{"id":"https://openalex.org/W2610696276","doi":"https://doi.org/10.1039/c7bm00266a","title":"Optimization of a polydopamine (PD)-based coating method and polydimethylsiloxane (PDMS) substrates for improved mouse embryonic stem cell (ESC) pluripotency maintenance and cardiac differentiation","display_name":"Optimization of a polydopamine (PD)-based coating method and polydimethylsiloxane (PDMS) substrates for improved mouse embryonic stem cell (ESC) pluripotency maintenance and cardiac differentiation","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2610696276","doi":"https://doi.org/10.1039/c7bm00266a","mag":"2610696276","pmid":"https://pubmed.ncbi.nlm.nih.gov/28509913"},"language":"en","primary_location":{"id":"doi:10.1039/c7bm00266a","doi":"https://doi.org/10.1039/c7bm00266a","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c7bm00266a","pdf_url":null,"source":{"id":"https://openalex.org/S2494179437","display_name":"Biomaterials Science","issn_l":"2047-4830","issn":["2047-4830","2047-4849"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009815987","display_name":"Jiayin Fu","orcid":"https://orcid.org/0000-0001-6671-6843","observed_orcids":["https://orcid.org/0000-0001-6671-6843"]},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Jiayin Fu","raw_affiliation_strings":["Division of Bioengineering","Nanyang Technological University","School of Chemical and Biomedical Engineering","Singapore 637457","Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637457"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Bioengineering","institution_ids":[]},{"raw_affiliation_string":"Nanyang Technological University","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"School of Chemical and Biomedical Engineering","institution_ids":[]},{"raw_affiliation_string":"Singapore 637457","institution_ids":[]},{"raw_affiliation_string":"Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637457","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011270646","display_name":"Yon Jin Chuah","orcid":"https://orcid.org/0000-0003-0579-6370","observed_orcids":["https://orcid.org/0000-0003-0579-6370"]},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Yon Jin Chuah","raw_affiliation_strings":["Division of Bioengineering","Nanyang Technological University","School of Chemical and Biomedical Engineering","Singapore 637457","Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637457"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Bioengineering","institution_ids":[]},{"raw_affiliation_string":"Nanyang Technological University","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"School of Chemical and Biomedical Engineering","institution_ids":[]},{"raw_affiliation_string":"Singapore 637457","institution_ids":[]},{"raw_affiliation_string":"Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637457","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039490410","display_name":"Wee Tong Ang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Wee Tong Ang","raw_affiliation_strings":["Division of Bioengineering","Nanyang Technological University","School of Chemical and Biomedical Engineering","Singapore 637457","Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637457"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Bioengineering","institution_ids":[]},{"raw_affiliation_string":"Nanyang Technological University","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"School of Chemical and Biomedical Engineering","institution_ids":[]},{"raw_affiliation_string":"Singapore 637457","institution_ids":[]},{"raw_affiliation_string":"Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637457","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Nan Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Nan Zheng","raw_affiliation_strings":["Division of Bioengineering","Nanyang Technological University","School of Chemical and Biomedical Engineering","Singapore 637457","Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637457"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Bioengineering","institution_ids":[]},{"raw_affiliation_string":"Nanyang Technological University","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"School of Chemical and Biomedical Engineering","institution_ids":[]},{"raw_affiliation_string":"Singapore 637457","institution_ids":[]},{"raw_affiliation_string":"Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637457","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048189450","display_name":"Dong\u2010An Wang","orcid":"https://orcid.org/0000-0002-7927-1422","observed_orcids":["https://orcid.org/0000-0002-7927-1422"]},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Dong-An Wang","raw_affiliation_strings":["Division of Bioengineering","Nanyang Technological University","School of Chemical and Biomedical Engineering","Singapore 637457","Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637457"],"raw_orcid":"https://orcid.org/0000-0002-7927-1422","affiliations":[{"raw_affiliation_string":"Division of Bioengineering","institution_ids":[]},{"raw_affiliation_string":"Nanyang Technological