{"id":"https://openalex.org/W2610474792","doi":"https://doi.org/10.1186/s12885-017-3297-2","title":"The E2F4 prognostic signature predicts pathological response to neoadjuvant chemotherapy in breast cancer patients","display_name":"The E2F4 prognostic signature predicts pathological response to neoadjuvant chemotherapy in breast cancer patients","publication_year":2017,"publication_date":"2017-05-02","ids":{"openalex":"https://openalex.org/W2610474792","doi":"https://doi.org/10.1186/s12885-017-3297-2","mag":"2610474792","pmid":"https://pubmed.ncbi.nlm.nih.gov/28464832"},"language":"en","primary_location":{"id":"doi:10.1186/s12885-017-3297-2","doi":"https://doi.org/10.1186/s12885-017-3297-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-017-3297-2","pdf_url":"https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-017-3297-2","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-017-3297-2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024814785","display_name":"Kenneth M. K. Mark","orcid":"https://orcid.org/0000-0003-1867-6212","observed_orcids":["https://orcid.org/0000-0003-1867-6212"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth M. K. Mark","raw_affiliation_strings":["Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, 03755, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, 03755, USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017653709","display_name":"Frederick S. Varn","orcid":"https://orcid.org/0000-0001-6307-016X","observed_orcids":["https://orcid.org/0000-0001-6307-016X"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederick S. Varn","raw_affiliation_strings":["Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, 03755, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, 03755, USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051431246","display_name":"Matthew H. Ung","orcid":"https://orcid.org/0000-0001-9820-6194","observed_orcids":["https://orcid.org/0000-0001-9820-6194"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew H. Ung","raw_affiliation_strings":["Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, 03755, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, 03755, USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101493059","display_name":"Qian Feng","orcid":"https://orcid.org/0000-0001-7088-9392","observed_orcids":["https://orcid.org/0000-0001-7088-9392"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Qian","raw_affiliation_strings":["Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, 200438, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, 200438, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082582585","display_name":"Chao Cheng","orcid":"https://orcid.org/0000-0002-5002-3417","observed_orcids":["https://orcid.org/0000-0002-5002-3417"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I4390039367","display_name":"Dartmouth Cancer Center","ror":"https://ror.org/044b05b34","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4390039367"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chao Cheng","raw_affiliation_strings":["Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Lebanon, NH, 03766, USA. chao.cheng@dartmouth.edu","Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, 03755, USA. chao.cheng@dartmouth.edu","Norris Cotton Cancer Center, Lebanon, NH, 03766, USA. chao.cheng@dartmouth.edu","Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Lebanon, NH, 03766, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Lebanon, NH, 03766, USA. chao.cheng@dartmouth.edu","institution_ids":["https://openalex.org/I107672454"]},{"raw_affiliation_string":"Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, 03755, USA. chao.cheng@dartmouth.edu","institution_ids":["https://openalex.org/I107672454"]},{"raw_affiliation_string":"Norris Cotton Cancer Center, Lebanon, NH, 03766, USA. chao.cheng@dartmouth.edu","institution_ids":["https://openalex.org/I4390039367"]},{"raw_affiliation_string":"Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Lebanon, NH, 03766, USA","institution_ids":["https://openalex.org/I107672454"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5082582585"],"corresponding_institution_ids":["https://openalex.org/I107672454","https://openalex.org/I4390039367"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":0.4912,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.5505556,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"17","issue":"1","first_page":"306","last_page":"306"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/e2f4","display_name":"E2F4","score":0.9599999785423279},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.6539999842643738},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.9670000076293945},{"id":"https://openalex.org/keywords/pathological-complete-response","display_name":"pathological complete