{"id":"https://openalex.org/W2610690787","doi":"https://doi.org/10.1161/atvb.32.suppl_1.a273","title":"Abstract 273: Phenotypic Differences Between Human Subcutaneous and Perivascular Adipose Tissues","display_name":"Abstract 273: Phenotypic Differences Between Human Subcutaneous and Perivascular Adipose Tissues","publication_year":2012,"publication_date":"2012-05-01","ids":{"openalex":"https://openalex.org/W2610690787","doi":"https://doi.org/10.1161/atvb.32.suppl_1.a273","mag":"2610690787"},"language":"en","primary_location":{"id":"doi:10.1161/atvb.32.suppl_1.a273","doi":"https://doi.org/10.1161/atvb.32.suppl_1.a273","is_oa":false,"landing_page_url":"https://doi.org/10.1161/atvb.32.suppl_1.a273","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037347196","display_name":"Christine R. Mauro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine R Mauro","raw_affiliation_strings":["Vascular Surgery, Brigham and Women\u2019s Hosp, Boston, MA","Christine R Mauro"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Surgery, Brigham and Women\u2019s Hosp, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Christine R Mauro","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054973665","display_name":"Godfrey Ilonzo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Godfrey Ilonzo","raw_affiliation_strings":["Vascular Surgery, Brigham and Women\u2019s Hosp, Boston, MA","Godfrey Ilonzo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Surgery, Brigham and Women\u2019s Hosp, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Godfrey Ilonzo","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103114367","display_name":"Binh Nguyen","orcid":"https://orcid.org/0009-0000-6543-6698","observed_orcids":["https://orcid.org/0009-0000-6543-6698"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Binh Nguyen","raw_affiliation_strings":["Vascular Surgery, Brigham and Women\u2019s Hosp, Boston, MA","Binh Nguyen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Surgery, Brigham and Women\u2019s Hosp, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Binh Nguyen","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048609057","display_name":"Peng Yu","orcid":"https://orcid.org/0000-0003-4942-7139","observed_orcids":["https://orcid.org/0000-0003-4942-7139"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peng Yu","raw_affiliation_strings":["Vascular Surgery, Brigham and Women\u2019s Hosp, Boston, MA","Peng Yu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Surgery, Brigham and Women\u2019s Hosp, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Peng Yu","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009771110","display_name":"Ming Tao","orcid":"https://orcid.org/0000-0003-1175-5380","observed_orcids":["https://orcid.org/0000-0003-1175-5380"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming Tao","raw_affiliation_strings":["Vascular Surgery, Brigham and Women\u2019s Hosp, Boston, MA","Ming Tao"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Surgery, Brigham and Women\u2019s Hosp, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Ming Tao","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074192669","display_name":"Ian Gao","orcid":"https://orcid.org/0000-0002-4622-5462","observed_orcids":["https://orcid.org/0000-0002-4622-5462"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ian Gao","raw_affiliation_strings":["Vascular Surgery, Brigham and Women\u2019s Hosp, Boston, MA","Ian Gao"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Surgery, Brigham and Women\u2019s Hosp, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Ian Gao","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003733519","display_name":"Michael A. Seidman","orcid":"https://orcid.org/0000-0002-9594-827X","observed_orcids":["https://orcid.org/0000-0002-9594-827X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A Seidman","raw_affiliation_strings":["Pathology, Brigham and Women\u2019s Hosp, Boston, MA","Michael A Seidman"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Brigham and Women\u2019s Hosp, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Michael A Seidman","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111825553","display_name":"Louis L. Nguyen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louis L Nguyen","raw_affiliation_strings":["Vascular Surgery, Brigham and Women\u2019s Hosp, Boston, MA","Louis L Nguyen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Surgery, Brigham and Women\u2019s Hosp, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Louis L Nguyen","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021660019","display_name":"Charles Keith Ozaki","orcid":"https://orcid.org/0000-0001-9906-6218","observed_orcids":["https://orcid.org/0000-0001-9906-6218"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C K Ozaki","raw_affiliation_strings":["Vascular Surgery, Brigham and Women\u2019s Hosp, Boston, MA","C K Ozaki"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Surgery, Brigham and Women\u2019s Hosp, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"C K Ozaki","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1283280774"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":"suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12979","display_name":"Cardiovascular Disease and