{"id":"https://openalex.org/W2610322342","doi":"https://doi.org/10.21089/njhs.22.0088","title":"Drug Induced Pure White Cell Aplasia: A Case Report and Review of Literature","display_name":"Drug Induced Pure White Cell Aplasia: A Case Report and Review of Literature","publication_year":2017,"publication_date":"2017-05-02","ids":{"openalex":"https://openalex.org/W2610322342","doi":"https://doi.org/10.21089/njhs.22.0088","mag":"2610322342"},"language":"en","primary_location":{"id":"doi:10.21089/njhs.22.0088","doi":"https://doi.org/10.21089/njhs.22.0088","is_oa":true,"landing_page_url":"http://doi.org/10.21089/njhs.22.0088","pdf_url":"https://doi.org/10.21089/njhs.22.0088","source":{"id":"https://openalex.org/S4210205398","display_name":"National Journal of Health Sciences","issn_l":"2519-7053","issn":["2519-7053","2519-7878"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"National Journal of Health Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.21089/njhs.22.0088","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075591162","display_name":"Aisha Jamal","orcid":"https://orcid.org/0000-0001-5022-7498","observed_orcids":["https://orcid.org/0000-0001-5022-7498"]},"institutions":[{"id":"https://openalex.org/I4210156346","display_name":"National Institute Of Blood Disease and Bone Marrow Transplantation","ror":"https://ror.org/05tn8z305","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I4210156346"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Aisha Jamal","raw_affiliation_strings":["Department of Adult Clinical Haematology, National Institute of Blood Diseases and Bone Marrow Transplantation, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Adult Clinical Haematology, National Institute of Blood Diseases and Bone Marrow Transplantation, Karachi, Pakistan","institution_ids":["https://openalex.org/I4210156346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072635468","display_name":"Uzma Zaidi","orcid":"https://orcid.org/0000-0003-1593-196X","observed_orcids":["https://orcid.org/0000-0003-1593-196X"]},"institutions":[{"id":"https://openalex.org/I4210156346","display_name":"National Institute Of Blood Disease and Bone Marrow Transplantation","ror":"https://ror.org/05tn8z305","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I4210156346"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Uzma Zaidi","raw_affiliation_strings":["Department of Adult Clinical Haematology, National Institute of Blood Diseases and Bone Marrow Transplantation, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Adult Clinical Haematology, National Institute of Blood Diseases and Bone Marrow Transplantation, Karachi, Pakistan","institution_ids":["https://openalex.org/I4210156346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047531680","display_name":"Jawad Hassan","orcid":"https://orcid.org/0000-0002-9670-4576","observed_orcids":["https://orcid.org/0000-0002-9670-4576"]},"institutions":[{"id":"https://openalex.org/I4210156346","display_name":"National Institute Of Blood Disease and Bone Marrow Transplantation","ror":"https://ror.org/05tn8z305","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I4210156346"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Jawad Hasan Kazmi","raw_affiliation_strings":["Department of Diagnostic Haematology, National Institute of Blood Diseases and Bone Marrow Transplantation, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic Haematology, National Institute of Blood Diseases and Bone Marrow Transplantation, Karachi, Pakistan","institution_ids":["https://openalex.org/I4210156346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083548590","display_name":"Munira Borhany","orcid":"https://orcid.org/0000-0001-7867-1275","observed_orcids":["https://orcid.org/0000-0001-7867-1275","https://orcid.org/0000-0002-1526-1620"]},"institutions":[{"id":"https://openalex.org/I4210156346","display_name":"National Institute Of Blood Disease and Bone Marrow Transplantation","ror":"https://ror.org/05tn8z305","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I4210156346"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Munira Borhany","raw_affiliation_strings":["Department of Adult Clinical Haematology, National Institute of Blood Diseases and Bone Marrow Transplantation, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Adult Clinical Haematology, National Institute of Blood Diseases and Bone Marrow Transplantation, Karachi, Pakistan","institution_ids":["https://openalex.org/I4210156346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057897337","display_name":"Quratulain Rizvi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156346","display_name":"National Institute Of Blood Disease and Bone Marrow Transplantation","ror":"https://ror.org/05tn8z305","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I4210156346"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Quratulain Rizvi","raw_affiliation_strings":["Department of Adult Clinical Haematology, National Institute of Blood Diseases and Bone Marrow Transplantation, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Adult Clinical Haematology, National Institute of Blood Diseases and Bone Marrow Transplantation, Karachi, Pakistan","institution_ids":["https://openalex.org/I4210156346"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077288071","display_name":"Tahir Sultan