, Department of Psychiatry, University of Melbourne, Melbourne, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I242743682"]},{"raw_affiliation_string":"IMPACT Strategic Research Centre (Barwon Health), School of Medicine, Deakin University, Geelong, VIC, Australia","institution_ids":["https://openalex.org/I132157203","https://openalex.org/I149704539"]},{"raw_affiliation_string":"Orygen, The National Centre of Excellence in Youth Mental Health, University of Melbourne, Melbourne, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061926369","display_name":"Eduard Vieta","orcid":"https://orcid.org/0000-0002-0548-0053","observed_orcids":["https://orcid.org/0000-0002-0548-0053"]},"institutions":[{"id":"https://openalex.org/I4210090703","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental","ror":"https://ror.org/009byq155","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210090703","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Eduard Vieta","raw_affiliation_strings":["Bipolar Unit, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bipolar Unit, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain","institution_ids":["https://openalex.org/I4210090703","https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I71999127"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017280751","display_name":"Andre Ferrer Carvalho","orcid":"https://orcid.org/0000-0001-5593-2778","observed_orcids":["https://orcid.org/0000-0001-5593-2778"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]},{"id":"https://openalex.org/I243754102","display_name":"Universidade Federal do Cear\u00e1","ror":"https://ror.org/03srtnf24","country_code":"BR","type":"education","lineage":["https://openalex.org/I243754102"]}],"countries":["BR","IT"],"is_corresponding":true,"raw_author_name":"Andr\u00e9 F. Carvalho","raw_affiliation_strings":["Department of Clinical Medicine and Translational Psychiatry Research Group Faculty of Medicine Federal University of Cear\u00e1  Fortaleza Cear\u00e1 Brazil","Institute for clinical Research and Education in Medicine, I.R.E.M., Padova, Italy"],"raw_orcid":"https://orcid.org/0000-0001-5593-2778","affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine and Translational Psychiatry Research Group Faculty of Medicine Federal University of Cear\u00e1  Fortaleza Cear\u00e1 Brazil","institution_ids":["https://openalex.org/I243754102"]},{"raw_affiliation_string":"Institute for clinical Research and Education in Medicine, I.R.E.M., Padova, Italy","institution_ids":["https://openalex.org/I138689650"]}]}],"institutions":[],"countries_distinct_count":7,"institutions_distinct_count":21,"corresponding_author_ids":["https://openalex.org/A5017280751"],"corresponding_institution_ids":["https://openalex.org/I138689650","https://openalex.org/I243754102"],"apc_list":{"value":4730,"currency":"USD","value_usd":4730},"apc_paid":null,"fwci":2.0316,"has_fulltext":true,"cited_by_count":195,"citation_normalized_percentile":{"value":0.89038786,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"19","issue":"2","first_page":"84","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10786","display_name":"Maternal Mental Health During Pregnancy and Postpartum","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":1.0},{"id":"https://openalex.org/keywords/environmental-risk-factors","display_name":"environmental risk factors","score":1.0},{"id":"https://openalex.org/keywords/irritable-bowel-syndrome","display_name":"irritable bowel syndrome","score":0.9850000143051147},{"id":"https://openalex.org/keywords/childhood-adversity","display_name":"childhood adversity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":1.0},{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.9900000095367432},{"id":"https://openalex.org/keywords/bias-in-meta-analysis","display_name":"meta-analysis bias","score":0.42500001192092896},{"id":"https://openalex.org/keywords/heterogeneity","display_name":"heterogeneity","score":0.5120000243186951}],"concepts":[{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.6362436413764954},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.5910014510154724},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.5407893657684326},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4215081036090851},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4106055796146393},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3946932256221771},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3166913390159607},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16130384802818298},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.1260705292224884},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11969834566116333},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000078202","descriptor_name":"Systematic