Adiposity","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12979","display_name":"Cardiovascular Disease and Adiposity","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subcutaneous-adipose-tissue","display_name":"subcutaneous adipose tissue","score":0.9980000257492065},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.890999972820282},{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":1.0},{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.8159999847412109},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.8119999766349792},{"id":"https://openalex.org/keywords/age","display_name":"age","score":0.5839999914169312},{"id":"https://openalex.org/keywords/peripheral-vascular-disease","display_name":"peripheral vascular disease","score":0.8709999918937683},{"id":"https://openalex.org/keywords/lower-extremity-amputation","display_name":"lower limb amputation","score":0.8870000243186951},{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.7940000295639038},{"id":"https://openalex.org/keywords/adipose-tissue-hormones","display_name":"adipose tissue hormones","score":0.39500001072883606}],"concepts":[{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.9332181215286255},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.7136783599853516},{"id":"https://openalex.org/C2776782570","wikidata":"https://www.wikidata.org/wiki/Q357439","display_name":"Adiponectin","level":4,"score":0.7011760473251343},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6109439134597778},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5533502101898193},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48408380150794983},{"id":"https://openalex.org/C2779760629","wikidata":"https://www.wikidata.org/wiki/Q419499","display_name":"Resistin","level":5,"score":0.4663578271865845},{"id":"https://openalex.org/C194832188","wikidata":"https://www.wikidata.org/wiki/Q2638593","display_name":"Adipokine","level":4,"score":0.4235183298587799},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3511708974838257},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.1698491871356964},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.14143431186676025}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/atvb.32.suppl_1.a273","doi":"https://doi.org/10.1161/atvb.32.suppl_1.a273","is_oa":false,"landing_page_url":"https://doi.org/10.1161/atvb.32.suppl_1.a273","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6600000262260437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2158040236","https://openalex.org/W2317741169","https://openalex.org/W2046560558","https://openalex.org/W2765648317","https://openalex.org/W2790865612","https://openalex.org/W2054745060","https://openalex.org/W4403765449","https://openalex.org/W2128429838","https://openalex.org/W2073916686","https://openalex.org/W2080902689"],"abstract_inverted_index":{"Objective:":[0],"Human":[1],"adipose":[2,9,38,53,61,111,142,156,164,190],"lies":[3],"in":[4,106,163,195],"specific":[5],"anatomic":[6],"depots.":[7],"Peri-vascular":[8],"appears":[10],"unique":[11,186],"and":[12,36,59,74,90,97,124,136,154,168],"impacts":[13],"blood":[14],"vessel":[15],"biology,":[16],"but":[17],"direct":[18,171],"human":[19,34,57,172],"data":[20,115],"is":[21],"limited.":[22],"In":[23],"view":[24],"of":[25,49,79,188],"their":[26],"theorized":[27],"roles,":[28],"we":[29],"tested":[30],"the":[31,47,80,161,185],"hypothesis":[32],"that":[33,174],"peri-vascular":[35,58,110,131,141,155,189],"subcutaneous":[37,60,107,153],"tissue":[39,176],"hold":[40,178],"distinct":[41,179],"phenotypic":[42],"signatures.":[43],"We":[44],"also":[45],"evaluated":[46],"impact":[48],"clinical":[50,122],"parameters":[51],"on":[52],"phenotype.":[54],"Methods:":[55],"Fresh":[56],"tissues":[62],"were":[63,102,116],"collected":[64],"intra-operatively":[65],"from":[66,157],"patients":[67],"undergoing":[68],"major":[69],"lower":[70],"extremity":[71],"amputation":[72,159],"(n=27)":[73],"assayed":[75],"for":[76],"protein":[77],"levels":[78],"adipose-associated":[81],"mediators":[82],"IL-6,":[83],"IL-8,":[84],"leptin,":[85],"TNF-\u03b1,":[86],"MCP-1,":[87],"adiponectin,":[88],"resistin":[89],"PAI-1.":[91],"Results:":[92],"Leptin":[93],"(2.4":[94],"fold,":[95,100],"p=0.045)":[96],"adiponectin":[98,143,169],"(1.8":[99],"p=0.007)":[101],"significantly":[103],"more":[104],"abundant":[105],"compared":[108],"to":[109,118],"(Table":[112],"I).":[113],"Clinical":[114],"used":[117],"model":[119],"associations":[120],"between":[121,152],"characteristics":[123],"mediator":[125],"levels.":[126],"Age":[127],"positively":[128],"correlated":[129,139],"with":[130,140],"PAI-1":[132],"expression":[133],"(\u03b2=0.64,":[134],"p=0.042),":[135],"hyperlipidemia":[137],"negatively":[138],"(\u03b2=-1.18,":[144],"p=0.039).":[145],"Conclusions:":[146],"While":[147],"significant":[148],"similarity":[149],"was":[150],"observed":[151],"leg":[158],"patients,":[160],"differential":[162],"derived":[165],"hormones":[166],"leptin":[167],"provides":[170],"evidence":[173],"these":[175],"compartments":[177],"biologic":[180],"roles.":[181],"Further":[182],"investigation":[183],"into":[184],"nature":[187],"may":[191],"provide":[192],"meaningful":[193],"guidance":[194],"managing":[196],"peripheral":[197],"vascular":[198],"disease.":[199]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2017-05-12T00:00:00"}