Shamsi","orcid":"https://orcid.org/0000-0001-7667-5838","observed_orcids":["https://orcid.org/0000-0001-7667-5838"]},"institutions":[{"id":"https://openalex.org/I4210156346","display_name":"National Institute Of Blood Disease and Bone Marrow Transplantation","ror":"https://ror.org/05tn8z305","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I4210156346"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Tahir Shamsi","raw_affiliation_strings":["Department of Adult Clinical Haematology, National Institute of Blood Diseases and Bone Marrow Transplantation, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Adult Clinical Haematology, National Institute of Blood Diseases and Bone Marrow Transplantation, Karachi, Pakistan","institution_ids":["https://openalex.org/I4210156346"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210156346"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"2","issue":"2","first_page":"88","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13374","display_name":"Hematological disorders and diagnostics","score":0.042100001126527786,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amodiaquine","display_name":"amodiaquine","score":0.9869999885559082},{"id":"https://openalex.org/keywords/febrile-neutropenia","display_name":"febrile neutropenia","score":0.9399999976158142},{"id":"https://openalex.org/keywords/oral-candidiasis","display_name":"oral candidiasis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/agranulocytosis","display_name":"agranulocytosis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/bone-marrow-findings","display_name":"bone marrow findings","score":0.4740000069141388},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6897892355918884},{"id":"https://openalex.org/C56273599","wikidata":"https://www.wikidata.org/wiki/Q3122841","display_name":"White (mutation)","level":3,"score":0.5114997625350952},{"id":"https://openalex.org/C2778368355","wikidata":"https://www.wikidata.org/wiki/Q5488","display_name":"Aplasia","level":2,"score":0.45968174934387207},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3996734321117401},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.28791072964668274},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.17445021867752075},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17394864559173584},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21089/njhs.22.0088","doi":"https://doi.org/10.21089/njhs.22.0088","is_oa":true,"landing_page_url":"http://doi.org/10.21089/njhs.22.0088","pdf_url":"https://doi.org/10.21089/njhs.22.0088","source":{"id":"https://openalex.org/S4210205398","display_name":"National Journal of Health Sciences","issn_l":"2519-7053","issn":["2519-7053","2519-7878"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"National Journal of Health Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.21089/njhs.22.0088","doi":"https://doi.org/10.21089/njhs.22.0088","is_oa":true,"landing_page_url":"http://doi.org/10.21089/njhs.22.0088","pdf_url":"https://doi.org/10.21089/njhs.22.0088","source":{"id":"https://openalex.org/S4210205398","display_name":"National Journal of Health Sciences","issn_l":"2519-7053","issn":["2519-7053","2519-7878"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"National Journal of Health Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2610322342.pdf","grobid_xml":"https://content.openalex.org/works/W2610322342.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W203012397","https://openalex.org/W1527533153","https://openalex.org/W1971165304","https://openalex.org/W1973214561","https://openalex.org/W1981480924","https://openalex.org/W2000385071","https://openalex.org/W2030791487","https://openalex.org/W2037190157","https://openalex.org/W2043969235","https://openalex.org/W2049088555","https://openalex.org/W2081121645","https://openalex.org/W2085921496","https://openalex.org/W2101739432","https://openalex.org/W2171894723","https://openalex.org/W4298837934"],"related_works":["https://openalex.org/W1973214561","https://openalex.org/W2165551995","https://openalex.org/W4366768350","https://openalex.org/W3178121426","https://openalex.org/W2419445213","https://openalex.org/W2006605221","https://openalex.org/W3216732905","https://openalex.org/W2148956663","https://openalex.org/W4408230470","https://openalex.org/W2051374049"],"abstract_inverted_index":{"Pure":[0],"White":[1],"Cell":[2],"Aplasia":[3],"(PWCA)":[4],"is":[5],"an":[6],"extremely":[7],"rare":[8],"haematological":[9],"entity.Various":[10],"causes":[11,45],"have":[12],"been":[13],"implicated":[14],"in":[15,57],"its":[16],"pathogenesis.We":[17],"are":[18],"reporting":[19],"here":[20],"a":[21,24],"case":[22],"of":[23,36,46,60,64],"sixty":[25],"seven":[26],"years":[27],"old":[28],"female,":[29],"referred":[30],"to":[31],"us":[32],"with":[33,54],"the":[34,58],"concern":[35],"febrile":[37],"neutropenia":[38],"and":[39,56],"extensive":[40],"oral":[41],"candidiasis.Workup":[42],"for":[43],"secondary":[44],"agranulocytosis":[47],"was":[48,68],"negative.Bone":[49],"marrow":[50],"findings":[51],"were":[52],"consistent":[53],"PWCA,":[55],"presence":[59],"convincing":[61],"previous":[62],"history":[63],"amodiaquine":[65],"intake,":[66],"she":[67],"diagnosed":[69],"as":[70],"drug":[71],"(amodiaquine)":[72],"induced":[73],"PWCA.":[74]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2017-05-12T00:00:00"}