response","score":0.9430000185966492},{"id":"https://openalex.org/keywords/prognostic-gene-signature","display_name":"prognostic gene signature","score":0.871999979019165},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.5170000195503235},{"id":"https://openalex.org/keywords/oncotype-dx","display_name":"Oncotype DX","score":0.7099999785423279},{"id":"https://openalex.org/keywords/mammaprint","display_name":"MammaPrint","score":1.0},{"id":"https://openalex.org/keywords/estrogen-receptor-status","display_name":"estrogen receptor status","score":0.9440000057220459},{"id":"https://openalex.org/keywords/breast-cancer-molecular-subtypes","display_name":"breast cancer molecular subtypes","score":0.800000011920929},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.8998478651046753},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7728577852249146},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.7530955076217651},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.7010994553565979},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6993021368980408},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6016502380371094},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5554757118225098},{"id":"https://openalex.org/C2778292576","wikidata":"https://www.wikidata.org/wiki/Q6991934","display_name":"Neoadjuvant therapy","level":4,"score":0.5036274790763855},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.34457308053970337}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020360","descriptor_name":"Neoadjuvant Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020360","descriptor_name":"Neoadjuvant Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020360","descriptor_name":"Neoadjuvant Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047369","descriptor_name":"Chromatin Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047369","descriptor_name":"Chromatin Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047369","descriptor_name":"Chromatin Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050704","descriptor_name":"E2F4 Transcription Factor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D050704","descriptor_name":"E2F4 Transcription Factor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D050704","descriptor_name":"E2F4 Transcription Factor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D050704","descriptor_name":"E2F4 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050704","descriptor_name":"E2F4 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050704","descriptor_name":"E2F4 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050704","descriptor_name":"E2F4 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050704","descriptor_name":"E2F4 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050704","descriptor_name":"E2F4 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050704","descriptor_name":"E2F4 Transcription Factor","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050704","descriptor_name":"E2F4 Transcription Factor","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050704","descriptor_name":"E2F4 Transcription Factor","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12885-017-3297-2","doi":"https://doi.org/10.1186/s12885-017-3297-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-017-3297-2","pdf_url":"https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-017-3297-2","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},{"id":"pmid:28464832","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28464832","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5414335","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5414335","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Cancer","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:7f87b7e060444d77a614679b0738ced6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7f87b7e060444d77a614679b0738ced6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Cancer, Vol 17, Iss 1, Pp 1-11 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12885-017-3297-2","doi":"https://doi.org/10.1186/s12885-017-3297-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-017-3297-2","pdf_url":"https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-017-3297-2","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8500000238418579,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1117573683","display_name":null,"funder_award_id":"#IRG-82-003-30","funder_id":"https://openalex.org/F4320306095","funder_display_name":"American Cancer Society"},{"id":"https://openalex.org/G1596248660","display_name":null,"funder_award_id":"T32-GM-008704","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3242082962","display_name":null,"funder_award_id":"UL1 TR001086","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G6981840230","display_name":"Molecular and Cellular Biology at Dartmouth","funder_award_id":"5t32gm008704-20","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2610474792.pdf","grobid_xml":"https://content.openalex.org/works/W2610474792.