University","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"School of Chemical and Biomedical Engineering","institution_ids":[]},{"raw_affiliation_string":"Singapore 637457","institution_ids":[]},{"raw_affiliation_string":"Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637457","institution_ids":["https://openalex.org/I172675005"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5048189450"],"corresponding_institution_ids":["https://openalex.org/I172675005"],"apc_list":null,"apc_paid":null,"fwci":1.9483,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.86447673,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"5","issue":"6","first_page":"1156","last_page":"1173"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.8403000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.8403000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.06260000169277191,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.03099999949336052,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polydopamine-coating","display_name":"polydopamine coating","score":0.9810000061988831},{"id":"https://openalex.org/keywords/polydimethylsiloxane-substrate","display_name":"polydimethylsiloxane substrate","score":0.9150000214576721},{"id":"https://openalex.org/keywords/mouse-embryonic-stem-cells","display_name":"mouse embryonic stem cells","score":0.890999972820282},{"id":"https://openalex.org/keywords/pluripotency-maintenance","display_name":"pluripotency maintenance","score":0.9459999799728394},{"id":"https://openalex.org/keywords/cardiac-differentiation","display_name":"cardiac differentiation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/heart-on-a-chip","display_name":"heart-on-a-chip","score":0.8640000224113464},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.6990000009536743},{"id":"https://openalex.org/keywords/surface-hydrophobicity","display_name":"surface hydrophobicity","score":0.8479999899864197},{"id":"https://openalex.org/keywords/gelatin-coating","display_name":"gelatin coating","score":0.8090000152587891},{"id":"https://openalex.org/keywords/biochips","display_name":"biochips","score":0.5849999785423279},{"id":"https://openalex.org/keywords/microfluidics","display_name":"microfluidics","score":0.6290000081062317},{"id":"https://openalex.org/keywords/high-throughput-drug-screening","display_name":"high-throughput drug screening","score":0.7960000038146973},{"id":"https://openalex.org/keywords/cardiac-tissue-engineering","display_name":"cardiac tissue engineering","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C2779849746","wikidata":"https://www.wikidata.org/wiki/Q411955","display_name":"Polydimethylsiloxane","level":2,"score":0.8824837803840637},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.8632704019546509},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5700064301490784},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5687505602836609},{"id":"https://openalex.org/C2781448156","wikidata":"https://www.wikidata.org/wiki/Q1570182","display_name":"Coating","level":2,"score":0.526941180229187},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5135005116462708},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.424888014793396},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27932119369506836},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21492096781730652},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07835093140602112},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000066450","descriptor_name":"Mouse Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D000066450","descriptor_name":"Mouse Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004129","descriptor_name":"Dimethylpolysiloxanes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005780","descriptor_name":"Gelatin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020099","descriptor_name":"Coated Materials, Biocompatible","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056656","descriptor_name":"Lab-On-A-Chip Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1039/c7bm00266a","doi":"https://doi.org/10.1039/c7bm00266a","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c7bm00266a","pdf_url":null,"source":{"id":"https://openalex.org/S2494179437","display_name":"Biomaterials Science","issn_l":"2047-4830","issn":["2047-4830","2047-4849"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials Science","raw_type":"journal-article"},{"id":"pmid:28509913","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28509913","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials