{"id":"https://openalex.org/W2610218399","doi":"https://doi.org/10.1182/blood.v128.22.2508.2508","title":"Plinabulin, a Novel Small Molecule That Ameliorates Chemotherapy-Induced Neutropenia, Is Administered on the Same Day of Chemotherapy and Has Anticancer Efficacy","display_name":"Plinabulin, a Novel Small Molecule That Ameliorates Chemotherapy-Induced Neutropenia, Is Administered on the Same Day of Chemotherapy and Has Anticancer Efficacy","publication_year":2016,"publication_date":"2016-12-02","ids":{"openalex":"https://openalex.org/W2610218399","doi":"https://doi.org/10.1182/blood.v128.22.2508.2508","mag":"2610218399"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v128.22.2508.2508","doi":"https://doi.org/10.1182/blood.v128.22.2508.2508","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v128.22.2508.2508","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061736755","display_name":"Douglas W. Blayney","orcid":"https://orcid.org/0000-0002-7931-4533","observed_orcids":["https://orcid.org/0000-0002-7931-4533"]},"institutions":[{"id":"https://openalex.org/I4390039303","display_name":"Stanford Cancer Institute","ror":"https://ror.org/014qe3j22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Douglas W Blayney","raw_affiliation_strings":["Stanford Cancer Institute, Stanford University, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Cancer Institute, Stanford University, Stanford, CA","institution_ids":["https://openalex.org/I4390039303","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036466135","display_name":"Lyudmila A. Bazhenova","orcid":"https://orcid.org/0000-0001-8764-4359","observed_orcids":["https://orcid.org/0000-0001-8764-4359"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lyudmila Bazhenova","raw_affiliation_strings":["University of California, San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110212659","display_name":"George Kenneth Lloyd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"G. Kenneth Lloyd","raw_affiliation_strings":["BeyondSpring Pharmaceuticals Inc., New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BeyondSpring Pharmaceuticals Inc., New York, NY","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070754234","display_name":"Lan Huang","orcid":"https://orcid.org/0000-0002-3140-4687","observed_orcids":["https://orcid.org/0000-0002-3140-4687"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lan Huang","raw_affiliation_strings":["BeyondSpring Pharmaceuticals Inc., New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BeyondSpring Pharmaceuticals Inc., New York, NY","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015687794","display_name":"Ramon W. Mohanlal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ramon Mohanlal","raw_affiliation_strings":["BeyondSpring Pharmaceuticals Inc., New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BeyondSpring Pharmaceuticals Inc., New York, NY","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5015687794","https://openalex.org/A5036466135","https://openalex.org/A5061736755","https://openalex.org/A5070754234","https://openalex.org/A5110212659"],"corresponding_institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039303","https://openalex.org/I97018004"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.3593,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.70921105,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"128","issue":"22","first_page":"2508","last_page":"2508"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plinabulin","display_name":"plinabulin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chemotherapy-induced-neutropenia","display_name":"chemotherapy-induced neutropenia","score":0.9639999866485596},{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":0.9919999837875366},{"id":"https://openalex.org/keywords/dendritic-cell-maturation","display_name":"dendritic cell maturation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.7639999985694885},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8539999723434448},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.9869999885559082},{"id":"https://openalex.org/keywords/neutrophil-survival","display_name":"neutrophil survival","score":0.8330000042915344},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.4880000054836273},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.5509999990463257},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.5099999904632568},{"id":"https://openalex.org/keywords/bone-pain","display_name":"bone pain","score":0.5090000033378601},{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.9544690847396851},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.8598698973655701},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7988426685333252},{"id":"https://openalex.org/C74133956","wikidata":"https://www.wikidata.org/wiki/Q4669824","display_name":"Absolute neutrophil count","level":4,"score":0.7008967995643616},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6311928033828735},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5725605487823486},{"id":"https://openalex.org/C2777767877","wikidata":"https://www.wikidata.org/wiki/Q419327","display_name":"Granulocyte colony-stimulating factor","level":3,"score":0.5676749348640442},{"id":"https://openalex.org/C2778850193","wikidata":"https://www.wikidata.org/wiki/Q3775974","display_name":"Febrile