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1534849470","https://openalex.org/W1967724582","https://openalex.org/W1989644540","https://openalex.org/W1991531502","https://openalex.org/W1992369775","https://openalex.org/W2012614658","https://openalex.org/W2018669222","https://openalex.org/W2028059322","https://openalex.org/W2031967690","https://openalex.org/W2032968026","https://openalex.org/W2044702943","https://openalex.org/W2064086133","https://openalex.org/W2070237809","https://openalex.org/W2070775961","https://openalex.org/W2078429592","https://openalex.org/W2102461795","https://openalex.org/W2105882193","https://openalex.org/W2110266019","https://openalex.org/W2120742047","https://openalex.org/W2128648326","https://openalex.org/W2128985829","https://openalex.org/W2130333852","https://openalex.org/W2131915049","https://openalex.org/W2132144873","https://openalex.org/W2133764807","https://openalex.org/W2135423354","https://openalex.org/W2147703218","https://openalex.org/W2149900235","https://openalex.org/W2157250162","https://openalex.org/W2158501247","https://openalex.org/W2160450758","https://openalex.org/W2163563958","https://openalex.org/W2170469857","https://openalex.org/W2560367415","https://openalex.org/W4232750513","https://openalex.org/W4301159569"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W4238067486","https://openalex.org/W4295540420","https://openalex.org/W2365243064","https://openalex.org/W4309413642","https://openalex.org/W2779530153","https://openalex.org/W4323306248","https://openalex.org/W4246054013","https://openalex.org/W2941613202","https://openalex.org/W4402477283"],"abstract_inverted_index":{"BACKGROUND:":[0],"Neoadjuvant":[1],"chemotherapy":[2,72,94,104,131,187,264],"is":[3,23,233,245],"a":[4,216,221],"key":[5],"component":[6],"of":[7,97,110,129,138,147,203,262],"breast":[8,75,91,166],"cancer":[9,92,167],"treatment":[10,273],"regimens":[11],"and":[12,114,143,165,175,210,248],"pathologic":[13,140],"complete":[14,141],"response":[15,73,105,142,238],"to":[16,26,69,108,171,198,220,239,252],"this":[17,243],"therapy":[18,55],"varies":[19],"among":[20],"patients.":[21],"This":[22],"presumably":[24],"due":[25],"differences":[27],"in":[28,74,101,184,194,235,250,259],"the":[29,52,98,111,172,260],"molecular":[30,168],"mechanisms":[31],"that":[32,42,109,229],"underlie":[33],"each":[34],"tumor's":[35],"disease":[36],"pathology.":[37],"Developing":[38],"genomic":[39,67],"clinical":[40],"assays":[41,258],"accurately":[43],"categorize":[44],"responders":[45],"from":[46,215],"non-responders":[47],"can":[48],"provide":[49],"patients":[50,157],"with":[51,133],"most":[53],"effective":[54],"for":[56,84],"their":[57],"individual":[58,78],"disease.":[59,149],"METHODS:":[60],"We":[61],"applied":[62],"our":[63,178,204,230],"previously":[64],"developed":[65],"E2F4":[66,77,99,122,135,179,231],"signature":[68,100,180,205,218,232,244],"predict":[70],"neoadjuvant":[71,93,103,130,186,240,263],"cancer.":[76],"regulatory":[79],"activity":[80,123],"scores":[81,136,145],"were":[82],"calculated":[83],"1129":[85],"patient":[86,237],"samples":[87],"across":[88,208],"5":[89],"independent":[90],"datasets.":[95],"Accuracy":[96],"predicting":[102,185,236],"was":[106,125,206,211],"compared":[107,197],"Oncotype":[112,173],"DX":[113,174],"MammaPrint":[115,176],"predictive":[116,137,146],"signatures.":[117],"RESULTS:":[118],"In":[119],"all":[120,190],"datasets,":[121],"level":[124],"an":[126],"accurate":[127,234],"predictor":[128],"response,":[132,188,265],"high":[134],"achieving":[139],"low":[144],"residual":[148],"These":[150],"results":[151],"remained":[152],"significant":[153],"even":[154],"after":[155],"stratifying":[156],"by":[158],"estrogen":[159],"receptor":[160],"(ER)":[161],"status,":[162],"tumor":[163],"stage,":[164],"subtypes.":[169],"Compared":[170],"signatures,":[177],"achieved":[181],"similar":[182],"performance":[183,251],"though":[189],"signatures":[191],"performed":[192],"better":[193],"ER+":[195],"tumors":[196],"ER-":[199],"ones.":[200],"The":[201],"accuracy":[202],"reproducible":[207],"datasets":[209],"maintained":[212],"when":[213,270],"refined":[214,247],"199-gene":[217],"down":[219],"clinic-friendly":[222],"33-gene":[223],"panel.":[224],"CONCLUSION:":[225],"Overall,":[226],"we":[227],"show":[228],"chemotherapy.":[241],"As":[242],"more":[246],"comparable":[249],"other":[253],"clinically":[254],"available":[255],"gene":[256],"expression":[257],"prediction":[261],"it":[266],"should":[267],"be":[268],"considered":[269],"evaluating":[271],"potential":[272],"options.":[274]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}