Reviews as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015201","descriptor_name":"Meta-Analysis as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064887","descriptor_name":"Observational Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1111/bdi.12490","doi":"https://doi.org/10.1111/bdi.12490","is_oa":true,"landing_page_url":"https://doi.org/10.1111/bdi.12490","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bdi.12490","source":{"id":"https://openalex.org/S58085280","display_name":"Bipolar Disorders","issn_l":"1398-5647","issn":["1398-5647","1399-5618"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bipolar Disorders","raw_type":"journal-article"},{"id":"pmid:28470927","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28470927","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bipolar disorders","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/ba7712ae-88a6-46eb-b362-6e59e5930f4d","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/ba7712ae-88a6-46eb-b362-6e59e5930f4d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bortolato, B, K\u00f6hler, C A, Evangelou, E, Le\u00f3n-Caballero, J, Solmi, M, Stubbs, B, Belbasis, L, Pacchiarotti, I, Kessing, L V, Berk, M, Vieta, E & Carvalho, A F 2017, 'Systematic assessment of environmental risk factors for bipolar disorder : an umbrella review of systematic reviews and meta-analyses', Bipolar Disorders, vol. 19, no. 2, pp. 84-96. https://doi.org/10.1111/bdi.12490","raw_type":"info:eu-repo/semantics/review"},{"id":"pmh:oai:repositorio.ufc.br:riufc/25065","doi":null,"is_oa":true,"landing_page_url":"http://www.repositorio.ufc.br/handle/riufc/25065","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UFC","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:figshare.com:article/20851738","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Systematic_assessment_of_environmental_risk_factors_for_bipolar_disorder_an_umbrella_review_of_systematic_reviews_and_meta-analyses/20851738","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/292573","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11343/292573","pdf_url":null,"source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/deba6093-2ad6-4d9f-92ca-0012fd882577","doi":null,"is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/deba6093-2ad6-4d9f-92ca-0012fd882577","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bortolato, B, K\u00f6hler, C A, Evangelou, E, Le\u00f3n-Caballero, J, Solmi, M, Stubbs, B, Belbasis, L, Pacchiarotti, I, Kessing, L V, Berk, M, Vieta, E & Carvalho, A F 2017, 'Systematic assessment of environmental risk factors for bipolar disorder : an umbrella review of systematic reviews and meta-analyses', Bipolar Disorders, vol. 19, no. 2, pp. 84-96. https://doi.org/10.1111/bdi.12490","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.research.unipd.it:11577/3241069","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11577/3241069","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1111/bdi.12490","doi":"https://doi.org/10.1111/bdi.12490","is_oa":true,"landing_page_url":"https://doi.org/10.1111/bdi.12490","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bdi.12490","source":{"id":"https://openalex.org/S58085280","display_name":"Bipolar Disorders","issn_l":"1398-5647","issn":["1398-5647","1399-5618"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bipolar Disorders","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8876264389","display_name":"Novel therapies, risk pathways and prevention of mood disorders","funder_award_id":"1059660","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2611091509.pdf","grobid_xml":"https://content.openalex.org/works/W2611091509.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W49566797","https://openalex.org/W90475194","https://openalex.org/W835203098","https://openalex.org/W967662607","https://openalex.org/W1550453530","https://openalex.org/W1839739819","https://openalex.org/W1890493318","https://openalex.org/W1969682776","https://openalex.org/W1970541415","https://openalex.org/W1971233916","https://openalex.org/W1974109338","https://openalex.org/W1976681359","https://openalex.org/W1978097115","https://openalex.org/W1982228885","https://openalex.org/W1984344128","https://openalex.org/W1991704577","https://openalex.org/W2000151841","https://openalex.org/W2001871336","https://openalex.org/W2011526626","https://openalex.org/W2017418025","https://openalex.org/W2018245375","https://openalex.org/W2019936648","https://openalex.org/W2022223826","https://openalex.org/W2022820188","https://openalex.org/W2041069795","https://openalex.org/W2045384854","https://openalex.org/W2051205370","https://openalex.org/W2059962099","https://openalex.org/W2067369841","https://openalex.org