science","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W365630364","https://openalex.org/W1537459781","https://openalex.org/W1570846537","https://openalex.org/W1572820526","https://openalex.org/W1948639450","https://openalex.org/W1956570055","https://openalex.org/W1973819505","https://openalex.org/W1981791383","https://openalex.org/W1984828462","https://openalex.org/W1987568997","https://openalex.org/W1996833161","https://openalex.org/W2002053852","https://openalex.org/W2002828554","https://openalex.org/W2008827477","https://openalex.org/W2011844821","https://openalex.org/W2016263863","https://openalex.org/W2021366288","https://openalex.org/W2028339715","https://openalex.org/W2029231027","https://openalex.org/W2030433820","https://openalex.org/W2037314810","https://openalex.org/W2037660499","https://openalex.org/W2058206852","https://openalex.org/W2060613028","https://openalex.org/W2062850928","https://openalex.org/W2067487010","https://openalex.org/W2067897176","https://openalex.org/W2069019884","https://openalex.org/W2072067362","https://openalex.org/W2074267926","https://openalex.org/W2076994662","https://openalex.org/W2086970036","https://openalex.org/W2092858957","https://openalex.org/W2093082572","https://openalex.org/W2095135703","https://openalex.org/W2099423350","https://openalex.org/W2100454719","https://openalex.org/W2107542980","https://openalex.org/W2110015307","https://openalex.org/W2110148884","https://openalex.org/W2110947634","https://openalex.org/W2112156060","https://openalex.org/W2115008041","https://openalex.org/W2124612875","https://openalex.org/W2128085444","https://openalex.org/W2129764832","https://openalex.org/W2133501984","https://openalex.org/W2137116096","https://openalex.org/W2141241503","https://openalex.org/W2151853866","https://openalex.org/W2152585695","https://openalex.org/W2154421213","https://openalex.org/W2154577831","https://openalex.org/W2156555850","https://openalex.org/W2162675383","https://openalex.org/W2166388268","https://openalex.org/W2167836626","https://openalex.org/W2169859308","https://openalex.org/W2170560537","https://openalex.org/W2195589116","https://openalex.org/W2213652914","https://openalex.org/W2536238820","https://openalex.org/W2554771871"],"related_works":["https://openalex.org/W2726659137","https://openalex.org/W4224443989","https://openalex.org/W2549515831","https://openalex.org/W3138273084","https://openalex.org/W7133050403","https://openalex.org/W2895205987","https://openalex.org/W4406853065","https://openalex.org/W2195589116","https://openalex.org/W2739254257","https://openalex.org/W7128705584"],"abstract_inverted_index":{"Myocardiocyte":[0],"derived":[1],"from":[2],"pluripotent":[3,9],"stem":[4,10,15],"cells,":[5],"such":[6],"as":[7,41,174,176],"induced":[8],"cells":[11,16],"(iPSCs)":[12],"and":[13,39,63,79,109,115,137,172,222,232,249,259],"embryonic":[14],"(ESCs),":[17],"is":[18,33,53,83],"a":[19,31,42,54,125,270],"promising":[20],"cell":[21,73,87],"source":[22],"for":[23,44,57,85,105,169,273],"cardiac":[24,110,138,202,260],"tissue":[25],"engineering.":[26],"Combined":[27],"with":[28,128,159,226],"microfluidic":[29],"technologies,":[30],"heart-on-a-chip":[32,272],"very":[34],"likely":[35],"to":[36,235,253,266],"be":[37],"developed":[38],"function":[40],"platform":[43],"high":[45],"throughput":[46],"drug":[47,275],"screening.":[48],"Polydimethylsiloxane":[49],"(PDMS)":[50],"silicone":[51],"elastomer":[52],"widely-used":[55],"biomaterial":[56],"the":[58,67,76,90,96,99,133,160,182,187,194,201,205,210,218,236,239,243,267,278],"investigation":[59],"of":[60,92,98,204,269],"cell-substrate":[61],"interactions":[62],"biochip":[64],"fabrication.":[65],"However,":[66],"intrinsic":[68],"PDMS":[69,77,80,93,112,146,164,184,198,214,223],"surface":[70,81,113,151],"hydrophobicity":[71],"inhibits":[72],"adhesion":[74,171],"on":[75,140,157,193,209,217,242],"surface,":[78],"modification":[82,114],"required":[84],"effective":[86],"adhesion.":[88],"Meanwhile,":[89],"formulation":[91,116],"also":[94],"affects":[95],"behaviors":[97],"cells.":[100],"To":[101],"fabricate":[102],"PDMS-based":[103],"biochips":[104,225,244],"ESC":[106,134,170,188,256],"pluripotency":[107,189,257],"maintenance":[108,258],"differentiation,":[111],"were":[117,230],"optimized":[118,219],"in":[119,149,277],"this":[120],"study.":[121],"We":[122],"found":[123],"that":[124],"polydopamine":[126],"(PD)":[127],"gelatin":[129],"coating":[130,220],"greatly":[131],"improved":[132,255],"adhesion,":[135],"proliferation":[136,173],"differentiation":[139,203],"its":[141],"surface.":[142],"In":[143],"addition,":[144],"different":[145,155,228],"substrates":[147],"varied":[148],"their":[150],"properties,":[152],"which":[153],"had":[154],"impacts":[156],"ESCs,":[158],"40":[161,211],":":[162,196,212],"1":[163,197,213],"substrate":[165],"being":[166],"more":[167,251],"favorable":[168],"well":[175],"embryoid":[177],"body":[178],"(EB)":[179],"attachment":[180],"than":[181],"other":[183],"substrates.":[185],"Moreover,":[186],"was":[190,207],"best":[191],"maintained":[192],"5":[195],"substrate,":[199],"while":[200],"ESCs":[206],"optimal":[208],"substrate.":[215],"Based":[216],"method":[221],"formulation,":[224],"two":[227],"designs":[229],"fabricated":[231],"evaluated.":[233],"Compared":[234],"single":[237],"channels,":[238],"multiple":[240],"channels":[241],"could":[245],"provide":[246],"larger":[247],"areas":[248],"accommodate":[250],"nutrients":[252],"support":[254],"differentiation.":[261],"These":[262],"results":[263],"may":[264],"contribute":[265],"development":[268],"real":[271],"high-throughput":[274],"screening":[276],"future.":[279]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-05-12T00:00:00"}