neutropenia","level":4,"score":0.5544007420539856},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.549098551273346},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.5324106216430664},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.4531481862068176},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.393723726272583},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38535749912261963},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.372580349445343},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34442710876464844},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34137535095214844}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v128.22.2508.2508","doi":"https://doi.org/10.1182/blood.v128.22.2508.2508","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v128.22.2508.2508","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2886406738","https://openalex.org/W2898196095","https://openalex.org/W2793797901","https://openalex.org/W4210381062","https://openalex.org/W4246018244","https://openalex.org/W4379654711","https://openalex.org/W2891882353","https://openalex.org/W3088375154","https://openalex.org/W2994028491","https://openalex.org/W3032793796"],"abstract_inverted_index":{"Abstract":[0],"Plinabulin":[1,11,119,229,260,309,321,364],"is":[2,322,328],"a":[3,42,123,262,323,356],"small":[4,325],"molecule":[5,326],"with":[6,181,199,236],"tumor-inhibiting":[7],"and":[8,16,21,58,158,247,277,284,379,397],"immune-enhancing":[9],"effects.":[10],"induces":[12],"dendritic":[13],"cell":[14],"maturation":[15],"cytokines":[17],"interleukin-1\u03b2":[18],"(IL-1\u03b2),":[19],"IL-6,":[20],"IL-12":[22],"production,":[23],"all":[24],"of":[25,44,49,63,133,160,170,179,197,256,279,334,345,359,387],"which":[26,65],"are":[27],"important":[28],"in":[29,189,222,254,275,355],"neutrophil":[30,204,223],"survival.":[31,142],"In":[32,55,80],"preclinical":[33],"studies,":[34],"plinabulin":[35,102,171,292,302,314,351],"prevented":[36],"docetaxel-":[37],"or":[38,96,108],"cyclophosphamide-induced":[39],"neutropenia":[40,184,202,238],"via":[41],"mechanism":[43],"action":[45],"different":[46],"from":[47,185],"that":[48,327],"granulocyte":[50],"colony-stimulating":[51],"factor":[52],"(G-CSF)":[53],"analogues.":[54],"phase":[56,82],"1":[57,129,347],"2":[59,83],"solid":[60],"tumor":[61],"trials":[62],"plinabulin,":[64,287],"included":[66,145],">140":[67],"patients,":[68],"routine":[69],"safety":[70,146,264],"laboratory":[71],"assessments":[72],"revealed":[73],"an":[74,370],"unexpected":[75],"protective":[76],"effect":[77],"against":[78],"neutropenia.":[79,336,389],"the":[81,168,177,195,211,219,232,266,332,342,366,385],"clinical":[84,233,401],"trial,":[85],"patients":[86,180,198,257,280],"were":[87],"randomized":[88],"to":[89,164,172,187,218,368,382,399],"receive":[90],"docetaxel":[91,97,165,173,215,244],"75":[92,98],"mg/m2":[93,99,106,111,283,286,294,304,311,316,361],"alone":[94],"(n=73)":[95],"followed":[100],"by":[101,122,338],"(NPI-2358-101)":[103],"at":[104,109],"30":[105,282,303,315],"(n=50)":[107],"20":[110,285,293,310,360],"(n=40),":[112],"repeated":[113],"every":[114],"3":[115,272],"weeks":[116],"(clinicaltrials.gov":[117],"NCT00630110).":[118],"was":[120,139,252,270],"given":[121,354],"30-minute":[124],"intravenous":[125],"(IV)":[126],"infusion,":[127],"starting":[128],"hour":[130],"after":[131,214],"administration":[132,216],"docetaxel.":[134],"The":[135,192],"primary":[136],"efficacy":[137],"endpoint":[138],"median":[140],"overall":[141],"Secondary":[143],"endpoints":[144],"assessments,":[147],"such":[148],"as":[149],"complete":[150],"blood":[151],"count":[152,205,224],"measurements,":[153],"on":[154,208,341],"Days":[155],"1,":[156],"8,":[157,210],"15":[159],"each":[161],"cycle.":[162,363],"Compared":[163],"treatment":[166],"alone,":[167],"addition":[169],"significantly":[174],"(p<0.0003)":[175],"reduced":[176,231],"proportion":[178],"grade":[182,200,271],"4":[183,201],"33.3%":[186],"4.6%":[188],"Cycle":[190],"1.":[191],"figure":[193],"shows":[194],"proportions":[196],"(absolute":[203],"[ANC]":[206],"<0.5x109/L)":[207],"Day":[209],"approximate":[212],"day":[213,344],"corresponding":[217],"largest":[220],"reduction":[221],"(Blackwell":[225],"Ann":[226],"Oncol":[227],"2015).":[228],"also":[230],"sequelae":[234],"associated":[235],"docetaxel-induced":[237],"(sepsis,":[239],"infections,":[240],"hospitalizations,":[241],"need":[242],"for":[243,331,384],"dose":[245,358],"reduction,":[246],"G-CSF":[248,383],"use).":[249],"Bone":[250],"pain":[251],"reported":[253],"4%":[255],"receiving":[258,281],"plinabulin.":[259],"had":[261],"favorable":[263],"profile;":[265],"most":[267],"prominent":[268],"finding":[269],"transient":[273],"hypertension":[274],"20%":[276],"5%":[278],"respectively.":[288],"Docetaxel":[289,299],"(n=65)":[290,300],"vs":[291,301,313],"(n=39):":[295],"p":[296,306,318],"=":[297,307,319],"0.00026":[298],"(n=47):":[305,317],"0.00018":[308],"(n=39)":[312],"0.68":[320],"novel":[324],"being":[329],"developed":[330],"mitigation":[333],"chemotherapy-induced":[335,388],"Administered":[337],"IV":[339],"infusion":[340],"same":[343],"(approximately":[346],"h":[348],"after)":[349],"chemotherapy,":[350],"will":[352],"be":[353,369],"single":[357],"per":[362],"has":[365],"potential":[367],"effective,":[371],"safe":[372],"(with":[373],"much":[374],"less":[375],"bone":[376],"pain),":[377],"cost-effective,":[378],"convenient":[380],"alternative":[381],"prevention":[386],"Figure":[390],"Figure.":[391],"Disclosures":[392],"Blayney:":[393],"BeyondSpring:":[394],"Other:":[395],"Travel":[396],"lodging":[398],"develop":[400],"trial":[402],"protocol.":[403],"Lloyd:BeyondSpring:":[404],"Consultancy.":[405],"Huang:BeyondSpring:":[406],"Employment.":[407,409],"Mohanlal:BeyondSpring:":[408]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2017-05-12T00:00:00"}