/W2073644162","https://openalex.org/W2073677120","https://openalex.org/W2077761938","https://openalex.org/W2077771099","https://openalex.org/W2088662012","https://openalex.org/W2102629776","https://openalex.org/W2105913548","https://openalex.org/W2106483383","https://openalex.org/W2108116635","https://openalex.org/W2119790985","https://openalex.org/W2121734518","https://openalex.org/W2126930838","https://openalex.org/W2130029062","https://openalex.org/W2154174213","https://openalex.org/W2156463549","https://openalex.org/W2157823046","https://openalex.org/W2165315953","https://openalex.org/W2179769211","https://openalex.org/W2187103524","https://openalex.org/W2189748275","https://openalex.org/W2200569858","https://openalex.org/W2201776847","https://openalex.org/W2209170701","https://openalex.org/W2257349255","https://openalex.org/W2258842160","https://openalex.org/W2266830118","https://openalex.org/W2276687554","https://openalex.org/W2396653525","https://openalex.org/W2399219407","https://openalex.org/W2400490165","https://openalex.org/W2403713647","https://openalex.org/W2406426927","https://openalex.org/W2411793229","https://openalex.org/W2473956915","https://openalex.org/W2516013654","https://openalex.org/W2517571389","https://openalex.org/W2528979297","https://openalex.org/W2529294285","https://openalex.org/W2562159229","https://openalex.org/W4211069648","https://openalex.org/W4238215801"],"related_works":["https://openalex.org/W2209170701","https://openalex.org/W3027268342","https://openalex.org/W1974109338","https://openalex.org/W3112204200","https://openalex.org/W7212259781","https://openalex.org/W2793422984","https://openalex.org/W2481731237","https://openalex.org/W3173578818","https://openalex.org/W7147704107","https://openalex.org/W2510581119"],"abstract_inverted_index":{"OBJECTIVES:":[0],"The":[1],"pathophysiology":[2],"of":[3,26,38,72,96,113,118,209,230],"bipolar":[4],"disorder":[5],"is":[6],"likely":[7],"to":[8,21,62,66,203,244],"involve":[9],"both":[10,97],"genetic":[11],"and":[12,43,58,70,83,99,110,116,133,180,190,201,206,238],"environmental":[13,27,80,140,221,247],"risk":[14,28,45,81,141,153,165,193,222,248],"factors.":[15],"In":[16,32],"our":[17],"study,":[18],"we":[19,34,88],"aimed":[20],"perform":[22],"a":[23,152,164,207],"systematic":[24,68,136],"search":[25],"factors":[29,46,82,142,194,223,249],"for":[30,143,155,167,195,224,250],"BD.":[31,84,156,251],"addition,":[33],"assessed":[35,76],"possible":[36],"hints":[37],"bias":[39,120],"in":[40],"this":[41],"literature,":[42],"identified":[44],"supported":[47,169,184,197,213],"by":[48,94,170,185,198,214],"high":[49],"epidemiological":[50],"credibility.":[51],"METHODS:":[52],"We":[53],"searched":[54],"the":[55,106,128,246],"Pubmed/MEDLINE,":[56],"EMBASE":[57],"PsycInfo":[59],"databases":[60],"up":[61],"7":[63],"October":[64],"2016":[65],"identify":[67],"reviews":[69],"meta-analyses":[71,132,148,229],"observational":[73,231],"studies":[74,232,241],"that":[75,219],"associations":[77,150],"between":[78],"putative":[79],"For":[85],"each":[86],"meta-analysis,":[87],"estimated":[89],"its":[90],"summary":[91],"effect":[92],"size":[93],"means":[95],"random-":[98],"fixed-effects":[100],"models,":[101],"95%":[102,107,177],"confidence":[103],"intervals":[104],"(CIs),":[105],"prediction":[108],"interval,":[109],"heterogeneity.":[111],"Evidence":[112],"small-study":[114],"effects":[115],"excess":[117],"significance":[119],"was":[121,183],"also":[122],"assessed.":[123],"RESULTS:":[124],"Sixteen":[125],"publications":[126],"met":[127],"inclusion":[129],"criteria":[130],"(seven":[131],"nine":[134],"qualitative":[135],"reviews).":[137],"Fifty-one":[138],"unique":[139],"BD":[144,168,196,225],"were":[145,192,212,226,233],"evaluated.":[146],"Six":[147],"investigated":[149],"with":[151],"factor":[154,166],"Only":[157],"irritable":[158],"bowel":[159],"syndrome":[160],"(IBS)":[161],"emerged":[162],"as":[163],"convincing":[171],"evidence":[172],"(k=6;":[173],"odds":[174],"ratio":[175],"[OR]=2.48;":[176],"CI=2.35-2.61;":[178],"P<.001),":[179],"childhood":[181],"adversity":[182],"highly":[186],"suggestive":[187,199],"evidence.":[188,216],"Asthma":[189],"obesity":[191],"evidence,":[200],"seropositivity":[202],"Toxoplasma":[204],"gondii":[205],"history":[208],"head":[210],"injury":[211],"weak":[215],"CONCLUSIONS:":[217],"Notwithstanding":[218],"several":[220],"identified,":[227],"few":[228],"available.":[234],"Therefore,":[235],"further":[236],"well-designed":[237],"adequately":[239],"powered":[240],"are":[242],"necessary":[243],"map":[245]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":56},{"year":2022,"cited_by_count":26},{"year":2021,"cited_by_count":28},{"year":2020,"cited_by_count":28},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2017-05-12T00:00:00"}